Intranasal Administration of PEGylated Transforming Growth Factor-α Improves Behavioral Deficits in a Chronic Stroke Model

Journal of Stroke and Cerebrovascular Diseases

Volumn 19, Issue 1, 2010, Pages 3-9

  Guerra Crespo, Magda ^a   Sistos, Andres ^a   Gleason, Darius ^b   Fallon, James H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adult stem cell; injury; intranasal; neurotrophic factor; PEGylation; proliferation

Indexed keywords

PEGYLATED TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; CELL MIGRATION; CELL PROLIFERATION; CHRONIC DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; HISTOPATHOLOGY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ADMINISTRATION, INTRANASAL; ANIMALS; BEHAVIOR, ANIMAL; CELL MOVEMENT; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DISEASE MODELS, ANIMAL; DRUG CARRIERS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MOTOR ACTIVITY; NEUROGENESIS; NEURONS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; STEM CELLS; TIME FACTORS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 72649087478     PISSN: 10523057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2009.09.005     Document Type: Article

References (33)

1. Kaser M.R., Lakshmanan J., and Fisher D.A. Comparison between epidermal growth factor, transforming growth factor-alpha and EGF receptor levels in regions of adult rat brain. Brain Res Mol Brain Res 16 (1992) 316-322
2. Lazar L.M., and Blum M. Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay. J Neurosci 12 (1992) 1688-1697
3. Kornblum H.I., Hussain R.J., Bronstein J.M., et al. Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain. J Comp Neurol 380 (1997) 243-261
4. Reynolds Jr. F.H., Todaro G.J., Fryling C., et al. Human transforming growth factors induce tyrosine phosphorylation of EGF receptors. Nature 292 (1981) 259-262
5. Weickert C.S., and Blum M. Striatal TGF-alpha: postnatal developmental expression and evidence for a role in the proliferation of subependymal cells. Brain Res Dev Brain Res 86 (1995) 203-216
6. Tropepe V., Craig C.G., Morshead C.M., et al. Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci 17 (1997) 7850-7859
7. Ezeonu I., Wang M., Kumar R., et al. Density-dependent differentiation in nontransformed human retinal progenitor cells in response to basic fibroblast growth factor and transforming growth factor-alpha. DNA Cell Biol 22 (2003) 607-620
8. Blum M. A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra. Nat Neurosci 1 (1998) 374-377
9. Fallon J., Reid S., Kinyamu R., et al. In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc Natl Acad Sci USA 97 (2000) 14686-14691
10. Gleason D., Fallon J.H., Guerra M., et al. Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury. Neuroscience 156 (2008) 81-88
11. Guerra-Crespo M., Gleason D., Sistos A., et al. Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model. Neuroscience 160 (2009) 470-483
12. Marquardt H., Hunkapiller M.W., Hood L.E., et al. Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc Natl Acad Sci USA 80 (1983) 4684-4688
13. Sherwin S.A., Twardzik D.R., Bohn W.H., et al. High-molecular-weight transforming growth factor activity in the urine of patients with disseminated cancer. Cancer Res 43 (1983) 403-407
14. Derynck R. Transforming growth factor alpha. Cell 54 (1988) 593-595
15. Pan W., Vallance K., and Kastin A.J. TGF-alpha and the blood-brain barrier: accumulation in cerebral vasculature. Exp Neurol 160 (1999) 454-459
16. Frey II W.H., Liu J., Chen X., et al. Delivery of 125 I-NGF to the brain via the olfactory route. Drug Deliver 4 (1997) 87-92
17. Capsoni S., Giannotta S., and Cattaneo A. Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci USA 99 (2002) 12432-12437
18. Liu X.F., Fawcett J.R., Hanson L.R., et al. The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor I in rats. J Stroke Cerebrovasc Dis 13 (2004) 16-23
19. De Rosa R., Garcia A.A., Braschi C., et al. Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci USA 102 (2005) 3811-3816
20. Yu Y.P., Xu Q.Q., Zhang Q., et al. Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia. Neurosci Lett 387 (2005) 5-10
21. Ma Y.P., Ma M.M., Cheng S.M., et al. Intranasal bFGF-induced progenitor cell proliferation and neuroprotection after transient focal cerebral ischemia. Neurosci Lett 437 (2008) 93-97
22. Thorne R.G., Pronk G.J., Padmanabhan V., et al. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127 (2004) 481-496
23. Fishburn C.S. The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics. J Pharm Sci 97 (2008) 4167-4183
24. Sakane T., and Pardridge W.M. Carboxyl-directed PEGylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity. Pharm Res 14 (1997) 1085-1091
25. Wu D., and Pardridge W.M. Neuroprotection with noninvasive neurotrophin delivery to the brain. Proc Natl Acad Sci USA 96 (1999) 254-259
26. Schallert T., Hernandez T.D., and Barth T.M. Recovery of function after brain damage: severe and chronic disruption by diazepam. Brain Res 379 (1986) 104-111
27. Zhang L., Schallert T., Zhang Z.G., et al. A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia. J Neurosci Methods 117 (2002) 207-214
28. Lendahl U., Zimmerman L.B., and McKay R.D. CNS stem cells express a new class of intermediate filament protein. Cell 60 (1990) 585-595
29. Reynolds B.A., Tetzlaff W., and Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 12 (1992) 4565-4574
30. Frisen J., Johansson C.B., Torok C., et al. Rapid, widespread, and long-lasting induction of nestin contributes to the generation of glial scar tissue after CNS injury. J Cell Biol 131 (1995) 453-464
31. Chen X.Q., Fawcett J.R., Rahman Y.E., et al. Delivery of nerve growth factor to the brain via the olfactory pathway. J Alzheimers Dis 1 (1998) 35-44
32. Cooper O., and Isacson O. Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. J Neurosci 24 (2004) 8924-8931
33. de Chevigny A., Cooper O., Vinuela A., et al. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells 26 (2008) 2349-2360