Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig

British Journal of Pharmacology

Volumn 169, Issue 3, 2013, Pages 580-589

  Changani, Kumar ^a   Hotee, Sarah ^a   Campbell, Simon ^a   Pindoria, Kashmira ^a   Dinnewell, Laura ^a   Saklatvala, Paula ^a   Thompson, Sally Anne ^a   Coe, Diane ^a   Biggadike, Keith ^a   Vitulli, Giovanni ^a   Lines, Marion ^a   Busza, Albert ^a   Denyer, Jane ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

atropine; capsaicin; guinea pig; hypertonic saline; MRI; nasal sensory nerves; parasympathetic reflex; SB 705498; TRPV1 ion channel

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; ATROPINE; CAPSAICIN; OVALBUMIN; SODIUM CHLORIDE; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG POTENCY; ELECTROPHYSIOLOGY; FEMALE; GUINEA PIG; IN VIVO STUDY; NERVE CELL CULTURE; NONHUMAN; NOSE MUCOSA; NOSE SECRETION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARASYMPATHETIC FUNCTION; PATCH CLAMP; PRIORITY JOURNAL; RHINITIS; SENSORY NERVE CELL; SUSPENSION; TRIGEMINUS GANGLION;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTI-ALLERGIC AGENTS; CAPSAICIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; FEMALE; GUINEA PIGS; MALE; NASAL MUCOSA; PARASYMPATHETIC NERVOUS SYSTEM; PARASYMPATHOLYTICS; PARTICLE SIZE; PYRROLIDINES; RHINITIS, ALLERGIC, PERENNIAL; SECRETORY PATHWAY; SENSORY SYSTEM AGENTS; TRIGEMINAL GANGLION; TRPV CATION CHANNELS; UREA;

EID: 84877822681     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12145     Document Type: Article

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