A randomized, 3-phase, 34-week, double-blind, long-term efficacy study of osmotic-release oral system-methylphenidate in adults with attention-deficit/ hyperactivity disorder

Journal of Clinical Psychopharmacology

Volumn 30, Issue 5, 2010, Pages 549-553

  Biederman, Joseph ^a   Mick, Eric ^a   Surman, Craig ^a   Doyle, Robert ^a   Hammerness, Paul ^a   Kotarski, Meghan ^a   Spencer, Thomas ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

ADHD; adult; methylphenidate; psychopharmacology; randomized trial; stimulant

Indexed keywords

METHYLPHENIDATE;

ADULT; AGITATION; ALLERGY; ANXIETY; ARTICLE; ATTENTION DEFICIT DISORDER; AUTONOMIC DYSFUNCTION; CARDIOVASCULAR DISEASE; CHRONIC DRUG ADMINISTRATION; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECREASED APPETITE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG WITHDRAWAL; ENERGY; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HYPERSALIVATION; INCREASED APPETITE; INFECTION; INSOMNIA; IRRITABILITY; LONG TERM CARE; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MUCOSAL DRYNESS; MUSCULOSKELETAL DISEASE; NERVOUSNESS; NEUROLOGIC DISEASE; OSMOTIC RELEASE ORAL SYSTEM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; SKIN DISEASE; SWEATING; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; UROGENITAL TRACT DISEASE;

ADMINISTRATION, ORAL; ADULT; AGE FACTORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHYLPHENIDATE; MIDDLE AGED; OSMOSIS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77957255293     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3181ee84a7     Document Type: Article

References (21)

1. Kessler RC, Adler L, Ames M, et al. The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med. 2005;47: 565-572. (Pubitemid 40847440)
2. Kessler RC, Adler L, Barkley R, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006; 163: 716-723. (Pubitemid 44464584)
3. Biederman J, Petty C, Fried R, et al. Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 2006;163: 1730-1738. (Pubitemid 44522481)
4. Faraone SV. Genetics of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004;27: 303-321.
5. Spencer T, Biederman J, Wilens T. Stimulant treatment of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004;27: 361-372. (Pubitemid 38452772)
6. Spencer T, Biederman J, Wilens T. Nonstimulant treatment of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004;27: 373-383. (Pubitemid 38452773)
7. Seidman LJ. Neuropsychological functioning in people with ADHD across the lifespan. Clin Psychol Rev. 2006;26: 466-485.
8. Valera E, Faraone SV, Murray K, et al. Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biological Psychiatry. 2007;61: 1361-1369. (Pubitemid 46855763)
9. Spencer T, Biederman J, Wilens T, et al. A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biological Psychiatry. 2005;57: 456-463. (Pubitemid 40311979)
10. Biederman J, Mick E, Surman C, et al. A randomized, placebo-controlled trial of OROS-methylphenidate in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry. 2006;59: 829-835.
11. Medori R, Ramos-Quiroga JA, Casas M, et al. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63: 981-989.
12. Spencer TJ, Adler LA, McGough JJ, et al. Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/ hyperactivity disorder. Biol Psychiatry. 2007;61: 1380-1387. (Pubitemid 46855767)
13. First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press; 1997.
14. Orvaschel H. Schedule for Affective Disorder and Schizophrenia for School-Age Children Epidemiologic Version. 5th ed. Ft. Lauderdale, FL: Nova Southeastern University, Center for Psychological Studies; 1994.
15. National Institute of Mental Health. CGI (Clinical Global Impression) ScaleVNIMH. Psychopharmacol Bull. 1985;21: 839-844.
16. Adler LA, Spencer T, Faraone SV, et al. Validity of pilot adult ADHD self report scale (ASRS) to rate adult ADHD symptoms. Ann Clin Psychiatry. 2006;18: 145-148. (Pubitemid 44576434)
17. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23: 56-62.
18. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32: 50-55.
19. Biederman J, Spencer TJ. Psychopharmacological interventions. Child Adolesc Psychiatr Clin N Am. 2008;17: 439-458. (Pubitemid 351258358)
20. Faraone SV, Glatt SJ. A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J Clin Psychiatry. 2010;71(6): 754-763.
21. Murphy P, Schachar R. Use of self-ratings in the assessment of symptoms of attention deficit hyperactivity disorder in adults. Am J Psychiatry. 2000;157: 1156-1159. (Pubitemid 30432499)