Nonthermal electromagnetic fields: From first messenger to therapeutic applications

Electromagnetic Biology and Medicine

Volumn 32, Issue 2, 2013, Pages 123-136

  Pilla, Arthur A ^a,b  

^a Department of Earth and Environmental Sciences   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Calmodulin; First messenger; Nitric oxide; Pulsed electromagnetic field; Radio frequency; Signaling; Tissue repair

Indexed keywords

BRAIN; CALMODULIN; CAMS; CELL SIGNALING; FRACTURE; NITRIC OXIDE; RADIO WAVES; TISSUE;

CHRONIC WOUNDS; FIRST MESSENGER; LOWER FREQUENCIES; NONTHERMAL; PULSE MODULATED; PULSED ELECTROMAGNETIC FIELDS; RADIOFREQUENCIES; SIGNALING; THERAPEUTIC APPLICATION; TISSUE REPAIR;

ELECTROMAGNETIC FIELDS;

CALMODULIN;

ANIMAL; ELECTROMAGNETIC FIELD; HUMAN; INJURY; MAGNETOTHERAPY; METABOLISM; METHODOLOGY; RADIATION EXPOSURE; RADIOFREQUENCY RADIATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CALMODULIN; ELECTROMAGNETIC FIELDS; HUMANS; MAGNETIC FIELD THERAPY; RADIO WAVES; SIGNAL TRANSDUCTION; WOUNDS AND INJURIES;

EID: 84877830045     PISSN: 15368378     EISSN: 15368386     Source Type: Journal    
DOI: 10.3109/15368378.2013.776335     Document Type: Conference Paper

References (79)

1. Arendash GW (2012). Transcranial electromagnetic treatment against Alzheimer's disease: why it has the potential to trump Alzheimer's disease drug development. J Alzheimers Dis. 32:243-266.
2. Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, et al. (2010). Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice. J Alzheimers Dis. 19:191-210.
3. Arendash GW, Mori T, Dorsey M, Gonzalez R, Tajiri N, Borlongan C (2012). Electromagnetic treatment to old Alzheimer's mice reverses b-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit. PLoS One. 7(4):e35751.
4. Batchelor AM, Bartus K, Reynell C, Constantinou S, Halvey EJ, Held KF, Dostmann WR, et al. (2010). Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors. Proc Natl Acad Sci USA. 107:22060-22065.
5. Blumenthal DK, Stull JT (1982). Effects of pH, ionic strength, and temperature on activation by calmodulin and catalytic activity of myosin light chain kinase. Biochemistry 21:2386-2391. (Pubitemid 12065041)
6. Bootman MD, Lipp P, Berridge MJ (2001). The organisation and functions of local Ca(2) signals. J Cell Sci 114:2213-2222. (Pubitemid 32633693)
7. Borhade N, Pathan AR, Halder S, Karwa M, Dhiman M, Pamidiboina V, Gund M, et al. (2012). NO-NSAIDs. Part 3: nitric oxide-releasing prodrugs of non-steroidal anti-inflammatory drugs. Chem Pharm Bull (Tokyo) 60:465-481.
8. Bredt DS, Snyder SH (1990). Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87:682-685.
9. Brighton CT, Wang W, Clark CC (2008). The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants. J Bone Joint Surg Am 90:833-848. (Pubitemid 351499973)
10. Broughton 2nd, G, Janis JE, Attinger CE (2006). Wound healing: an overview. Plast Reconstr Surg 117 (7 Suppl):1e-S-32e-S.
11. Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, Simon BJ, Gurtner GC (2008). Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg 121:130-141.
12. Chang K, Lee SJ, Cheong I, Billiar TR, Chung HT, Han JA, Kwon YG, et al. (2004). Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB. Exp Mol Med. 36:311-324. (Pubitemid 39279527)
13. Chen Y, Boettger MK, Reif A, Schmitt A, Uceyler N, Sommer C, et al. (2010). Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice. Mol Pain 6: 13-17.
14. Cheng DK (1959). Analysis of linear systems. London: Addison-Wesley.
15. Chiabrera A, Bianco B, Moggia E (1993). Effect of lifetimes on ligand binding modeled by the density operator. Bioelectrochem Bioenerg 30:35-42.
16. Chiarini A, Dal Pra I, Whitfield JF, Armato U (2006). The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines. Ital J Anat Embryol 111:221-246.
17. Cho HJ, Xie QW, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Nathan C (1992). Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med 176:599-604.
18. Cooke JP (2003). NO and angiogenesis. Atheroscler Suppl 4:53-60. (Pubitemid 38234495)
19. Cury Y, Picolo G, Gutierrez VP, Ferreira SH, et al. (2011). Pain and analgesia. The dual effect of nitric oxide in the nociceptive system. Nitric Oxide 25:243-254.
20. Daff S (2003). Calmodulin-dependent regulation of mammalian nitric oxide synthase. Biochem Soc Trans 31:502-505. (Pubitemid 36750720)
21. DeFelice LJ (1981). Introduction to membrane noise. New York: Plenum. pp 243-245.
22. De Mattei M, Varani K, Masieri FF, Pellati A, Ongaro A, Fini M, Cadossi R, et al. (2009). Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts. Osteoarthritis Cartilage 17:252-262.
23. Delle Monache S, Alessandro R, Iorio R, Gualtieri G, Colonna R (2008). Extremely low frequency electromagnetic fields (ELF-EMFs) induce in vitro angiogenesis process in human endothelial cells. Bioelectromagnetics 29:640-648. (Pubitemid 352772622)
24. Dragicevic N, Bradshaw PC, Mamcarz M, Lin X, Wang L, Cao C, Arendash GW (2011). Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit? Neuroscience 185:135-149.
25. Durán WN, Breslin JW, Sánchez FA (2010). The NO cascade, eNOS location, and microvascular permeability. Cardiovasc Res. 87:254-261.
26. Edmonds DT (1993). Larmor precession as a mechanism for the detection of static and alternating magnetic fields. Bioelectrochem Bioenergetics 30:3-12.
27. Faas GC, Raghavachari S, Lisman JE, Mody I (2011). Calmodulin as a direct detector of Ca2 signals. Nat Neurosci 14:301-304.
28. Harzheim D, Roderick HL, Bootman MD (2010). Intracellular calcium signaling. Handbook of cell signaling. 2nd ed. Amsterdam Netherlands: Academic Press. Vol. 2 pp 937-942.
29. Hedén P, Pilla AA (2008). Effects of pulsed electromagnetic fields on postoperative pain: a double-blind randomized pilot study in breast augmentation patients. Aesthet Plast Surg 32:660-666.
30. Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE (1993). Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA 90:8103-8107. (Pubitemid 23260863)
31. Kavaliers M, Ossenkopp KP (1991). Opioid systems and magnetic field effects in the land snail. Cepaea nemoralis. Bio Bull 180:301-309.
32. Konieczny V, Keebler MV, Taylor CW (2012). Spatial organization of intracellular Ca2 signals. Semin Cell Dev Biol. 23:172-180.
33. Kowalczuk C, Yarwood G, Blackwell R, Priestner M, Sienkiewicz Z, Bouffler S, Ahmed I, et al. (2010). Absence of nonlinear responses in cells and tissues exposed to RF energy at mobile phone frequencies using a doubly resonant cavity. Bioelectromagnetics 31:556-565.
34. Kwon MS, Vorobyev V, Kännälä S, Laine M, Rinne JO, Toivonen T, Johansson J, et al. (2012). No effects of short-term GSM mobile phone radiation on cerebral blood flow measured using positron emission tomography. Bioelectromagnetics. 33:247-256.
35. Lauretti GR, de Oliveira R, Reis MP, Mattos AL, Pereira NL (1999). Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopedic surgery. Anesthesiology 90(3):734-739. (Pubitemid 29113693)
36. Lee RH, Efron D, Tantry U, Barbul A (2001). Nitric oxide in the healing wound: a time-course study. J Surg Res. 101:104-118.
37. Markov MS, Muehsam DJ, Pilla AA (1994). Modulation of cell-free myosin phosphorylation with pulsed radio frequency electromagnetic fields. In: Allen MJ, Cleary SF, Sowers AE, editors. Charge and field effects in biosystems. River Edge, NJ: World Scientific. Vol. 4 pp 274-288.
38. Mellstrom B, Savignac M, Gomez-Villafuertes R, Naranjo JR (2008). Ca2-operated transcriptional networks: molecular mechanisms and in vivo models. Physiol Rev 88:421-449. (Pubitemid 351520085)
39. Mo E, Amin H, Bianco IH, Garthwaite J (2004). Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway. J Biol Chem. 279:26149-26158. (Pubitemid 38798760)
40. Moffett J, Griffin NE, Ritz MC, George FR (2010). Pulsed radio frequency energy field treatment of cells in culture results in increased expression of genes involved in the inflammation phase of lower extremity diabetic wound healing. J Diabetic Foot Complications 2:57-64.
41. Moffett J, Kubat NJ, Griffin NE, Ritz MC, George FR (2011). Pulsed radio frequency energy field treatment of cells in culture results in increased expression of genes involved in angiogenesis and tissue remodeling during wound healing. J Diabetic Foot Complications 3:30-39.
42. Moffett J, Fray LM, Kubat NJ (2012). Activation of endogenous opioid gene expression in human keratinocytes and fibroblasts by pulsed radiofrequency energy fields. J Pain Res 12:347-357.
43. Muehsam DJ, Pilla AA (2009a). A Lorentz model for weak magnetic field bioeffects: Part I - thermal noise is an essential component of AC/DC effects on bound ion trajectory. Bioelectromagnetics 30: 462-475.
44. Muehsam DJ, Pilla AA (2009b). A Lorentz model for weak magnetic field bioeffects: Part II - secondary transduction mechanisms and measures of reactivity. Bioelectromagnetics 30:476-488.
45. Nelson FR, Zvirbulis R, Pilla AA (2012). Non-invasive electromagnetic field therapy produces rapid and substantial pain reduction in early knee osteoarthritis: a randomized double-blind pilot study. Rheumatol Int [Epub ahead of print].
46. Palmi M, Meini A (2002). Role of the nitric oxide/cyclic GMP/Ca2 signaling pathway in the pyrogenic effect of interleukin-1beta. Mol Neurobiol 25:133-147. (Pubitemid 34246227)
47. Parazzini M, Brazzale AR, Paglialonga A, Tognola G, Collet L, Moulin A, Lutman ME, et al. (2007). Effects of GSM cellular phones on human hearing: the European project "GUARD". Radiat Res 168: 608-613. (Pubitemid 351295125)
48. Patel MK, Factor SM, Wang J, Jana S, Strauch B (2006). Limited myocardial muscle necrosis model allowing for evaluation of angiogenic treatment modalities. J Reconstr Microsurg 22:611-615.
49. Pilla AA (1970). A transient impedance technique for the study of electrode kinetics. J Electrochem Soc 117: 467-477.
50. Pilla AA (1972). Electrochemical information and energy transfer in vivo. Proceedings 7th IECEC. Washington, DC: ACS. pp 761-764.
51. Pilla AA (1974a). Mechanisms of electrochemical phenomena in tissue growth and repair. Bioelectrochem Bioenerg 1:227-243.
52. Pilla AA (1974b). Electrochemical information transfer at living cell membranes. Ann NY Acad Sci 238: 149-170.
53. Pilla AA (2006). Mechanisms and therapeutic applications of time varying and static magnetic fields. In: Barnes F, Greenebaum B, editors. Biological and medical aspects of electromagnetic fields. Boca Raton FL: CRC Press. pp 351-411.
54. Pilla AA (2012). Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems. Biochem Biophys Res Commun. 426:330-333.
55. Pilla AA, Muehsam DJ, Kavaliers M, (2010). Non-thermal bioeffects from radio frequency signals: evidence from basic and clinical studies, and a proposed mechanism. Proceedings, 32nd Annual Meeting, Bioelectromagnetics Society, Frederick, MD, June 2010
56. Pilla AA, Nasser PR, Kaufman JJ (1994). Gap junction impedance, tissue dielectrics and thermal noise limits for electromagnetic field bioeffects. Bioelectrochem Bioenerg 35:63-69.
57. Pilla AA, Muehsam DJ, Markov MS, Sisken BF (1999). EMF signals and ion/ligand binding kinetics: prediction of bioeffective waveform parameters. Bioelectrochem Bioenerg 48:27-34. (Pubitemid 29150359)
58. Pilla AA, Fitzsimmons R, Muehsam DJ, Rohde C, Wu JK, Casper D (2011). Electromagnetic fields as first messenger in biological signaling: application to calmodulin-dependent signaling in tissue repair. Biochem Biophys Acta 1810:1236-1245.
59. Prato FS, Carson JJ, Ossenkopp KP, Kavaliers M (1995). Possible mechanisms by which extremely low frequency magnetic fields affect opioid function. FASEB J 9:807-814.
60. Rawe IM, Lowenstein A, Barcelo CR, Genecov DG (2012). Control of postoperative pain with a wearable continuously operating pulsed radiofrequency energy device: a preliminary study. Aesthet Plast Surg 36:458-463.
61. Reale M, De Lutiis MA, Patruno A, Speranza L, Felaco M, Grilli A, Macr?̀ MA, et al. (2006). Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field. Nitric Oxide 15:50-57. (Pubitemid 43963424)
62. Ren K, Torres R (2009). Role of interleukin-1beta during pain and inflammation. Brain Res Rev 60:57-64.
63. Rohde C, Chiang A, Adipoju O, Casper D, Pilla AA (2009). Effects of pulsed electromagnetic fields on IL-1b and post operative pain: a double-blind, placebo-controlled pilot study in breast reduction patients. Plast Reconstr Surg 125:1620-1629.
64. Roland D, Ferder MS, Kothuru R, Faierman T, Strauch B (2000). Effects of pulsed magnetic energy on a microsurgically transferred vessel. Plast Reconstr Surg 105:1371-1374. (Pubitemid 30169470)
65. Shen M, Asher C, Chandy M, Scridon T, Dandes E, Vargas E, Hernandez A, et al. (2009). Use of pulsed electromagnetic fields for ischemic cardiomyopathy therapy (EFFECT trial): a randomized, doubleblind parallel, placebo-controlled, prospective trial. J Am Coll Cardiol 53:A346-A347.
66. Sluka KA, Deacon M, Stibal A, Strissel S, Terpstra A (1999). Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats. J Pharmacol Exp Ther 289:840-846. (Pubitemid 29191240)
67. Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, Pilla AA (2006). Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model. J Hand Surg 31:1131-1135. (Pubitemid 44308514)
68. Strauch B, Patel MK, Rosen D, Casper D, Pilla AA (2006). Pulsed magnetic fields increase angiogenesis in a rat myocardial ischemia model. Proceedings, 28th Annual Meeting, Bioelectromagnetics Society, Frederick, MD, June
69. Strauch B, Patel MK, Navarro A, Berdischevsky M, Pilla AA (2007). Pulsed magnetic fields accelerate wound repair in a cutaneous wound model in the rat. Plast Reconstr Surg 120:425-430. (Pubitemid 47067493)
70. Strauch B, Herman C, Dabb R, Ignarro LJ, Pilla AA (2009). Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthet Surg J. 29:135-143.
71. Tepper OM, Callaghan MJ, Chang EI, Galiano RD, Bhatt KA, Baharestani S, Gan J, et al. (2004). Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J 18:1231-1233. (Pubitemid 39561560)
72. Tsoukias NM (2008). Nitric oxide bioavailability in the microcirculation: insights from mathematical models. Microcirculation 15:813-834.
73. Varani K, Vincenzi F, Targa M, Corciulo C, Fini M, Setti S, Cadossi R, et al. (2011). Effect of pulsed electromagnetic field exposure on adenosine receptors in rat brain. Bioelectromagnetics. Doi: 10.1002/bem.20704. 33:276-287.
74. Velazquez C, Praveen Rao PN, Knaus EE (2005). Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies. J Med Chem 48:4061-4067. (Pubitemid 40800614)
75. Vianale G, Reale M, Amerio P, Stefanachi M, Di Luzio S, Muraro R (2008). Extremely low frequency electromagnetic field enhances human keratinocyte cell growth and decreases proinflammatory chemokine production. Br J Dermatol 158:1189-1196. (Pubitemid 351692868)
76. Wang Z, Clark CC, Brighton CT (2006). Up-regulation of bone morphogenetic proteins in cultured murine bone cells with use of specific electric fields. J Bone Joint Surg Am 88:1053-1065.
77. Weber RV, Navarro A, Wu JK, Yu HL, Strauch B (2005). Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap. Plast Reconstr Surg 114:1185-1189. (Pubitemid 40362042)
78. Werner S, Grose R (2003). Regulation of wound healing by growth factors and cytokines. Physiol Rev 83: 835-870. (Pubitemid 36828927)
79. Yen-Patton GP, Patton WF, Beer DM, Jacobson BS (1988). Endothelial cell response to pulsed electromagnetic fields: stimulation of growth rate and angiogenesis in vitro. J Cell Physiol 134:37-39.