Regional imbalanced activation of the calcineurin/BAD apoptotic pathway and the PI3K/Akt survival pathway after myocardial infarction

International Journal of Cardiology

Volumn 166, Issue 1, 2013, Pages 158-165

  Li, Tieluo ^a   Kilic, Ahmet ^a   Wei, Xufeng ^a   Wu, Changfu ^a   Schwartzbauer, Gary ^a   Yankey, G Kwame ^a   Defilippi, Christopher ^a   Bond, Meredith ^a   Wu, Zhongjun J ^a   Griffith, Bartley P ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; BAD; Calcineurin; Myocardial infarction; Remodeling; Strain

Indexed keywords

CALCINEURIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; ENZYME ACTIVATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FAILURE; HEART OUTPUT; HEART RATE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SHEEP;

ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CALCINEURIN; CELL SURVIVAL; MALE; MYOCARDIAL INFARCTION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SHEEP; SIGNAL TRANSDUCTION;

EID: 84877765373     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.10.107     Document Type: Article

References (25)

1. M.A. Pfeffer, and E. Braunwald Ventricular remodeling after myocardial infarction, experimental observations and clinical implications Circulation 81 1990 1161 1172
2. H.D. White, R.M. Norris, M.A. Brown, P.W. Brandt, R.M. Whitlock, and C.J. Wild Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction Circulation 76 1987 44 51
3. P. Gaudron, C. Eilles, I. Kugler, and G. Ertl Progressive left ventricular dysfunction and remodeling after myocardial infarction, potential mechanisms and early predictors Circulation 87 1993 755 763
4. K.R. Hutchinson, J.A. Stewart Jr., and P.A. Lucchesi Extracellular matrix remodeling during the progression of volume overload-induced heart failure J Mol Cell Cardiol 48 2010 564 569
5. G.K. Yankey, T. Li, and A. Kilic Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model J Thorac Cardiovasc Surg 135 2008 991 998
6. S. Haq, G. Choukroun, and H. Lim Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure Circulation 103 2001 670 677
7. G.W. Dorn II, and T. Force Protein kinase cascades in the regulation of cardiac hypertrophy J Clin Invest 115 2005 527 537
8. B. Levine, S. Sinha, and G. Kroemer Bcl-2 family members: dual regulators of apoptosis and autophagy Autophagy 4 2008 600 606
9. M.F. Van Delft, and D.C. Huang How the Bcl-2 family of proteins interact to regulate apoptosis Cell Res 16 2006 203 213
10. N.N. Danial BAD: undertaker by night, candyman by day. Oncogene. 2008;27 Suppl 1:S53-70.Downward J. How BAD phosphorylation is good for survival Nat Cell Biol 1 1999 E33 E35
11. A. Clerk, S.M. Cole, T.E. Cullingford, J.G. Harrison, M. Jormakka, and D.M. Valks Regulation of cardiac myocyte cell death Pharmacol Ther 97 2003 223 261
12. H.G. Wang, N. Pathan, and I.M. Ethell Ca2 +-induced apoptosis through calcineurin dephosphorylation of BAD Science 284 1999 339 343
13. J.J. Nienaber, H. Tachibana, and S.V. Naga Prasad Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure J Clin Invest 112 2003 1067 1079
14. H. Yin, L. Chao, and J. Chao Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-BAD.14-3-3 signaling pathways J Biol Chem 280 2005 8022 8030
15. K. Kuwahara, Y. Saito, and I. Kishimoto Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes J Mol Cell Cardiol 32 2000 1385 1394
16. J.R. McMullen, T. Shioi, and L. Zhang Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy Proc Natl Acad Sci U S A 100 2003 12355 12360
17. G. Alloatti, G. Montrucchio, G. Lembo, and E. Hirsch Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease Biochem Soc Trans 32 2004 383 386
18. A. Perino, A. Ghigo, F. Damilano, and E. Hirsch Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels Biochem Soc Trans 34 2006 502 503
19. P.H. Sugden Ras, Akt, and mechanotransduction in the cardiac myocyte Circ Res 93 2003 1179 1192
20. Y. Zou, H. Takano, H. Akazawa, T. Nagai, M. Mizukami, and I. Komuro Molecular and cellular mechanisms of mechanical stress-induced cardiac hypertrophy Endocr J 49 2002 1 13
21. A. Clerk, T.E. Cullingford, and S.J. Fuller Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses J Cell Physiol 212 2007 311 322
22. J. Heineke, and J.D. Molkentin Regulation of cardiac hypertrophy by intracellular signalling pathways Nat Rev Mol Cell Biol 7 2006 589 600
23. M.B. Ratcliffe Non-ischemic infarct extension: A new type of infarct enlargement and a potential therapeutic target J Am Coll Cardiol 40 2002 1168 1171
24. C. Ruwhof, and A. van der Laarse Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways Cardiovasc Res 47 2000 23 37
25. M.F. Bierhuizen, M. Boulaksil, and L. van Stuijvenberg In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms J Mol Cell Cardiol 45 2008 373 384