Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 5, 2013, Pages 3240-3249

  Sugita, Sunao ^a,b   Kawazoe, Yuko ^a   Imai, Ayano ^a   Usui, Yoshihiko ^c   Iwakura, Yoichiro ^d   Isoda, Kikuo ^e   Ito, Masataka ^e   Mochizuki, Manabu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b RIKEN Center for Biosystems Dynamics Research   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

^e NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Cytokine; Dendritic cells; IL 1 receptor antagonist

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CYTOKINE; DENDRITIC CELLS; IL-1 RECEPTOR ANTAGONIST;

ANIMALS; ANTIGEN PRESENTATION; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIPOPOLYSACCHARIDES; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RETINAL PIGMENT EPITHELIUM; T-LYMPHOCYTES;

EID: 84877675994     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11483     Document Type: Article

References (45)

1. Cella M, Engering A, Pinet V, et al. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 1997;388:782-787.
2. Romani N, Reider D, Heuer M, et al. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods. 1996;196:137-151.
3. Ni K, O'Neill HC. The role of dendritic cells in T cell activation. Immunol Cell Biol. 1997;75:223-230.
4. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-252.
5. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol. 2000;18:767-811.
6. Banchereau J, Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity. 2006;25:383-392.
7. Banchereau J, Pascual V, Palucka AK. Autoimmunity through cytokine-induced dendritic cell activation. Immunity. 2004; 20:539-550.
8. Melli K, Friedman RS, Martin AE, et al. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol. 2009;182:2590-2600.
9. Kim TW, Kang JS, Kong JM, et al. Maturation profiles of peripheral blood dendritic cells in patients with endogenous uveitis. Immunol Lett. 2012;142:14-19.
10. Sugita S, Streilein JW. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003;198:161-171.
11. Sugita S, Ng TF, Schwartzkopff J, et al. CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation. J Immunol. 2004;172:4184-4194.
12. Sugita S, Futagami Y, Smith SB, et al. Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta. Exp Eye Res. 2006;83:1459-1471.
13. Sugita S, Usui Y, Horie S, et al. T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. Invest Ophthalmol Vis Sci. 2009;50:2862-2870.
14. Sugita S, Horie S, Yamada Y, et al. Suppression of interleukin 17-producing T-helper 17 cells by retinal pigment epithelial cells. Jpn J Ophthalmol. 2011;55:565-575.
15. Ishida K, Panjwani N, Cao Z, et al. Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms. Ocul Immunol Inflamm. 2003;11:91-105.
16. Liversidge J, McKay D, Mullen G, et al. Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms. Cell Immunol. 1993;149:315-330.
17. Sugita S, Horie S, Nakamura O, et al. Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J Immunol. 2008;181:7525-7536.
18. Sugita S, Horie S, Nakamura O, et al. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eyederived CTLA-2a during inflammatory conditions. J Immunol. 2009;183:5013-5022.
19. Vega JL, Saban D, Carrier Y, et al. Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-beta. Ocul Immunol Inflamm. 2010;18:459-469.
20. Sugita S, Horie S, Yamada Y, et al. Inhibition of B cell activation by retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2010;51:5783-5798.
21. Zamiri P, Masli S, Streilein JW, Taylor AW. Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. Invest Ophthalmol Vis Sci. 2006;47:3912-3918.
22. Horai R, Asano M, Sudo K, et al. Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1βeta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1βeta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med. 1998;187:1463-1475.
23. Isoda K, Shiigai M, Ishigami N, et al. Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury. Circulation. 2003;108:516-518.
24. Sugita S, Yamada Y, Horie S, et al. Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2 alpha on corneal endothelial cells. Invest Ophthalmol Vis Sci. 2011;52:2598-2605.
25. Shen L, Barabino S, Taylor AW, Dana MR. Effect of the ocular microenvironment in regulating corneal dendritic cell maturation. Arch Ophthalmol. 2007;125:908-915.
26. Usui Y, Takeuchi M, Hattori T, et al. Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice. Arch Ophthalmol. 2009;127:514-519.
27. Futagami Y, Sugita S, Vega J, et al. Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells. J Immunol. 2007;178:6994-7005.
28. Jaffe GJ, Van Le L, Valea F, et al. Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. Exp Eye Res. 1992;55:325-335.
29. Holtkamp GM, de Vos AF, Kijlstra A, Peek R. Expression of multiple forms of IL-1 receptor antagonist (IL-1ra) by human retinal pigment epithelial cells: identification of a new IL-1ra exon. Eur J Immunol. 1999;29:215-224.
30. Arend WP, Malyak M, Bigler CF, et al. The biological role of naturally-occurring cytokine inhibitors. Br J Rheumatol. 1991; 30:49-52.
31. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol. 1993;54:167-227.
32. Heur M, Chaurasia SS, Wilson SE. Expression of interleukin-1 receptor antagonist in human cornea. Exp Eye Res. 2009;88: 992-994.
33. Yamada J, Dana MR, Zhu SN, et al. Interleukin 1 receptor antagonist suppresses allosensitization in corneal transplantation. Arch Ophthalmol. 1998;116:1351-1357.
34. Benson MT, Shepherd L, Rees RC, Rennie IG. Production of interleukin-6 by human retinal pigment epithelium in vitro and its regulation by other cytokines. Curr Eye Res. 1992;11:173-179.
35. McMenamin PG, Crewe J, Morrison S, Holt PG. Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye. Invest Ophthalmol Vis Sci. 1994;35:3234-3250.
36. McMenamin PG, Crewe J. Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol Vis Sci. 1995;36:1949-1959.
37. Jiang HR, Lumsden L, Forrester JV. Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice. Invest Ophthalmol Vis Sci. 1999;40:3177-3185.
38. Streilein JW. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol. 2003;3: 879-889.
39. Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol Allergy. 2007;92:71-85.
40. Granstein RD, Staszewski R, Knisely TL, et al. Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation. J Immunol. 1990;144:3021-3027.
41. Kawazoe Y, Sugita S, Keino H, et al. Retinoic acid from retinal pigment epithelium induces T regulatory cells. Exp Eye Res. 2012;94:32-40.
42. Jiang HR, Muckersie E, Robertson M, Forrester JV. Antigen specific inhibition of experimental autoimmune uveoretinitis by bone marrow-derived immature dendritic cells. Invest Ophthalmol Vis Sci. 2003;44:1598-607.
43. Huang H, Dawicki W, Zhang X, et al. Tolerogenic dendritic cells induce CD4+CD25hiFoxp3+ regulatory T cell differentiation from CD4+CD25-/loFoxp3-effector T cells. J Immunol. 2010;185:5003-5010.
44. Maldonado RA, von Andrian UH. How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol. 2010;108:111-165.
45. Tu Z, Li Y, Smith D, et al. Myeloid suppressor cells induced by retinal pigment epithelial cells inhibit autoreactive T-cell responses that lead to experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012;53:959-966.