Correlation of symptomatic improvements with functional improvements and patient-reported outcomes in adults with attention-deficit/hyperactivity disorder treated with OROS methylphenidate

World Journal of Biological Psychiatry

Volumn 14, Issue 4, 2013, Pages 282-290

  Rösler, Michael ^a   Ginsberg, Ylva ^b   Arngrim, Torben ^c   Adamou, Marios ^d   Niemelä, Asko ^e   Dejonkheere, Joachim ^f   Van Oene, Joop ^g   Schäuble, Barbara ^h  

^a SAARLAND UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Private Practice of Chiropractic   (Denmark)

^d SOUTH WEST YORKSHIRE PARTNERSHIP NHS FOUNDATION TRUST   (United Kingdom)

^e Wellmind Health Ltd   (Finland)

^f SGS Medisearch International NV   (Belgium)

^g Janssen Cilag BV Netherlands   (Netherlands)

^h JANSSEN CILAG GMBH   (Germany)

Author keywords

Adults; Attention deficit hyperactivity disorder; Daily functioning; Health related quality of life; OROS methylphenidate

Indexed keywords

METHYLPHENIDATE; PLACEBO;

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL EFFECTIVENESS; CLINICAL GLOBAL IMPRESSION SCALE; CONNER ADULT ADHD RATING SCALE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OSMOTIC RELEASE ORAL SYSTEM; OUTCOME ASSESSMENT; POST HOC ANALYSIS; PSYCHOLOGICAL RATING SCALE; QUALITY OF LIFE; QUALITY OF LIFE ENJOYMENT AND SATISFACTION QUESTIONNAIRE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SHEEHAN DISABILITY SCALE;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHYLPHENIDATE; OSMOSIS; QUALITY OF LIFE; REGRESSION ANALYSIS; SELF REPORT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84877632316     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.571283     Document Type: Article

References (50)

1. Abram KM, Teplin LA, McClelland GM, Dulcan MK. 2003. Comorbid psychiatric disorders in youth in juvenile detention. Arch Gen Psychiatry 60:1097-1108. (Pubitemid 37429649)
2. Adler LA, Spencer TJ, Levine LR, Ramsey JL, Tamura R, Kelsey D, et al. 2008a. Functional outcomes in the treatment of adults with ADHD. J Atten Disord 11:720-727.
3. Adler LA, Spencer TJ, Williams DW, Moore RJ, Michelson D. 2008b. Long-term, open-label safety and effi cacy of atomoxetine in adults with ADHD: fi nal report of a 4-year study. J Atten Disord 12:248-253.
4. Adler LA, Liebowitz M, Kronenberger W, Qiao M, Rubin R, Hollandbeck M, et al. 2009a. Atomoxetine treatment in adults with attention-defi cit/hyperactivity disorder and comorbid social anxiety disorder. Depress Anxiety 26:212-221.
5. Adler LA, Zimmerman B, Starr HL, Silber S, Palumbo J, Orman C, et al. 2009b. Effi cacy and safety of OROS methylphenidate in adults with attention-defi cit/hyperactivity disorder: a randomized, placebo-controlled, double-blind, parallel group, doseescalation study. J Clin Psychopharmacol 29:239-247.
6. Anckarsater H, Nilsson T, St a hlberg O, Gustafson M, Saury JM, R a stam M, et al. 2007. Prevalences and confi gurations of mental disorders among institutionalized adolescents. Dev Neurorehabil 10:57-65. (Pubitemid 47555474)
7. Andrade RC, Silva VA, Assumpcao FB Jr. 2004. Preliminary data on the prevalence of psychiatric disorders in Brazilian male and female juvenile delinquents. Braz J Med Biol Res 37:1155-1160. (Pubitemid 39172549)
8. Arbuckle R, Frye MA, Brecher M, Paulsson B, Rajagopalan K, Palmer S, et al. 2009. The psychometric validation of the Sheehan Disability Scale (SDS) in patients with bipolar disorder. Psychiatry Res 165:163-174.
9. Babinski LM, Hartsough CS, Lambert NM. 1999. Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity. J Child Psychol Psychiatry 40:347-355. (Pubitemid 29108102)
10. Barkley RA, Fischer M, Smallish L, Fletcher K. 2004. Young adult follow-up of hyperactive children: antisocial activities and drug use. J Child Psychol Psychiatry 45:195-211. (Pubitemid 38240269)
11. Barkley RA, Cunningham CE, Gordon M, Faraone SV, Lewandowski L, Murphy KR. 2006. ADHD symptoms vs. impairment: revisited. ADHD Report 14:1-9.
12. Barkley RA, Murphy KR, Fischer M. 2008. ADHD in adults: What the science says. New York: Guilford Press.
13. Baron RM, Kenny DA. 1986. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173-1182.
14. Biederman J. 2004. Impact of comorbidity in adults with attention-defi cit/hyperactivity disorder. J Clin Psychiatry 65(Suppl 3):3-7.
15. Biederman J, Faraone SV, Spencer TJ, Mick J, Monuteaux MC, Aleardi M. 2006. Functional impairments in adults with selfreports of diagnosed ADHD: a controlled study of 1001 adults in the community. J Clin Psychiatry 67:524-540. (Pubitemid 43764229)
16. Biederman J, Mick E, Surman C, Doyle R, Hammerness P, Kotarski M, et al. 2010. A randomized, 3-phase, 34-week, double-blind, long-term effi cacy study of osmotic-release oral system-methylphenidate in adults with attention-defi cit/hyperactivity disorder. J Clin Psychopharmacol 30:549-553.
17. Blocher D, Henkel K, Retz W, Retz-Junginger P, Thorne D, R ö sler M. 2001. [Symptoms from the spectrum of Attention-Defi cit/Hyperactivity Disorder (ADHD) in sexual delinquents]. Fortschr Neurol Psychiatr 69:453-459. (Pubitemid 33000651)
18. Buitelaar JK, Wilens TE, Zhang S, Ning Y, Feldman PD. 2009. Comparison of symptomatic versus functional changes in children and adolescents with ADHD during randomized, doubleblind treatment with psychostimulants, atomoxetine, or placebo. J Child Psychol Psychiatry 50:335-342.
19. Conners C, Erhardt D, Sparrow E. 1999. Conners ' Adult ADHD Rating Scales (CAARS): technical manual. North Tonawanda, NY: Multi-Health Systems.
20. Doreleijers TA, Moser F, Thijs P, van Engeland H, Bayaert FH. 2000. Forensic assessment of juvenile delinquents: prevalence of psychopathology and decision-making at court in the Netherlands. J Adolesc 23:263-275. (Pubitemid 30655496)
21. Eakin L, Minde K, Hechtman L, Ochs E, Krane E, Bouffard R, et al. 2004. The marital and family functioning of adults with ADHD and their spouses. J Atten Disord 8:1-10. (Pubitemid 39407101)
22. Endicott J, Nee J, Harrison W, Blumenthal R. 1993. Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure. Psychopharmacol Bull 29:321-326. (Pubitemid 23311543)
23. Fallu A, Richard C, Prinzo R, Binder C. 2006. Does OROSmethylphenidate improve core symptoms and defi cits in executive function? Results of an open-label trial in adults with attention defi cit hyperactivity disorder. Curr Med Res Opin 22:2557-2566. (Pubitemid 46048371)
24. Fazel M, L a ngstrom N, Grann M, Fazel S. 2008. Psychopathology in adolescent and young adult criminal offenders (15-21 years) in Sweden. Soc Psychiatry Psychiatr Epidemiol 43:319-324.
25. Gathje RA, Lewandowski LJ, Gordon M. 2008. The role of impairment in the diagnosis of ADHD. J Atten Disord 11:529-537.
26. Gosden NP, Kramp P, Gabrielsen G, Sestoft D. 2003. Prevalence of mental disorders among 15-17-year-old male adolescent remand prisoners in Denmark. Acta Psychiatr Scand 107:102-110. (Pubitemid 36164477)
27. Greenhill LL, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J, et al. 2001. Summary of the practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 40:1352-1355.
28. Halmoy A, Fasmer OB, Gillberg C, Haavik J. 2009. Occupational outcome in adult ADHD: impact of symptom profi le, comorbid psychiatric problems, and treatment: a cross-sectional study of 414 clinically diagnosed adult ADHD patients. J Atten Disord 13:175-187.
29. Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler C, et al. 2006. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163:716-723. (Pubitemid 44464584)
30. Leon AC, Shear MK, Portera L, Klerman GL. 1992. Assessing impairment in patients with panic disorder: the Sheehan Disability Scale. Soc Psychiatry Psychiatr Epidemiol 27:78-82.
31. Leon AC, Olfson M, Portera L, Farber L, Sheehan DV. 1997. Assessing psychiatric impairment in primary care with the Sheehan Disability Scale. Int J Psychiatry Med 27:93-105. (Pubitemid 27407503)
32. Lewandowski LJ, Lovett BJ, Codding RS, Gordon M. 2008. Symptoms of ADHD and academic concerns in college students with and without ADHD diagnoses. J Atten Disord 12: 156-161.
33. Mannuzza S, Klein RG, Moulton JL III. 2008. Lifetime criminality among boys with attention defi cit hyperactivity disorder: a prospective follow-up study into adulthood using offi cial arrest records. Psychiatry Res 160:237-246.
34. Matza LS, Johnston JA, Faries DE, Malley KG, Brod M. 2007. Responsiveness of the Adult Attention-Defi cit/Hyperactivity Disorder Quality of Life Scale (AAQoL). Qual Life Res 16: 1511-1520. (Pubitemid 47561727)
35. Medori R, Ramos-Quiroga JA, Casas M, Kooij JJ, Niemel ä A, Trott GE, et al. 2008. A randomized, placebo-controlled trial of 3 fi xed dosages of prolonged-release OROS methylphenidate in adults with attention-defi cit/hyperactivity disorder. Biol Psychiatry 63:981-989.
36. Michelson D, Adler L, Spencer T, Reimherr FW, West SA, Allen AJ, et al. 2003. Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies. Biol Psychiatry 53:112-120. (Pubitemid 36126473)
37. Mick E, Faraone SV, Spencer T, Zhang HF, Biederman J. 2008. Assessing the validity of the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form in adults with ADHD. J Atten Disord 11:504-509.
38. National Institute of Mental Health (NIMH). 1985. CGI (Clinical Global Impression Scale). Psychopharmacol Bull 21:843.
39. Reimherr FW, Williams ED, Strong RE, Mestas R, Soni P, Marchant BK. 2007. A double-blind, placebo-controlled, crossover study of osmotic release oral system methylphenidate in adults with ADHD with assessment of oppositional and emotional dimensions of the disorder. J Clin Psychiatry 68:93-101. (Pubitemid 46220130)
40. R ö sler M, Retz W, Yaqoobi K, Burg E, Retz-Junginger P. 2009. Attention defi cit/hyperactivity disorder in female offenders: prevalence, psychiatric comorbidity and psychosocial implications. Eur Arch Psychiatry Clin Neurosci 259: 98-105.
41. R ö sler M, Retz W, Fischer R, Ose C, Alm B, Deckert J, et al. 2010. Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD. World J Biol Psychiatry 11:709-718.
42. Sheehan DV, Harnett-Sheehan K, Raj BA. 1996. The measurement of disability. Int Clin Psychopharmacol 11(Suppl 3):89-95. (Pubitemid 26373761)
43. Sheehan KH, Sheehan DV. 2008. Assessing treatment effects in clinical trials with the discan metric of the Sheehan Disability Scale. Int Clin Psychopharmacol 23:70-83. (Pubitemid 351317279)
44. Siponmaa L, Kristiansson M, Jonson C, Nyd é n A, Gillberg C. 2001. Juvenile and young adult mentally disordered offenders: the role of child neuropsychiatric disorders. J Am Acad Psychiatry Law 29:420-426. (Pubitemid 34015107)
45. Spencer TJ, Faraone SV, Michelson D, Adler LA, Reimherr FW, Glatt SJ, et al. 2006. Atomoxetine and adult attention-defi cit/hyperactivity disorder: the effects of comorbidity. J Clin Psychiatry 67:415-20.
46. Spencer TJ, Adler LA, Weisler RH, Youcha SH. 2008a. Triple-bead mixed amphetamine salts (SPD465), a novel, enhanced extended-release amphetamine formulation for the treatment of adults with ADHD: a randomized, double-blind, multicenter, placebocontrolled study. J Clin Psychiatry 69:1437-1448.
47. Spencer TJ, Landgraf JM, Adler LA, Weisler RH, Anderson CS, Youcha SH. 2008b. Attention-defi cit/hyperactivity disorderspecifi c quality of life with triple-bead mixed amphetamine salts (SPD465) in adults: results of a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 69:1766-1775.
48. Teplin LA, Abram KM, McClelland GM, Dulcan MK, Mericle AA. 2002. Psychiatric disorders in youth in juvenile detention. Arch Gen Psychiatry 59:1133-1143. (Pubitemid 35424024)
49. Vermeiren R, de Clippele A, Deboutte D. 2000. A descriptive survey of Flemish delinquent adolescents. J Adolesc 23:277-285. (Pubitemid 30654884)
50. Vreugdenhil C, Doreleijers TA, Vermeiren R, Wouters LF, van den Brink W. 2004. Psychiatric disorders in a representative sample of incarcerated boys in the Netherlands. J Am Acad Child Adolesc Psychiatry 43:97-104. (Pubitemid 41615027)