Granulocyte-colony stimulating factor ameliorates irradiation-induced suppression of hippocampal neurogenesis in adult mice

Neuroscience Letters

Volumn 486, Issue 1, 2010, Pages 43-46

  Kim, Joong Sun ^a,b   Yang, Miyoung ^a   Jang, Hyosun ^a   Oui, Heejin ^a   Kim, Sung Ho ^a   Shin, Taekyun ^c   Jang, Won Suk ^d   Lee, Seung Sook ^d   Moon, Changjong ^a  

^a Chonnam National University   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Jeju National University   (South Korea)

^d Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

G csf; Hippocampus; Irradiation; Neurogenesis

Indexed keywords

DOUBLECORTIN; KI 67 ANTIGEN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN RADIATION; DRUG SCREENING; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PROTECTION;

ANIMALS; APOPTOSIS; CRANIAL IRRADIATION; DENTATE GYRUS; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HIPPOCAMPUS; KI-67 ANTIGEN; MALE; MICE; MICE, INBRED C3H; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGENESIS; NEUROPEPTIDES; NEUROPROTECTIVE AGENTS; RADIATION-PROTECTIVE AGENTS;

EID: 77957914143     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.09.041     Document Type: Article

References (24)

1. Bodine D.M., Seidel N.E., Gale M.S., Nienhuis A.W., Orlic D. Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor. Blood 1994, 84:1482-1491.
2. Couillard-Despres S., Winner B., Schaubeck S., Aigner R., Vroemen M., Weidner N., Bogdahn U., Winkler J., Kuhn H.G., Aigner L. Doublecortin expression levels in adult brain reflect neurogenesis. Eur. J. Neurosci. 2005, 21:1-14.
3. Crossen J.R., Garwood D., Glatstein E., Neuwelt E.A. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J. Clin. Oncol. 1994, 12:627-642.
4. Diederich K., Schäbitz W.R., Kuhnert K., Hellström N., Sachser N., Schneider A., Kuhn H.G., Knecht S. Synergetic effects of granulocyte-colony stimulating factor and cognitive training on spatial learning and survival of newborn hippocampal neurons. PLoS One 2009, 4:5303.
5. Ding J., Yu J.Z., Li Q.Y., Wang X., Lu C.Z., Xiao B.G. Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF. Brain Behav. Immunol. 2009, 23:1083-1088.
6. Gleeson J.G., Lin P.T., Flanagan L.A., Walsh C.A. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 1999, 23:257-271.
7. Francis F., Koulakoff A., Boucher D., Chafey P., Schaar B., Vinet M.C., Friocourt G., McDonnell N., Reiner O., Kahn A., McConnell S.K., Berwald-Netter Y., Denoulet P., Chelly J. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 1999, 23:247-256.
8. Harada M., Qin Y., Takano H., Minamino T., Zou Y., Toko H., Ohtsuka M., Matsuura K., Sano M., Nishi J., Iwanaga K., Akazawa H., Kunieda T., Zhu W., Hasegawa H., Kunisada K., Nagai T., Nakaya H., Yamauchi-Takihara K., Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat. Med. 2005, 11:305-311.
9. Hérodin F., Drouet M. Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp. Hematol. 2005, 33:1071-1080.
10. Jung K.H., Chu K., Lee S.T., Kang L., Kim S.U., Kim M., Roh J.K. G-CSF protects human cerebral hybrid neurons against in vitro ischemia. Neurosci. Lett. 2006, 394:168-173.
11. Kawada H., Takizawa S., Takanashi T., Morita Y., Fujita J., Fukuda K., Takagi S., Okano H., Ando K., Hotta T. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation 2006, 113:701-710.
12. Kim J.S., Lee H.J., Kim J.C., Kang S.S., Bae C.S., Shin T., Jin J.K., Kim S.H., Wang H., Moon C. Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. J. Radiat. Res. 2008, 49:517-526.
13. Kim J.S., Jung J., Lee H.J., Kim J.C., Wang H., Kim S.H., Shin T., Moon C. Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice. Acta Histochem. 2009, 111:150-156.
14. J.S. Kim, S.S. Lee, B.J. Jeon, W.S. Jang, C. Moon, S.H. Kim, Protection of spermatogenesis against γ-ray-induced damage by granulocyte-colony stimulating factor in mice, Andrologia in press.
15. Komine-Kobayashi M., Zhang N., Liu M., Tanaka R., Hara H., Osaka A., Mochizuki H., Mizuno Y., Urabe T. Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. J. Cereb. Blood Flow. Metab. 2006, 26:402-413.
16. Lombaert I.M., Brunsting J.F., Wierenga P.K., Kampinga H.H., de Haan G., Coppes R.P. Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation. Clin. Cancer Res. 2008, 14:7741-7750.
17. Lu C.Z., Xiao B.G. G-CSF neuroprotection: a therapeutic perspective in cerebral ischaemia. Biochem. Soc. Trans. 2006, 34:1327-1333.
18. Raber J., Rola R., LeFevour A., Morhardt D., Curley J., Mizumatsu S., VandenBerg S.R., Fike J.R. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat. Res. 2004, 162:39-47.
19. Rao M.S., Shetty A.K. Efficacy of doublecortin as a marker to analyze the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. Eur J. Neurosci. 2004, 19:234-246.
20. Sanchez-Ramos J., Song S., Sava V., Catlow B., Lin X., Mori T., Cao C., Arendash G.W. Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience 2009, 163:55-72.
21. Schäbitz W.R., Schneider A. Developing granulocyte-colony stimulating factor for the treatment of stroke: current status of clinical trials. Stroke 2006, 37:1654.
22. Schneider A., Krüger C., Steigleder T., Weber D., Pitzer C., Laage R., Aronowski J., Maurer M.H., Gassler N., Mier W., Hasselblatt M., Kollmar R., Schwab S., Sommer C., Bach A., Kuhn H.G., Schäbitz W.R. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 2005, 115:2083-2098.
23. Uckun F.M., Souza L., Waddick K.G., Wick M., Song C.W. In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice. Blood 1990, 75:638-645.
24. von Bohlen Und Halbach O. Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res. 2007, 329:409-420.