-
2
-
-
38549151817
-
-
Database issue, D.901
-
D. S. Wishart, C. Knox, A. C. Guo, D. Cheng, S. Shrivastaya, D. Tzur, B. Gautam, M. Hassanali, Nucleic Acids Res. 2008, 36 Database issue, D.901.
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastaya, S.5
Tzur, D.6
Gautam, B.7
Hassanali, M.8
-
3
-
-
84872200984
-
-
For some recent examples on the synthesis of substituted pyrrolidines, see:, O. S. Artamonov, E. Y. Slobodyanyuk, O. V. Shishkin, I. V. Komarov, P. K. Mykhailiuk, Synthesis 2013, 45, 225.
-
(2013)
Synthesis
, vol.45
, pp. 225
-
-
Artamonov, O.S.1
Slobodyanyuk, E.Y.2
Shishkin, O.V.3
Komarov, I.V.4
Mykhailiuk, P.K.5
-
4
-
-
84862908390
-
-
G. He, Y. Zhao, S. Zhang, C. Lu, G. Chen, J. Am. Chem. Soc. 2012, 134, 3.
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 3
-
-
He, G.1
Zhao, Y.2
Zhang, S.3
Lu, C.4
Chen, G.5
-
7
-
-
0036178434
-
-
S. J. Keam, K. L. Goa, D. P. Figgitt, Drugs 2002, 62, 387.
-
(2002)
Drugs
, vol.62
, pp. 387
-
-
Keam, S.J.1
Goa, K.L.2
Figgitt, D.P.3
-
8
-
-
84877784618
-
-
http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/009818s018lbl. pdf.
-
-
-
-
14
-
-
38149070200
-
-
S. Purser, P. R. Moore, S. Swallow, V. Gouverneur, Chem. Soc. Rev. 2008, 37, 320.
-
(2008)
Chem. Soc. Rev.
, vol.37
, pp. 320
-
-
Purser, S.1
Moore, P.R.2
Swallow, S.3
Gouverneur, V.4
-
16
-
-
4444355871
-
-
H.-J. Böhm, D. Banner, S. Bendels, M. Kansy, B. Kuhn, K. Müller, U. Obst-Sander, M. Stahl, ChemBioChem 2004, 5, 637.
-
(2004)
ChemBioChem
, vol.5
, pp. 637
-
-
Böhm, H.-J.1
Banner, D.2
Bendels, S.3
Kansy, M.4
Kuhn, B.5
Müller, K.6
Obst-Sander, U.7
Stahl, M.8
-
17
-
-
9444248521
-
-
(Ed.:, P. Kirsch), Wiley-VCH, Weinheim, Germany
-
Modern Fluoroorganic Chemistry (Ed.:, P. Kirsch), Wiley-VCH, Weinheim, Germany, 2004.
-
(2004)
Modern Fluoroorganic Chemistry
-
-
-
23
-
-
0035038661
-
-
B. K. Park, N. R. Kitteringham, P. M. O'Neill, Annu. Rev. Pharmacol. Toxicol. 2001, 41, 443.
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 443
-
-
Park, B.K.1
Kitteringham, N.R.2
O'Neill, P.M.3
-
25
-
-
77953491258
-
-
G. Chaume, O. Barbeau, P. Lesot, T. Brigaud, J. Org. Chem. 2010, 75, 4135.
-
(2010)
J. Org. Chem.
, vol.75
, pp. 4135
-
-
Chaume, G.1
Barbeau, O.2
Lesot, P.3
Brigaud, T.4
-
26
-
-
25744432552
-
-
G. V. Shustov, S. N. Denisenko, I. I. Chervin, R. G. Kostyanovskii, Izv. Akad. Nauk SSSR, Ser. Khim. 1988, 37, 1606;
-
(1988)
Izv. Akad. Nauk SSSR, Ser. Khim.
, vol.37
, pp. 1606
-
-
Shustov, G.V.1
Denisenko, S.N.2
Chervin, I.I.3
Kostyanovskii, R.G.4
-
27
-
-
34249970456
-
-
Russ. Chem. Bull. 1988, 37, 1665.
-
(1988)
Russ. Chem. Bull.
, vol.37
, pp. 1665
-
-
-
28
-
-
76149094533
-
-
N. E. Shevchenko, E. S. Balenkova, G.-V. Röschenthaler, V. G. Nenajdenko, Synthesis 2010, 120.
-
(2010)
Synthesis
, pp. 120
-
-
Shevchenko, N.E.1
Balenkova, E.S.2
Röschenthaler, G.-V.3
Nenajdenko, V.G.4
-
29
-
-
84877781807
-
-
A. V. Bezdudny, A. N. Alekseenko, P. K. Mykhailiuk, O. V. Manoilenko, O. V. Shishkin, Y. M. Pustovit, Eur. J. Org. Chem. 2011, 1172.
-
(2011)
Eur. J. Org. Chem.
, pp. 1172
-
-
Bezdudny, A.V.1
Alekseenko, A.N.2
Mykhailiuk, P.K.3
Manoilenko, O.V.4
Shishkin, O.V.5
Pustovit, Y.M.6
-
30
-
-
78649770496
-
-
N. E. Shevchenko, K. Vlasov, V. G. Nenajdenko, G.-V. Roeschenthaler, Tetrahedron 2011, 67, 69.
-
(2011)
Tetrahedron
, vol.67
, pp. 69
-
-
Shevchenko, N.E.1
Vlasov, K.2
Nenajdenko, V.G.3
Roeschenthaler, G.-V.4
-
32
-
-
0347060916
-
Azomethine ylides
-
Padwa A. Pearson) W.H. (Eds.:, Wiley, New York
-
L. M. Harwood, R. J. Vickers, Azomethine ylides, in: Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products (Eds.:, A. Padwa, W. H. Pearson), Wiley, New York, 2003, p. 169.
-
(2003)
Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products
, pp. 169
-
-
Harwood, L.M.1
Vickers, R.J.2
-
33
-
-
4444287013
-
-
L. Yan, J. J. Hale, C. L. Lynch, R. Budhu, A. Gentry, S. G. Mills, R. Hajdu, C. A. Keohane, M. J. Rosenbach, J. A. Milligan, G.-J. Shei, Bioorg. Med. Chem. Lett. 2004, 14, 4861.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 4861
-
-
Yan, L.1
Hale, J.J.2
Lynch, C.L.3
Budhu, R.4
Gentry, A.5
Mills, S.G.6
Hajdu, R.7
Keohane, C.A.8
Rosenbach, M.J.9
Milligan, J.A.10
Shei, G.-J.11
-
34
-
-
65949087689
-
Garcbox Drawings Light Down And Lefta-Cerrada
-
O. Frutos, M. L. Puente, R. L. Gu, V. V. Khau
-
J. Mendiola, S. Garcbox drawings light down and lefta-Cerrada, O. Frutos, M. L. Puente, R. L. Gu, V. V. Khau, Org. Process Res. Dev. 2009, 13, 292.
-
(2009)
Org. Process Res. Dev.
, vol.13
, pp. 292
-
-
Mendiola, J.1
-
35
-
-
0006625649
-
-
S. Marriott, W. F. Reynolds, R. W. Taft, R. D. Topsom, J. Org. Chem. 1984, 49, 959.
-
(1984)
J. Org. Chem.
, vol.49
, pp. 959
-
-
Marriott, S.1
Reynolds, W.F.2
Taft, R.W.3
Topsom, R.D.4
-
36
-
-
0027191960
-
-
J.-P. Begue, D. Bonnet-Delpon, T. Lequeux, Tetrahedron Lett. 1993, 34, 3279.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 3279
-
-
Begue, J.-P.1
Bonnet-Delpon, D.2
Lequeux, T.3
-
37
-
-
0029656082
-
-
D. Bonnet-Delpon, J.-P. Begue, T. Lequeux, M. Ourevitch, Tetrahedron 1996, 52, 59.
-
(1996)
Tetrahedron
, vol.52
, pp. 59
-
-
Bonnet-Delpon, D.1
Begue, J.-P.2
Lequeux, T.3
Ourevitch, M.4
-
38
-
-
0032552934
-
-
H. Fukui, T. Shibata, T. Naito, J. Nakano, T. Maejima, H. Senda, W. Iwatani, Y. Tatsumi, M. Suda, T. Arika, Bioorg. Med. Chem. Lett. 1998, 8, 2833.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 2833
-
-
Fukui, H.1
Shibata, T.2
Naito, T.3
Nakano, J.4
Maejima, T.5
Senda, H.6
Iwatani, W.7
Tatsumi, Y.8
Suda, M.9
Arika, T.10
-
39
-
-
0032483068
-
-
Q. Li, W. Wang, K. B. Berst, A. Claiborne, L. Hasvold, K. Raye, M. Tufano, A. Nilius, L. L. Shen, R. Flamm, J. Alder, K. Marsh, D. Crowell, D. T. W. Chu, J. J. Plattner, Bioorg. Med. Chem. Lett. 1998, 8, 1953.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 1953
-
-
Li, Q.1
Wang, W.2
Berst, K.B.3
Claiborne, A.4
Hasvold, L.5
Raye, K.6
Tufano, M.7
Nilius, A.8
Shen, L.L.9
Flamm, R.10
Alder, J.11
Marsh, K.12
Crowell, D.13
Chu, D.T.W.14
Plattner, J.J.15
-
40
-
-
79951769827
-
-
US2009/0004140 A1
-
Y.-L. Qiu, L. Ying, Y. S. Or, C. Wang, J. Long, US2009/0004140 A1, 2009; Chem. Abstr. 2009, 150, 98139.
-
(2009)
Chem. Abstr. 2009
, vol.150
, pp. 98139
-
-
Qiu, Y.-L.1
Ying, L.2
Or, Y.S.3
Wang, C.4
Long, J.5
-
41
-
-
52449133195
-
-
J. M. Mason, A. S. Murkin, L. Li, V. L. Schramm, G. J. Gainsford, B. W. Skelton, J. Med. Chem. 2008, 51, 5880.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5880
-
-
Mason, J.M.1
Murkin, A.S.2
Li, L.3
Schramm, V.L.4
Gainsford, G.J.5
Skelton, B.W.6
-
42
-
-
79951772578
-
-
WO2007/140980 A1
-
O. Rogel, J.-M. Rondeau, H. Rueeger, O. Simic, F. Sirockin, M. Tintelnot-Blombey, WO2007/140980 A1, 2007; Chem. Abstr. 2007, 147, 323011.
-
(2007)
Chem. Abstr. 2007
, vol.147
, pp. 323011
-
-
Rogel, O.1
Rondeau, J.-M.2
Rueeger, H.3
Simic, O.4
Sirockin, F.5
Tintelnot-Blombey, M.6
-
43
-
-
33644999409
-
-
B. F. Bonini, F. Boschi, M. C. Franchini, M. Fochi, F. Fini, A. Mazzanti, A. Ricci, Synlett 2006, 543.
-
(2006)
Synlett
, pp. 543
-
-
Bonini, B.F.1
Boschi, F.2
Franchini, M.C.3
Fochi, M.4
Fini, F.5
Mazzanti, A.6
Ricci, A.7
-
44
-
-
79951772646
-
-
V. S. Yarmolchuk, P. K. Mykhailiuk, I. V. Komarov, Tetrahedron Lett. 2011, 52, 1300.
-
(2011)
Tetrahedron Lett.
, vol.52
, pp. 1300
-
-
Yarmolchuk, V.S.1
Mykhailiuk, P.K.2
Komarov, I.V.3
-
45
-
-
0000628655
-
-
P. Tarrant, A. M. Lovelace, M. R. Lilyquist, J. Am. Chem. Soc. 1955, 77, 2783.
-
(1955)
J. Am. Chem. Soc.
, vol.77
, pp. 2783
-
-
Tarrant, P.1
Lovelace, A.M.2
Lilyquist, M.R.3
-
46
-
-
34848921683
-
-
M. Morgenthaler, E. Schweizer, A. Hoffmann-Roeder, F. Benini, R. E. Martin, G. Jaeschke, B. Wagner, H. Fischer, S. Bendels, D. Zimmerli, J. Schneider, F. Diederich, M. Kansy, K. Muller, ChemMedChem 2007, 2, 1100.
-
(2007)
ChemMedChem
, vol.2
, pp. 1100
-
-
Morgenthaler, M.1
Schweizer, E.2
Hoffmann-Roeder, A.3
Benini, F.4
Martin, R.E.5
Jaeschke, G.6
Wagner, B.7
Fischer, H.8
Bendels, S.9
Zimmerli, D.10
Schneider, J.11
Diederich, F.12
Kansy, M.13
Muller, K.14
-
47
-
-
77951095524
-
-
For an excellent review on the topic, see:, G. Wuitschik, E. M. Carreira, B. Wagner, H. Fischer, I. Parrilla, F. Schuler, M. Rogers-Evans, K. Muller, J. Med. Chem. 2010, 53, 3227.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 3227
-
-
Wuitschik, G.1
Carreira, E.M.2
Wagner, B.3
Fischer, H.4
Parrilla, I.5
Schuler, F.6
Rogers-Evans, M.7
Muller, K.8
-
48
-
-
84896787326
-
-
Wiley-VCH, Weinheim, Germany
-
F. Z. Doerwald, Lead optimizations for medicinal chemists, Wiley-VCH, Weinheim, Germany, 2012, p. 107.
-
(2012)
Lead Optimizations for Medicinal Chemists
, pp. 107
-
-
Doerwald, F.Z.1
-
50
-
-
23944522336
-
-
T. Sparey, D. Beher, J. Best, M. Biba, J. L. Castro, E. Clarke, J. Hannam, T. Harrison, H. Lewis, A. Madin, M. Shearman, B. Sohal, N. Tsou, C. Welch, J. Wrigley, Bioorg. Med. Chem. Lett. 2005, 15, 4212.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 4212
-
-
Sparey, T.1
Beher, D.2
Best, J.3
Biba, M.4
Castro, J.L.5
Clarke, E.6
Hannam, J.7
Harrison, T.8
Lewis, H.9
Madin, A.10
Shearman, M.11
Sohal, B.12
Tsou, N.13
Welch, C.14
Wrigley, J.15
-
51
-
-
49849105560
-
-
Fluorine and the Environment (Ed.:), Elsevier
-
G. Theodoridis, Fluorine Containing Agrochemicals: An Overview of Recent Developments, in: Fluorine and the Environment (Ed.:, A. Tressaud,), Elsevier, 2006, p. 121.
-
(2006)
Fluorine Containing Agrochemicals: An Overview of Recent Developments
, pp. 121
-
-
Theodoridis, G.1
Tressaud, A.2
-
52
-
-
84872195227
-
-
J. R. Woods, H. Mo, A. A. Bieberich, T. Alavanja, D. A. Colby, J. Med. Chem. 2011, 54, 7933.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 7933
-
-
Woods, J.R.1
Mo, H.2
Bieberich, A.A.3
Alavanja, T.4
Colby, D.A.5
-
53
-
-
55249093492
-
-
G. Evans, T. J. K. Gibbs, R. L. Jenkins, S. J. Coles, M. B. Hursthouse, J. A. Platts, N. C. O. Tomkinson, Angew. Chem. 2008, 120, 2862;
-
(2008)
Angew. Chem.
, vol.120
, pp. 2862
-
-
Evans, G.1
Gibbs, T.J.K.2
Jenkins, R.L.3
Coles, S.J.4
Hursthouse, M.B.5
Platts, J.A.6
Tomkinson, N.C.O.7
|