Anticariogenic effect of xylitol versus fluoride - A quantitative systematic review of clinical trials

International Dental Journal

Volumn 62, Issue 1, 2012, Pages 6-20

  Mickenautsch, Steffen ^a   Yengopal, Veerasamy ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

caries; fluoride; systematic review; Xylitol

Indexed keywords

ANTICARIES AGENT; FLUORIDE; XYLITOL;

CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; DENTAL CARIES; EPIDEMIOLOGY; FOLLOW UP; HUMAN; PUBLISHING; REVIEW; STATISTICAL MODEL;

CARIOSTATIC AGENTS; CLINICAL TRIALS AS TOPIC; CONFOUNDING FACTORS (EPIDEMIOLOGY); DENTAL CARIES; FLUORIDES; HUMANS; LINEAR MODELS; LOST TO FOLLOW-UP; PUBLICATION BIAS; XYLITOL;

EID: 84856026971     PISSN: 00206539     EISSN: 1875595X     Source Type: Journal    
DOI: 10.1111/j.1875-595X.2011.00086.x     Document Type: Review

References (37)

1. Bresson JL, Flynn A, Heinonen M, et al. Xylitol chewing gum/pastilles and reduction of the risk of tooth decay. EFSA J 2008 852: 1-15.
2. Burt BA,. The use of sorbitol- and xylitol-sweetened chewing gum in caries control. J Am Dent Assoc 2006 137: 190-196. (Pubitemid 43287309)
3. Van Loveren C,. Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects? Caries Res 2004 38: 286-293. (Pubitemid 38720225)
4. Imfeld T,. Efficacy of sweeteners and sugar substitutes in caries prevention. Caries Res 1993 27 (Suppl 1): 50-55.
5. Tanzer JM,. Xylitol chewing gum and dental caries. Int Dent J 1995 45 (Suppl 1): 65-76.
6. Topitsoglou V, Birkhed D, Larsson LA, et al. Effect of chewing gums containing xylitol, sorbitol or a mixture of xylitol and sorbitol on plaque formation, pH changes and acid production in human dental plaque. Caries Res 1983 17: 369-378. (Pubitemid 13031024)
7. Vadeboncoeur C, Trahan L, Mouton C, et al. Effect of xylitol on the growth and glycolysis of acidogenic oral bacteria. J Dent Res 1983 62: 882-884. (Pubitemid 13011289)
8. Mäkinen KK,. Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review. Int J Dent 2010 doi:.
9. Walsh T, Worthington HV, Glenny AM, et al. Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2010 Issue 1. Art. No.: CD007868. DOI:.
10. Marinho VCC, Higgins JPT, Sheiham A, et al. One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2004 Issue 1. Art. No.: CD002780. DOI:.
11. Marinho VCC, Higgins JPT, Logan S, et al. Fluoride gels for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2002 Issue 1. Art. No.: CD002280. DOI:.
12. Benson PE, Parkin N, Millett DT, et al. Fluorides for the prevention of white spots on teeth during fixed brace treatment. Cochrane Database Syst Rev 2004 Issue 3. Art. No.: CD003809. DOI:.
13. Yeung A, Hitchings JL, Macfarlane TV, et al. Fluoridated milk for preventing dental caries. Cochrane Database Syst Rev 2005 Issue 3. Art. No.: CD003876. DOI:.
14. Marinho VCC, Higgins JPT, Logan S, et al. Fluoride mouthrinses for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2003 Issue 3. Art. No.: CD002284. DOI:.
15. Marinho VCC, Higgins JPT, Sheiham A, et al. Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2004 Issue 1. Art. No.: CD002781. DOI:.
16. Berger VW,. Selection Bias and Covariate Imbalances in Randomised Clinical Trials. Chichester, UK: John Wiley & Sons, Ltd; 2005.
17. Berger VW, Alperson SY,. A general framework for the evaluation of clinical trial quality. Rev Recent Clin Trials 2009 4: 79-88.
18. Bax L, Yu LM, Ikeda N, et al. Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Med Res Methodol 2006 6: 50.
19. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997 315: 629-634. (Pubitemid 27387172)
20. Pearl J,. Causal diagrams for empirical research. Biometrika 1995 82: 669-710.
21. Greenland S, Pearl J, Robins JM,. Causal diagrams for epidemiologic research. Epidemiology 1999 10: 37-48. (Pubitemid 29014427)
22. Kandelman D, Bär A, Hefti A,. Collaborative WHO xylitol field study in French Polynesia. I. Baseline prevalence and 32-month caries increment. Caries Res 1988 22: 55-62. (Pubitemid 18002144)
23. Stecksén-Blicks C, Holgerson PL, Twetman S,. Effect of xylitol and xylitol-fluoride lozenges on approximal caries development in high-caries-risk children. Int J Paediatr Dent 2008 18: 170-177.
24. Sintes JL, Elías-Boneta A, Stewart B, et al. Anticaries efficacy of a sodium monofluorophosphate dentifrice containing xylitol in a dicalcium phosphate dihydrate base. A 30-month caries clinical study in Costa Rica. Am J Dent 2002 15: 215-219.
25. Sintes JL, Escalante C, Stewart B, et al. Enhanced anticaries efficacy of a 0.243% sodium fluoride/10% xylitol/silica dentifrice: 3-year clinical results. Am J Dent 1995 8: 231-235.
26. Scheinin A, Bánõczy J, Szöke J, et al. Collaborative WHO xylitol field studies in Hungary. I. Three-year caries activity in institutionalized children. Acta Odontol Scand 1985 43: 327-347. (Pubitemid 16157135)
27. Scheinin A, Pienihäkkinen K, Tiekso J, et al. Collaborative WHO xylitol field studies in Hungary. VII. Two-year caries incidence in 976 institutionalized children. Acta Odontol Scand 1985 43: 381-387. (Pubitemid 16157141)
28. Milgrom P, Tut OK,. Evaluation of Pacific Islands Early Childhood Caries Prevention Project: Republic of the Marshall Islands. J Public Health Dent 2009 69: 201-203.
29. Petersson LG, Birkhed D, Gleerup A, et al. Caries-preventive effect of dentifrices containing various types and concentrations of fluorides and sugar alcohols. Caries Res 1991 25: 74-79.
30. Isokangas P, Alanen P, Tiekso J, et al. Xylitol chewing gum in caries prevention: a field study in children. J Am Dent Assoc 1988 117: 315-320.
31. Isokangas P, Mäkinen KK, Tiekso J, et al. Long-term effect of xylitol chewing gum in the prevention of dental caries: a follow-up 5 years after termination of a prevention program. Caries Res 1993 27: 495-498.
32. Isokangas P, Tiekso J, Alanen P, et al. Long-term effect of xylitol chewing gum on dental caries. Community Dent Oral Epidemiol 1989 17: 200-203.
33. Kandelman D, Gagnon G,. Clinical results after 12 months from a study of the incidence and progression of dental caries in relation to consumption of chewing-gum containing xylitol in school preventive programs. J Dent Res 1987 66: 1407-1411.
34. Egger M, Jüni P, Bartlett C, et al. How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study. Health Technol Assess 2003 7: 1-76.
35. Pocock SJ,. Clinical Trials. A Practical Approach. Chichester, UK: Wiley; 1983.
36. Rothstein HR, Sutton AJ, Borenstein M, (Eds). Publication Bias in Meta-Analysis-Prevention, Assessment and Adjustment. Chichester, UK: John Wiley & Sons; 2005. p. 1-7.
37. Schulz KF, Altman DG, Moher D, et al. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMC Med 2010 8: 18.