The role of novel biomarkers in early diagnosis and prognosis of acute kidney injury in newborns

American Journal of Perinatology

Volumn 30, Issue 5, 2013, Pages 347-352

  Argyri, Ioanna ^a   Xanthos, Theodoros ^a   Varsami, Marianna ^a   Aroni, Filippia ^a   Papalois, Apostolos ^b   Dontas, Ismene ^a   Fanos, Vassillios ^c   Iacovidou, Nicoletta ^d  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b ELPEN Pharmaceuticals   (Greece)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d UNIVERSITY OF ATHENS   (Greece)

Author keywords

acute kidney injury; biomarkers; creatinine; newborns

Indexed keywords

CREATININE; CYCLOSPORIN; CYSTATIN C; FUROSEMIDE; IBUPROFEN; INDOMETACIN; INTERLEUKIN 18; KIDNEY INJURY MOLECULE 1; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

ACUTE KIDNEY FAILURE; APOPTOSIS; CELL DEATH; CREATININE BLOOD LEVEL; DISEASE MARKER; EARLY DIAGNOSIS; HUMAN; KIDNEY FUNCTION; KIDNEY MALFORMATION; LOW BIRTH WEIGHT; NEPHROTOXICITY; NEWBORN DISEASE; NONHUMAN; PERINATAL ASPHYXIA; PREMATURITY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; REVIEW; SEPTIC SHOCK; VERY LOW BIRTH WEIGHT;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; CYSTATIN C; EARLY DIAGNOSIS; HUMANS; INFANT, NEWBORN; INTERLEUKIN-18; LIPOCALINS; MEMBRANE GLYCOPROTEINS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTORS, VIRUS;

EID: 84877819071     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0032-1326985     Document Type: Review

References (69)

1. Liangos O., Wald R., O'Bell J. W., Price L., Pereira B. J., Jaber B. L. Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. Clin J Am Soc Nephrol: 2006; 1 43 51
2. Andreoli S. P. Acute renal failure in the newborn. Semin Perinatol: 2004; 28 112 123 (Pubitemid 38590912)
3. Durkan A. M., Alexander R. T. Acute kidney injury post neonatal asphyxia. J Pediatr: 2011; 158 2 Suppl e29 e33
4. Askenazi D. J., Griffin R., McGwin G., Carlo W., Ambalavanan N. Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysis. Pediatr Nephrol: 2009; 24 991 997
5. Agras P. I., Tarcan A., Baskin E., Cengiz N., Gürakan B., Saatci U. Acute renal failure in the neonatal period. Ren Fail: 2004; 26 305 309 (Pubitemid 39050673)
6. Abitbol C. L., Bauer C. R., Montané B., Chandar J., Duara S., Zilleruelo G. Long-term follow-up of extremely low birth weight infants with neonatal renal failure. Pediatr Nephrol: 2003; 18 887 893 (Pubitemid 37121620)
7. Askenazi D. J., Ambalavanan N., Goldstein S. L. Acute kidney injury in critically ill newborns: what do we know? What do we need to learn? Pediatr Nephrol: 2009; 24 265 274
8. Murray P. T., Le Gall J. R., Dos Reis Miranda D., Pinsky M. R., Tetta C. Physiologic endpoints (efficacy) for acute renal failure studies. Curr Opin Crit Care: 2002; 8 519 525 (Pubitemid 35388206)
9. Bariciak E., Yasin A., Harrold J., Walker M., Lepage N., Filler G. Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates. Clin Biochem: 2011; 44 1156 1159
10. Drukker A., Guignard J. P. Renal aspects of the term and preterm infant: a selective update. Curr Opin Pediatr: 2002; 14 175 182 (Pubitemid 34412161)
11. Stevens L. A., Coresh J., Greene T., Levey A. S. Assessing kidney function measured and estimated glomerular filtration rate. N Engl J Med: 2006; 354 2473 2483 (Pubitemid 43855050)
12. Parikh C. R., Devarajan P. New biomarkers of acute kidney injury. Crit Care Med: 2008; 36 4 Suppl S159 S165 (Pubitemid 351483046)
13. Stevens L. A., Coresh J., Schmid C. H., et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis: 2008; 51 395 406 (Pubitemid 351273480)
14. Dent C. L., Ma Q., Dastrala S., et al. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care: 2007; 11 R127
15. Kingsmore S. F., Kennedy N., Halliday H. L., et al. Identification of diagnostic biomarkers for infection in premature neonates. Mol Cell Proteomics: 2008; 7 1863 1875
16. Li Y., Fu C., Zhou X., et al. Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates. Pediatr Nephrol: 2012; 27 851 860
17. Du Y., Zappitelli M., Mian A., et al. Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol: 2011; 26 267 274
18. Westhuyzen J. Cystatin C: a promising marker and predictor of impaired renal function. Ann Clin Lab Sci: 2006; 36 387 394 (Pubitemid 44786685)
19. Plebani M., Mussap M., Bertelli L., et al. [Determination of blood cystatin C in pregnant women during labor and in their newborns]. Pediatr Med Chir: 1997; 19 325 329
20. Cataldi L., Mussap M., Bertelli L., Ruzzante N., Fanos V., Plebani M. Cystatin C in healthy women at term pregnancy and in their infant newborns: relationship between maternal and neonatal serum levels and reference values. Am J Perinatol: 1999; 16 287 295
21. Novo A. C., Sadeck LdosS, Okay T. S., Leone C. R. Longitudinal study of Cystatin C in healthy term newborns. Clinics (Sao Paulo): 2011; 66 217 220
22. Gokmen T., Erdeve O., Altug N., Oguz S. S., Uras N., Dilmen U. Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus. J Pediatr: 2011; 158 549 554, e1
23. Lee B. S., Byun S. Y., Chung M. L., et al. Effect of furosemide on ductal closure and renal function in indomethacin-treated preterm infants during the early neonatal period. Neonatology: 2010; 98 191 199
24. Askenazi D. J., Koralkar R., Hundley H. E., et al. Urine biomarkers predict acute kidney injury in newborns. J Pediatr: 2012; 161 2 270 275.e1. Epub 2012 Mar 16
25. Maruniak-Chudek I., Owsianka-Podleśny T., Wróblewska J., Jadamus-Niebrój D. Is serum cystatin C a better marker of kidney function than serum creatinine in septic newborns? Postepy Hig Med Dosw (Online): 2012; 66 175 180
26. Treiber M., Pecovnik-Balon B., Gorenjak M. Cystatin C versus creatinine as a marker of glomerular filtration rate in the newborn. Wien Klin Wochenschr: 2006; 118 02 66 70 (Pubitemid 43989538)
27. Armangil D., Yurdakök M., Canpolat F. E., Korkmaz A., Yiǧit S., Tekinalp G. Determination of reference values for plasma cystatin C and comparison with creatinine in premature infants. Pediatr Nephrol: 2008; 23 2081 2083
28. Nielsen E. I., Sandström M., Honoré P. H., Ewald U., Friberg L. E. Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study. Clin Pharmacokinet: 2009; 48 253 263
29. Parvex P., Combescure C., Rodriguez M., Girardin E. Is Cystatin C a promising marker of renal function, at birth, in neonates prenatally diagnosed with congenital kidney abnormalities? Nephrol Dial Transplant: 2012; 27 9 3477 3482 10.1093/ndt/gfs051
30. Bolignano D., Donato V., Coppolino G., et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis: 2008; 52 595 605
31. Mishra J., Ma Q., Prada A., et al. Identification of NGAL as a novel urine biomarker for ischemic injury. J Am Soc Nephrol: 2003; 14 2534 2543
32. Mishra J., Mori K., Ma Q., Kelly C., Barasch J., Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol: 2004; 24 307 315 (Pubitemid 39070114)
33. Mishra J., Ma Q., Kelly C., et al. Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol: 2006; 21 856 863 (Pubitemid 43740956)
34. Wasilewska A., Zoch-Zwierz W., Taranta-Janusz K., Michaluk-Skutnik J. Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of cyclosporine nephrotoxicity? Pediatr Nephrol: 2010; 25 889 897
35. Lavery A. P., Meinzen-Derr J. K., Anderson E., et al. Urinary NGAL in premature infants. Pediatr Res: 2008; 64 423 428
36. Krawczeski C. D., Woo J. G., Wang Y., Bennett M. R., Ma Q., Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr: 2011; 158 1009 1015, e1
37. Koch A. M., Dittrich S., Cesnjevar R., Rüffer A., Breuer C., Glöckler M. Plasma neutrophil gelatinase-associated lipocalin measured in consecutive patients after congenital heart surgery using point-of-care technology. Interact Cardiovasc Thorac Surg: 2011; 13 133 136
38. Sarafidis K., Tsepkentzi E., Agakidou E., et al. Serum and urine acute kidney injury biomarkers in asphyxiated neonates. Pediatr Nephrol: 2012; 27 9 1575 1582 10.1007/s00467-012-2162-4
39. Tadesse S., Luo G., Park J. S., et al. Intra-amniotic infection upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the maternal-fetal interface at term: implications for infection-related preterm birth. Reprod Sci: 2011; 18 713 722
40. Parravicini E., Nemerofsky S. L., Michelson K. A., et al. Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. Pediatr Res: 2010; 67 636 640
41. La Manna G., Galletti S., Capelli I., et al. Urinary neutrophil gelatinase-associated lipocalin at birth predicts early renal function in very low birth weight infants. Pediatr Res: 2011; 70 379 383
42. Bonventre J. V. Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant: 2009; 24 3265 3268
43. Vaidya V. S., Ramirez V., Ichimura T., Bobadilla N. A., Bonventre J. V. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol: 2006; 290 F517 F529 (Pubitemid 43725006)
44. Zhou Y., Vaidya V. S., Brown R. P., et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci: 2008; 101 159 170 (Pubitemid 350239020)
45. Ichimura T., Hung C. C., Yang S. A., Stevens J. L., Bonventre J. V. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol: 2004; 286 F552 F563 (Pubitemid 38233650)
46. Askenazi D. J., Montesanti A., Hunley H., et al. Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants. J Pediatr: 2011; 159 907 912, e1
47. McWilliam S. J., Antoine D. J., Turner M., et al. Urinary KIM-1 as a biomarker of aminoglycoside-induced nephrotoxicity in premature neonates. Pediatr Res: 2011; 70 107
48. Dinarello C. A., Novick D., Puren A. J., et al. Overview of interleukin-18: more than an interferon-γ inducing factor. J Leukoc Biol: 1998; 63 658 664 (Pubitemid 28274825)
49. Melnikov V. Y., Ecder T., Fantuzzi G., et al. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest: 2001; 107 1145 1152 (Pubitemid 32422911)
50. Cusumano V., Midiri A., Cusumano V. V., et al. Interleukin-18 is an essential element in host resistance to experimental group B streptococcal disease in neonates. Infect Immun: 2004; 72 295 300 (Pubitemid 38018188)
51. Bender L., Thaarup J., Varming K., Krarup H., Ellermann-Eriksen S., Ebbesen F. Early and late markers for the detection of early-onset neonatal sepsis. Dan Med Bull: 2008; 55 219 223
52. Devarajan P. Proteomics for biomarker discovery in acute kidney injury. Semin Nephrol: 2007; 27 637 651 (Pubitemid 350180173)
53. Bellomo R., Kellum J. A., Ronco C. Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria. Intensive Care Med: 2007; 33 409 413 (Pubitemid 46333828)
54. Bagshaw S. M., George C., Bellomo R. ANZICS Database Management Committee A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients. Nephrol Dial Transplant: 2008; 23 1569 1574 (Pubitemid 351767782)
55. Mussap M., Degrandi R., Fravega M., Fanos V. Acute kidney injury in critically ill infants: the role of urine Neutrophil Gelatinase-Associated Lipocalin (NGAL). J Matern Fetal Neonatal Med: 2010; 23 03 70 72
56. Krawczeski C. D., Vandevoorde R. G., Kathman T., et al. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol: 2010; 5 1552 1557
57. Han W. K., Waikar S. S., Johnson A., et al. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int: 2008; 73 863 869 (Pubitemid 351398278)
58. Parikh C. R., Mishra J., Thiessen-Philbrook H., et al. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int: 2006; 70 199 203 (Pubitemid 44000139)
59. Harmoinen A., Ylinen E., Ala-Houhala M., Janas M., Kaila M., Kouri T. Reference intervals for cystatin C in pre- and full-term infants and children. Pediatr Nephrol: 2000; 15 105 108
60. Askenazi D. J., Koralkar R., Levitan E. B., et al. Baseline values of candidate urine acute kidney injury biomarkers vary by gestational age in premature infants. Pediatr Res: 2011; 70 302 306
61. Parravicini E., Lorenz J. M., Nemerofsky S. L., O'Rourke M., Barasch J., Bateman D. Reference range of urinary neutrophil gelatinase-associated lipocalin in very low-birth-weight infants: preliminary data. Am J Perinatol: 2009; 26 437 440
62. Huynh T. K., Bateman D. A., Parravicini E., et al. Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr Res: 2009; 66 528 532
63. Koralkar R., Ambalavanan N., Levitan E. B., McGwin G., Goldstein S., Askenazi D. Acute kidney injury reduces survival in very low birth weight infants. Pediatr Res: 2011; 69 354 358
64. Lindon J. C., Holmes E., Bollard M. E., Stanley E. G., Nicholson J. K. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers: 2004; 9 1 31 (Pubitemid 38660013)
65. Pan Z., Raftery D. Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics. Anal Bioanal Chem: 2007; 387 525 527 (Pubitemid 46067468)
66. Weiss R. H., Kim K. Metabolomics in the study of kidney diseases. Nat Rev Nephrol: 2012; 8 22 33
67. Atzori L., Xanthos T., Barberini L., et al. A metabolomic approach in an experimental model of hypoxia-reoxygenation in newborn piglets: urine predicts outcome. J Matern Fetal Neonatal Med: 2010; 23 03 134 137
68. Beger R. D., Holland R. D., Sun J., et al. Metabonomics of acute kidney injury in children after cardiac surgery. Pediatr Nephrol: 2008; 23 977 984
69. Atzori L., Mussap M., Noto A., et al. Clinical metabolomics and urinary NGAL for the early prediction of chronic kidney disease in healthy adults born ELBW. J Matern Fetal Neonatal Med: 2011; 24 02 40 43