Cytotoxic activity of an octadecenoic acid extract from Euphorbia kansui (Euphorbiaceae) on human tumour cell strains

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 2, 2008, Pages 253-259

  Yu, Farong ^a,c   Lu, Shunqing ^b   Yu, Fahong ^c   Shi, Junnian ^a   McGuire, Peter M ^c   Wang, Rui ^d  

^a Gansu University of Political Science and Law   (China)

^b HUANGSHAN UNIVERSITY   (China)

^c UNIVERSITY OF FLORIDA   (United States)

^d LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EUPHORBIA KANSUI EXTRACT; FLUOROURACIL; LINOLEIC ACID; OLEIC ACID; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG INHIBITION; EUPHORBIA KANSUI; HUMAN; HUMAN CELL; PLANT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EUPHORBIA; FLOW CYTOMETRY; FLUOROURACIL; G0 PHASE; G1 PHASE; HUMANS; LINOLEIC ACIDS; OLEIC ACIDS; PLANT EXTRACTS;

EID: 38949185298     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.2.0015     Document Type: Article

References (34)

1. Anel, A., Naval, J., Desportes, P., Gonzalez, B., Uriel, J., Pineiro, A. (1992) Increased cytotoxicity of polyunsaturated fatty acids on human tumoral B and T-cell lines compared with normal lymphocytes. Leukemia 6: 680-688
2. Artwohl, M., Roden, M., Waldhäusl, W., Freudenthaler, A., Baumgartner-Parzer, S. M. (2004) Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. FASEB J. 18: 146-148
3. Badway, J. A., Curnutte, J. T., Robinson, J. M., Borde, C. B., Karnovsky, M. J., Karnovsky, M. L. (1984) Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. J. Biol. Chem. 259: 7870-7877
4. Begin, M. E., Das, U. N., Ells, G. (1986) Cytotoxic effects of essential fatty acids in mixed cultures of normal and malignant human cells. Prog. Lipid Res. 25: 573-576
5. Calder, P. C. (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am. J. Clin. Nutr. 83: 1505S-1519S
6. Chen, W. F., Huang, M. H., Tzang, C. H., Yang, M., Wong, M. S. (2003) Inhibitory actions of genistein in human breast cancer (MCF-7) cells. Biochim. Biophys. Acta 1638: 187-196
7. Chiu, L. C., Wong, E. Y., Ooi, V. E. (2004) Docosahexaenoic acid modulates different genes in cell cycle and apoptosis to control growth of human leukemia HL-60 cells. Int. J. Oncol. 25: 737-744
8. Deckelbaum, R. J., Worgall, T. S., Seo, T. (2006) N-3 fatty acids and gene expression. Am. J. Clin. Nutr. 83: 1520S-1535S
9. Deschner, E. E., Ruperto, J., Wong, G., Newmark, H. L. (1991) Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 12: 1193-1196
10. Di Leonard, A., Clarkin, K., Wahl, G. M. (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8: 2540-2551
11. Field, C. J., Schley, P. D. (2004) Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Am. J. Clin. Nutr. 79: 1190S-1198S
12. Finstad, H. S., Kolset, S. O., Holme, J. A., Wiger, R., Farrants, A. K., Blomhoff, R., Drevon, C. A. (1994) Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells. Blood 84: 3799-3809
13. Germain, E., Chajes, V., Cognault, S., Lhuillery, C., Bougnoux, P. (1998) Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line Mad-Mb-231: relationship to lipid peroxidation. Int. J. Cancer 75: 578-583
14. Harrell, M. D., Stimers, J. R. (2002) Differential effects of linoleic acid metabolites on cardiac sodium current. J. Pharmacol. Exp. Ther. 303: 347-355
15. Hartwell, L. H., Weinert, T. A. (1989) Checkpoints: controls that ensure the order of cell cycle events. Science 246: 629-634
16. Hengartner, M. O. (2000) The biochemistry of apoptosis. Nature 407: 770-776
17. Hohmann, J., Molnar, J., Redei, D., Evanics, F., Forgo, P., Kalman, A., Argay, G., Szabo, P. (2000) Discovery and biological evaluation of a new family of potent modulators of multidrug resistance: reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species. J. Med. Chem. 45: 2425-2431
18. Hunt, J. V., Dean, R. T. (1989) Free radical mediated degradation of proteins: the protective and deleterious effects of membranes. Biochem. Biophys. Res. Commun. 162: 1076-1084
19. Ikushima, S., Fujiwara, F., Todo, S., Imashuku, S. (1990) Gamma linolenic acid alters the cytotoxic activity of anticancer drugs on cultured human neuroblastoma cells. Anticancer Res. 10: 1055-1059
20. Kageyma, K., Onoyama, Y., Nakanishi, M., Matsui-Yuasa, I., Otani, S., Morisawa, S. (1989) Synergistic inhibition of DNA synthesis in Ehrlich ascites tumor cells by combination of unsaturated fatty acids and hyperthermia. J. Appl. Toxicol. 9: 1-4
21. King, Von R., Huang, W. L., Dyall, S. C., Curran, O. E., Priestley, J. V., Michael-Titus, A. T. (2006) Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J. Neurosci. 26: 4672-4680
22. Luk, S. C. W., Siu, S. W. F., Lai, C. K., Wu, Y. J., Pang, S. F. (2005) Cell cycle arrest by a natural product via G2/M checkpoint. Int. J. Med. Sci. 2: 64-69
23. Mengeaud, V., Nano, J. L., Fournel, S., Rampal, P. (1992) Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. Prostaglandins Leukot. Essent. Fatty Acids 47: 313-319
24. Nasu, K., Nishida, M., Ueda, T., Takai, N., Bing, S., Narahara, H., Miyakawa, I. (2005) Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis. Mol. Hum. Reprod. 11: 817-823
25. Nguyen, N., Glanzm, D., Glaesser, D. (2000) Fatty acid cytotoxicity of bovine lens epithelial cells: investigations on cell viability, ecto-ATPase, Na+, K+-ATPase and intracellular sodium concentrations. Exp. Eye Res. 71: 405-413
26. Palozza, P., Calviello, G., Maggiano, N., Lanza, P., Raneletti, F. O., Bartoli, G. M. (2000) Beta-carotene antagonizes the effects of eicosapentaenoic acid on cell growth and lipid peroxidation in WiDr adenocarcinoma cells - an unusual type of lipid antioxidant. Free Rad. Biol. Med. 28: 228-234
27. Pettersson, F., Dalgleish, A. G., Bissonnette, R. P., Colston, K.W. (2002) Retinoids cause apoptosis in pancreatic cancer cell via activation of RAR-γ and altered expression of bcl-2/bax. Br. J. Cancer 87: 555-561
28. Sravan, K. G., Das, U. N. (1995) Free radical dependent suppression of growth of mouse myeloma cells by alpha-linolenic acid and eicosapentaenoic acid in vitro. Cancer Lett. 92: 27-38
29. Srivastava, S. K., Singh, S.V. (2004) Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in antiproliferative activity of benzyl isothiocyanate against human pancreatic cancer cells. Carcinogenesis 25: 1701-1709
30. Stulnig, T. M. (2003) Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. Int. Arch. Allergy Immunol. 132: 310-321
31. Swarts, H. G,, Schuurmanns, S. F. M., De Pont, J. J. (1990) Binding of unsaturated fatty acids to Na+, K+-ATPase leading to inhibition and inactivation. Biochim. Biophys. Acta 1024: 32-40
32. Szachowicz-Petelska, B., Sulkowski, S., Figaszewski, Z. A. (2007) Altered membrane of free unsaturated fatty acid composition in human colorectal cancer tissue. Mol. Cell Biochem. 294: 237-242
33. Yasukawa, K., Akihisa, T., Yoshida, Z. Y. (2002) Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumor promotion by 12-o-tetradecanoylphorbol- 13-acetate in two-stage carcinogenesis in mouse skin. J. Pharm. Pharmacol. 52: 119-124
34. Yu, F. R., Lian, X. Z., Guo, H. Y., McGuire, P. M., Li, R. D., Wang, R., Yu, F. H. (2005) Vegetable acids from the roots of Euphorbia kansui and their inhibitory effects on the human SGC-7901 cells. J. Pharm. Pharmaceut. Sci. 8: 528-535