Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

Oncogene

Volumn 32, Issue 18, 2013, Pages 2304-2314

  Garcia, I ^a   Crowther, A J ^a   Gama, V ^b   Ryan Miller, C ^a   Deshmukh, M ^a,b   Gershon, T R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Bax; cerebellar neurogenesis; CGNPs; medulloblastoma; SmoA1 transgenic mouse

Indexed keywords

CASPASE 3; CYCLIN D2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN MCL 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; GRANULE CELL; HUMAN; HUMAN TISSUE; MEDULLOBLASTOMA; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROPATHOLOGY; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; TECTUM; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIFFERENTIATION; CELL MOVEMENT; CEREBELLAR NEOPLASMS; CEREBELLUM; DOWN-REGULATION; MEDULLOBLASTOMA; MICE; MICE, TRANSGENIC; NEUROGENESIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS;

MUS; MUS MUSCULUS;

EID: 84877579729     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.248     Document Type: Article

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