Predictive Value of Neutrophil to Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome

Archives of Medical Research

Volumn 41, Issue 8, 2010, Pages 618-622

  Muhmmed Suliman, Muhammed Abdul Rheem ^a   Bahnacy Juma, Abdullah Abdulaziz ^a   Ali Almadhani, Ali Ahmed ^a   Pathare, Anil Vasant ^b   Alkindi, Salam Salim Amur ^b   Uwe Werner, Fass ^c  

^a Sohar Hospital   (Oman)

^b SULTAN QABOOS UNIVERSITY   (Oman)

^c OMAN MEDICAL COLLEGE   (Oman)

Author keywords

Acute coronary syndrome; Inflammation; Ischemia; Neutrophil lymphocyte ratio

Indexed keywords

ACUTE CORONARY SYNDROME; ADULT; ARTICLE; CARDIAC PATIENT; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HOSPITAL ADMISSION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; PREDICTION; PROGNOSIS; RISK ASSESSMENT; SMOKING;

ACUTE CORONARY SYNDROME; AGED; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 78650742189     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2010.11.006     Document Type: Article

References (26)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340:115-126.
2. Libby P. Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol 2003, 91:3A-6A.
3. Libby P. Molecular basis of the acute coronary syndromes. Circulation 1995, 91:2844-2852.
4. Falk E., Shah P., Fuster V. Coronary plaque disruption. Circulation 1995, 92:657-671.
5. Hoffman M., Blum A., Baruch R., et al. Leukocytes and coronary heart disease. Atherosclerosis 2004, 172:1-6.
6. Ott I., Neumann F.J., Gawaz M., et al. Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation 1996, 94:1239-1246.
7. Sarma J., Laan C.A., Alam S., et al. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002, 105:2166-2171.
8. Maxwell S.R.J., Lip G.Y.H. Reperfusion injury: review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol 1997, 58:95-117.
9. Pearson T., Mensah G., Alexander R., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003, 107:499-511.
10. Ensrud K., Grimm R.J. The white blood cell count and risk for coronary heart disease. Am Heart J 1992, 124:207-213.
11. Haim M., Boyko V., Goldbourt U., et al. Predictive value of elevated white blood cell count in patients with preexisting coronary heart disease. The Bezafibrate Infarction Prevention Study. Arch Intern Med 2004, 164:433-439.
12. Barron H., Cannon C., Murphy S., et al. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction thrombolysis in myocardial infarction 10 sub study. Circulation 2000, 102:2329-2334.
13. Pelizzon G., Dixon S., Stone G., et al. Relation of admission white blood cell count to long-term outcomes after primary coronary angioplasty for acute myocardial infarction. Am J Cardiol 2003, 91:729-731.
14. Tamhane U.U., Aneja S., Montgomery D., et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008, 102:653-657.
15. Fiarresga A.J., Ferreira R.C., Feliciano J., et al. Prognostic value of neutrophil response in the era of acute myocardial infarction mechanical reperfusion. Rev Port Cardiol 2004, 23:1387-1396.
16. Shah P., Galis Z. Matrix metalloproteinase hypothesis of plaque rupture players keep piling up but questions remain. Circulation 2001, 104:1878-1880.
17. Mazzone A., DeServi S., Ricevuti G., et al. Increased expression of neutrophil and monocyte adhesion molecules in unstable angina. Circulation 1993, 88:358-363.
18. Naruko T., Ueda M., Haze K., et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002, 106:2894-2900.
19. Roy D., Quiles J., Avanzas P., et al. A comparative study of markers of inflammation for the assessment of cardiovascular risk in patients presenting to the emergency department with acute chest pain suggestive of acute coronary syndrome. Int J Cardiol 2006, 109:317-321.
20. Zouridakis E.G., Garcia-Moll X., Kaski J.C. Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina. Am J Cardiol 2000, 86:449-451.
21. Horne B.D., Anderson J.L., John J.M., et al. Which white blood cell subtypes predict increased cardiovascular risk?. J Am Coll Cardiol 2005, 45:1638-1643.
22. Duffy B.K., Gurm H.S., Rajagopal V., et al. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006, 97:993-996.
23. Caligiuri G., Nicollitti A. Lymphocyte responses in acute coronary syndrome: lack of regulation spawns deviant behavior. Eur Heart J 2006, 27:2485-2486.
24. Koenig W., Lowel H., Baumert J., et al. C-reactive protein modulates risk prediction based on the Framingham score. Circulation 2004, 109:1349-1353.
25. Karabinos I., Koulouris S., Kranidis A., et al. Neutrophil count on admission predicts major in-hospital events in patients with a non-ST-segment elevation acute coronary syndrome. Clin Cardiol 2009, 32:561-568.
26. Kao S.C., Pavlakis N., Harvie R., et al. High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clin Cancer Res 2010 Oct 18, [Epub ahead of print].