Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats

British Journal of Pharmacology

Volumn 169, Issue 3, 2013, Pages 685-692

  Rock, E M ^a   Parker, L A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

cancer; cannabinoid; gastro pharmacology; psychopharmacology; serotonin

Indexed keywords

CANNABIDIOLIC ACID; CANNABINOID; LITHIUM CHLORIDE; ONDANSETRON; SEROTONIN 3 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOTHERAPY; CONDITIONED GAPING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; FLAVOR; LOW DRUG DOSE; NAUSEA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIEMETICS; ANTINEOPLASTIC AGENTS; BEHAVIOR, ANIMAL; CANNABINOIDS; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; INJECTIONS, INTRAPERITONEAL; LITHIUM CHLORIDE; MALE; NAUSEA; ONDANSETRON; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS; TASTE;

EID: 84877824482     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12162     Document Type: Article

References (39)

1. Ballatori E, Roila F, Ruggeri B, Betti M, Sarti S, Soru G, et al. (2007). The impact of chemotherapy-induced nausea and vomiting on health-related quality of life. Support Care Cancer 15: 179-185.
2. Blier P, de Montigny C, (1987). Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1: 470-480.
3. de Boer-Dennert M, de Wit R, Schmitz PI, Djontono J, v Beurden V, Stoter G, et al. (1997). Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists. Br J Cancer 76: 1055-1061.
4. Bolognini D, Rock E, Cluny N, Cascio MG, Limebeer C, Duncan M, et al. (2013). Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behavior in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol 168: 1456-1470.
5. Campos AC, Guimaraes FS, (2008). Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl) 199: 223-230.
6. Cluny NL, Naylor RJ, Whittle BA, Javid FA, (2011). The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus. Arch Pharm Res 34: 1509-1517.
7. De Petrocellis L, Vellani V, Schiano-Moriello A, Marini P, Magherini PC, Orlando P, et al. (2008). Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 325: 1007-1015.
8. De Petrocellis L, Ligresti A, Moriello AS, Allara M, Bisogno T, Petrosino S, et al. (2011). Effects of cannabinoids and cannabinoid-enriched cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol 163: 1479-1494.
9. Duran M, Perez E, Abanades S, Vidal X, Saura C, Majem M, et al. (2010). Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. Br J Clin Pharmacol 70: 656-663.
10. Foubert J, Vaessen G, (2005). Nausea: the neglected symptom? Eur J Oncol Nurs 9: 21-32.
11. Grill HJ, Norgren R, (1978). The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res 143: 263-279.
12. Hickok JT, Roscoe JA, Morrow GR, King DK, Atkins JN, Fitch TR, (2003). Nausea and emesis remain significant problems of chemotherapy despite prophylaxis with 5-hydroxytryptamine-3 antiemetics: a University of Rochester James P. Wilmot Cancer Center Community Clinical Oncology Program Study of 360 cancer patients treated in the community. Cancer 97: 2880-2886.
13. Kwiatkowska M, Parker LA, Burton P, Mechoulam R, (2004). A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew). Psychopharmacology (Berl) 174: 254-259.
14. Limebeer CL, Parker LA, (1999). Delta-9-tetrahydrocannabinol interferes with the establishment and the expression of conditioned rejection reactions produced by cyclophosphamide: a rat model of nausea. Neuroreport 10: 3769-3772.
15. Limebeer CL, Parker LA, (2000). The antiemetic drug ondansetron interferes with lithium-induced conditioned rejection reactions, but not lithium-induced taste avoidance in rats. J Exp Psychol Anim Behav Process 26: 371-384.
16. Limebeer CL, Parker LA, (2003). The 5-HT1A agonist 8-OH-DPAT dose-dependently interferes with the establishment and the expression of lithium-induced conditioned rejection reactions in rats. Psychopharmacology (Berl) 166: 120-126.
17. Limebeer CL, Hall G, Parker LA, (2006). Exposure to a lithium-paired context elicits gaping in rats: a model of anticipatory nausea. Physiol Behav 88: 398-403.
18. Limebeer CL, Litt DE, Parker LA, (2009). Effect of 5-HT3 antagonists and a 5-HT(1A) agonist on fluoxetine-induced conditioned gaping reactions in rats. Psychopharmacology (Berl) 203: 763-770.
19. Mechoulam R, Gaoni Y, (1965). The isolation and structure of cannabinolic, cannabidiolic and cannabigerolic acids. Tetrahedron 21: 1223-1229.
20. Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, et al. (2005). Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 36: 1077-1082.
21. Morrow GR, Roscoe JA, Hynes HE, Flynn PJ, Pierce HI, Burish T, (1998). Progress in reducing anticipatory nausea and vomiting: a study of community practice. Support Care Cancer 6: 46-50.
22. Parker LA, (2003). Taste avoidance and taste aversion: evidence for two different processes. Learn Behav 31: 165-172.
23. Parker LA, Limebeer CL, (2006). Conditioned gaping in rats: a selective measure of nausea. Auton Neurosci 129: 36-41.
24. Parker LA, Limebeer CL, (2008). Cannabinoids in the management of nausea and vomiting. In:, Köfalvi A, (ed.). Cannabinoids and the Brain. Springer: New York, pp. 259-273.
25. Parker LA, Mechoulam R, Schlievert C, (2002). Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats. Neuroreport 13: 567-570.
26. Parker LA, Kwiatkowska M, Burton P, Mechoulam R, (2004). Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology (Berl) 171: 156-161.
27. Parker LA, Kwiatkowska M, Mechoulam R, (2006). Delta-9- tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: an animal model of anticipatory nausea and vomiting. Physiol Behav 87: 66-71.
28. Parker LA, Rana SA, Limebeer CL, (2008). Conditioned nausea in rats: assessment by conditioned disgust reactions, rather than conditioned taste avoidance. Can J Exp Psychol 62: 198-209.
29. Pertwee RG, (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 153: 199-215.
30. Potter DJ, Clark P, Brown MB, (2008). Potency of delta 9-THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology. J Forensic Sci 53: 90-94.
31. Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, et al. (2012). Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol 165: 2620-2634.
32. Rock EM, Limebeer CL, Mechoulam R, Piomelli D, Parker LA, (2008). The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat. Psychopharmacology (Berl) 196: 389-395.
33. Rock EM, Goodwin JM, Limebeer CL, Breuer A, Pertwee RG, Mechoulam R, et al. (2011). Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. Psychopharmacology (Berl) 215: 505-512.
34. Ruhaak LR, Felth J, Karlsson PC, Rafter JJ, Verpoorte R, Bohlin L, (2011). Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. Biol Pharm Bull 34: 774-778.
35. Takeda S, Misawa K, Yamamoto I, Watanabe K, (2008). Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metab Dispos 36: 1917-1921.
36. Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, et al. (2012). Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol Lett 214: 314-319.
37. Tuerke KJ, Limebeer CL, Fletcher PJ, Parker LA, (2012). Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT3 receptor in the posterior and anterior insular cortex. J Neurosci 32: 13709-13717.
38. Verge D, Daval G, Patey A, Gozlan H, el Mestikawy S, Hamon M, (1985). Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur J Pharmacol 113: 463-464.
39. Zanelati TV, Biojone C, Moreira FA, Guimaraes FS, Joca SR, (2010). Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol 159: 122-128.