Association between HLA-DR1 and -DR3 antigens and unexplained repeated miscarriage

Human Reproduction Update

Volumn 5, Issue 3, 1999, Pages 249-255

  Christiansen, Ole B ^a   Ring, Morten ^a   Rosgaard, Anni ^a   Grunnet, Niels ^b   Gluud, Christian ^c  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c The Capital Region   (Denmark)

Author keywords

Abortion; HLA class II; Immunology; Meta analysis; Recurrent spontaneous abortion

Indexed keywords

HLA DR1 ANTIGEN; HLA DR3 ANTIGEN;

CAUCASIAN; CLINICAL TRIAL; FEMALE; HUMAN; MEDICAL INFORMATION; META ANALYSIS; METHODOLOGY; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HLA-DR1 ANTIGEN; HLA-DR3 ANTIGEN; HUMANS; ODDS RATIO; PREGNANCY;

EID: 0032974499     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/5.3.249     Document Type: Review

References (52)

1. Aoki, K., Kajiura, S., Matsumoto, Y. et al. (1995) Preconceptional natural-killer activity as a predictor of miscarriage. Lancet, 345, 1340-1342.
2. Bach, J.-F. (1995) Organ-specific autoimmunity. Immunol. Today, 16, 353-355.
3. Beer, A.E., Semprini, A.E., Zhu, X. et al. (1985) Pregnancy outcome in human couples with recurrent spontaneous abortions: HLA antigen profiles; HLA antigen sharing; female serum MLR blocking factors; and paternal leukocyte immunization. Exp. Clin. Immunogenet., 2, 137-153.
4. Cauchi, M.N., Tait, B., Wilshire, M.I. et al. (1988) Histocompatibility antigens and habitual abortion. Am. J. Reprod. Immunol., 18, 28-31.
5. Christiansen, O.B., Riisom, K., Lauritsen, J.G. et al. (1989) No increased histocompatibility antigen sharing in couples with idiopathic habitual abortions. Hum. Reprod., 4, 160-162.
6. Christiansen, O.B., Christiansen, B.S., Husth, M. et al. (1992) Prospective study of anticardiolipin antibodies in immunized and untreated women with recurrent spontaneous abortions. Fertil. Steril., 58, 328-334.
7. Christiansen, O.B., Mathiesen, O., Husth, M. et al. (1993) Prognostic significance of maternal DR histocompatibility types in Danish women with recurrent miscarriages. Hum. Reprod., 8, 1843-1847.
8. Christiansen, O.B., Rasmussen, K.L., Jersild, C. et al. (1994) HLA class II alleles confer susceptibility to recurrent fetal losses in Danish women. Tissue Antigens, 44, 225-233.
9. Christiansen, O.B., Andersen, H.H., Højbjerre, M. et al. (1995) Maternal HLA Class II allogenotypes are markers for the predisposition to fetal losses in families of women with unexplained recurrent fetal loss. Eur. J. Immunogenet., 22, 323-334.
10. Christiansen, O.B., Ulcova-Gallova, Z., Mohapeloa, H. et al. (1998) Studies on associations between human leukocyte antigen (HLA) class II alleles and antiphospholipid antibodies in Danish and Çzech women with recurrent miscarriages. Hum. Reprod., 13, 3326-3331.
11. Collins, J.A. (1997) Guides for practitioners: meta-analysis. Clinical research and clinical practice. Hum. Reprod., 12, 1847-1850.
12. Coulam, C.B., Moore, S.B. and O'Fallon, W.M. (1987) Association between major histocompatibility antigen and reproductive performance. Am. J. Reprod. Immunol. Microbiol., 14, 54-58.
13. DerSimonian, R. and Laird, N. (1986) Meta-analysis in clinical trials. Controlled Clinical Trials, 7, 177-188.
14. Edelman, P., Rouquette, A.M., Verdy, E. et al. (1986) Immunity, fetal losses, lupus anticoagulant: beginning of systemic lupus erythematosus or new autoimmune entity with gynaeco-obstetrical expression? Hum. Reprod., 1, 295-297.
15. Egger, M., Smith, G.D., Schneidser, M. et al. (1997) Bias in meta-analysis detected by a simple, graphical test. Br. Med. J., 315, 629-634.
16. Eroglu, G., Betz, G. and Torregano, C. (1992) Impact of histocompatibility antigens on pregnancy outcome. Am. J. Obstet. Gynecol., 166, 1364-1369.
17. Faulk, W.P., Temple, A., Lovins, R. et al. (1978) Antigens of human trophoblast: a working hypothesis for their role in normal and abnormal pregnancies. Proc. Natl Acad. Sci. USA, 75, 1947-1951.
18. Gerencer, M. and Kastelan, A. (1983) The role of HLA-D region in feto-maternal interactions. Transplant. Proc., XV, 893-895.
19. Hill, J.A., Polgar, K., Harlow, B.L. et al. (1992) Evidence of embryo-and trophoblast-toxic cellular immune response(s) in women with recurrent spontaneous abortion. Am. J. Obstet. Gynecol., 166, 1044-1052.
20. Ho, H., Gill, T.J., Nsieh, R. et al. (1990) Sharing of human leukocyte antigens in primary and secondary recurrent spontaneous abortions. Am. J. Obstet. Gynecol., 163, 179-188.
21. Houlihan, J.M., Biro, P.A., Harper, H.M. et al. (1995) The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. J. Immunol., 154, 5665-5674.
22. Jazwinska, E.C., Kilpatrick, D.C., Smart, G.E. et al. (1987) Feto-maternal HLA compatibility does not have a major influence on human pregnancy except for lymphocytotoxin production. Clin. Exp. Immunol., 68, 116-122.
23. Kilpatrick, D.C., Bevan, B.H. and Liston, W.A. (1995) Association between mannan binding protein deficiency and recurrent miscarriage. Mol. Hum. Reprod., 10, 2501-2505.
24. Komlos, L., Zamir, R., Joshua, H. et al. (1977) Common HLA antigens in couples with repeated abortions. Clin. Immunol. Immunopathol., 7, 330-335.
25. Kovats, S., Main, E., Libranch, C. et al. (1990) A class I antigen, HLA G, expressed in human trophoblasts. Science, 248, 220-223.
26. Laitinen, T., Koskimies, S. and Westman, P. (1993) Foeto-maternal compatibility in HLA-DR, -DQ, and -DP loci in Finnish couples suffering from recurrent spontaneous abortions. Eur. J. Immunogenet., 20, 249-258.
27. McIntyre, J.A., McConnachie, P.R., Taylor, C.G. et al. (1984) Clinical, immunological, and genetic definitions of primary and secondary recurrent spontaneous abortions. Fertil. Steril., 42, 849-855.
28. Mohapeloa, H., Christiansen, O.B. and Grunnet, N. (1998) HLA-DR typing of women with recurrent late spontaneous abortion and unsuccessful cervical cerclage. Hum. Reprod., 13, 1079-1082.
29. Mueller-Eckhardt, G., Mallmann, P., Neppert, J. et al. (1994) Immunogenetic and serological investigations in nonpregnant and in pregnant women with a history of recurrent spontaneous abortions. German RSA/IVIG Study Group. J. Reprod. Immunol., 27, 95-109.
30. Oksenberg, J.R., Persitz, E., Amar, A. et al. (1984). Maternal-paternal histocompatibility: lack of association with habitual abortions. Fertil. Steril., 42, 389-395.
31. Parham, P. (1995) Antigen presentation by Class I major histo-compatibility complex molecules: a context for thinking about HLA-G. Am. J. Reprod. Immunol., 34, 10-19.
32. Pazmany, L., Madelboim, O., Vales-Gomez, M. et al. (1996) Protection from natural killer cell mediated lysis by HLA-G expression on target cells. Science, 274, 792-795.
33. Pociot, F., Briant, L., Jongeneel, C.V. et al. (1993) Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alfa and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur. J. Immunol., 23, 224-231.
34. Purandare, A.S., Smith, D.S. and Wilson, P.J. (1993) HLA frequency, HLA sharing and immunotherapy in the management of recurrent miscarriage. Int. J. Fertil., 38, 219-224.
35. Reznikoff-Etievant, M.F., Edelman, P., Muller, J.Y. et al. (1984) HLA-DR locus and maternal-fetal relation. Tissue Antigens, 24, 30-34.
36. Riley, E. and Olerup, O. (1992) HLA polymorphisms and evolution. Immunol. Today, 13, 333-334.
37. Schlesselman, J.J. (1997) Risk of endometrial cancer in relation to use of combined oral contraceptives. A practitioner's guide to meta-analysis. Hum. Reprod., 12, 1851-1863.
38. Sciorelli, G., Bontempelli, M., Carella, G. et al. (1988) HLA sharing in Italian recurrent abortion couples. Acta Eur. Fertilitatis, 19, 257-261.
39. Smith, J.B., Cowchock, F.S., Hankinson, B. et al. (1989) Association of HLA-DR5 with recurrent spontaneous abortion in women treated with paternal leukocytes. Arthritis Rheum., 32, 1572-1576.
40. Stagnaro-Green, A., Roman, S.H., Cobin, R. et al. (1990) Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. JAMA, 264, 1422-1425.
41. Sunderland, C.A., Najem, M., Mason, D.Y. et al. (1981) The expression of major histo-compatibility antigens by human chorionic villi. J. Reprod. Immunol., 3, 323-331.
42. The Cochrane Library (database on disk and CDROM). The Cochrane Collaboration. Oxford Update Software, 1996, Updated quarterly.
43. The Recurrent Miscarriage Immunotherapy Trialists Group (1994) Worldwide collaborative observational study and meta-analysis on allogeneic leukocyte immunotherapy for recurrent spontaneous abortion. Am. J. Reprod. Immunol., 32, 55-72.
44. Thomas, M.L., Harger, J.H., Wagener, D.K. et al. (1985) HLA sharing and spontaneous abortion in humans. Am. J. Obstet. Gynecol., 151, 1053-1058.
45. Tiwari, J.L. and Terasaki, P.I. (1985) HLA and Disease Associations. Springer-Verlag, New York.
46. Todd, J.A., Acha-Orbea, H., Bell, J.I. et al. (1988) A molecular basis for MHC class II associated autoimmunity. Science, 240, 1003-1009.
47. Trabace, S., Nicotra, M., Cappellacci, S. et al. (1991) HLA-DR and DQ antigens and anticardiolipin antibodies in women with recurrent spontaneous abortions. Am. J. Reprod. Immunol., 26, 147-149.
48. Unander, A.M. and Olding, L. (1983) Habitual abortion: parental sharing of HLA antigens, absence of maternal blocking antibody, and suppression of maternal lymphocytes. Am. J. Reprod. Immunol., 4, 171-178.
49. Unander, A.M., Norberg, R., Hahn, L. et al. (1987) Anticardiolipin antibodies and complement in ninety-nine women with habitual abortion. Am. J. Obstet. Gynecol., 156, 114-119.
50. Vanoli, M., Fabio, G., Eisera, N. et al. (1985) Histocompatibility in Italian couples with recurrent spontaneous abortions of unknown origin and with normal fertility. Tissue Antigens, 26, 227-233.
51. Xu, L., Chang, V., Murphy, A. et al. (1990) Antinuclear antibodies in sera of patients with recurrent pregnancy wastage. Am. J. Obstet. Gynecol., 163, 1493-1497.
52. Yusuf, S., Peto, R., Lewis, J. et al. (1985) Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog. Cardiovasc. Dis., 27, 335-371.