MiR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

Biochemical and Biophysical Research Communications

Volumn 433, Issue 2, 2013, Pages 207-212

  Zhou, Jing ^a   Tian, Ye ^b   Li, Juan ^a   Lu, Binbin ^a   Sun, Ming ^c   Zou, Yanfen ^d   Kong, Rong ^c   Luo, Yanhong ^c   Shi, Yongguo ^a   Wang, Keming ^a   Ji, Guozhong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b WANNAN MEDICAL COLLEGE   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

^d THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; CyclinD2; MiR 206; Target

Indexed keywords

CYCLIN D2; MESSENGER RNA;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CANCER PATIENT; CANCER SIZE; CANCER STAGING; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 84877647993     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.02.084     Document Type: Article

References (25)

1. Coughlin S.S., Ekwueme D.U. Breast cancer as a global health concern. Cancer Epidemiol. 2009, 33:315-318.
2. Jemal A., Center M.M., DeSantis C., Ward E.M. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol. Biomarkers Prev. 2010, 19:1893-1907.
3. Lin S.X., Chen J., Mazumdar M., Poirier D., Wang C., Azzi A., Zhou M. Molecular therapy of breast cancer: progress and future directions. Nat. Rev. Endocrinol. 2010, 6:485-493.
4. Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
5. Ambros V. MicroRNAs: tiny regulators with great potential. Cell 2001, 107:823-826.
6. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
7. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
8. Pillai R.S., Bhattacharyya S.N., Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms?. Trends Cell Biol. 2007, 17:118-126.
9. Garzon R., Calin G.A., Croce C.M. MicroRNAs in cancer. Annu. Rev. Med. 2009, 60:167-179.
10. Esquela-Kerscher A., Slack F.J. Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
11. Frankel L.B., Christoffersen N.R., Jacobsen A., Lindow M., Krogh A., Lund A.H. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J. Biol. Chem. 2008, 283:1026-1033.
12. Selcuklu S.D., Donoghue M.T., Spillane C. MiR-21 as a key regulator of oncogenic processes. Biochem. Soc. Trans. 2009, 37:918-925.
13. Medina P.P., Nolde M., Slack F.J. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 2010, 467:86-90.
14. Johnson S.M., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K.L., Brown D., Slack F.J. RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647.
15. Iorio M.V., Croce C.M. Causes and consequences of microRNA dysregulation. Cancer J. 2012, 18:215-222.
16. Hertel J., Lindemeyer M., Missal K., Fried C., Tanzer A., Flamm C., Hofacker I.L., Stadler P.F. The expansion of the metazoan microRNA repertoire. BMC Genomics 2006, 7:25.
17. Tavazoie S.F., Alarcon C., Oskarsson T., Padua D., Wang Q., Bos P.D., Gerald W.L., Massague J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008, 451:147-152.
18. Musiyenko A., Bitko V., Barik S. Ectopic expression of miR-126, an intronic product of the vascular endothelial EGF-like 7 gene, regulates protein translation and invasiveness of prostate cancer LNCaP cells. J. Mol. Med. 2008, 86:313-322.
19. Negrini M., Calin G.A. Breast cancer metastasis: a microRNA story. Breast Cancer Res. 2008, 10:203.
20. Adams B.D., Furneaux H., White B.A. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-a (ERa) and represses ER a messenger RNA and protein expression in breast cancer cell lines. Mol. Endocrinol. 2007, 21:1132-1147.
21. Kim H.K., Lee Y.S., Sivaprasad U., Malhotra A., Dutta A. Muscle-specific microRNA miR-206 promotes muscle differentiation. J. Cell Biol. 2006, 174:677-687.
22. Meyyappan M., Wong H., Hull C., Riabowol K.T. Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells. Mol. Cell. Biol. 1998, 18:3163-3172.
23. Sicinski P., Donaher J.L., Geng Y., Parker S.B., Gardner H., Park M.Y., Robker R.L., Richards J.S., McGinnis L.K., Biggers J.D., Eppig J.J., Bronson R.T., Elledge S.J., Weinberg R.A. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature (London) 1996, 384:470-474.
24. Bouchard C., Thieke K., Maier A., Saffrich R., Hanley-Hyde J., Ansorge W., Reed S., Sicinski P., Bartek J., Eilers M. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J. 1999, 18:5321-5333.
25. Perez-Roger I., Kim S.H., Griffiths B., Sewing A., Land H. Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1). EMBO J. 1999, 18:5310-5320.