Total leukocyte counts and neutrophil-lymphocyte count ratios among helicobacter pylori-infected patients with peptic ulcers: Independent of bacterial CagA status

Southeast Asian Journal of Tropical Medicine and Public Health

Volumn 44, Issue 1, 2013, Pages 82-88

  Jafarzadeh, Abdollah ^a   Akbarpoor, V ^a   Nabizadeh, M ^a   Nemati, M ^a   Rezayati, M T ^a  

^a RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Anti CagA; Helicobacter pylori; Leukocyte count; Neutrophils lymphocyte count ratio; Peptic ulcer

Indexed keywords

EID: 84877681598     PISSN: 01251562     EISSN: 26975718     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Basso D, Plebani MH. H. pylori infection: bacterial virulence factors and cytokine gene polymorphisms as determinants of infection outcome. Crit Rev Clin Lab Sci 2004; 41: 313-37.
2. Cappon A, Babolin C, Segat D, et al. Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils. Cell Microbiol 2010; 12: 754-64.
3. Costa AC, Figueiredo C, Touati E. Pathogenesis of Helicobacter pylori infection. Helicobacter 2009; 14 (suppl 1): 15-20.
4. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010; 14: R192.
5. George EL, Panos A. Does a high WBC count signal infection? Nursing 2005; 35: 20-1.
6. Hawley TS, Burns BF, Hawley RG. Leukocytosis in mice following long-term reconstitution with genetically-modified bone marrow cells constitutively expressing interleukin 1 alpha or interleukin 6. Leuk Res 1991; 15: 659-73.
7. Huang B, Chen Y, Xie Q, et al. CagA-positive Helicobacter pylori strains enhanced coronary atherosclerosis by increasing serum OxLDL and HsCRP in patients with coronary heart disease. Dig Dis Sci 2011; 56: 109-14.
8. Huang G, Zhong XN, Zhong B, et al. Significance of white blood cell count and its subtypes in patients with acute coronary syndrome. Eur J Clin Invest 2009; 39: 348-58.
9. Jafarzadeh A, Esmaeeli-Nadimi A, Nemati M, Tahmasbi M, Ahmadi P. Serum concentrations of Helicobacter pylori IgG and the virulence factor CagA in patients with ischaemic heart disease. East Mediterr Health J 2010; 16: 1039-44.
10. Jafarzadeh A, Hassanshahi GH, Nemati M. Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial CagA virulence Factor. Dig Dis Sci 2009a; 22: 22.
11. Jafarzadeh A, Meerzaie W, Ahmad-Beygi H, Nemati M, Rezayati MT. Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients. J Dig Dis 2009b; 10: 107-12.
12. Jafarzadeh A, Rezayati MT, Nemati M. Specific serum immunoglobulin G to H. pylori and CagA in healthy children and adults (south-east of Iran). World J Gastroenterol 2007; 13: 3117-21.
13. Jafarzadeh A, Salari M. Seroprevalence of anti-Helicobacter pylori and anti-CagA antibodies in peptic ulcer and healthy subjects in the city of Rafsanjan. J Res Med Sci 2006; 11: 285-291.
14. Jha HC, Prasad J, Mittal A. High immunoglobulin A seropositivity for combined Chlamy-dia pneumoniae, Helicobacter pylori infection, and high-sensitivity C-reactive protein in coronary artery disease patients in India can serve as atherosclerotic marker. Heart Vessels 2008; 23: 390-6.
15. Kim JM, Kim JS, Jung HC, Song IS, Kim CY. Virulence factors of Helicobacter pylori in Korean isolates do not influence proinflammatory cytokine gene expression and apoptosis in human gastric epithelial cells, nor do these factors influence the clinical outcome. J Gastroenterol 2000; 35: 898-906.
16. Kimang'a A, Revathi G, Kariuki S, et al. IL-17A and IL-17F gene expression is strongly induced in the mucosa of H. pylori-infected subjects from Kenya and Germany. Scand J Immunol 2010; 72: 522-8.
17. Kondo Y, Joh T, Sasaki M, et al. Helicobacter pylori eradication decreases blood neutrophil and monocyte counts. Aliment Pharmacol Ther 2004; 20 (suppl 1): 74-9.
18. Lopez-Vidal Y, Ponce-de-Leon S, Castillo-Rojas G, Barreto-Zuniga R, Torre-Delgadillo A. High diversity of vacA and cagA Helicobacter pylori genotypes in patients with and without gastric cancer. PLoS One 2008; 3: e3849.
19. Madjid M, Awan I, Willerson JT, Casscells SW. Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol 2004; 44: 1945-56.
20. Manolakis A, Kapsoritakis AN, Potamianos SP. A review of the postulated mechanisms concerning the association of Helicobacter pylori with ischemic heart disease. Helicobacter 2007; 12: 287-97.
21. Muhmmed Suliman MA, Bahnacy Juma AA, Ali Almadhani AA, Pathare AV, Alkindi SS, Uwe Werner F. Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome. Arch Med Res 2010; 41: 618-22.
22. Nagatomi R. The implication of alterations in leukocyte subset counts on immune function. Exerc Immunol Rev 2006; 12: 54-71.
23. Randall TD, Carragher DM, Rangel-Moreno J. Development of secondary lymphoid organs. Annu Rev Immunol 2008; 26: 627-50.
24. Romero-Adrian TB, Leal-Montiel J, Monsalve-Castillo F, et al. Helicobacter pylori: bacterial factors and the role of cytokines in the immune response. Curr Microbiol 2010; 60: 143-55.
25. Ruddle NH, Akirav EM. Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response. J Immunol 2009; 183: 2205-12.
26. Sanchez-Zauco NA, Giono-Cerezo S, Maldonado-Bernal C. [Toll-like receptors, pathogenesis and immune response to Helicobacter pylori]. Salud Publica Mex 2010; 52: 447-54.
27. Snaith A, El-Omar EM. Helicobacter pylori: host genetics and disease outcomes. Expert Rev Gastroenterol Hepatol 2008; 2: 577-85.
28. Ubukata H, Motohashi G, Tabuchi T, Nagata H, Konishi S. Evaluations of interferon-gamma/interleukin-4 ratio and neutrophil/lymphocyte ratio as prognostic indicators in gastric cancer patients. J Surg Oncol 2010; 102: 742-7.
29. von Vietinghoff S, Ley K. IL-17A controls IL-17F production and maintains blood neutrophil counts in mice. J Immunol 2009; 183: 865-73.