Association of HLA-DQB1 coding region with unexplained recurrent spontaneous abortion

Chinese Medical Journal

Volumn 117, Issue 4, 2004, Pages 492-497

  Wang, Xi Peng ^a   Lin, Qi De ^a   Lu, Pei Hua ^b   Ma, Zheng Wen ^b   Zhao, Ai Min ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Immunology Institute   (China)

Author keywords

Abortion; HLA DQB1; Open reading frames; Promoter region (genetics); Spontaneous

Indexed keywords

HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN;

ADULT; ARTICLE; CHI SQUARE TEST; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; FISHER EXACT TEST; GENE FREQUENCY; GENETIC CODE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION; RECURRENT DISEASE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; SPONTANEOUS ABORTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ABORTION, HABITUAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-DQ ANTIGENS; HUMANS; OPEN READING FRAMES; POLYMORPHISM, GENETIC; PREGNANCY;

EID: 2342650783     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Scott JR, Rote NS, Branch DW. Immunologic aspects of recurrent abortion and fetal death. Obstet Gynecol 1987;70: 645-656.
2. Lin QD, Zhou HC, Zhao AM, et al. Investigation of the association between autoantibody and recurrent abortion. Chin J Obstet Gynecol (Chin) 1993;28:674-677.
3. Lin QD, Zhou HC, Zhao AM, et al. Immunologic diagnosis and treatment on the case with unexplained habitual abortion. Chin J Obstet Gynecol (Chin) 1993;28:143-146.
4. Lin QD. Progress in basic and clinic research of unexplained recurrent abortion, Chin J Obstet Gynecol (Chin) 2003;38: 481-483.
5. Stephenson MD. Frequence of factors associated with habitual abortion in 197 couples. Fertil Steril 1996;66:24-29.
6. Jin K, Ho HN, Speed TP, et al. Reproductive failure and the major histocompatibility complex. Am J Hum Genet 1995;56: 1456-1467.
7. Gill TJ 3rd. Invited editorial: influence of MHC and MHC-linked genes on reproduction. Am J Hum Genet 1992;50:1-5.
8. Eroglu G, Betz G, Torregano C. Impact of histocompatibility antigens on pregnancy outcome. Am J Obstet Gynecol 1992; 166:1364-1369.
9. Steck T, van der Ven K, Kwak J, et al. HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion. J Reprod Immunol 1995;29: 95-104.
10. Christiansen OB, Rasmussen KL, Jersild C, et al. HLA class II alleles confer susceptibility to recurrent fetal losses in Danish women. Tissue Antigens 1994;44:225-233.
11. Nomura N, Ota M, Tsuji K, et al. HLA-DQB1 genotyping by a modified PCR-RFLP method combined with group-specific primers. Tissue Antigens 1991;38:53-59.
12. Reichstetter S, Brunnler G, Kalden JR, et al. DQB1 promotor sequence variability and linkage in caucasoids. Hum Immunol 1996;51:73-80.
13. Ober C. The maternal-fetal relationship in human pregnancy: an innunogenetic perspective. Exp Clin Immunogenet 1992; 9:1-14.
14. Christiansen OB, Mathiesen O, Husth M, et al. Studies of RFLP-infered HLA-DR-DQ haplotypes in Danish women with recurrent fetal losses. Tissue Antigens 1992;40:134-139.
15. Sasaki T, Yamada H, Kato EH, et al. Increased frequency of HLA-DR4 allele in women with unexplained recurrent spontaneous abortions, detected by the method of PCR-SSP. J Reprod Immunol 1997;32:273-279.
16. Deschamps I, Khalil I. The role of DQ alpha-bata heterodimers in genetic susceptibility to insulin-dependent diabetes. Diabetes Metab Revi 1993;9:71-92.
17. Leech N, Sorrentino R, McCulloch DK, et al. Ultrastructural allelic variation in HLA-DQB1 promoter elements. Hum Immunol 1995;43:251-258.
18. Christiansen OB, Pedersen B, Mathiesen O, et al. Maternal HLA class II alleles predispose to pregnancy losses in Danish women with recurrent spontaneous abortions and their female relatives. Am J Reprod Immunol 1996;35:239-244.
19. Christiansen OB, Ring M, Rosgaard A, et al. Association between HLA-DR1 and -DR3 antigens and unexplained repeated miscarriage. Hum Reprod Update 1999;5:249-255.