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Volumn 8, Issue 5, 2013, Pages

Efferocytosis Promotes Suppressive Effects on Dendritic Cells through Prostaglandin E2 Production in the Context of Autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84877768008     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063296     Document Type: Article
Times cited : (31)

References (51)
  • 1
    • 34547656330 scopus 로고    scopus 로고
    • Immunological consequences of apoptotic cell phagocytosis
    • Erwig LP, Henson PM, (2007) Immunological consequences of apoptotic cell phagocytosis. Am J Pathol 171: 2-8.
    • (2007) Am J Pathol , vol.171 , pp. 2-8
    • Erwig, L.P.1    Henson, P.M.2
  • 3
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman RM, Turley S, Mellman I, Inaba K, (2000) The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 191: 411-416.
    • (2000) J Exp Med , vol.191 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 4
    • 32644454550 scopus 로고    scopus 로고
    • Regulation of cytokine production during phagocytosis of apoptotic cells
    • Chung EY, Kim SJ, Ma XJ, (2006) Regulation of cytokine production during phagocytosis of apoptotic cells. Cell Res 16: 154-161.
    • (2006) Cell Res , vol.16 , pp. 154-161
    • Chung, E.Y.1    Kim, S.J.2    Ma, X.J.3
  • 5
    • 0035856952 scopus 로고    scopus 로고
    • beta-Cell death during progression to diabetes
    • Mathis D, Vence L, Benoist C, (2001) beta-Cell death during progression to diabetes. Nature 414: 792-798.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 6
    • 50949092228 scopus 로고    scopus 로고
    • Autoimmune mechanisms in type 1 diabetes
    • Knip M, Siljander H, (2008) Autoimmune mechanisms in type 1 diabetes. Autoimmun Rev 7: 550-557.
    • (2008) Autoimmun Rev , vol.7 , pp. 550-557
    • Knip, M.1    Siljander, H.2
  • 8
    • 31344476162 scopus 로고    scopus 로고
    • A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse
    • O'Brien BA, Geng X, Orteu CH, Huang Y, Ghoreishi M, et al. (2006) A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse. J Autoimmun 26: 104-115.
    • (2006) J Autoimmun , vol.26 , pp. 104-115
    • O'Brien, B.A.1    Geng, X.2    Orteu, C.H.3    Huang, Y.4    Ghoreishi, M.5
  • 9
    • 84863205630 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy
    • Faleo G, Fotino C, Bocca N, Molano RD, Zahr-Akrawi E, et al. (2012) Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy. Diabetes 61: 1769-1778.
    • (2012) Diabetes , vol.61 , pp. 1769-1778
    • Faleo, G.1    Fotino, C.2    Bocca, N.3    Molano, R.D.4    Zahr-Akrawi, E.5
  • 11
    • 77956943707 scopus 로고    scopus 로고
    • Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells
    • Morelli AE, Larregina AT, (2010) Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells. Apoptosis 15: 1083-1097.
    • (2010) Apoptosis , vol.15 , pp. 1083-1097
    • Morelli, A.E.1    Larregina, A.T.2
  • 12
    • 77956360380 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential
    • Peakman M, von Herrath M, (2010) Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential. Diabetes 59: 2087-2093.
    • (2010) Diabetes , vol.59 , pp. 2087-2093
    • Peakman, M.1    von Herrath, M.2
  • 13
    • 0025878776 scopus 로고
    • NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse
    • Hamaguchi K, Gaskins HR, Leiter EH, (1991) NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes 40: 842-849.
    • (1991) Diabetes , vol.40 , pp. 842-849
    • Hamaguchi, K.1    Gaskins, H.R.2    Leiter, E.H.3
  • 14
    • 0028262128 scopus 로고
    • Determination of lymphocyte division by flow cytometry
    • Lyons AB, Parish CR, (1994) Determination of lymphocyte division by flow cytometry. J Immunol Methods 171: 131-137.
    • (1994) J Immunol Methods , vol.171 , pp. 131-137
    • Lyons, A.B.1    Parish, C.R.2
  • 15
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1    Hobbs, B.2    Collin, F.3    Beazer-Barclay, Y.D.4    Antonellis, K.J.5
  • 16
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 17
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser B 57: 289-300.
    • (1995) J R Stat Soc Ser B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 18
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 20
    • 77952538760 scopus 로고    scopus 로고
    • Development of dendritic cell-based immunotherapy for autoimmunity
    • Hilkens CM, Isaacs JD, Thomson AW, (2010) Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol 29: 156-183.
    • (2010) Int Rev Immunol , vol.29 , pp. 156-183
    • Hilkens, C.M.1    Isaacs, J.D.2    Thomson, A.W.3
  • 21
    • 2342584674 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: getting rid of the corpses
    • Lauber K, Blumenthal SG, Waibel M, Wesselborg S, (2004) Clearance of apoptotic cells: getting rid of the corpses. Mol Cell 14: 277-287.
    • (2004) Mol Cell , vol.14 , pp. 277-287
    • Lauber, K.1    Blumenthal, S.G.2    Waibel, M.3    Wesselborg, S.4
  • 23
    • 22744441633 scopus 로고    scopus 로고
    • Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation
    • Blachere NE, Darnell RB, Albert ML, (2005) Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol 3: e185.
    • (2005) PLoS Biol , vol.3
    • Blachere, N.E.1    Darnell, R.B.2    Albert, M.L.3
  • 24
    • 0032543225 scopus 로고    scopus 로고
    • CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells
    • Adler AJ, Marsh DW, Yochum GS, Guzzo JL, Nigam A, et al. (1998) CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J Exp Med 187: 1555-1564.
    • (1998) J Exp Med , vol.187 , pp. 1555-1564
    • Adler, A.J.1    Marsh, D.W.2    Yochum, G.S.3    Guzzo, J.L.4    Nigam, A.5
  • 25
    • 84856373688 scopus 로고    scopus 로고
    • A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells
    • Miles K, Heaney J, Sibinska Z, Salter D, Savill J, et al. (2012) A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. Proc Natl Acad Sci U S A 109: 887-892.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 887-892
    • Miles, K.1    Heaney, J.2    Sibinska, Z.3    Salter, D.4    Savill, J.5
  • 26
    • 77951033594 scopus 로고    scopus 로고
    • Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg
    • Kushwah R, Wu J, Oliver JR, Jiang G, Zhang J, et al. (2010) Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg. Eur J Immunol 40: 1022-1035.
    • (2010) Eur J Immunol , vol.40 , pp. 1022-1035
    • Kushwah, R.1    Wu, J.2    Oliver, J.R.3    Jiang, G.4    Zhang, J.5
  • 27
    • 0027170482 scopus 로고
    • Antigen-presenting cells in adoptively transferred and spontaneous autoimmune diabetes
    • Lo D, Reilly CR, Scott B, Liblau R, McDevitt HO, et al. (1993) Antigen-presenting cells in adoptively transferred and spontaneous autoimmune diabetes. Eur J Immunol 23: 1693-1698.
    • (1993) Eur J Immunol , vol.23 , pp. 1693-1698
    • Lo, D.1    Reilly, C.R.2    Scott, B.3    Liblau, R.4    McDevitt, H.O.5
  • 28
    • 0034166862 scopus 로고    scopus 로고
    • Defects in the differentiation and function of bone marrow-derived dendritic cells in non-obese diabetic mice
    • Lee M, Kim AY, Kang Y, (2000) Defects in the differentiation and function of bone marrow-derived dendritic cells in non-obese diabetic mice. J Korean Med Sci 15: 217-223.
    • (2000) J Korean Med Sci , vol.15 , pp. 217-223
    • Lee, M.1    Kim, A.Y.2    Kang, Y.3
  • 29
    • 78650602365 scopus 로고    scopus 로고
    • Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation
    • Sandahl M, Hunter DM, Strunk KE, Earp HS, Cook RS, (2010) Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation. BMC Dev Biol 10: 122.
    • (2010) BMC Dev Biol , vol.10 , pp. 122
    • Sandahl, M.1    Hunter, D.M.2    Strunk, K.E.3    Earp, H.S.4    Cook, R.S.5
  • 30
    • 69249202402 scopus 로고    scopus 로고
    • Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells
    • Creusot RJ, Yaghoubi SS, Chang P, Chia J, Contag CH, et al. (2009) Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells. Blood 113: 6638-6647.
    • (2009) Blood , vol.113 , pp. 6638-6647
    • Creusot, R.J.1    Yaghoubi, S.S.2    Chang, P.3    Chia, J.4    Contag, C.H.5
  • 31
    • 0025343677 scopus 로고
    • Autologous CD4 T-cell responses to ectopic class II major histocompatibility complex antigen-expressing single-cell islet cells: an in vitro insight into the pathogenesis of lymphocytic insulitis in nonobese diabetic mice
    • Formby B, Miller N, (1990) Autologous CD4 T-cell responses to ectopic class II major histocompatibility complex antigen-expressing single-cell islet cells: an in vitro insight into the pathogenesis of lymphocytic insulitis in nonobese diabetic mice. Proc Natl Acad Sci U S A 87: 2438-2442.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 2438-2442
    • Formby, B.1    Miller, N.2
  • 32
    • 0035073058 scopus 로고    scopus 로고
    • A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouse
    • Strid J, Lopes L, Marcinkiewicz J, Petrovska L, Nowak B, et al. (2001) A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouse. Clin Exp Immunol 123: 375-381.
    • (2001) Clin Exp Immunol , vol.123 , pp. 375-381
    • Strid, J.1    Lopes, L.2    Marcinkiewicz, J.3    Petrovska, L.4    Nowak, B.5
  • 33
    • 66649113381 scopus 로고    scopus 로고
    • Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice
    • Emamaullee JA, Davis J, Merani S, Toso C, Elliott JF, et al. (2009) Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes 58: 1302-1311.
    • (2009) Diabetes , vol.58 , pp. 1302-1311
    • Emamaullee, J.A.1    Davis, J.2    Merani, S.3    Toso, C.4    Elliott, J.F.5
  • 34
    • 33645405365 scopus 로고    scopus 로고
    • Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells
    • Keino H, Takeuchi M, Kezuka T, Hattori T, Usui M, et al. (2006) Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells. Invest Ophthalmol Vis Sci 47: 1047-1055.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 1047-1055
    • Keino, H.1    Takeuchi, M.2    Kezuka, T.3    Hattori, T.4    Usui, M.5
  • 35
    • 40749084404 scopus 로고    scopus 로고
    • Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing
    • Hanig J, Lutz MB, (2008) Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing. J Immunol 180: 1405-1413.
    • (2008) J Immunol , vol.180 , pp. 1405-1413
    • Hanig, J.1    Lutz, M.B.2
  • 36
    • 0021043226 scopus 로고
    • Regulation of the immune response by prostaglandins
    • Goodwin JS, Ceuppens J, (1983) Regulation of the immune response by prostaglandins. J Clin Immunol 3: 295-315.
    • (1983) J Clin Immunol , vol.3 , pp. 295-315
    • Goodwin, J.S.1    Ceuppens, J.2
  • 38
    • 22544436066 scopus 로고    scopus 로고
    • Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells
    • Baratelli F, Lin Y, Zhu L, Yang SC, Heuze-Vourc'h N, et al. (2005) Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J Immunol 175: 1483-1490.
    • (2005) J Immunol , vol.175 , pp. 1483-1490
    • Baratelli, F.1    Lin, Y.2    Zhu, L.3    Yang, S.C.4    Heuze-Vourc'h, N.5
  • 39
    • 0028882673 scopus 로고
    • Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E
    • Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL, (1995) Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and-10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol 147: 1193-1199.
    • (1995) Am J Pathol , vol.147 , pp. 1193-1199
    • Hancock, W.W.1    Polanski, M.2    Zhang, J.3    Blogg, N.4    Weiner, H.L.5
  • 40
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, et al. (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101: 890-898.
    • (1998) J Clin Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5
  • 41
    • 28244436739 scopus 로고    scopus 로고
    • Leukotrienes modulate cytokine release from dendritic cells
    • Jozefowski S, Biedron R, Bobek M, Marcinkiewicz J, (2005) Leukotrienes modulate cytokine release from dendritic cells. Immunology 116: 418-428.
    • (2005) Immunology , vol.116 , pp. 418-428
    • Jozefowski, S.1    Biedron, R.2    Bobek, M.3    Marcinkiewicz, J.4
  • 42
    • 0038116167 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses
    • Nencioni A, Wesselborg S, Brossart P, (2003) Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses. Crit Rev Immunol 23: 1-13.
    • (2003) Crit Rev Immunol , vol.23 , pp. 1-13
    • Nencioni, A.1    Wesselborg, S.2    Brossart, P.3
  • 43
    • 79251561239 scopus 로고    scopus 로고
    • Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency
    • Roszer T, Menendez-Gutierrez MP, Lefterova MI, Alameda D, Nunez V, et al. (2011) Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. J Immunol 186: 621-631.
    • (2011) J Immunol , vol.186 , pp. 621-631
    • Roszer, T.1    Menendez-Gutierrez, M.P.2    Lefterova, M.I.3    Alameda, D.4    Nunez, V.5
  • 44
    • 77949893984 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells
    • Torres-Aguilar H, Aguilar-Ruiz SR, Gonzalez-Perez G, Munguia R, Bajana S, et al. (2010) Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells. J Immunol 184: 1765-1775.
    • (2010) J Immunol , vol.184 , pp. 1765-1775
    • Torres-Aguilar, H.1    Aguilar-Ruiz, S.R.2    Gonzalez-Perez, G.3    Munguia, R.4    Bajana, S.5
  • 46
    • 79961173140 scopus 로고    scopus 로고
    • Gene expression analysis of dendritic cells that prevent diabetes in NOD mice: analysis of chemokines and costimulatory molecules
    • Morel PA, Srinivas M, Turner MS, Fuschiotti P, Munshi R, et al. (2011) Gene expression analysis of dendritic cells that prevent diabetes in NOD mice: analysis of chemokines and costimulatory molecules. J Leukoc Biol 90: 539-550.
    • (2011) J Leukoc Biol , vol.90 , pp. 539-550
    • Morel, P.A.1    Srinivas, M.2    Turner, M.S.3    Fuschiotti, P.4    Munshi, R.5
  • 47
    • 78149361779 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity
    • Torres-Aguilar H, Blank M, Jara LJ, Shoenfeld Y, (2010) Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity. Autoimmun Rev 10: 8-17.
    • (2010) Autoimmun Rev , vol.10 , pp. 8-17
    • Torres-Aguilar, H.1    Blank, M.2    Jara, L.J.3    Shoenfeld, Y.4
  • 48
    • 80052401660 scopus 로고    scopus 로고
    • Inflammation-restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation
    • Van Elssen CH, Vanderlocht J, Oth T, Senden-Gijsbers BL, Germeraad WT, et al. (2011) Inflammation-restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation. Blood 118: 2473-2482.
    • (2011) Blood , vol.118 , pp. 2473-2482
    • Van Elssen, C.H.1    Vanderlocht, J.2    Oth, T.3    Senden-Gijsbers, B.L.4    Germeraad, W.T.5
  • 49
    • 77956599685 scopus 로고    scopus 로고
    • PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
    • Muthuswamy R, Mueller-Berghaus J, Haberkorn U, Reinhart TA, Schadendorf D, et al. (2010) PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells. Blood 116: 1454-1459.
    • (2010) Blood , vol.116 , pp. 1454-1459
    • Muthuswamy, R.1    Mueller-Berghaus, J.2    Haberkorn, U.3    Reinhart, T.A.4    Schadendorf, D.5
  • 50
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert ML, Sauter B, Bhardwaj N, (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392: 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 51
    • 68449088814 scopus 로고    scopus 로고
    • High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction
    • Brandmaier AG, Leitner WW, Ha SP, Sidney J, Restifo NP, et al. (2009) High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction. J Immunother 32: 677-688.
    • (2009) J Immunother , vol.32 , pp. 677-688
    • Brandmaier, A.G.1    Leitner, W.W.2    Ha, S.P.3    Sidney, J.4    Restifo, N.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.