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Volumn 73, Issue 9, 2013, Pages 2897-2904

Hepatocarcinogenesis driven by GSNOR deficiency is prevented by iNOS inhibition

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 8 HYDROXYDEOXYGUANOSINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; S NITROSOGLUTATHIONE REDUCTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84877739715     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3980     Document Type: Article
Times cited : (36)

References (44)
  • 2
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132: 2557-76.
    • (2007) Gastroenterology , vol.132 , pp. 2557-76
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 3
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6:674-87.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-87
    • Farazi, P.A.1    DePinho, R.A.2
  • 5
    • 0031148437 scopus 로고    scopus 로고
    • Chronic hepatitis c virus infection in humans: Induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis
    • Kane JM 3rd, Shears LL 2nd, Hierholzer C, Ambs S, Billiar TR, Posner MC. Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis. J Surg Res 1997;69:321-4.
    • (1997) J Surg Res , vol.69 , pp. 321-4
    • Kane III, J.M.1    Shears II, L.L.2    Hierholzer, C.3    Ambs, S.4    Billiar, T.R.5    Posner, M.C.6
  • 6
    • 0034906314 scopus 로고    scopus 로고
    • Coexpression of inducible nitric oxide synthase and cox-2 in hepatocellular carcinoma and surrounding liver: Possible involvement of cox-2 in the angiogenesis of hepatitis c virus-positive cases
    • Rahman MA, Dhar DK, Yamaguchi E, Maruyama S, Sato T, Hayashi H, et al. Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases. Clin Cancer Res 2001;7:1325-32.
    • (2001) Clin Cancer Res , vol.7 , pp. 1325-32
    • Rahman, M.A.1    Dhar, D.K.2    Yamaguchi, E.3    Maruyama, S.4    Sato, T.5    Hayashi, H.6
  • 7
    • 0000707647 scopus 로고    scopus 로고
    • Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: Oxyradical overload diseases
    • Hussain SP, Raja K, Amstad PA, Sawyer M, Trudel LJ,Wogan GN, et al. Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. Proc Natl Acad Sci U S A 2000;97:12770-5.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12770-5
    • Hussain, S.P.1    Raja, K.2    Amstad, P.A.3    Sawyer, M.4    Trudel, L.J.5    Wogan, G.N.6
  • 9
    • 0036793871 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and survivin messenger rna expression in hepatocellular carcinoma
    • Ikeguchi M, Ueta T, Yamane Y, Hirooka Y, Kaibara N. Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. Clin Cancer Res 2002;8:3131-6.
    • (2002) Clin Cancer Res , vol.8 , pp. 3131-6
    • Ikeguchi, M.1    Ueta, T.2    Yamane, Y.3    Hirooka, Y.4    Kaibara, N.5
  • 10
    • 0034026736 scopus 로고    scopus 로고
    • Plasma nitrites/nitrates in hcv infection and hepatocellular carcinoma
    • Moussa YI, Plevris JN, Hayes PC. Plasma nitrites/nitrates in HCV infection and hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2000;12:159-63.
    • (2000) Eur J Gastroenterol Hepatol , vol.12 , pp. 159-63
    • Moussa, Y.I.1    Plevris, J.N.2    Hayes, P.C.3
  • 11
    • 0030766747 scopus 로고    scopus 로고
    • High plasma concentrations of nitrite/nitrate in patients with hepatocellular carcinoma
    • Moriyama A, Masumoto A, Nanri H, Tabaru A, Unoki H, Imoto I, et al. High plasma concentrations of nitrite/nitrate in patients with hepatocellular carcinoma. Am J Gastroenterol 1997;92:1520-3.
    • (1997) Am J Gastroenterol , vol.92 , pp. 1520-3
    • Moriyama, A.1    Masumoto, A.2    Nanri, H.3    Tabaru, A.4    Unoki, H.5    Imoto, I.6
  • 12
    • 33751423908 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide (no) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, l-amino acid-defined diet in rats and mice
    • Denda A, Kitayama W, Kishida H, Murata N, Tamura K, Kusuoka O, et al. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice. Nitric Oxide 2007;16:164-76.
    • (2007) Nitric Oxide , vol.16 , pp. 164-76
    • Denda, A.1    Kitayama, W.2    Kishida, H.3    Murata, N.4    Tamura, K.5    Kusuoka, O.6
  • 13
    • 0032780340 scopus 로고    scopus 로고
    • Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by n-nitrosodiethylamine
    • Ahn B, Han BS, Kim DJ, Ohshima H. Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. Carcinogenesis 1999;20:1337-44.
    • (1999) Carcinogenesis , vol.20 , pp. 1337-44
    • Ahn, B.1    Han, B.S.2    Kim, D.J.3    Ohshima, H.4
  • 14
    • 54049130500 scopus 로고    scopus 로고
    • Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome p450 2e1 and 1a2 activities in diethylnitrosamine- and phenobarbital-treated rats
    • Zhao X, Zhang JJ, Wang X, Bu XY, Lou YQ, Zhang GL. Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats. Biomed Pharmacother 2008;62:567-72.
    • (2008) Biomed Pharmacother , vol.62 , pp. 567-72
    • Zhao, X.1    Zhang, J.J.2    Wang, X.3    Bu, X.Y.4    Lou, Y.Q.5    Zhang, G.L.6
  • 16
    • 0035932413 scopus 로고    scopus 로고
    • A metabolic enzyme for s-nitrosothiol conserved from bacteria to humans
    • Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001;410:490-4.
    • (2001) Nature , vol.410 , pp. 490-4
    • Liu, L.1    Hausladen, A.2    Zeng, M.3    Que, L.4    Heitman, J.5    Stamler, J.S.6
  • 17
    • 10744230465 scopus 로고    scopus 로고
    • Essential roles of s-nitrosothiols in vascular homeostasis and endotoxic shock
    • Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, et al. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell 2004;116:617-28.
    • (2004) Cell , vol.116 , pp. 617-28
    • Liu, L.1    Yan, Y.2    Zeng, M.3    Zhang, J.4    Hanes, M.A.5    Ahearn, G.6
  • 19
  • 20
    • 27944491603 scopus 로고    scopus 로고
    • Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and jab1 as a potential target for 8q gain in hepatocellular carcinoma
    • Patil MA, Gutgemann I, Zhang J, Ho C, Cheung ST, Ginzinger D, et al. Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and JAB1 as a potential target for 8q gain in hepatocellular carcinoma. Carcinogenesis 2005;26:2050-7.
    • (2005) Carcinogenesis , vol.26 , pp. 2050-7
    • Patil, M.A.1    Gutgemann, I.2    Zhang, J.3    Ho, C.4    Cheung, S.T.5    Ginzinger, D.6
  • 21
    • 0032919172 scopus 로고    scopus 로고
    • Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: Relationship to disease stage, tumor size, and cirrhosis
    • Wong N, Lai P, Lee SW, Fan S, Pang E, Liew CT, et al. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol 1999;154:37-43.
    • (1999) Am J Pathol , vol.154 , pp. 37-43
    • Wong, N.1    Lai, P.2    Lee, S.W.3    Fan, S.4    Pang, E.5    Liew, C.T.6
  • 22
    • 84983725887 scopus 로고    scopus 로고
    • Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma
    • Yeh SH, Chen PJ, Shau WY, Chen YW, Lee PH, Chen JT, et al. Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma. Gastroenterology 2001;121:699-709.
    • (2001) Gastroenterology , vol.121 , pp. 699-709
    • Yeh, S.H.1    Chen, P.J.2    Shau, W.Y.3    Chen, Y.W.4    Lee, P.H.5    Chen, J.T.6
  • 24
    • 77952963414 scopus 로고    scopus 로고
    • S-nitrosylation from gsnor deficiency impairs dna repair and promotes hepatocarcinogenesis
    • Wei W, Li B, Hanes MA, Kakar S, Chen X, Liu L. S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Sci Transl Med 2010;2:19ra13.
    • (2010) Sci Transl Med , vol.2
    • Wei, W.1    Li, B.2    Hanes, M.A.3    Kakar, S.4    Chen, X.5    Liu, L.6
  • 26
    • 0034028030 scopus 로고    scopus 로고
    • Repair of o (6)-alkylguanine by alkyltransferases
    • Pegg AE. Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res 2000;462:83-100.
    • (2000) Mutat Res , vol.462 , pp. 83-100
    • Pegg, A.E.1
  • 27
    • 0031427721 scopus 로고    scopus 로고
    • High incidence of nitrosamine-induced tumorigenesis in mice lacking dna repair methyltransferase
    • Iwakuma T, Sakumi K, Nakatsuru Y, Kawate H, Igarashi H, Shiraishi A, et al. High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase. Carcinogenesis 1997;18: 1631-5.
    • (1997) Carcinogenesis , vol.18 , pp. 1631-5
    • Iwakuma, T.1    Sakumi, K.2    Nakatsuru, Y.3    Kawate, H.4    Igarashi, H.5    Shiraishi, A.6
  • 29
    • 0036605987 scopus 로고    scopus 로고
    • Inactivation and degradation of o (6)-alkylguanine-dna alkyltransferase after reaction with nitric oxide
    • Liu L, Xu-Welliver M, Kanugula S, Pegg AE. Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide. Cancer Res 2002;62:3037-43.
    • (2002) Cancer Res , vol.62 , pp. 3037-43
    • Liu, L.1    Xu-Welliver, M.2    Kanugula, S.3    Pegg, A.E.4
  • 30
    • 79960030755 scopus 로고    scopus 로고
    • Targeted deletion of gsnor in hepatocytes of mice causes nitrosative inactivation of o6-alkylguanine- dna alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine
    • Wei W, Yang Z, Tang CH, Liu L. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine- DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 2011;32:973-7.
    • (2011) Carcinogenesis , vol.32 , pp. 973-7
    • Wei, W.1    Yang, Z.2    Tang, C.H.3    Liu, L.4
  • 31
    • 0032522535 scopus 로고    scopus 로고
    • S-nitrosoglutathione is a substrate for rat alcohol dehydrogenase class iii isoenzyme
    • Jensen DE, Belka GK, Du Bois GC. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem. J 1998;331:659-68.
    • (1998) Biochem. J , vol.331 , pp. 659-68
    • Jensen, D.E.1    Belka, G.K.2    Du Bois, G.C.3
  • 32
    • 0031040613 scopus 로고    scopus 로고
    • 1400w is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
    • Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 1997;272:4959-63.
    • (1997) J Biol Chem , vol.272 , pp. 4959-63
    • Garvey, E.P.1    Oplinger, J.A.2    Furfine, E.S.3    Kiff, R.J.4    Laszlo, F.5    Whittle, B.J.6
  • 33
    • 79959968677 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of inhibitors of inducible nitric oxide synthase (inos) in mice
    • Rebello S, Zhu B, McMonagle-Strucko K, Pulicicchio C, Merrill J, Luo Y, et al. Pharmacokinetic and pharmacodynamic evaluation of inhibitors of inducible nitric oxide synthase (iNOS) in mice (http://www.aapsj. org/abstracts/AM-2002/ AAPS2002-002237.pdf). AAPS PharmSci 2002;4 (Suppl 1).
    • (2002) AAPS PharmSci , vol.4 , Issue.SUPPL. 1
    • Rebello, S.1    Zhu, B.2    McMonagle-Strucko, K.3    Pulicicchio, C.4    Merrill, J.5    Luo, Y.6
  • 34
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
    • Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980; 106:207-12.
    • (1980) Anal Biochem , vol.106 , pp. 207-12
    • Griffith, O.W.1
  • 35
    • 0024199997 scopus 로고
    • Assay of glutathione reductase in crude tissue homogenates using 5,50-dithiobis(2-nitrobenzoic acid
    • Smith IK, Vierheller TL, Thorne CA. Assay of glutathione reductase in crude tissue homogenates using 5,50-dithiobis(2-nitrobenzoic acid). Anal Biochem 1988;175:408-13.
    • (1988) Anal Biochem , vol.175 , pp. 408-13
    • Smith, I.K.1    Vierheller, T.L.2    Thorne, C.A.3
  • 36
    • 0031816428 scopus 로고    scopus 로고
    • Dna adducts, mutant frequencies and mutation spectra in lambda lacz transgenic mice treated with n-nitrosodimethylamine
    • Souliotis VL, van Delft JH, Steenwinkel MJ, Baan RA, Kyrtopoulos SA. DNA adducts, mutant frequencies and mutation spectra in lambda lacZ transgenic mice treated with N-nitrosodimethylamine. Carcinogenesis 1998;19:731-9.
    • (1998) Carcinogenesis , vol.19 , pp. 731-9
    • Souliotis, V.L.1    Van Delft, J.H.2    Steenwinkel, M.J.3    Baan, R.A.4    Kyrtopoulos, S.A.5
  • 37
    • 21244472975 scopus 로고    scopus 로고
    • Ikkbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-90.
    • (2005) Cell , vol.121 , pp. 977-90
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 38
    • 4644324186 scopus 로고    scopus 로고
    • Nf-kappab functions as a tumour promoter in inflammation-associated cancer
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-6.
    • (2004) Nature , vol.431 , pp. 461-6
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 39
    • 0030940501 scopus 로고    scopus 로고
    • Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of n-nitrosodiethylamine
    • Nakae D, Kobayashi Y, Akai H, Andoh N, Satoh H, Ohashi K, et al. Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine. Cancer Res 1997;57:1281-7.
    • (1997) Cancer Res , vol.57 , pp. 1281-7
    • Nakae, D.1    Kobayashi, Y.2    Akai, H.3    Andoh, N.4    Satoh, H.5    Ohashi, K.6
  • 40
    • 13244277942 scopus 로고    scopus 로고
    • Cuznsod deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
    • Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 2005;24:367-80.
    • (2005) Oncogene , vol.24 , pp. 367-80
    • Elchuri, S.1    Oberley, T.D.2    Qi, W.3    Eisenstein, R.S.4    Jackson Roberts, L.5    Van Remmen, H.6
  • 41
    • 84877130928 scopus 로고    scopus 로고
    • S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liver
    • Epub 2013 Feb 15
    • Leung J, Wei W, Liu L. S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liver. Carcinogenesis. Epub 2013 Feb 15.
    • Carcinogenesis
    • Leung, J.1    Wei, W.2    Liu, L.3
  • 42
    • 84860441601 scopus 로고    scopus 로고
    • Regulation of dna repair by s-nitrosylation
    • Tang CH, Wei W, Liu L. Regulation of DNA repair by S-nitrosylation. Biochim Biophys Acta 2012;1820:730-5.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 730-5
    • Tang, C.H.1    Wei, W.2    Liu, L.3
  • 43
    • 49449090229 scopus 로고    scopus 로고
    • Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid
    • Chen L, Zhang Y, Kong X, Lan E, Huang Z, Peng S, et al. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem 2008;51:4834-8.
    • (2008) J Med Chem , vol.51 , pp. 4834-8
    • Chen, L.1    Zhang, Y.2    Kong, X.3    Lan, E.4    Huang, Z.5    Peng, S.6
  • 44
    • 0032737039 scopus 로고    scopus 로고
    • No: An inhibitor of cell death
    • Liu L, Stamler JS. NO: an inhibitor of cell death. Cell Death Differ 1999;6:937-42.
    • (1999) Cell Death Differ , vol.6 , pp. 937-42
    • Liu, L.1    Stamler, J.S.2


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