Effect of pulsed electromagnetic field exposure on adenosine receptors in rat brain

Bioelectromagnetics

Volumn 33, Issue 4, 2012, Pages 279-287

  Varani, Katia ^a   Vincenzi, Fabrizio ^a   Targa, Martina ^a   Corciulo, Carmen ^a   Fini, Milena ^b   Setti, Stefania ^c   Cadossi, Ruggero ^c   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c Igea Biophysics Laboratory   (Italy)

Author keywords

Adenosine receptors; Brain; Cortical neurons; PEMFs

Indexed keywords

ELECTROMAGNETIC FIELDS; NEURONS; POLYMERASE CHAIN REACTION; RATS;

ADENOSINE RECEPTOR; CEREBRAL CORTEX; CORTICAL NEURONS; DIFFERENT EFFECTS; ELECTROMAGNETIC FIELD EXPOSURE; FIELD TREATMENTS; PEMF; PULSED ELECTROMAGNETIC FIELDS; RAT CORTICAL NEURONS; RATS BRAIN;

BRAIN;

RATTUS;

ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; MESSENGER RNA;

ADVERSE EFFECTS; ANIMAL; BRAIN; CELL MEMBRANE; CYTOLOGY; ELECTROMAGNETIC FIELD; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; NERVE CELL; RADIATION RESPONSE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CELL MEMBRANE; ELECTROMAGNETIC FIELDS; GENE EXPRESSION REGULATION; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; RECEPTORS, ADENOSINE A2; RNA, MESSENGER;

EID: 84859155778     PISSN: 01978462     EISSN: 1521186X     Source Type: Journal    
DOI: 10.1002/bem.20704     Document Type: Article

References (33)

1. Bersani F, Marinelli F, Ognibene A, Matteucci A, Cecchi S, Santi S, Squarzoni S, Maraldi NM. 1997. Intramembrane protein distribution in cell cultures is affected by 50Hz pulsed magnetic fields. Bioelectromagnetics 18(7): 463-469.
2. Boison D. 2007. Adenosine as a modulator of brain activity. Drug News Perspect 20: 607-611.
3. 2A receptor ligands. Biochem Pharmacol 49: 461-469.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 72: 248-254.
5. 2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog Neurobiol 83: 310-331.
6. Capone F, Dileone M, Profice P, Pilato F, Musumeci G, Minicuci G, Ranieri F, Cadossi R, Setti S, Tonali PA, Di Lazzaro V. 2009. Does exposure to extremely low frequency magnetic fields produce functional changes in human brain? J Neuronal Transm 116: 257-265.
7. Chiabrera A, Bianco B, Moggia E, Kaufman JJ. 2000. Zeeman-Stark modeling of the RF EMF interaction with ligand binding. Bioelectromagnetics 21: 312-324.
8. Choleris E, Del Seppia C, Thomas AW, Luschi P, Ghione G, Moran GR, Prato FS. 2002. Shielding, but not zeroing of the ambient magnetic field reduces stress-induced analgesia in mice. Proc Biol Sci 269: 193-201.
9. De Mattei M, Varani K, Masieri FF, Pellati A, Ongaro A, Fini M, Cadossi R, Vincenzi F, Borea PA, Caruso A. 2009. Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts. Osteoarthritis Cartilage 17(2): 252-262.
10. Di Loreto S, Falone S, Caracciolo PS, D'Alessandro A, Mirabilio A, Zimitti V, Amicarelli F. 2008. Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons. J Cell Physiol 219: 334-343.
11. 2 receptor interactions: Implications for the function of G protein-coupled receptors. Curr Pharm Des 14(15): 1468-1474.
12. Fini M, Giavaresi G, Torricelli P, Cavani F, Setti S, Cane V, Giardino R. 2005. Pulsed electromagnetic fields reduce knee osteoarthritic lesion progression in the aged Dunkin Hartley guinea pig. J Orthop Res 23: 899-908.
13. Fredholm BB. 2010. Adenosine receptors as drug targets. Exp Cell Res 316(8): 1284-1288.
14. Grant G, Cadossi R, Steinberg G. 1994. Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field. Bioelectromagnetics 15(3): 205-216.
15. Hardell L, Sage C. 2008. Biological effects from electromagnetic field exposure and public exposure standards. Biomed Pharmacother 62: 104-109.
16. 2A adenosine receptor gene: A 4.8-kb promoter-proximal DNA fragment confers selective expression in the central nervous system. Eur J Neurosci 18(7): 1786-1796.
17. 2A and group III metabotropic glutamate receptors to reduce parkinsonian symptoms in rats. Neuropharmacology 55(4): 483-490.
18. Massari L, Benazzo F, De Mattei M, Setti S, Fini M. 2007. Effects of electrical physical stimuli on articular cartilage. J Bone Joint Surg Am 89: 152-161.
19. Massot O, Grimaldi B, Bailly JM, Kochanek M, Deschamps F, Lambrozo J, Fillion G. 2000. Magnetic field desensitizes 5-HT(1B) receptor in brain: Pharmacological and functional studies. Brain Res 858: 143-150.
20. Melo JB, Agostinho P, Oliveira CR. 2007. Prion protein aggregation and neurotoxicity in cortical neurons. Ann NY Acad Sci 1096: 220-229.
21. Munson PJ, Rodbard D. 1980. Ligand: A versatile computerized approach for the characterization of ligand binding systems. Anal Biochem 107: 220-239.
22. Nelson FR, Brighton CT, Ryaby J, Simon BJ, Nielson JH, Lorich DJ, Bolander M, Seelig J. 2003. Use of physical forces in bone healing. J Am Acad Orthop Surg 11: 344-354.
23. Sandyk R. 1994. A drug naive parkinsonian patient successfully treated with weak electromagnetic fields. Int J Neurosci 79(1-2): 99-110.
24. 1 receptors ligands: Past, present and future trends. Curr Top Med Chem 10(9): 878-901.
25. Shupak NM, Hensel JM, Cross-Mellor SK, Kavaliers M, Prato FS, Thomas AW. 2004. Analgesic and behavioral effects of a 100 microT specific pulsed extremely low frequency magnetic field on control and morphine treated CF-1 mice. Neurosci Lett 354: 30-33.
26. Stone TW. 2002. Purines and neuroprotection. Adv Exp Med Biol 513: 249-280.
27. 2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: A possible key mechanism in the modulation of N-methyl-D-aspartate effects. J Neurochem 95: 1188-1200.
28. 2A adenosine receptors in human neutrophils. Br J Pharmacol 136(1): 57-66.
29. 3 adenosine receptors in human neutrophils and low frequency electromagnetic fields. Biochem Pharmacol 66(10): 1897-1906.
30. Varani K, de Mattei M, Vincenzi F, Gessi S, Merighi S, Pellati A, Ongaro A, Caruso A, Cadossi R, Borea PA. 2008. Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields. Osteoarthritis Cartilage 16: 292-304.
31. 3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. Arthritis Rheum 60(10): 2880-2891.
32. 2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease. FASEB J 24(2): 587-598.
33. Wieraszko A, Armani J, Maqsood N, Raja H, Philip S. 2005. Modification of the synaptic glutamate turnover in the hippocampal tissue exposed to low-frequency, pulsed magnetic fields. Brain Res 1052(2): 232-235.