-
1
-
-
24144484876
-
The metabolic syndrome: Time for a critical appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
-
16123508 10.2337/diacare.28.9.2289
-
Kahn R, Buse J, Ferrannini E, Stern M (2005) The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28:2289-2304
-
(2005)
Diabetes Care
, vol.28
, pp. 2289-2304
-
-
Kahn, R.1
Buse, J.2
Ferrannini, E.3
Stern, M.4
-
2
-
-
41449117908
-
Should we dump the metabolic syndrome?
-
18356232 10.1136/bmj.39484.636586.94 1:STN:280:DC%2BD1c7pslGmsQ%3D%3D
-
Alberti KG, Zimmet PZ (2008) Should we dump the metabolic syndrome? BMJ 336:641
-
(2008)
BMJ
, vol.336
, pp. 641
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
3
-
-
33745861300
-
Inflammation and insulin resistance
-
16823477 10.1172/JCI29069 1:CAS:528:DC%2BD28XmvV2ltLo%3D
-
Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793-1801
-
(2006)
J Clin Invest
, vol.116
, pp. 1793-1801
-
-
Shoelson, S.E.1
Lee, J.2
Goldfine, A.B.3
-
4
-
-
0036325531
-
Genetic approaches to studying energy balance: Perception and integration
-
12154382 10.1038/nrn902 1:CAS:528:DC%2BD38XlslamsLo%3D
-
Barsh GS, Schwartz MW (2002) Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 3:589-600
-
(2002)
Nat Rev Genet
, vol.3
, pp. 589-600
-
-
Barsh, G.S.1
Schwartz, M.W.2
-
5
-
-
12344277552
-
Diabetes, obesity, and the brain
-
15662002 10.1126/science.1104344 1:CAS:528:DC%2BD2MXksFyhsQ%3D%3D
-
Schwartz MW, Porte D Jr (2005) Diabetes, obesity, and the brain. Science 307:375-379
-
(2005)
Science
, vol.307
, pp. 375-379
-
-
Schwartz, M.W.1
Porte, Jr.D.2
-
6
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
-
15467830 1:CAS:528:DC%2BD2cXot12gtrg%3D
-
Kubota N, Terauchi Y, Tobe K et al (2004) Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 114:917-927
-
(2004)
J Clin Invest
, vol.114
, pp. 917-927
-
-
Kubota, N.1
Terauchi, Y.2
Tobe, K.3
-
7
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
15467829 1:CAS:528:DC%2BD2cXot12gtr0%3D
-
Lin X, Taguchi A, Park S et al (2004) Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114:908-916
-
(2004)
J Clin Invest
, vol.114
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
-
8
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
15137936 10.1016/S0092-8674(04)00452-0 1:CAS:528:DC%2BD2cXktlCqtrw%3D
-
Accili D, Arden KC (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
9
-
-
33646590947
-
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
-
16604086 10.1038/nm1392 1:CAS:528:DC%2BD28Xkt1Kjurc%3D
-
Kitamura T, Feng Y, Kitamura YI et al (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med 12:534-540
-
(2006)
Nat Med
, vol.12
, pp. 534-540
-
-
Kitamura, T.1
Feng, Y.2
Kitamura, Y.I.3
-
10
-
-
84862909085
-
Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance
-
22186407 10.1210/en.2011-1635 1:CAS:528:DC%2BC38XitVegsbs%3D
-
Kim HJ, Kobayashi M, Sasaki T et al (2012) Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. Endocrinology 153:659-671
-
(2012)
Endocrinology
, vol.153
, pp. 659-671
-
-
Kim, H.J.1
Kobayashi, M.2
Sasaki, T.3
-
11
-
-
0030972807
-
Transcriptional regulation by cyclic AMP
-
9242925 10.1146/annurev.biochem.66.1.807 1:CAS:528:DyaK2sXktFOksbk%3D
-
Montminy M (1997) Transcriptional regulation by cyclic AMP. Annu Rev Biochem 66:807-822
-
(1997)
Annu Rev Biochem
, vol.66
, pp. 807-822
-
-
Montminy, M.1
-
12
-
-
0035948624
-
The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis
-
11483355 10.1016/S0378-1119(01)00551-0 1:CAS:528:DC%2BD3MXlsFKhsrk%3D
-
Hai T, Hartman MG (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273:1-11
-
(2001)
Gene
, vol.273
, pp. 1-11
-
-
Hai, T.1
Hartman, M.G.2
-
13
-
-
39849106936
-
Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
-
18305237 10.1523/JNEUROSCI.5273-07.2008 1:CAS:528:DC%2BD1cXjt1Cqt7k%3D
-
Green TA, Alibhai IN, Unterberg S et al (2008) Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. J Neurosci 28:2025-2032
-
(2008)
J Neurosci
, vol.28
, pp. 2025-2032
-
-
Green, T.A.1
Alibhai, I.N.2
Unterberg, S.3
-
14
-
-
78449308832
-
ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: Is modulation of inflammation a unifying component?
-
21061913 10.3727/105221610X12819686555015 1:CAS:528:DC%2BC3cXhsF2qsr%2FP
-
Hai T, Wolford CC, Chang YS (2010) ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component? Gene Expr 15:1-11
-
(2010)
Gene Expr
, vol.15
, pp. 1-11
-
-
Hai, T.1
Wolford, C.C.2
Chang, Y.S.3
-
15
-
-
0036121111
-
Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: Colocalization and possible involvement in cell death of vascular endothelial cells
-
11888510 10.1016/S0021-9150(01)00639-6 1:CAS:528:DC%2BD38XhvVWksLk%3D
-
Nawa T, Nawa MT, Adachi MT et al (2002) Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and possible involvement in cell death of vascular endothelial cells. Atherosclerosis 161:281-291
-
(2002)
Atherosclerosis
, vol.161
, pp. 281-291
-
-
Nawa, T.1
Nawa, M.T.2
Adachi, M.T.3
-
16
-
-
0034665653
-
Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: Activation of c-Jun NH(2)-terminal kinase and promoter response element
-
10979959 1:CAS:528:DC%2BD3cXms1ChsLs%3D
-
Cai Y, Zhang C, Nawa T et al (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Blood 96:2140-2148
-
(2000)
Blood
, vol.96
, pp. 2140-2148
-
-
Cai, Y.1
Zhang, C.2
Nawa, T.3
-
17
-
-
0242300119
-
Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells
-
14557546 10.1073/pnas.1735286100 1:CAS:528:DC%2BD3sXoslKnt78%3D
-
Wang J, Webb G, Cao Y, Steiner DF (2003) Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells. Proc Natl Acad Sci U S A 100:12660-12665
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12660-12665
-
-
Wang, J.1
Webb, G.2
Cao, Y.3
Steiner, D.F.4
-
18
-
-
2942718697
-
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis
-
15199129 10.1128/MCB.24.13.5721-5732.2004 1:CAS:528:DC%2BD2cXls1aqsbc%3D
-
Hartman MG, Lu D, Kim ML et al (2004) Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol 24:5721-5732
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5721-5732
-
-
Hartman, M.G.1
Lu, D.2
Kim, M.L.3
-
19
-
-
0041355491
-
Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter
-
12815047 10.1074/jbc.M305456200 1:CAS:528:DC%2BD3sXms1amu74%3D
-
Wang J, Cao Y, Steiner DF (2003) Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter. J Biol Chem 278:32899-32904
-
(2003)
J Biol Chem
, vol.278
, pp. 32899-32904
-
-
Wang, J.1
Cao, Y.2
Steiner, D.F.3
-
20
-
-
77954825385
-
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction
-
20519332 10.1210/me.2009-0463 1:CAS:528:DC%2BC3cXpt1Cnt78%3D
-
Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T (2010) The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol 24:1423-1433
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1423-1433
-
-
Zmuda, E.J.1
Qi, L.2
Zhu, M.X.3
Mirmira, R.G.4
Montminy, M.R.5
Hai, T.6
-
21
-
-
40949116757
-
The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis
-
18057093 10.2337/db07-0717 1:CAS:528:DC%2BD1cXjt1Chtb0%3D
-
Li D, Yin X, Zmuda EJ et al (2008) The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes 57:635-644
-
(2008)
Diabetes
, vol.57
, pp. 635-644
-
-
Li, D.1
Yin, X.2
Zmuda, E.J.3
-
22
-
-
79955721239
-
A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage
-
21451036 10.1523/JNEUROSCI.2672-10.2011 1:CAS:528:DC%2BC3MXkslSltbo%3D
-
Zhang SJ, Buchthal B, Lau D et al (2011) A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage. J Neurosci 31:4978-4990
-
(2011)
J Neurosci
, vol.31
, pp. 4978-4990
-
-
Zhang, S.J.1
Buchthal, B.2
Lau, D.3
-
23
-
-
79955535158
-
Transcriptional profiling of fetal hypothalamic TRH neurons
-
10.1186/1471-2164-12-222 1:CAS:528:DC%2BC3MXmtlKlsb0%3D
-
Guerra-Crespo M, Perez-Monter C, Janga SC et al (2011) Transcriptional profiling of fetal hypothalamic TRH neurons. BMC Genom 12:222
-
(2011)
BMC Genom
, vol.12
, pp. 222
-
-
Guerra-Crespo, M.1
Perez-Monter, C.2
Janga, S.C.3
-
24
-
-
0037064094
-
Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription
-
12161427 10.1074/jbc.M202974200 1:CAS:528:DC%2BD38Xns1Cnu7Y%3D
-
Kawauchi J, Zhang C, Nobori K et al (2002) Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. J Biol Chem 277:39025-39034
-
(2002)
J Biol Chem
, vol.277
, pp. 39025-39034
-
-
Kawauchi, J.1
Zhang, C.2
Nobori, K.3
-
25
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
11973276 1:CAS:528:DC%2BD38XksFWnur0%3D
-
Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
26
-
-
84860284366
-
Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells
-
21927023 10.1038/onc.2011.397 1:CAS:528:DC%2BC3MXhtFylsLvF
-
Taketani K, Kawauchi J, Tanaka-Okamoto M et al (2012) Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. Oncogene 31:2210-2221
-
(2012)
Oncogene
, vol.31
, pp. 2210-2221
-
-
Taketani, K.1
Kawauchi, J.2
Tanaka-Okamoto, M.3
-
27
-
-
0034941125
-
Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor
-
11463843 10.1128/MCB.21.16.5624-5630.2001 1:CAS:528:DC%2BD3MXlslOjuro%3D
-
Kitamura T, Kido Y, Nef S, Merenmies J, Parada LF, Accili D (2001) Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor. Mol Cell Biol 21:5624-5630
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5624-5630
-
-
Kitamura, T.1
Kido, Y.2
Nef, S.3
Merenmies, J.4
Parada, L.F.5
Accili, D.6
-
28
-
-
78049446505
-
Conditional gene targeting in mouse pancreatic ss-Cells: Analysis of ectopic Cre transgene expression in the brain
-
20802254 10.2337/db10-0624 1:CAS:528:DC%2BC3MXlsVamuw%3D%3D
-
Wicksteed B, Brissova M, Yan W et al (2010) Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59:3090-3098
-
(2010)
Diabetes
, vol.59
, pp. 3090-3098
-
-
Wicksteed, B.1
Brissova, M.2
Yan, W.3
-
29
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
21123942 10.1172/JCI44271 1:CAS:528:DC%2BC3MXis1ynsA%3D%3D
-
Seale P, Conroe HM, Estall J et al (2011) Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 121:96-105
-
(2011)
J Clin Invest
, vol.121
, pp. 96-105
-
-
Seale, P.1
Conroe, H.M.2
Estall, J.3
-
30
-
-
84858039282
-
PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
-
22405074 10.1016/j.cmet.2012.01.019 1:CAS:528:DC%2BC38XjsFOhsrs%3D
-
Ohno H, Shinoda K, Spiegelman BM, Kajimura S (2012) PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 15:395-404
-
(2012)
Cell Metab
, vol.15
, pp. 395-404
-
-
Ohno, H.1
Shinoda, K.2
Spiegelman, B.M.3
Kajimura, S.4
-
31
-
-
0032872203
-
Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
-
10512369 10.2337/diabetes.48.10.2028 1:CAS:528:DyaK1MXmsVCjs7g%3D
-
Ebihara K, Ogawa Y, Katsuura G et al (1999) Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes 48:2028-2033
-
(1999)
Diabetes
, vol.48
, pp. 2028-2033
-
-
Ebihara, K.1
Ogawa, Y.2
Katsuura, G.3
-
32
-
-
58149391976
-
Monitoring FoxO1 localization in chemically identified neurons
-
19074037 10.1523/JNEUROSCI.4023-08.2008 1:CAS:528:DC%2BD1cXhsFCqsb7E
-
Fukuda M, Jones JE, Olson D et al (2008) Monitoring FoxO1 localization in chemically identified neurons. J Neurosci 28:13640-13648
-
(2008)
J Neurosci
, vol.28
, pp. 13640-13648
-
-
Fukuda, M.1
Jones, J.E.2
Olson, D.3
-
33
-
-
0036288345
-
Neither agouti-related protein nor neuropeptide y is critically required for the regulation of energy homeostasis in mice
-
12077332 10.1128/MCB.22.14.5027-5035.2002 1:CAS:528:DC%2BD38XltVOqsbY%3D
-
Qian S, Chen H, Weingarth D et al (2002) Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 22:5027-5035
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5027-5035
-
-
Qian, S.1
Chen, H.2
Weingarth, D.3
-
34
-
-
33644877070
-
Agouti-related protein-deficient mice display an age-related lean phenotype
-
16330327 10.1016/j.cmet.2005.11.004 1:CAS:528:DC%2BD2MXhtlequrnO
-
Wortley KE, Anderson KD, Yasenchak J et al (2005) Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab 2:421-427
-
(2005)
Cell Metab
, vol.2
, pp. 421-427
-
-
Wortley, K.E.1
Anderson, K.D.2
Yasenchak, J.3
-
35
-
-
26444540359
-
Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
-
16099943 1:CAS:528:DC%2BD2MXhtFSjsb3I
-
Bewick GA, Gardiner JV, Dhillo WS et al (2005) Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J 19:1680-1682
-
(2005)
FASEB J
, vol.19
, pp. 1680-1682
-
-
Bewick, G.A.1
Gardiner, J.V.2
Dhillo, W.S.3
-
36
-
-
0028176738
-
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms
-
7515060 1:CAS:528:DyaK2cXksFWgtLs%3D
-
Chen BP, Liang G, Whelan J, Hai T (1994) ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. J Biol Chem 269:15819-15826
-
(1994)
J Biol Chem
, vol.269
, pp. 15819-15826
-
-
Chen, B.P.1
Liang, G.2
Whelan, J.3
Hai, T.4
|