Association of human leucocyte antigen sharing with recurrent spontaneous abortions

Tissue Antigens

Volumn 65, Issue 2, 2005, Pages 123-135

  Beydoun, H ^a   Saftlas, Audrey F ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Human leucocyte antigen; Immunogenetics; Major histocompatibility complex; Maternal foetal sharing; Recurrent spontaneous abortion

Indexed keywords

HLA A ANTIGEN; HLA ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ADULT; ALLELE; CASE CONTROL STUDY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FETUS; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HLA SYSTEM; HUMAN; IMMUNOGENETICS; IMPLANTATION; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; META ANALYSIS; PRIORITY JOURNAL; RECURRENT ABORTION; REPRODUCTION; REVIEW; RISK; SEROLOGY; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW;

ABORTION, HABITUAL; ABORTION, SPONTANEOUS; ALLELES; CASE-CONTROL STUDIES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HAPLOTYPES; HLA ANTIGENS; HUMANS; IMMUNITY, MATERNALLY-ACQUIRED; LEUKOCYTES; PREGNANCY; REPRODUCTION;

EID: 14844333302     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2005.00367.x     Document Type: Review

References (79)

1. Redman CWG, Bodmer JG, Bodmer WF, Beilin LJ, Bonnar J. HLA antigens in severe pre-eclampsia. Lancet 1978: 2: 397-9.
2. De Luca Brunori I, Battini L, Simonelli M et al. HLA-DR in couples associated with preeclampsia: background and updating by DNA sequencing. J Reprod Immunol 2003: 59: 235-43.
3. Hunt JS, Orr HT. HLA and maternal-fetal recognition. FASEB J 1992: 6: 2344-8.
4. Medawar PB. Some immunological and endocrinological problems raised by the evolution of vivparity in vertebrates. Symp Soc Exp Biol 1953: 7: 320-38.
5. Colbern GT, Chiang MH, Main EK. Expression of the nonclassic histocompatibility antigen HLA-G by preeclamptic placenta. Am J Obstet Gynecol 1994: 170: 1244-50.
6. McMaster MT, Librach CL, Zhou Y et al. Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol 1995: 154: 3771-8.
7. De Luca Brunori I, Battini L, Simonelli N et al. Increased HLA-DR homozygosity associated with pre-eclampsia. Hum Reprod 2000: 15: 1807-12.
8. Hunt JS, Jadhav L, Chu W, Geraghty DE, Ober C. Soluble HLA-G circulates in maternal blood during pregnancy. Am J Obstet Gynecol 2000: 183: 682-8.
9. Sibai BM. Immunologic aspects of preeclampsia. Clin Obstet Gynecol 1991: 34: 27-34.
10. Colbern GT, Main EK. Immunology of the maternal-placental interface in normal pregnancy. Semin Perinatol 1991: 15: 196-205.
11. Le Bouteiller P, Mallet V. HLA-G and pregnancy. Rev Reprod 1997: 2: 7-13.
12. Cowan LD, Hudson L, Bobele G, Chancellor I, Baker J. Maternal-fetal HLA sharing and risk of newborn encephalophathy and seizure: a pilot study. J Child Neurol 1994: 9: 173-7.
13. Verp MS, Sibul M, Billstarnd C, Bellen G, Hsu M, Ober L. Maternal-fetal histocompatibility in intrauterine growth retarded and normal weight babies. Am J Reprod Immunol 1993: 29: 195-8.
14. Hara N, Fujii T, Yamashita T, Kozuma S, Okai T, Taketani Y. Altered expression of human leukocyte antigen G (HLA-G) on extravillous trophoblasts in preeclampsia: immunological demonstration with anti-HLA-G antibody '87G' and anti-cytokeratin antibody 'CAM5.2'. Am J Reprod Immunol 1996: 36: 349-58.
15. Takakuwa K, Honda K, Ishii K, Hataya I, Yasuda M, Tanaka K. Studies on the HLA-DRB1 genotypes in Japanese women with severe preeclampsia positive and negative for anticardiolipin antibody using a PCR-RFLP method. Hum Reprod 1999: 14: 2980-6.
16. Purandare AS, Smith DS, Wilson PJ. HLA frequency, HLA sharing and immunotherapy in the management of recurrent miscarriage. Int J Fertil Menopausal Stud 1993: 38: 219-24.
17. Thomas ML, Harger JH, Wagener DK, Rabin BS, Gill TJ III. HLA sharing and spontaneous abortion in humans. Am J Obstet Gynecol 1985: 151: 1053-8.
18. Koyama M, Saji F, Takahashi S et al. Probabilistic assessment of the HLA sharing of recurrent spontaneous abortion couples in the Japanese population. Tissue Antigens 1991: 37: 211-7.
19. Kilpatrick DC, Liston WA. Parental HLA sharing, feto-maternal compatibility and neonatal birthweight in families with a history of recurrent spontaneous abortion. Dis Markers 1993: 11: 125-30.
20. Pfeiffer KA, Fimmers R, Engels G et al. The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion. Mol Hum Reprod 2001: 7: 373-8.
21. Aldrich C, Verp MS, Walker MA, Ober C. A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation. J Reprod Immunol 2000: 47: 41-8.
22. Beer AE, Quebbeman JF, Ayers JWT, Haines RF. Major histocompatibility antigens, maternal and paternal immune response, and chronic habitual abortions in humans. Am J Obstet Gynecol 1981: 141: 987-99.
23. Lauritsen JG, Jorgensen J, Kissmeyer-Nielson F. Significance of HLA and blood-group incompatibility in spontaneous abortion. Clin Genet 1976: 7: 575-82.
24. Komlos L, Zamir R, Joshua H, Halbrecht I. Common HLA antigens in couples with repeated abortions. Clin Immunol Immunopathol 1977: 7: 330-5.
25. Gill TJ III. Immunogenetics of spontaneous abortions in humans. Transplantation 1983: 35: 1-6.
26. Beer AE, Need JA. Immunological aspects of preeclampsia/eclampsia. Birth Defects Orig Artic Ser 1985: 21: 131-54.
27. Ober C, Elias S, O'Brien E et al. HLA sharing and fertility in Hutterite couples: evidence for prenatal selection against compatible fetuses. Am J Reprod Immunol Microbiol 1988: 18: 111-5.
28. Hauck WW, Ober C. Statistical analysis of outcomes from repeated pregnancies: effects of HLA sharing on fetal loss rates. Genet Epidemiol 1991: 8: 187-97.
29. Hedrick PW. HLA-sharing, recurrent spontaneous abortion and the genetic hypothesis. Genetics 1988: 119: 199-204.
30. Ober C, van Der Ven K. Immunogenetics of reproduction: an overview. In: Hunt JB, ed. HLA and the Maternal-Fetal Relationship. Austin: RG Landes 1995: 133-56.
31. Gerencer M, Drazancic A, Kuvacic I, Tomaskovic Z, Kastelan A. HLA antigen studies in women with recurrent gestational disorders. Fertil Steril 1979: 31: 401-4.
32. Schacter B, Muir A, Gyves M, Tasin M. HLA-A B compatibility in parents of offspring with neural-tube defects or couples experiencing involuntary fetal wastage. Lancet 1979: 1: 796-9.
33. Caudle MR, Rote NS, Scott JR, DeWitt C, Barney MD. Histocompatibility in couples with idiopathic recurrent spontaneous abortion and normal fertility. Fertil Steril 1983: 39: 793-7.
34. Unander AM, Olding LB. Habitual abortion: parental sharing of HLA antigens, absence of maternal blocking antibody, and suppression of maternal lymphocytes. Am J Reprod Immunol 1983: 4: 171-8.
35. Oksenberg JR, Persitz E, Amar A, Brautbar C. Maternal-paternal histocompatibility: lack of association with habitual abortions. Fertil Steril 1984: 42: 389-95.
36. Reznikoff-Etievant MF, Edelman P, Muller JY, Pinon F, Sureau C. HLA-DR locus and maternal-fetal relation. Tissue Antigens 1984: 24: 30-4.
37. Schacter B, Weitkamp LR, Johnson WE. Parental HLA compatibility in parents of offspring with neural-tube defects: evidence for a T/t-like locus in humans. Am J Hum Genet 1984: 36: 1082-91.
38. Beer AE, Semprini AE, Zhu XY, Quebbeman JF. Pregnancy outcome in human couples with recurrent spontaneous abortions: HLA antigen profiles; HLA antigen sharing; female serum MLR blocking factors; and paternal leukocyte immunization. Exp Clin Immunogenet 1985: 2: 137-53.
39. Bolis PF, Soro V, Martinetti Bianchi M, Belvedere M. HLA compatibility and human reproduction. Clin Exp Obstet Gynecol 1985: 12: 9-12.
40. Casciani CU, Pasetto N, Forleo R, Adorno D, Valeri M, Piazza A. HLA sharing in couples with recurrent abortion. Exp Clin Immunogenet 1985: 2: 65-9.
41. Taylor CG, Faulk WP, McIntyre JA. Prevention of recurrent spontaneous abortions by leukocyte transfusions. J R Soc Med 1985: 78: 623-7.
42. Vanoli M, Fabio G, Bonara P et al. Histocompatibility in Italian couples with recurrent spontaneous abortions of unknown origin and with normal fertility. Tissue Antigens 1985: 26: 227-33.
43. McIntyre JA, Faulk WP, Nicholas-Johnson VR, Taylor CG. Immunologic testing and immunotherapy in recurrent spontaneous abortion. Obstet Gynecol 1986: 67: 169-74.
44. Takakuwa K, Kanazawa K, Takeuchi S. Production of blocking antibodies by vaccination with husband's lymphocytes in unexplained recurrent aborters: the role of successful pregnancy. Am J Reprod Immunol Microbiol 1986: 10: 1-9.
45. Coulam CB, Moore SB, O'Fallon WM. Association between major histocompatibility antigen and reproductive performance. Am J Reprod Immunol Microbiol 1987: 14: 54-8.
46. Cauchi MN, Tait B, Wilshire MI et al. Histocompatibility antigens and habitual abortion. Am J Reprod Immunol 1988: 18: 28-31.
47. Johnson PM, Chia KV, Risk JM, Barnes RMR, Woodrow JC. Immunological and immunogenetic investigation of recurrent spontaneous abortion. Dis Markers 1988: 6: 163-71.
48. Sargent IL, Wilkins T, Redman CW. Maternal immune responses to the fetus in early pregnancy and recurrent miscarriage. Lancet 1988: 2: 1099-104.
49. Sciorelli G, Bontempelli M, Carella G et al. HLA sharing in Italian recurrent abortion couples. Acta Eur Fertil 1988: 19: 257-61.
50. Smith JB, Cowchock FS. Immunological studies in recurrent spontaneous abortion: effects of immunization of women with paternal mononuclear cells on lymphocytotoxic and mixed lymphocyte reaction blocking antibodies and correlation with sharing of HLA and pregnancy outcome. J Reprod Immunol 1988: 14: 99-113.
51. Balasch J, Coll O, Martorell J, Jove IC, Gaya A, Vanrell JA. Further data against HLA sharing in couples with recurrent spontaneous abortion. Gynecol Endocrinol 1989: 3: 63-9.
52. Christiansen OB, Riisom K, Lauritsen JG, Grunnet N. No increased histocompatibility antigen sharing in couples with idiopathic habitual abortion. Hum Reprod 1989: 4: 160-2.
53. Ho H-N, Gill TJ, Nsieh R-P, Hsieh H-J, Lee T-Y. Sharing of human leukocyte antigens in primary and secondary recurrent spontaneous abortions. Am J Obstet Gynecol 1990: 163: 178-88.
54. Chang M-Y, Soong Y-K, Huang C-C. Comparison of histocompatibility between couples with idiopathic recurrent spontaneous abortion and normal multipara. J Formos Med Assoc 1991: 90: 153-9.
55. Eroglu G, Betz G, Torregano C. Impact of histocompatibility antigens on pregnancy outcome. Am J Obstet Gynecol 1992: 166: 1364-9.
56. Ito K, Obata F, Tanaka T, Tsustumi N, Kashiwagi N. Analysis of HLA-DR types of unexplained recurrent spontaneous aborters in the Japanese population by oligonucleotide-DNA typing. Tissue Antigens 1992: 40: 204-9.
57. Takakuwa K, Higashino M, Ueda H et al. Significant compatibility does not exist at the HLA-DQB gene locus in couples with unexplained recurrent abortions. Am J Reprod Immunol 1992: 28: 12-6.
58. Laitinen T, Koskimies S, Westman P. Foeto-maternal compatibility in HLA-DR, -DQ, and -DP loci in Finnish couples suffering from recurrent spontaneous abortions. Eur J Immunogenet 1993: 20: 249-58.
59. Ober C, Steck T, van der Ven K et al. MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. J Reprod Immunol 1993: 25: 195-207.
60. Karhukorpi J, Laitinen R, Tiilikainen AS. HLA-G polymorphism in Finnish couples with recurrent spontaneous miscarriage. BJOG 1997: 104: 1212-4.
61. Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW. Human leukocyte antigen matching and fetal loss results of a 10 year prospective study. Hum Reprod 1998: 13: 33-8.
62. Penzes M, Rajczy K, Gyodi E et al. HLA-G gene polymorphism in the normal population and in recurrent spontaneous abortion in Hungary. Transplant Proc 1999: 31: 1832-3.
63. Yamashita T, Fujii R, Tokunaga K et al. Analysis of human leukcocyte antigen-G polymorphism including intron-4 in Japanese couples with habitual abortion. Am J Reprod Immunol 1999: 41: 159-63.
64. Aldrich CL, Stephenson MD, Karrison T et al. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod 2001: 7: 1167-72.
65. Emmer PM, Steegers AP, Kerstens HMJ et al. Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies. Hum Reprod 2002: 17: 1072-80.
66. Ober C, Aldrich CL, Chervoneva I et al. Variation in the HLA-G promoter region influences miscarriage rates. Am J Hum Genet 2003: 72: 1425-35.
67. Hviid TV, Hylenius S, Hoegh AM, Kruse C, Christiansen OB. HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens 2002: 60: 122-32.
68. Hviid TVF, Hylenius S, Lindhard A, Christiansen OB. Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome. Tissue Antigens 2004: 64: 66-9.
69. Engels EA, Schmid CH, Terrin N, Olkin I, Lau J. Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses. Stat Med 2000: 19: 1707-28.
70. Stroup DF, Berlin JA, Morton SC et al. Meta-analysis of observational studies in epidemiology - a proposal for reporting. JAMA 2000: 283: 2008-12.
71. Attia J, Thakkinstian A, D'Este C. Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol 2003: 56: 297-303.
72. Schneider K, Knutson F, Tamsen L, Sjoberg O. HLA antigen sharing in preeclampsia. Gynecol Obstet Invest 1994: 37: 87-90.
73. Scott JR. Immunotherapy for recurrent miscarriage. Cochrane Database Syst Rev 2003: 1: CD000112.
74. Hoff C, Peevy K, Giattina K, Spinnato JA, Peterson RDA. Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension. Obstet Gynecol 1992: 80: 1007-12.
75. Williams MA, Farrand A, Mittendorf R et al. Maternal second trimester serum tumor necrosis factor-alpha-soluble receptor p55 (sTNFp55) and subsequent risk of preeclampsia. Am J Epidemiol 1999: 149: 323-9.
76. Chen G, Diallo JT, Volumenie JL et al. Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann. Am J Reprod Immunol 1997: 37: 427-34.
77. Saito S, Sakai M, Sasaki Y, Tanabe K, Tsuda H, Michimata T. Quantitative analysis of peripheral Th0, Th1, Th2 and Th1:Th2 cell ratio during normal human pregnancy and preeclampsia. Clin Exp Immunol 1999a: 117: 550-5.
78. Goldsby RA, Kindt TJ, Osborne BA. Kuby Immunology, 4th edn. New York: Freeman W H & Co 2000: 1-648.
79. Saito S, Umekage H, Sakamoto Y et al. Increased T-Helper-1-type immunity and decreased T-Helper-2-type immunity in patients with preeclampsia. Am J Reprod Immunol 1999b: 41: 297-306.