메뉴 건너뛰기




Volumn 22, Issue 6, 2013, Pages 977-991

Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice

Author keywords

Bone marrow mesenchymal stem cells (BMSCs); Cell homing; Hypoxic preconditioning; Intranasal delivery; Ischemic stroke

Indexed keywords

CELL SURFACE MARKER; CHEMOKINE RECEPTOR CXCR4; GELATINASE A; GELATINASE B;

EID: 84877709953     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X657251     Document Type: Article
Times cited : (154)

References (59)
  • 1
    • 77952319188 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy: Two steps forward, one step back
    • Ankrum, J.; Karp, J. M. Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol. Med. 16(5):203-209; 2010.
    • (2010) Trends Mol. Med , vol.16 , Issue.5 , pp. 203-209
    • Ankrum, J.1    Karp, J.M.2
  • 3
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang, O. Y.; Lee, J. S.; Lee, P. H.; Lee, G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann. Neurol. 57(6):874-882; 2005.
    • (2005) Ann. Neurol , vol.57 , Issue.6 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 5
    • 0033839757 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
    • Bergeron, M.; Gidday, J. M.; Yu, A. Y.; Semenza, G. L.; Ferriero, D. M.; Sharp, F. R. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann. Neurol. 48(3):285-296; 2000.
    • (2000) Ann. Neurol , vol.48 , Issue.3 , pp. 285-296
    • Bergeron, M.1    Gidday, J.M.2    Yu, A.Y.3    Semenza, G.L.4    Ferriero, D.M.5    Sharp, F.R.6
  • 8
    • 0035075998 scopus 로고    scopus 로고
    • Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    • Chen, J.; Li, Y.; Wang, L.; Zhang, Z.; Lu, D.; Lu, M.; Chopp, M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32(4):1005-1011; 2001.
    • (2001) Stroke , vol.32 , Issue.4 , pp. 1005-1011
    • Chen, J.1    Li, Y.2    Wang, L.3    Zhang, Z.4    Lu, D.5    Lu, M.6    Chopp, M.7
  • 11
    • 34547650992 scopus 로고    scopus 로고
    • Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3
    • De Becker, A.; Van Hummelen, P.; Bakkus, M.; Vande Broek, I.; De Wever, J.; De Waele, M.; Van Riet, I. Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3. Haematologica 92(4):440-449; 2007.
    • (2007) Haematologica , vol.92 , Issue.4 , pp. 440-449
    • de Becker, A.1    van Hummelen, P.2    Bakkus, M.3    Vande Broek, I.4    de Wever, J.5    de Waele, M.6    van Riet, I.7
  • 12
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • Dhuria, S. V.; Hanson, L. R.; Frey, 2nd. W. H. Intranasal delivery to the central nervous system: Mechanisms and experimental considerations. J. Pharm. Sci. 99(4):1654- 1673; 2010.
    • (2010) J. Pharm. Sci , vol.99 , Issue.4 , pp. 1654
    • Dhuria, S.V.1    Hanson, L.R.2    Frey II, W.H.3
  • 15
    • 72649087478 scopus 로고    scopus 로고
    • Intranasal administration of PEGylated transforming growth factor-α improves behavioral deficits in a chronic stroke model
    • Guerra-Crespo, M.; Sistos, A.; Gleason, D.; Fallon, J. H. Intranasal administration of PEGylated transforming growth factor-α improves behavioral deficits in a chronic stroke model. J. Stroke Cerebrovasc. Dis. 19(1):3-9; 2010.
    • (2010) J. Stroke Cerebrovasc. Dis , vol.19 , Issue.1 , pp. 3-9
    • Guerra-Crespo, M.1    Sistos, A.2    Gleason, D.3    Fallon, J.H.4
  • 16
    • 33745275175 scopus 로고    scopus 로고
    • The perivascular pump driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain
    • Hadaczek, P.; Yamashita, Y.; Mirek, H.; Tamas, L.; Bohn, M. C.; Noble, C.; Park, J. W.; Bankiewicz, K. The perivascular pump driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol. Ther. 14(1):69-78; 2006.
    • (2006) Mol. Ther , vol.14 , Issue.1 , pp. 69-78
    • Hadaczek, P.1    Yamashita, Y.2    Mirek, H.3    Tamas, L.4    Bohn, M.C.5    Noble, C.6    Park, J.W.7    Bankiewicz, K.8
  • 19
    • 79957796744 scopus 로고    scopus 로고
    • Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
    • Honmou, O.; Houkin, K.; Matsunaga, T.; Niitsu, Y.; Ishiai, S.; Onodera, R.; Waxman, S. G.; Kocsis, J. D. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain 134(Pt 6):1790- 1807; 2011.
    • (2011) Brain , vol.134 , Issue.PART 6 , pp. 1790
    • Honmou, O.1    Houkin, K.2    Matsunaga, T.3    Niitsu, Y.4    Ishiai, S.5    Onodera, R.6    Waxman, S.G.7    Kocsis, J.D.8
  • 20
    • 79961015156 scopus 로고    scopus 로고
    • Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation
    • Hu, X.; Wei, L.; Taylor, T. M.; Wei, J.; Zhou, X.; Wang, J. A.; Ping Yu, S. Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Am. J. Physiol. Cell Physiol. 301(2):C362-C372; 2011.
    • (2011) Am. J. Physiol. Cell Physiol , vol.301 , Issue.2
    • Hu, X.1    Wei, L.2    Taylor, T.M.3    Wei, J.4    Zhou, X.5    Wang, J.A.6    Ping Yu, S.7
  • 21
    • 40949085086 scopus 로고    scopus 로고
    • Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis
    • Hu, X.; Yu, S. P.; Fraser, J. L.; Lu, Z.; Ogle, M. E.; Wang, J. A.; Wei L. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J. Thorac. Cardiovasc. Surg. 135(4):799-808; 2008.
    • (2008) J. Thorac. Cardiovasc. Surg , vol.135 , Issue.4 , pp. 799-808
    • Hu, X.1    Yu, S.P.2    Fraser, J.L.3    Lu, Z.4    Ogle, M.E.5    Wang, J.A.6    Wei, L.7
  • 23
    • 65349114240 scopus 로고    scopus 로고
    • Ischemic preconditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase
    • Kamota, T.; Li, T. S.; Morikage, N.; Murakami, M.; Ohshima, M.; Kubo, M.; Kobayashi, T.; Mikamo, A.; Ikeda, Y.; Matsuzaki, M.; Hamano, K. Ischemic preconditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase. J. Am. Coll. Cardiol. 53(19):1814-1822; 2009.
    • (2009) J. Am. Coll. Cardiol , vol.53 , Issue.19 , pp. 1814-1822
    • Kamota, T.1    Li, T.S.2    Morikage, N.3    Murakami, M.4    Ohshima, M.5    Kubo, M.6    Kobayashi, T.7    Mikamo, A.8    Ikeda, Y.9    Matsuzaki, M.10    Hamano, K.11
  • 24
    • 60849136593 scopus 로고    scopus 로고
    • Mesenchymal stem cell homing: The devil is in the details
    • Karp, J. M.; Leng Teo, G. S. Mesenchymal stem cell homing: The devil is in the details. Cell Stem Cell 4(3):206- 216; 2009.
    • (2009) Cell Stem Cell , vol.4 , Issue.3 , pp. 206
    • Karp, J.M.1    Leng Teo, G.S.2
  • 27
    • 77956638921 scopus 로고    scopus 로고
    • A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke
    • Lee, J. S.; Hong, J. M.; Moon, G. J.; Lee, P. H.; Ahn, Y. H.; Bang, O. Y. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 28(6):1099- 1106; 2010.
    • (2010) Stem Cells , vol.28 , Issue.6 , pp. 1099
    • Lee, J.S.1    Hong, J.M.2    Moon, G.J.3    Lee, P.H.4    Ahn, Y.H.5    Bang, O.Y.6
  • 28
    • 34347218991 scopus 로고    scopus 로고
    • In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro
    • Liang, C. C.; Park, A. Y.; Guan, J. L. In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat. Protoc. 2(2):329-333; 2007.
    • (2007) Nat. Protoc , vol.2 , Issue.2 , pp. 329-333
    • Liang, C.C.1    Park, A.Y.2    Guan, J.L.3
  • 30
    • 42749087764 scopus 로고    scopus 로고
    • Intranasal bFGF-induced progenitor cell proliferation and neuroprotection after transient focal cerebral ischemia
    • Ma, Y. P.; Ma, M. M.; Cheng, S. M.; Ma, H. H.; Yi, X. M.; Xu, G. L.; Liu, X. F. Intranasal bFGF-induced progenitor cell proliferation and neuroprotection after transient focal cerebral ischemia. Neurosci. Lett. 437(2):93-97; 2008.
    • (2008) Neurosci. Lett , vol.437 , Issue.2 , pp. 93-97
    • Ma, Y.P.1    Ma, M.M.2    Cheng, S.M.3    Ma, H.H.4    Yi, X.M.5    Xu, G.L.6    Liu, X.F.7
  • 32
    • 0034532106 scopus 로고    scopus 로고
    • Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow
    • Mezey, E.; Chandross, K. J.; Harta, G.; Maki, R. A.; McKercher, S. R. Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow. Science 290(5497):1779-1782; 2000.
    • (2000) Science , vol.290 , Issue.5497 , pp. 1779-1782
    • Mezey, E.1    Chandross, K.J.2    Harta, G.3    Maki, R.A.4    McKercher, S.R.5
  • 34
    • 55749098498 scopus 로고    scopus 로고
    • Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    • USA
    • Ohtaki, H.; Ylostalo, J. H.; Foraker, J. E.; Robinson, A. P.; Reger, R. L.; Shioda, S.; Prockop, D. J. Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc. Natl. Acad. Sci. USA 105(38):14638-14643; 2008.
    • (2008) Proc. Natl. Acad. Sci , vol.105 , Issue.38 , pp. 14638-14643
    • Ohtaki, H.1    Ylostalo, J.H.2    Foraker, J.E.3    Robinson, A.P.4    Reger, R.L.5    Shioda, S.6    Prockop, D.J.7
  • 35
    • 34247368028 scopus 로고    scopus 로고
    • MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: Differential regulation by inflammatory cytokines
    • Ries, C.; Egea, V.; Karow, M.; Kolb, H.; Jochum, M.; Neth, P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: Differential regulation by inflammatory cytokines. Blood 109(9):4055-4063; 2007.
    • (2007) Blood , vol.109 , Issue.9 , pp. 4055-4063
    • Ries, C.1    Egea, V.2    Karow, M.3    Kolb, H.4    Jochum, M.5    Neth, P.6
  • 36
    • 55049084643 scopus 로고    scopus 로고
    • Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells
    • Rosova, I.; Dao, M.; Capoccia, B.; Link, D.; Nolta, J. A. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 26(8):2173-2182; 2008.
    • (2008) Stem Cells , vol.26 , Issue.8 , pp. 2173-2182
    • Rosova, I.1    Dao, M.2    Capoccia, B.3    Link, D.4    Nolta, J.A.5
  • 37
    • 38949183635 scopus 로고    scopus 로고
    • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
    • Sackstein, R.; Merzaban, J. S.; Cain, D. W.; Dagia, N. M.; Spencer, J. A.; Lin, C. P.; Wohlgemuth, R. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat. Med. 14(2):181-187; 2008.
    • (2008) Nat. Med , vol.14 , Issue.2 , pp. 181-187
    • Sackstein, R.1    Merzaban, J.S.2    Cain, D.W.3    Dagia, N.M.4    Spencer, J.A.5    Lin, C.P.6    Wohlgemuth, R.7
  • 38
    • 77950551326 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Current understanding and clinical status
    • Salem, H. K.; Thiemermann, C. Mesenchymal stromal cells: Current understanding and clinical status. Stem Cells 28(3):585-596; 2010.
    • (2010) Stem Cells , vol.28 , Issue.3 , pp. 585-596
    • Salem, H.K.1    Thiemermann, C.2
  • 39
    • 57049138194 scopus 로고    scopus 로고
    • Gene expression patterns in mouse cortical penumbra after focal ischemic brain injury and reperfusion
    • Sarabi, A. S.; Shen, H.; Wang, Y.; Hoffer, B. J.; Backman, C. M. Gene expression patterns in mouse cortical penumbra after focal ischemic brain injury and reperfusion. J. Neurosci. Res. 86(13):2912-2924; 2008.
    • (2008) J. Neurosci. Res , vol.86 , Issue.13 , pp. 2912-2924
    • Sarabi, A.S.1    Shen, H.2    Wang, Y.3    Hoffer, B.J.4    Backman, C.M.5
  • 41
    • 34548790066 scopus 로고    scopus 로고
    • Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: Role in homing efficiency in NOD/SCID mice
    • Shi, M.; Li, J.; Liao, L.; Chen, B.; Li, B.; Chen, L.; Jia, H.; Zhao, R. C. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: Role in homing efficiency in NOD/SCID mice. Haematologica 92(7):897-904; 2007.
    • (2007) Haematologica , vol.92 , Issue.7 , pp. 897-904
    • Shi, M.1    Li, J.2    Liao, L.3    Chen, B.4    Li, B.5    Chen, L.6    Jia, H.7    Zhao, R.C.8
  • 42
    • 80055121059 scopus 로고    scopus 로고
    • Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions
    • Song, C. H.; Honmou, O.; Furuoka, H.; Horiuchi, M. Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions. J. Virology 85(21): 11069-11078; 2011.
    • (2011) J. Virology , vol.85 , Issue.21 , pp. 11069-11078
    • Song, C.H.1    Honmou, O.2    Furuoka, H.3    Horiuchi, M.4
  • 43
    • 66149102475 scopus 로고    scopus 로고
    • Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prions
    • Song, C. H.; Honmou, O.; Ohsawa, N.; Nakamura, K.; Hamada, H.; Furuoka, H.; Hasebe, R.; Horiuchi, M. Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prions. J. Virology 83(11):5918-5927; 2009.
    • (2009) J. Virology , vol.83 , Issue.11 , pp. 5918-5927
    • Song, C.H.1    Honmou, O.2    Ohsawa, N.3    Nakamura, K.4    Hamada, H.5    Furuoka, H.6    Hasebe, R.7    Horiuchi, M.8
  • 44
    • 79959445828 scopus 로고    scopus 로고
    • Repetitive hypoxia extends endogenous neurovascular protection for stroke
    • Stowe, A. M.; Altay, T.; Freie, A. B.; Gidday, J. M. Repetitive hypoxia extends endogenous neurovascular protection for stroke. Ann. Neurol. 69(6):975-985; 2011.
    • (2011) Ann. Neurol , vol.69 , Issue.6 , pp. 975-985
    • Stowe, A.M.1    Altay, T.2    Freie, A.B.3    Gidday, J.M.4
  • 47
    • 66949162281 scopus 로고    scopus 로고
    • Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression
    • Tang, Y. L.; Zhu, W.; Cheng, M.; Chen, L.; Zhang, J.; Sun, T.; Kishore, R.; Phillips, M. I.; Losordo, D. W.; Qin, G. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ. Res. 104(10):1209- 1216; 2009.
    • (2009) Circ. Res , vol.104 , Issue.10 , pp. 1209
    • Tang, Y.L.1    Zhu, W.2    Cheng, M.3    Chen, L.4    Zhang, J.5    Sun, T.6    Kishore, R.7    Phillips, M.I.8    Losordo, D.W.9    Qin, G.10
  • 48
    • 41149111290 scopus 로고    scopus 로고
    • In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain
    • Theus, M. H.; Wei, L.; Cui, L.; Francis, K.; Hu, X.; Keogh, C.; Yu, S. P. In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain. Exp. Neurol. 210(2):656-670; 2008.
    • (2008) Exp. Neurol , vol.210 , Issue.2 , pp. 656-670
    • Theus, M.H.1    Wei, L.2    Cui, L.3    Francis, K.4    Hu, X.5    Keogh, C.6    Yu, S.P.7
  • 49
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne, R. G.; Pronk, G. J.; Padmanabhan, V.; Frey, 2nd. W. H. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127(2):481-496; 2004.
    • (2004) Neuroscience , vol.127 , Issue.2 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey II, W.H.4
  • 50
  • 51
    • 77958450795 scopus 로고    scopus 로고
    • Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage
    • van Velthoven, C. T.; Kavelaars, A.; van Bel, F.; Heijnen, C. J. Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage. Pediatr. Res. 68(5):419-422; 2010.
    • (2010) Pediatr. Res , vol.68 , Issue.5 , pp. 419-422
    • van Velthoven, C.T.1    Kavelaars, A.2    van Bel, F.3    Heijnen, C.J.4
  • 53
    • 77950179422 scopus 로고    scopus 로고
    • Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model
    • Wakabayashi, K.; Nagai, A.; Sheikh, A. M.; Shiota, Y.; Narantuya, D.; Watanabe, T.; Masuda, J.; Kobayashi, S.; Kim, S. U.; Yamaguchi, S. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J. Neurosci. Res. 88(5):1017-1025; 2010.
    • (2010) J. Neurosci. Res , vol.88 , Issue.5 , pp. 1017-1025
    • Wakabayashi, K.1    Nagai, A.2    Sheikh, A.M.3    Shiota, Y.4    Narantuya, D.5    Watanabe, T.6    Masuda, J.7    Kobayashi, S.8    Kim, S.U.9    Yamaguchi, S.10
  • 55
    • 55049099223 scopus 로고    scopus 로고
    • Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia
    • Wang, Z. L.; Cheng, S. M.; Ma, M. M.; Ma, Y. P.; Yang, J. P.; Xu, G. L.; Liu, X. F. Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia. Neurosci. Lett. 446(1):30-35; 2008.
    • (2008) Neurosci. Lett , vol.446 , Issue.1 , pp. 30-35
    • Wang, Z.L.1    Cheng, S.M.2    Ma, M.M.3    Ma, Y.P.4    Yang, J.P.5    Xu, G.L.6    Liu, X.F.7
  • 56
    • 20344385515 scopus 로고    scopus 로고
    • Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke
    • Wei, L.; Keogh, C. L.; Whitaker, V. R.; Theus, M. H.; Yu, S. P. Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke. Pathophysiology 12(1):47-62; 2005.
    • (2005) Pathophysiology , vol.12 , Issue.1 , pp. 47-62
    • Wei, L.1    Keogh, C.L.2    Whitaker, V.R.3    Theus, M.H.4    Yu, S.P.5
  • 57
    • 33845794061 scopus 로고    scopus 로고
    • Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice
    • Whitaker, V. R.; Cui, L.; Miller, S.; Yu, S. P.; Wei, L. Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. J. Cereb. Blood Flow Metab. 27(1):57-68; 2007.
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , Issue.1 , pp. 57-68
    • Whitaker, V.R.1    Cui, L.2    Miller, S.3    Yu, S.P.4    Wei, L.5
  • 58
    • 0034663515 scopus 로고    scopus 로고
    • Adult rat and human bone marrow stromal cells differentiate into neurons
    • Woodbury, D.; Schwarz, E. J.; Prockop, D. J.; Black, I. B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61(4):364-370; 2000.
    • (2000) J. Neurosci. Res , vol.61 , Issue.4 , pp. 364-370
    • Woodbury, D.1    Schwarz, E.J.2    Prockop, D.J.3    Black, I.B.4
  • 59
    • 44349145552 scopus 로고    scopus 로고
    • Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats
    • Wu, J.; Sun, Z.; Sun, H. S.; Weisel, R. D.; Keating, A.; Li, Z. H.; Feng, Z. P.; Li, R. K. Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats. Cell Transplant. 16(10):993-1005; 2007.
    • (2007) Cell Transplant , vol.16 , Issue.10 , pp. 993-1005
    • Wu, J.1    Sun, Z.2    Sun, H.S.3    Weisel, R.D.4    Keating, A.5    Li, Z.H.6    Feng, Z.P.7    Li, R.K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.