Synthesis of bisboron compounds and their strong inhibitory activity on store-operated calcium entry

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1395-1398

  Suzuki, Akinobu Z ^a   Ozaki, Shoichiro ^a   Goto, Jun Ichi ^a   Mikoshiba, Katsuhiko ^a,b  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

2 APB; Boron; Calcium; Inhibitor; SOCE

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; BISBORON COMPOUND; BORINIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; LEUKEMIA CELL LINE;

BORINIC ACIDS; BORON COMPOUNDS; CALCIUM; CALCIUM CHANNELS; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION;

EID: 75449106238     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.108     Document Type: Article

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25. 3 to give 3,3′-[(2-aminoethoxy)phenylboryl]dibenzyl ether 7 (157 mg, 0.319 mmol, 84.6%, total 31.9%) as a light yellow powder.
26. +] 438.2241, found 438.2244.
27. 2+ entry of Jurkat T cells in same plate, and the inhibitory activities of borinate esters were calculated from dividing the maximal emission ratio in the presence of borinate esters by the maximal emission ratio in control.