Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Son, Tae Gen ^a   Gong, Eun Ji ^a   Bae, Min Ji ^a   Kim, Sung Dae ^a   Heo, Kyu ^a   Moon, Changjong ^b   Yang, Kwangmo ^a   Kim, Joong Sun ^a  

^a Dongnam Institute of Radiological and Medical Science   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; KI 67 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CANCER GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; INTESTINE CRYPT; INTESTINE INJURY; INTESTINE VILLUS; IRRADIATION; JEJUNUM; MOUSE; NONHUMAN; RADIATION DOSE; RADIATION INJURY; RADIATION PROTECTION; RADIOSENSITIVITY; TUMOR VOLUME;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; FEMALE; GENISTEIN; INTESTINAL MUCOSA; INTESTINE, SMALL; JEJUNUM; MALE; MICE; MICE, INBRED BALB C; MUCOSITIS; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; RADIATION INJURIES; SOYBEANS;

EID: 84877635854     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-103     Document Type: Article

References (40)

1. Babb RR. Radiation proctitis: a review. Am J Gastroenterol 1996, 91(7):1309-1311.
2. Szabo S, Sandor Z, Vincze A, Gombos Z, Mohiuddin A, Viravathana T. Radiation-induced enterocolitis: basic and applied science. Eur J Surg Suppl 1998, 582(582):85-89.
3. Vigneulle RM, Rao S, Fasano A, MacVittie TJ. Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey. Dig Dis Sci 2002, 47(7):1480-1491. 10.1023/A:1015846514471, 12141804.
4. Jagetia GC. Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr 2007, 40(2):74-81. 10.3164/jcbn.40.74, 2127223, 18188408.
5. Moon C, Kim SH, Kim JC, Hyun JW, Lee NH, Park JW, Shin T. Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice. Phytother Res 2008, 22(2):238-242. 10.1002/ptr.2298, 17886227.
6. Kim SH, Lee HJ, Kim JS, Moon C, Kim JC, Park HR, Jung U, Jang JS, Jo SK. Protective effect of an herbal preparation (HemoHIM) on radiation-induced intestinal injury in mice. J Med Food 2009, 12(6):1353-1358. 10.1089/jmf.2008.1322, 20041793.
7. Kim JS, Ryoo SB, Heo K, Kim JG, Son TG, Moon C, Yang K. Attenuating effects of Granulocyte-colony stimulating factor (G-CSF) in radiation induced intestinal injury in mice. Food Chem Toxicol 2012, 50(9):3174-3180. 10.1016/j.fct.2012.05.059, 22699087.
8. Kim JS, Heo K, Yi JM, Gong EJ, Yang K, Moon C, Kim SH. Genistein mitigates radiation-induced testicular injury. Phytother Res 2012, 26(8):1119-1125. 10.1002/ptr.3689, 22162311.
9. Kruk I, Aboul-Enein HY, Michalska T, Lichszteld K, Kladna A. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence 2005, 20(2):81-89. 10.1002/bio.808, 15803505.
10. Filipe P, Silva JN, Haigle J, Freitas JP, Fernandes A, Santus R, Morliere P. Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblasts by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic. Photochem Photobiol Sci 2005, 4(5):420-428. 10.1039/b416811a, 15875075.
11. Landauer MR, Srinivasan V, Seed TM. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol 2003, 23(6):379-385. 10.1002/jat.904, 14635262.
12. Zhou Y, Mi MT. Genistein stimulates hematopoiesis and increases survival in irradiated mice. J Radiat Res 2005, 46(4):425-433. 10.1269/jrr.46.425, 16394633.
13. Davis TA, Mungunsukh O, Zins S, Day RM, Landauer MR. Genistein induces radioprotection by hematopoietic stem cell quiescence. Int J Radiat Biol 2008, 84(9):713-726. 10.1080/09553000802317778, 18821385.
14. Day RM, Barshishat-Kupper M, Mog SR, McCart EA, Prasanna PG, Davis TA, Landauer MR. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res 2008, 49(4):361-372. 10.1269/jrr.07121, 2575019, 18434686.
15. Hillman GG, Singh-Gupta V, Runyan L, Yunker CK, Rakowski JT, Sarkar FH, Miller S, Gadgeel SM, Sethi S, Joiner MC, Konski AA. Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury. Radiother Oncol 2011, 101(2):329-336. 10.1016/j.radonc.2011.10.020, 3229191, 22079530.
16. Polkowski K, Mazurek AP. Biological properties of genistein. A review of in vitro and in vivo data. Acta Pol Pharm 2000, 57(2):135-155.
17. Sarkar FH, Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 2002, 21(3-4):265-280.
18. Hillman GG, Wang Y, Kucuk O, Che M, Doerge DR, Yudelev M, Joiner MC, Marples B, Forman JD, Sarkar FH. Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Mol Cancer Ther 2004, 3(10):1271-1279.
19. Hillman GG, Wang Y, Che M, Raffoul JJ, Yudelev M, Kucuk O, Sarkar FH. Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. BMC Cancer 2007, 7:4. 10.1186/1471-2407-7-4, 1783858, 17212824.
20. Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 2006, 6:107. 10.1186/1471-2407-6-107, 1464148, 16640785.
21. Lee HJ, Kim JS, Moon C, Kim JC, Jo SK, Kim SH. Relative biological effectiveness of fast neutrons in a multiorgan assay for apoptosis in mouse. Environ Toxicol 2008, 23(2):233-239. 10.1002/tox.20328, 18214905.
22. Holt PR, Moss SF, Kapetanakis AM, Petrotos A, Wang S. Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen?. Cancer Epidemiol Biomarkers Prev 1997, 6(2):131-135.
23. Booth C, Booth D, Williamson S, Demchyshyn LL, Potten CS. Teduglutide ([Gly2]GLP-2) protects small intestinal stem cells from radiation damage. Cell Prolif 2004, 37(6):385-400. 10.1111/j.1365-2184.2004.00320.x, 15548172.
24. Driak D, Osterreicher J, Vavrova J, Rehakova Z, Vilasova Z. Morphological changes of rat jejunum after whole body gamma-irradiation and their impact in biodosimetry. Physiol Res 2008, 57(3):475-479.
25. Quastler H. The nature of intestinal radiation death. Radiat Res 1956, 4(4):303-320. 10.2307/3570211, 13310750.
26. Gunnlaugsson A, Nilsson P, Kjellén E, Johnsson A. The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay. Radiat Oncol 2009, 4:61. 10.1186/1748-717X-4-61, 2797511, 20003187.
27. Arora A, Byrem TM, Nair MG, Strasburg GM. Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch Biochem Biophys 2000, 373(1):102-109. 10.1006/abbi.1999.1525, 10620328.
28. Klein CB, King AA. Genistein genotoxicity: critical considerations of in vitro exposure dose. Toxicol Appl Pharmacol 2007, 224(1):1-11. 10.1016/j.taap.2007.06.022, 17688899.
29. Wang HK. The therapeutic potential of flavonoids. Expert Opin Investig Drugs 2000, 9(9):2103-2119. 10.1517/13543784.9.9.2103, 11060796.
30. Harnish DC, Albert LM, Leathurby Y, Eckert AM, Ciarletta A, Kasaian M, Keith JC. Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2004, 286(1):G118-G125.
31. Yu HP, Hsieh YC, Suzuki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway. J Leukoc Biol 2007, 82(3):774-780. 10.1189/jlb.0307182, 17586659.
32. Singh VK, Grace MB, Parekh VI, Whitnall MH, Landauer MR. Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice. Int Immunopharmacol 2009, 9(12):1401-1410. 10.1016/j.intimp.2009.08.012, 19716438.
33. Grace MB, Singh VK, Rhee JG, Jackson WE, Kao TC, Whitnall MH. 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis. J Radiat Res 2012, 53(6):840-853. 10.1093/jrr/rrs060, 22843381.
34. Singh-Gupta V, Zhang H, Banerjee S, Kong D, Raffoul JJ, Sarkar FH, Hillman GG. Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer 2009, 124(7):1675-1684. 10.1002/ijc.24015, 2670478, 19101986.
35. Kim JS, Yang M, Jang H, Oui H, Kim SH, Shin T, Jang WS, Lee SS, Moon C. Granulocyte-colony stimulating factor ameliorates irradiation-induced suppression of hippocampal neurogenesis in adult mice. Neurosci Lett 2010, 486(1):43-46. 10.1016/j.neulet.2010.09.041, 20854880.
36. Kim J, Lee S, Jeon B, Jang W, Moon C, Kim S. Protection of spermatogenesis against gamma ray-induced damage by granulocyte colony-stimulating factor in mice. Andrologia 2011, 43(2):87-93. 10.1111/j.1439-0272.2009.01023.x, 21382061.
37. Li M, Zhang Z, Hill DL, Chen X, Wang H, Zhang R. Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Res 2005, 65(18):8200-8208. 10.1158/0008-5472.CAN-05-1302, 16166295.
38. Fang MZ, Chen D, Sun Y, Jin Z, Christman JK, Yang CS. Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clin Cancer Res 2005, 11(19 Pt 1):7033-7041.
39. Pietras RJ, Weinberg OK. Antiangiogenic steroids in human cancer therapy. Evid Based Complement Alternat Med 2005, 2(1):49-57. 10.1093/ecam/neh066, 1062159, 15841278.
40. Maria-Aggeliki KS, Nikolaos KL, Kyrias GM, Vassilis KE. The potential clinical impact of probiotic treatment for the prevention and/or anti-inflammatory therapeutic effect against radiation induced intestinal mucositis. A review. Recent Pat Inflamm Allergy Drug Discov 2009, 2(1):195-200.