Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB): 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites

European Journal of Biochemistry

Volumn 269, Issue 15, 2002, Pages 3678-3687

  Bilmen, Jonathan G ^a   Wootton, Laura L ^a   Godfrey, Rita E ^a   Smart, Oliver S ^a   Michelangeli, Francesco ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

2 APB; Ca2+ ATPase; Inhibition; SERCA

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATE; BENZENE DERIVATIVE; CALCIUM CHANNEL; UNCLASSIFIED DRUG; 2-AMINOETHOXYDIPHENYL BORATE; BORON DERIVATIVE; CALCIUM; ENZYME INHIBITOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM BINDING; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DISSOCIATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; FLUORESCENCE; IC 50; MEMBRANE PERMEABILITY; NONHUMAN; PH; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL MEMBRANE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; KINETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION;

ANIMALIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; BORON COMPOUNDS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELL MEMBRANE; ENZYME INHIBITORS; FLUORESCENCE; KINETICS; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TRYPTOPHAN;

EID: 0035984392     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03060.x     Document Type: Article

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