Arecoline cytotoxicity on human oral mucosal fibroblasts related to cellular thiol and esterase activities

Food and Chemical Toxicology

Volumn 37, Issue 7, 1999, Pages 751-756

  Jeng, J H ^a   Tsai, C L ^a   Hahn, L J ^a   Yang, P J ^a   Kuo, Y S ^a   Kuo, M Y P ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Arecoline; Betel quid chewing; Cytotoxicity; Esterase; Glutathione; Submucous fibrosis

Indexed keywords

ARECOLINE; ESTERASE; GLUTATHIONE; THIOL;

ARTICLE; BETEL NUT; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; HUMAN; HUMAN CELL; METABOLISM; MOUTH MUCOSA;

ACETYLCYSTEINE; ANTIMETABOLITES; ARECA; ARECOLINE; ATROPINE; BUTHIONINE SULFOXIMINE; CELL SURVIVAL; CELLS, CULTURED; ESTERASES; EXPECTORANTS; FIBROBLASTS; GANGLIONIC STIMULANTS; HUMANS; MALEATES; MOUTH MUCOSA; MUSCARINIC ANTAGONISTS; PLANTS, MEDICINAL; SULFHYDRYL COMPOUNDS; THIOLESTER HYDROLASES;

PIPER BETEL;

EID: 0032800138     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00050-2     Document Type: Article

References (39)

1. Ann E.B., Donald J.R. Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells. Toxicology and Applied Pharmacology. 77:1985;381-387.
2. Boyland E., Nery R. Mercapturic acid formation during metabolism of arecoline and arecaidine in the rat. Biochemical Journal. 113:1969;123-130.
3. Canniff J.P., Harvey W., Harris M. Oral submucous fibrosis : its pathogenesis and management. British Dental Journal. 160:1986;429-434.
4. Cassone M.C., Molinengo L., Orsetti M. Effects of combinations of arecoline and atropine on mouse motor activity. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 14:1990;83-90.
5. Dave B.J., Trivedi A.H., Adhvaryu S.G. In vitro genotoxic effects of areca nut extract and arecoline. Journal of Cancer Research and Clinical Oncology. 118:1992;283-288.
6. Deneke S.M., Fanburg B.L. Regulation of cellular glutathione. American Journal of Physiology. 257:1989;L163-173.
7. De Vries N., De Flora S. N-acetyl-l-cysteine. Journal of Cell Biochemistry. 17F:(Suppl.):1993;270-277.
8. Harvey W., Scutt A., Meghji S., Canniff J.P. Stimulation of human buccal mucosal fibroblasts in vitro by betel nut alkaloids. Archives of Oral Biology. 31:1986;45-49.
9. Haubrich D.R., Reid W.D. Effects of pilocarpine or arecoline administration on acetylcholine levels and serotonin turnover in rat brain. Journal of Pharmacology and Experimental Therapeutics. 181:1972;19-27.
10. IARC (1985) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans Vol. 37. Tobacco Habits Other than Smoking: Betel-Quid and Areca-Nut Chewing; and Some Related Nitrosamines. International Agency for Research on Cancer, Lyon.
11. Issels R.D., Nagele A., Eckert K.G., Wilmanns W. Promotion of cysteine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine. Biochemical Pharmacology. 37:1988;881-888.
12. James F.F., Gary E.S., Arthur C. Two-drug combination of memory enhancers : effect of dose ratio upon potency and therapeutic window in mice. Life Sciences. 42:1988;2145-2154.
13. Jeng J.H., Kuo M.L., Hahn L.J., Kuo M.Y.P. Genotoxic and non-genotoxic effects of betel quid ingredients upon oral mucosal fibroblasts in vitro. Journal of Dental Research. 73:1994;1043-1049.
14. Jeng J.H., Lan W.H., Hahn L.J., Hsieh C.C., Kuo M.Y.P. Inhibition of the migration, attachment, spreading, growth and collagen synthesis of human gingival fibroblasts by arecoline, a major areca alkaloid, in vitro. Journal of Oral Pathology and Medicine. 25:1996;371-375.
15. Juhl M., Holmstrup P. Epithelial - naphthyl acetate esterases in the green vervet monkey gingiva before and after periodontal surgery and during tooth eruption. Scandinavian Journal of Dental Research. 101:1993;92-97.
16. Ko Y.C., Chiang T.A., Chang S.J., Hsieh S.F. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. Journal of Oral Pathological Medicine. 21:1992;261-264.
17. Kosower N.S., Kosower E.M. The glutathione status of cells. International Review of Cytology. 54:1978;109-159.
18. Kwan H.W. A statistically study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: A preliminary report. Journal of the Formosan Medical Association. 75:1976;497-505.
19. Larsen I.B., Freund M., Munksgaard E.C. Changs in surface hardness of BisGMA/TEGDMA polymer due to enzymatic action. Journal of Dental Research. 71:0000;1851-1853.
20. Larsen I.B., Munksgaard E.C. Effect of human saliva on surface degradation of composite resins. Scandinavian Journal of Dental Research. 99:1991;254-261.
21. Matthews N. and Neale M. L. (1987) Cytotoxicity assays for tumor necrosis factor and lymphotoxin. In Lymphokines and Interferons: A Practical Approach, ed. M. J. Clemens, A. G. Mooris and A. J. H. Gearing, pp. 221-225. IRL Press, Oxford.
22. Meghji S., Scutt A., Harvey W., Canniff J.P. An in vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue. Archives of Oral Biology. 32:1987;213-215.
23. Mulder G.J., Ouwerkerk-Mahadevan S. Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular systems in vitro. Chemico-Biological Interactions. 105:1997;17-34.
24. Nadi N.S., Nurnberger J.I., Gershon E.S. Muscarinic cholinergic receptors on skin fibroblasts in familial affective disorder. New England Journal of Medicine. 311:1984;225-230.
25. Nery R. The metabolic interconversion of arecoline and arecoline 1-oxide in the rat. Biochemical Journal. 122:1971;503-508.
26. Patterson T.A., Kosh J.W. Elucidation of the rapid in vivo metabolism of arecoline in the mouse. General Pharmacology. 24:1993;641-647.
27. Patterson C.E., Rhoades R.A. Protective role of sulfhydryl reagents in oxidant lung injury. Experimental Lung Research. 14:(Suppl.):1988;1005-1019.
28. Ramchand C.N., Gliddon A.E., Clark A.E., Hemmings G.P. Glucose oxidation and monoamine oxidase activity from the fibroblasts of schizophrenic patients and controls. Life Sciences. 56:1995;1639-1646.
29. Richardson J.S. On the functions of monoamine oxidase, the emotion and adaptation to stress. International Journal of Neuroscience. 70:1993;75-84.
30. Richman P., Meister A. Regulation of γ-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. Journal of Biological Chemistry. 25:1975;1422-1426.
31. Sethy V.H., Francis J.W. Regulation of brain acetylcholine concentration by muscarinic receptors. Journal of Pharmacology and Experimental Therapeutics. 246:1988;243-248.
32. Sharan R.N., Wary K.K. Study of unscheduled DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro. Mutation Research. 278:1992;271-276.
33. Shaw J.P., Chou I.N. Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblast. Journal of Cell Physiology. 129:1986;193-198.
34. Shirname L.P., Menon M.M., Bhide S.V. Mutagenicity of betel quid and its ingredients using mammalian test systems. Carcinogenesis. 5:1984;501-503.
35. Shirname L.P., Menon M.M., Nair J., Bhide S.V. Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients. Nutrition and Cancer. 5:1983;87-91.
36. Sriram K., Pai K.S., Ravindranath V. Protection and potention of 1-methyl-4-phenylpyridinium-induced toxicity by cytochrome P450 inhibitors and inducer may be due to the altered uptake of the toxin. Journal of Neurochemistry. 64:1995;1203-1208.
37. Sundqvist K., Liu Y., Nair J., Bartsch H., Arvidson K., Graftstrom R.C. Cytotoxic and genotoxic effects of areca nut related compounds in cultured human buccal epithelial cells. Cancer Research. 49:1989;5294-5298.
38. Tsai C.L., Kuo M.Y.P., Hahn L.J., Kuo Y.S., Yang P.J., Jeng J.H. Cytotoxic and cytostatic effects of arecoline on oral mucosal fibroblasts. Proceedings of the National Science Council of the R.O.C. 21:(B):1997;161-167.
39. Yolande B.R., Sally B.C., Josiane S., Pascal S., Adriana R., Jongeneel C.V., Jacques M. Role of glutathione in macrophage activation: Effect of cellular glutathione depletion on nitrite production and leishmanicidal activity. Cellular Immunology. 164:1995;73-80.