Tooth-surface-specific effects of xylitol: Randomized trial results

Journal of Dental Research

Volumn 92, Issue 6, 2013, Pages 512-517

  Ritter, A V ^a   Bader, J D ^a   Leo, M C ^b   Preisser, J S ^a   Shugars, D A ^a   Vollmer, W M ^b   Amaechi, B T ^c   Holland, J C ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b CENTER FOR HEALTH RESEARCH   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

caries data analysis; clinical trials; dental caries prevention; root caries; sugar substitutes

Indexed keywords

ANTICARIES AGENT; FLUORIDE; FLUORIDE VARNISH; PLACEBO; TOOTHPASTE; XYLITOL;

ADULT; AGED; ARTICLE; CARIES DATA ANALYSIS; CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTAL CARIES; DENTAL CARIES PREVENTION; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HEALTH SURVEY; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; SUGAR SUBSTITUTES; TABLET; TOOTH BRUSHING; TOOTH CROWN; TREATMENT OUTCOME; VERY ELDERLY;

CARIES DATA ANALYSIS; CLINICAL TRIALS; DENTAL CARIES PREVENTION; ROOT CARIES; SUGAR SUBSTITUTES;

ADULT; AGED; AGED, 80 AND OVER; CARIOSTATIC AGENTS; DENTAL CARIES; DENTAL CARIES SUSCEPTIBILITY; DMF INDEX; DOUBLE-BLIND METHOD; FEMALE; FLUORIDES; FLUORIDES, TOPICAL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PLACEBOS; ROOT CARIES; TABLETS; TOOTH CROWN; TOOTHBRUSHING; TOOTHPASTES; TREATMENT OUTCOME; XYLITOL; YOUNG ADULT;

EID: 84877869128     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034513487211     Document Type: Article

References (36)

1. Aamdal-Scheie A, Luan WM, Dahlén G, Fejerskov O. Plaque pH and microflora of dental plaque on sound and carious root surfaces. J Dent Res. 1996 ; 75: 1901-1908 (Pubitemid 32770414)
2. Antonio AG, Pierro VS, Maia LC. Caries preventive effects of xylitol-based candies and lozenges: a systematic review. J Public Health Dent. 2011 ; 71: 117-124
3. Bader JD, Shugars DA, Vollmer WM, Gullion CM, Gilbert GH, Amaechi BT, et al. Design of the xylitol for adult caries trial (X-ACT). BMC Oral Health. 2010 ; 10: 22
4. Bader JD, Vollmer WM, Shugars DA, Gilbert GH, Amaechi BT, Brown JP, et al. Principal results from the Xylitol for Adult Caries Trial (X-ACT). J Am Dent Assoc. 2013 ; 144: 21-30
5. Banting DW, Amaechi BT, Bader JD, Blanchard P, Gilbert GH, Gullion CM, et al. Examiner training and reliability in two randomized clinical trials of adult dental caries. J Public Health Dent. 2011 ; 71: 335-344
6. Dawes C. What is the critical pH and why does a tooth dissolve in acid?. J Can Dent Assoc. 2003 ; 69: 722-724
7. Deshpande A, Jadad AR. The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc. 2008 ; 139: 1602-1614
8. Ekstrand K, Martignon S, Holm-Pedersen P. Development and evaluation of two root caries controlling programmes for home-based frail people older than 75 years. Gerodontology. 2008 ; 25: 67-75
9. Featherstone JD. The continuum of dental caries - evidence for a dynamic disease process. J Dent Res. 2004 ; 83 (Spec No C). C39 - C42
10. Featherstone JD. Dental caries: a dynamic disease process. Aust Dent J. 2008 ; 53: 286-291
11. Fejerskov O, Kidd EAM Oxford, UK: Wiley-Blackwell ; 2008:
12. Griffin SO, Griffin PM, Swann JL, Zlobin N. Estimating rates of new root caries in older adults. J Dent Res. 2004 ; 83: 634-638 (Pubitemid 41766073)
13. Huang R, Li M, Gregory RL. Bacterial interactions in dental biofilm. Virulence. 2011 ; 2: 435-444
14. Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, et al. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol. 2007 ; 35: 170-178
15. Jensen ME, Kohout F. The effect of a fluoridated dentifrice on root and coronal caries in an older adult population. J Am Dent Assoc. 1988 ; 117: 829-832
16. Khoo G, Zhan L, Hoover C, Featherstone JD. Cariogenic virulence characteristics of mutans streptococci isolated from caries-active and caries-free adults. J Calif Dent Assoc. 2005 ; 33: 973-980
17. Ly KA, Milgrom P, Roberts MC, Yamaguchi DK, Rothen M, Mueller G. Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. BMC Oral Health. 2006 ; 6: 6
18. Maguire A, Rugg-Gunn AJ. Xylitol and caries prevention - is it a magic bullet?. Br Dent J. 2003 ; 194: 429-436 (Pubitemid 38844040)
19. Mäkinen KK. Xylitol-based caries prevention: is there enough evidence for the existence of a specific xylitol effect?. Oral Dis. 1998 ; 4: 226-230 (Pubitemid 29011528)
20. Mäkinen KK, Bennett CA, Hujoel PP, Isokangas PJ, Isotupa KP, Pape HR, et al. Xylitol chewing gums and caries rates: a 40-month cohort study. J Dent Res. 1995 ; 74: 1904-1913
21. Mäkinen KK, Pemberton D, Mäkinen PL, Chen CY, Cole J, Hujoel PP, et al. Polyol-combinant saliva stimulants and oral health in Veterans Affairs patients - an exploratory study. Spec Care Dentist. 1996 ; 16: 104-115
22. Mandel ID, Grotz VL. Dental considerations in sucralose use. J Clin Dent. 2002 ; 13: 116-118
23. McDonald SP, Sheiham A. The distribution of caries on different tooth surfaces at varying levels of caries - a compilation of data from 18 previous studies. Community Dent Health. 1992 ; 9: 39-48
24. McIntyre JM, Featherstone JD, Fu J. Studies of dental root surface caries. 2: The role of cementum in root surface caries. Aust Dent J. 2000 ; 45: 97-102
25. Mickenautsch S, Yengopal V. Anticariogenic effect of xylitol versus fluoride - a quantitative systematic review of clinical trials. Int Dent J. 2012 ; 62: 6-20
26. Milgrom P, Ly KA, Roberts MC, Rothen M, Mueller G, Yamaguchi DK. Mutans streptococci dose response to xylitol chewing gum. J Dent Res. 2006 ; 85: 177-181 (Pubitemid 43827752)
27. Milgrom P, Ly KA, Rothen M. Xylitol and its vehicles for public health needs. Adv Dent Res. 2009 ; 21: 44-47
28. Preisser JS, Stamm JW, Long DL, Kincade ME. Review and recommendations for zero-inflated count regression modeling of dental caries indices in epidemiological studies. Caries Res. 2012 ; 46: 413-423
29. Ritter AV, Shugars DA, Bader JD. Root caries risk indicators: a systematic review of risk models. Community Dent Oral Epidemiol. 2010 ; 38: 383-397
30. Sansone C, Van Houte J, Joshipura K, Kent R, Margolis HC. The association of mutans streptococci and non-mutans streptococci capable of acidogenesis at a low pH with dental caries on enamel and root surfaces. J Dent Res. 1993 ; 72: 508-516
31. Scheie AA, Fejerskov OB. Xylitol in caries prevention: what is the evidence for clinical efficacy?. Oral Dis. 1998 ; 4: 268-278 (Pubitemid 29011534)
32. Seneviratne CJ, Zhang CF, Samaranayake LP. Dental plaque biofilm in oral health and disease. Chin J Dent Res. 2011 ; 14: 87-94
33. Söderling EM. Xylitol, mutans streptococci, and dental plaque. Adv Dent Res. 2009 ; 21: 74-78
34. Tan HP, Lo EC, Dyson JE, Luo Y, Corbet EF. A randomized trial on root caries prevention in elders. J Dent Res. 2010 ; 89: 1086-1090
35. ten Cate JM. Novel anticaries and remineralizing agents: prospects for the future. J Dent Res. 2012 ; 91: 813-815
36. Walls AW, Meurman JH. Approaches to caries prevention and therapy in the elderly. Adv Dent Res. 2012 ; 24: 36-40