Results from the xylitol for adult caries trial (X-ACT)

Journal of the American Dental Association

Volumn 144, Issue 1, 2013, Pages 21-30

  Bader, James D ^a   Vollmer, William M ^b   Shugars, Daniel A ^a   Gilbert, Gregg H ^c   Amaechi, Bennett T ^d   Brown, John P ^d   Laws, Reesa L ^b   Funkhouser, Kimberly A ^b   Makhija, Sonia K ^c   Ritter, André V ^a   Leo, Michael C ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b CENTER FOR HEALTH RESEARCH   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Adults; Dental caries prevention; Randomized controlled trial; Xylitol

Indexed keywords

EID: 84873342692     PISSN: 00028177     EISSN: None     Source Type: Journal    
DOI: 10.14219/jada.archive.2013.0010     Document Type: Article

References (26)

1. Thomson WM. Dental caries experience in older people over time: what can the large cohort studies tell us? Br Dent J 2004; 196(2): 89-92.
2. Bader JD, Shugars DA, White BA, Rindal DB. Development of effectiveness of care and use of services measures for dental care plans. J Public Health Dent 1999; 59(3): 142-149.
3. Bader JD, Shugars DA, Kennedy JE, Hayden WJ Jr, Baker S. A pilot study of risk-based prevention in private practice. JADA 2003; 134(9): 1195-1202.
4. National Institutes of Health, Office of Medical Application of Research. Consensus Development Conference Statement: Diagnosis and Management of Dental Caries Throughout Life, March 26-28, 2001. http://ronsensus.nih.gov/2001/ 2001DentalCaries115html.htm. Accessed Nov. 5, 2012.
5. Recommendations for using fluoride to prevent and control dental caries in the United States: Centers for Disease Control and Prevention. MMWR Recomm Rep 2001; 5CKRR-14): 1-42.
6. Bader JD, Shugars DA, Bonito AJ. A systematic review of selected caries prevention and management methods. Community Dent Oral Epidemiol 2001; 29(6): 399-411.
7. Scheie AA, Fejerskov OB. Xylitol in caries prevention: what is the evidence for clinical efficacy? Oral Dis 1998; 4(4): 268-278.
8. Twetman S. Current controversies: is there merit? Adv Dent Res 2009; 21(1): 48-52.
9. Mäkinen KK. Xylitol-based caries prevention: is there enough evidence for the existence of a specific xylitol effect? (Comment on Scheie AA, Fejerskov OB. Xylitol in caries prevention: what is the evidence for clinical efficacy? Oral Dis 1998; 4(4): 268-278). Oral Dis 1998; 4(4): 226-230.
10. Hayes C. The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidence. J Dent Educ 2001; 65(10): 1106-1109.
11. Lingström P, Holm AK, Mejàre I, et al. Dietary factors in the prevention of dental caries: a systematic review. Acta Odontol Scand 2003; 61(6): 331-340.
12. Maguire A, Rugg-Gunn AJ. Xylitol and caries prevention: is it a magic bullet? Br Dent J 2003; 194(8): 429-436.
13. Van Loveren C. Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects? Caries Res 2004; 38(3): 286-293.
14. Deshpande A, Jadad AR. The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies. JADA 2008; 139(12): 1602-1614.
15. Mäkinen KK. Sugar alcohols, caries incidence, and reminerali-zation of caries lesions: a literature review (published online ahead of print Jan. 5, 2010). Int J Dent 2010; 2010: 981072. doi: 10.1155/2010/981072.
16. Antonio AG, Pierro VS, Maia LC. Caries preventive effects of xylitol-based candies and lozenges: a systematic review. J Public Health Dent 2011; 71(2): 117-124.
17. Rethman MP, Beltrán-Aguilar ED, Billings RJ, et al; American Dental Association Council on Scientific Affairs Expert Panel on Nonfluoride Caries-Preventive Agents. Nonfluoride caries-preventive agents: executive summary of evidence-based clinical recommendations. JADA 2011; 142(9): 1065-1071.
18. Bader JD, Shugars DA, Vollmer WM, et al. Design of the xylitol for adult caries trial (X-ACT). BMC Oral Health 2010; 10: 22.
19. Bader JD, Robinson DS, Gilbert GH, et al; X-ACT Collaborative Research Group. Four "lessons learned" while implementing a multi-site caries prevention trial. J Public Health Dent 2010; 70(3): 171-175.
20. International Caries Detection and Assessment System Coordinating Committee. Criteria Manual: International Caries Detection and Assessment System (ICDASII). Report of a workshop held in Baltimore, Md., March 12-14, 2005. www.dundee.ac.uk/dhsru/docs/ ICDAS II criteria document September 10.doc. Accessed Nov. 5, 2012.
21. Banting DW, Amaechi BT, Bader JD, et al. Examiner training and reliability in two randomized clinical trials of adult dental caries (published online ahead of print Aug. 17, 2011). J Public Health Dent 2011; 71(4): 335-344.doi: 10.1111/j.1752-7325.2011.00278.x.
22. Collins LM, Schafer JL, Kam CM. A comparison of inclusive and restrictive strategies in modern missing data procedures. Psychol Methods 2001; 6(4): 330-351.
23. Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York City: John Wiley & Sons; 1987.
24. Twetman S. Consistent evidence to support the use of xylitol-and sorbitol-containing chewing gum to prevent dental caries. Evid Based Dent 2009; 10(1): 10-11.
25. Addy M, Perriam E, Sterry A. Effects of sugared and sugar-free chewing gum on the accumulation of plaque and debris on the teeth. J Clin Periodontal 1982; 9(4): 346-354.
26. Milgrom P, Ly KA, Rothen M. Xylitol and its vehicles for public health needs (published online ahead of print July 31, 2009). Adv Dent Res 2009; 21(1): 44-47. doi: 10.1177/0895937409335623.