Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 8, 2013, Pages 4218-4228

  Veillard, Florian ^a   Sztukowska, Maryta ^a   Mizgalska, Danuta ^b   Ksiazek, Mirosław ^b   Houston, John ^a   Potempa, Barbara ^a   Enghild, Jan J ^c,d   Thogersen, Ida B ^c,d   Gomis Rüth, F Xavier ^e   Nguyen, Ky Anh ^f,g   Potempa, Jan ^a,b  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c AARHUS UNIVERSITY   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^f Westmead Centre for Oral Health   (Australia)

^g UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Inhibitor; Pathogen; Periodontitis; Proteolysis control; Zymogen activation

Indexed keywords

ARGININE; CYSTEINE; DEXTRO PHENYLALANYLPROLYLARGINYL CHLOROMETHYL KETONE; GINGIPAIN R; GLYCINE; LYSINE; PROTEINASE; TOSYLLYSYL CHLOROMETHYL KETONE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SUBSTRATE; GEL FILTRATION; HYDROLYSIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MODIFICATION;

ADHESINS, BACTERIAL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; GLYCOSYLATION; PEPTIDE FRAGMENTS; PORPHYROMONAS GINGIVALIS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

PORPHYROMONAS GINGIVALIS;

EID: 84877866907     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.04.005     Document Type: Article

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