HLA class II polymorphisms and recurrent spontaneous abortion in a Southern Brazilian cohort

International Journal of Immunogenetics

Volumn 40, Issue 3, 2013, Pages 186-191

  Bompeixe, E P ^a   Carvalho Santos, P S ^a,b   Vargas, R G ^a   Von Linsingen, R ^a   Zeck, S C ^a   Wowk, P F ^a   Bicalho, M G ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b LEIBNIZ INSTITUTE FOR ZOO AND WILDLIFE RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 2; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ARTICLE; BLOOD LEVEL; BRAZIL; CASE CONTROL STUDY; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECURRENT ABORTION; RECURRENT SPONTANEOUS ABORTION; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; ADULT; BRAZIL; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; GENE FREQUENCY; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DQ BETA-CHAINS; HLA-DRB1 CHAINS; HUMANS; PHENOTYPE; POLYMORPHISM, GENETIC; PREGNANCY;

EID: 84877836440     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/j.1744-313X.2012.01155.x     Document Type: Article

References (66)

1. Albuquerque, A.G., Moraes, M., Vanderborght, P.R., Romero, M., Santos, A.R., Moraes, M.O. & Moraes, J.R. (2004) Tumor necrosis factor and interleukin-10 gene promoter polymorphisms in Brazilian population and in Terena Indians. Transplant Proceedings, 36, 825.
2. Arck, P.C., Troutt, A.B. & Clark, D.A. (1997) Soluble receptors neutralizing TNF-alpha and IL-1 block stress-triggered murine abortion. American Journal of Reproductive Immunology, 37, 262.
3. Arslan, E., Colakoglu, M., Celik, C., Gezginc, K., Acar, A., Capar, M., Akoz, M. & Akyurek, C. (2004) Serum TNF-alpha, IL-6, lupus anticoagulant and anticardiolipin antibody in women with and without a past history of recurrent miscarriage. Archives of Gynecology and Obstetrics, 270, 227.
4. Babbage, S.J., Arkwright, P.D., Vince, G.S., Perrey, C., Pravica, V., Quenby, S., Bates, M. & Hutchinson, I.V. (2001) Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss. Journal of Reproductive Immunology, 51, 21.
5. Beydoun, H. & Saftlas, A.F. (2005) Association of human leucocyte antigen sharing with recurrent spontaneous abortions. Tissue Antigens, 65, 123.
6. Billington, W.D. & Bell, S.C. (1983) Fetal histocompatibility antigens and maternal immune responses. Ciba Foundation Symposium, 96, 69.
7. Boue, J., Bou, A. & Lazar, P. (1975) Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology, 12, 11.
8. Cauchi, M.N., Tait, B., Wilshire, M.I., Koh, S.H., Mraz, G., Kloss, M. & Pepperell, R. (1988) Histocompatibility antigens and habitual abortion. American Journal of Reproductive Immunology and Microbiology, 18, 28.
9. Chaouat, G., Menu, E., Clark, D.A., Dy, M., Minkowski, M. & Wegmann, T.G. (1990) Control of fetal survival in CBA x DBA/2 mice by lymphokine therapy. Journal of Reproduction and Fertility, 89, 447.
10. Chaouat, G., Assal Meliani, A., Martal, J., Raghupathy, R., Elliott, J.F., Mosmann, T. & Wegmann, T.G. (1995) IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. Journal of Immunology, 154, 4261.
11. Christiansen, O.B., Riisom, K., Lauritsen, J.G. & Grunnet, N. (1989) No increased histocompatibility antigen-sharing in couples with idiopathic habitual abortions. Human Reproduction, 4, 160.
12. Christiansen, O.B., Rasmussen, K.L., Jersild, C. & Grunnet, N. (1994) HLA class II alleles confer susceptibility to recurrent fetal losses in Danish women. Tissue Antigens, 44, 225.
13. Christiansen, O.B., Pedersen, B., Mathiesen, O., Husth, M. & Grunnet, N. (1996) Maternal HLA class II alleles predispose to pregnancy losses in Danish women with recurrent spontaneous abortions and their female relatives. American Journal of Reproductive Immunology, 35, 239.
14. Christiansen, O.B., Ring, M., Rosgaard, A., Grunnet, N. & Gluud, C. (1999) Association between HLA-DR1 and -DR3 antigens and unexplained repeated miscarriage. Human Reproductive Update, 5, 249.
15. Clark, D.A. (1991) Controversies in reproductive immunology. Critical Reviews in Immunology, 11, 215.
16. Clark, D.A. & Chaouat, G. (1989) What do we know about spontaneous abortion mechanisms? American Journal of Reproductive Immunology, 19, 28.
17. Coulam, C.B. (1986) Unexplained recurrent pregnancy loss: epilogue. Clinical Obstetrics and Gynecology, 29, 999.
18. Coulam, C.B., Moore, S.B. & O'Fallon, W.M. (1987) Association between major histocompatibility antigen and reproductive performance. American Journal of Reproductive Immunology and Microbiology, 14, 54.
19. Daher, S., Shulzhenko, N., Morgun, A., Mattar, R., Rampim, G.F., Camano, L. & DeLima, M.G. (2003) Associations between cytokine gene polymorphisms and recurrent pregnancy loss. Journal of Reproductive Immunology, 58, 69.
20. Daher, S., de Arruda Geraldes Denardi, K., Blotta, M.H., Mamoni, R.L., Reck, A.P., Camano, L. & Mattar, R. (2004) Cytokines in recurrent pregnancy loss. Journal of Reproductive Immunology, 62, 151.
21. Edmonds, D.K., Lindsay, K.S., Miller, J.F., Williamson, E. & Wood, P.J. (1982) Early embryonic mortality in women. Fertility and Sterility, 38, 447.
22. Erlebacher, A. (2010) Immune surveillance of the maternal/fetal interface: controversies and implications. Trends in Endocrinology and Metabolism, 21, 428.
23. Excoffier, L. & Lischer, H.E. (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Molecular Ecology Resources, 10, 564.
24. Garcia-Lloret, M.I., Yui, J., Winkler-Lowen, B. & Guilbert, L.J. (1996) Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts. Journal of Cellular Physiology, 167, 324.
25. Gendron, R.L., Nestel, F.P., Lapp, W.S. & Baines, M.G. (1990) Lipopolysaccharide-induced fetal resorption in mice is associated with the intrauterine production of tumour necrosis factor-alpha. Journal of Reproduction and Fertility, 90, 395.
26. Guerin, L.R., Prins, J.R. & Robertson, S.A. (2009) Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Human Reproductive Update, 15, 517.
27. Hill, J.A. & Choi, B.C. (2000) Maternal immunological aspects of pregnancy success and failure. Journal of Reproduction and Fertility. Supplement, 55, 91.
28. Johnson, P.M., Barnes, R.M., Risk, J.M., Molloy, C.M. & Woodrow, J.C. (1985) Immunogenetic studies of recurrent spontaneous abortions in humans. Experimental and Clinical Immunogenetics, 2, 77.
29. Kamali-Sarvestani, E., Zolghadri, J., Gharesi-Fard, B. & Sarvari, J. (2005) Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women. Journal of Reproductive Immunology, 65, 171.
30. Karhukorpi, J., Laitinen, T., Karttunen, R. & Tiilikainen, A.S. (2001) The functionally important IL-10 promoter polymorphism (-1082G->A) is not a major genetic regulator in recurrent spontaneous abortions. Molecular Human Reproduction, 7, 201.
31. Kruse, C., Steffensen, R., Varming, K. & Christiansen, O.B. (2004) A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage. Human Reproduction, 19, 1215.
32. Kumpel, B.M. & Manoussaka, M.S. (2012) Placental immunology and maternal alloimmune responses. Vox Sanguinis, 102, 2.
33. Lahiri, D.K. & Nurnberger, J.I. Jr. (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research, 19, 5444.
34. von Linsingen, R., Bompeixe, E.P. & Bicalho, M.G. (2005) A case-control study in IL6 and TGFB1 gene polymorphisms and recurrent spontaneous abortion in southern Brazilian patients. American Journal of Reproductive Immunology, 53, 94.
35. Liu, C., Wang, J., Zhou, S., Wang, B. & Ma, X. (2010) Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population. Reproductive Biology and Endocrinology, 8, 114.
36. Moraes, M.O., Santos, A.R., Schonkeren, J.J., Vanderborght, P.R., Ottenhoff, T.H., Moraes, M.E., Moraes, J.R., Sampaio, E.P., Sarno, E.N. & Huizinga, T.W. (2003) Interleukin-10 promoter haplotypes are differently distributed in the Brazilian versus the Dutch population. Immunogenetics, 54, 896.
37. Mueller-Eckhardt, G., Mallmann, P., Neppert, J., Lattermann, A., Melk, A., Heine, O., Pfeiffer, R., Zingsem, J., Domke, N. & Mohr-Pennert, A. (1994) Immunogenetic and serological investigations in nonpregnant and in pregnant women with a history of recurrent spontaneous abortions. German RSA/IVIG Study Group. Journal of Reproductive Immunology, 27, 95.
38. Oksenberg, J.R., Persitz, E., Amar, A. & Brautbar, C. (1984) Maternal-paternal histocompatibility: lack of association with habitual abortions. Fertility and Sterility, 42, 389.
39. Perrey, C., Pravica, V., Sinnott, P.J. & Hutchinson, I.V. (1998) Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta 1 and tumour necrosis factor-alpha genes: a technical report. Transplant Immunology, 6, 193.
40. Perrey, C., Turner, S.J., Pravica, V., Howell, W.M. & Hutchinson, I.V. (1999) ARMS-PCR methodologies to determine IL-10, TNF-alpha, TNF-beta and TGF-beta 1 gene polymorphisms. Transplant Immunology, 7, 127.
41. Piccinni, M.P. (2006) T cells in normal pregnancy and recurrent pregnancy loss. Reproductive Biomedicine Online, 13, 840.
42. Pravica, V., Perrey, C., Stevens, A., Lee, J.H. & Hutchinson, I.V. (2000) A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Human Immunology, 61, 863.
43. Probst, C.M., Bompeixe, E.P., Pereira, N.F., de O Dalalio, M.M., Visentainer, J.E., Tsuneto, L.T. & Petzl-Erler, M.L. (2000) HLA polymorphism and evaluation of European, African, and Amerindian contribution to the white and mulatto populations from Parana, Brazil. Human Biology, 72, 597.
44. Reid, J.G., Simpson, N.A., Walker, R.G., Economidou, O., Shillito, J., Gooi, H.C., Duffy, S.R. & Walker, J.J. (2001) The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss. American Journal of Reproductive Immunology, 45, 35.
45. Ruiz, T.M., da Costa, S.M., Ribas, F., Luz, P.R., Lima, S.S. & da Graca Bicalho, M. (2005) Human leukocyte antigen allelic groups and haplotypes in a brazilian sample of volunteer donors for bone marrow transplant in Curitiba, Parana, Brazil. Transplant Proceedings, 37, 2293.
46. Sasaki, T., Yamada, H., Kato, E.H., Sudo, S., Kishida, T., Sasaki, T., Nishigaki, F. & Fujimoto, S. (1997) Increased frequency of HLA-DR4 allele in women with unexplained recurrent spontaneous abortions, detected by the method of PCR-SSP. Journal of Reproductive Immunology, 32, 273.
47. Shaarawy, M. & Nagui, A.R. (1997) Enhanced expression of cytokines may play a fundamental role in the mechanisms of immunologically mediated recurrent spontaneous abortion. Acta Obstetricia et Gynecologica Scandinavica, 76, 205.
48. Shankarkumar, U., Pawar, A. & Ghosh, K. (2008) Implications of HLA sequence-based typing in transplantation. Journal of Postgraduate Medicine, 54, 41.
49. Shankarkumar, U., Pradhan, V.D., Patwardhan, M.M., Shankarkumar, A. & Ghosh, K. (2011) Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients. Nigerian Medical Journal, 52, 163.
50. Steck, T., van der Ven, K., Kwak, J., Beer, A. & Ober, C. (1995) HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion. Journal of Reproductive Immunology, 29, 95.
51. Suthanthiran, M. & Strom, T.B. (1995) Immunobiology and immunopharmacology of organ allograft rejection. Journal of Clinical Immunology, 15, 161.
52. Tafuri, A., Alferink, J., Moller, P., Hammerling, G.J. & Arnold, B. (1995) T cell awareness of paternal alloantigens during pregnancy. Science, 270, 630.
53. Takakuwa, K., Adachi, H., Hataya, I., Ishii, K., Tamura, M. & Tanaka, K. (2003) Molecular genetic studies of HLA-DRB1 alleles in patients with unexplained recurrent abortion in the Japanese population. Human Reproduction, 18, 728.
54. Takamizawa, M., Juji, T., Tsuneyoshi, H., Nieda, M., Fujii, T., Kawana, T. & Mizuno, M. (1987) Recurrent spontaneous abortion and human leukocyte antigen DRw8. American Journal of Obstetrics and Gynecology, 157, 514.
55. Turner, D.M., Williams, D.M., Sankaran, D., Lazarus, M., Sinnott, P.J. & Hutchinson, I.V. (1997) An investigation of polymorphism in the interleukin-10 gene promoter. European Journal of Immunogenetics, 24, 1.
56. Vargas, R.G., Bompeixe, E.P., Franca, P.P., Marques de Moraes, M. & da Graca Bicalho, M. (2009) Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage. American Journal of Reproductive Immunology, 62, 34.
57. Vargas, R.G., Sarturi, P.R., Mattar, S.B., Bompeixe, E.P., Silva Jdos, S., Pirri, A. & Bicalho Mda, G. (2011) Association of HLA-G alleles and 3′ UTR 14 bp haplotypes with recurrent miscarriage in Brazilian couples. Human Immunology, 72, 479.
58. Visentainer, J.E., Sell, A.M., da Silva, G.C., Cavichioli, A.D., Franceschi, D.S., Lieber, S.R. & de Souza, C.A. (2008) TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil. International Journal of Immunogenetics, 35, 287.
59. Wagenknecht, D.R., Green, K.M. & McIntyre, J.A. (1997) Analyses of HLA-DQ alleles in recurrent spontaneous abortion (RSA) couples. American Journal of Reproductive Immunology, 37, 1.
60. Wang, X.P., Lin, Q.D., Lu, P.H., Ma, Z.W. & Zhao, A.M. (2004) Association of HLA-DQB1 coding region with unexplained recurrent spontaneous abortion. Chinese Medical Journal, 117, 492.
61. Warburton, D. & Fraser, F.C. (1964) Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. American Journal of Human Genetics, 16, 1.
62. Wegmann, T.G., Lin, H., Guilbert, L. & Mosmann, T.R. (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunology Today, 14, 353.
63. Weinberg, C.R. & Wilcox, A.J. (1988) Incidence rate of implantation in "nonpregnant" patients. Fertility and Sterility, 50, 993.
64. Wilson, A.G., di Giovine, F.S., Blakemore, A.I. & Duff, G.W. (1992) Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Human Molecular Genetics, 1, 353.
65. Wilson, R., Jenkins, C., Miller, H., McInnes, I.B., Moore, J., McLean, M.A. & Walker, J.J. (2004) Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 115, 51.
66. Zhou, M. & Mellor, A.L. (1998) Expanded cohorts of maternal CD8 + T-cells specific for paternal MHC class I accumulate during pregnancy. Journal of Reproductive Immunology, 40, 47.