The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII

Biochemical Journal

Volumn 452, Issue 2, 2013, Pages 345-357

  Yamazaki, Tomoko ^a   Suehiro, Jun Ichi ^b   Miyazaki, Hideki ^a   Minami, Takashi ^b   Kodama, Tatsuhiki ^b   Miyazono, Kohei ^a   Watabe, Tetsuro ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Dominant negative; Hepatocyte; Nuclear receptor; Transcriptional repression

Indexed keywords

CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 2; CHOLESTEROL 7ALPHA MONOOXYGENASE; DNA;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DELETION MUTANT; DIMERIZATION; DNA BINDING; DNA PROTEIN COMPLEX; GEL MOBILITY SHIFT ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER CELL CARCINOMA; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; RNA INTERFERENCE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CELL LINE, TUMOR; CHOLESTEROL 7-ALPHA-HYDROXYLASE; COUP TRANSCRIPTION FACTOR II; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; GENETIC VARIATION; HEP G2 CELLS; HUMANS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84877753301     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121200     Document Type: Article

References (43)

1. Russell, D. W. (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72, 137-174
2. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A. and Willson, T. M. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272, 3137-3140
3. Chiang, J. Y., Kimmel, R. and Stroup, D. (2001) Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 262, 257-265
4. Mitro, N., Godio, C., De Fabiani, E., Scotti, E., Galmozzi, A., Gilardi, F., Caruso, D., Vigil Chacon, A. B. and Crestani, M. (2007) Insights in the regulation of cholesterol 7α-hydroxylase gene reveal a target for modulating bile acid synthesis. Hepatology 46, 885-897
5. Crestani, M., Sadeghpour, A., Stroup, D., Galli, G. and Chiang, J. Y. (1998) Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors. J. Lipid Res. 39, 2192-2200
6. Stroup, D., Crestani, M. and Chiang, J. Y. (1997) Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7α-hydroxylase gene (CYP7A) . J. Biol. Chem. 272, 9833-9839
7. Wang, L. H., Tsai, S. Y., Cook, R. G., Beattie, W. G., Tsai, M. J. and O'Malley, B. W. (1989) COUP transcription factor is a member of the steroid receptor superfamily. Nature 340, 163-166
8. Power, R. F., Lydon, J. P., Conneely, O. M. and O'Malley, B. W. (1991) Dopamine activation of an orphan of the steroid receptor superfamily. Science 252, 1546-1548
9. Pereira, F. A., Qiu, Y., Zhou, G., Tsai, M. J. and Tsai, S. Y. (1999) The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 13, 1037-1049
10. You, L. R., Lin, F. J., Lee, C. T., DeMayo, F. J., Tsai, M. J. and Tsai, S. Y. (2005) Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435, 98-104
11. Yamazaki, T., Yoshimatsu, Y., Morishita, Y., Miyazono, K. and Watabe, T. (2009) COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes Cells 14, 425-434
12. Lee, S., Kang, J., Yoo, J., Ganesan, S. K., Cook, S. C., Aguilar, B., Ramu, S., Lee, J. and Hong, Y. K. (2009) Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood 113, 1856-1859
13. Srinivasan, R. S., Geng, X., Yang, Y., Wang, Y., Mukatira, S., Studer, M., Porto, M. P., Lagutin, O. and Oliver, G. (2010) The nuclear hormone receptor COUP-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 24, 696-707
14. Qiu, Y., Pereira, F. A., DeMayo, F. J., Lydon, J. P., Tsai, S. Y. and Tsai, M. J. (1997) Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 11, 1925-1937
15. Lee, C. T., Li, L., Takamoto, N., Martin, J. F., Demayo, F. J., Tsai, M. J. and Tsai, S. Y. (2004) The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development. Mol. Cell. Biol. 24, 10835-10843
16. Takamoto, N., Kurihara, I., Lee, K., Demayo, F. J., Tsai, M. J. and Tsai, S. Y. (2005) Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction. Mol. Endocrinol. 19, 2299-2308
17. Xie, X., Qin, J., Lin, S. H., Tsai, S. Y. and Tsai, M. J. (2011) Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment and differentiation. Proc. Natl. Acad. Sci. U.S.A. 108, 14843-14848
18. Li, L., Xie, X., Qin, J., Jeha, G. S., Saha, P. K., Yan, J., Haueter, C. M., Chan, L., Tsai, S. Y. and Tsai, M. J. (2009) The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 9, 77-87
19. Cooney, A. J., Leng, X., Tsai, S. Y., O'Malley, B. W. and Tsai, M. J. (1993) Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. J. Biol. Chem. 268, 4152-4160
20. Kliewer, S. A., Lehmann, J. M. and Willson, T. M. (1999) Orphan nuclear receptors: shifting endocrinology into reverse. Science 284, 757-760
21. Stroup, D. and Chiang, J. Y. (2000) HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1). J. Lipid Res. 41, 1-11
22. De Martino, M. U., Bhattachryya, N., Alesci, S., Ichijo, T., Chrousos, G. P. and Kino, T. (2004) The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism. Mol. Endocrinol. 18, 820-833
23. Achatz, G., Hölzl, B., Speckmayer, R., Hauser, C., Sandhofer, F. and Paulweber, B. (1997) Functional domains of the human orphan receptor ARP-1/COUP-TFII involved in active repression and transrepression. Mol. Cell. Biol. 17, 4914-4932
24. Rosa, A. and Brivanlou, A. H. (2011) A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J. 30, 237-248
25. Watabe, T., Nishihara, A., Mishima, K., Yamashita, J., Shimizu, K., Miyazawa, K., Nishikawa, S. and Miyazono, K. (2003) TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J. Cell Biol. 163, 1303-1311
26. Yoshimatsu, Y., Yamazaki, T., Mihira, H., Itoh, T., Suehiro, J., Yuki, K., Harada, K., Morikawa, M., Iwata, C., Minami, T. et al. (2011) Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J. Cell Sci. 124, 2753-2762
27. Song, H., Suehiro, J., Kanki, Y., Kawai, Y., Inoue, K., Daida, H., Yano, K., Ohhashi, T., Oettgen, P., Aird, W. C. et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 284, 29109-29124
28. Kiyono, K., Suzuki, H. I., Morishita, Y., Komuro, A., Iwata, C., Yashiro, M., Hirakawa, K., Kano, M. R. and Miyazono, K. (2009) c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-β signaling in diffuse-type gastric carcinoma. Cancer Sci. 100, 1809-1816
29. Minami, T. and Aird, W. C. (2001) Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-κB and GATA motifs. J. Biol. Chem. 276, 47632-47641
30. Andrews, N. C. (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19, 2499
31. De Martino, M. U., Alesci, S., Chrousos, G. P. and Kino, T. (2004) Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism. Ann. N.Y. Acad. Sci. 1024, 72-85
32. Berrodin, T. J., Marks, M. S., Ozato, K., Linney, E. and Lazar, M. A. (1992) Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Mol. Endocrinol. 6, 1468-1478
33. Li, Y., Lambert, M. H. and Xu, H. E. (2003) Activation of nuclear receptors: a perspective from structural genomics. Structure 11, 741-746
34. Kruse, S. W., Suino-Powell, K., Zhou, X. E., Kretschman, J. E., Reynolds, R., Vonrhein, C., Xu, Y., Wang, L., Tsai, S. Y., Tsai, M. J. and Xu, H. E. (2008) Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 6, e227
35. Pramfalk, C., Angelin, B., Eriksson, M. and Parini, P. (2007) Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells. Biochem. Biophys. Res. Commun. 364, 402-409
36. Kang, S., Spann, N. J., Hui, T. Y. and Davis, R. A. (2003) ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. J. Biol. Chem. 278, 30478-30486
37. Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L. and Weintraub, H. (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61, 49-59
38. Miyazono, K. and Miyazawa, K. (2002) Id: a target of BMP signaling. Sci. STKE 2002, pe40
39. O'Toole, P. J., Inoue, T., Emerson, L., Morrison, I. E., Mackie, A. R., Cherry, R. J. and Norton, J. D. (2003) Id proteins negatively regulate basic helix-loop-helix transcription factor function by disrupting subnuclear compartmentalization. J. Biol. Chem. 278, 45770-45776
40. Chen, Y. and Young, M. A. (2010) Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element. Mol. Endocrinol. 24, 1650-1664
41. Park, J. I., Tsai, S. Y. and Tsai, M. J. (2003) Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions. Keio J. Med. 52, 174-181
42. Pipaón, C., Tsai, S. Y. and Tsai, M. J. (1999) COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site. Mol. Cell. Biol. 19, 2734-2745
43. Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D'Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y. et al. (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466, 253-257