Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3467-3469

  Byeon, Seong Rim ^a   Kim, Hyunjin Vincent ^a   Jeon, Mijin ^a   Ahn, Young Gil ^b   Kim, Maeng Sup ^b   Kong, Jae Yang ^c   Kim, Hye Yun ^a   Kim, Young Soo ^a   Kim, Dong Jin ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Hanmi Pharmaceutical Co Ltd   (South Korea)

^c Keimyung University   (South Korea)

Author keywords

Aggregation inhibitor; Alzheimer's disease; Amyloid ; Behavior test; Pharmacokinetics

Indexed keywords

AMYLOID; KMS 80013; NOOTROPIC AGENT; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; COGNITIVE DEFECT; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG EFFICACY; DRUG PENETRATION; DRUG SAFETY; DRUG STRUCTURE; IN VIVO STUDY; MOUSE; NONHUMAN; PARAMETERS;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANILINE COMPOUNDS; ANIMALS; BENZENE DERIVATIVES; BRAIN; DISEASE MODELS, ANIMAL; ETHER-A-GO-GO POTASSIUM CHANNELS; HALF-LIFE; MALE; MICE; MICE, INBRED ICR; STILBENES;

EID: 84877586188     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.104     Document Type: Article

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