Role of integrin αvβ6 in the pathogenesis of ischemia-related biliary fibrosis after liver transplantation

Transplantation

Volumn 95, Issue 9, 2013, Pages 1092-1099

  Chen, Geng ^a   Zhang, Leida ^a   Chen, Liping ^b   Wang, Huaizhi ^a   Zhang, Yujun ^a   Bie, Ping ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Biliary fibrosis; Integrin v 6; Ischemia; Liver transplantation

Indexed keywords

ALPHAVBETA6 INTEGRIN; BLOCKING ANTIBODY; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; BILE DUCT INJURY; BILIARY FIBROSIS; BIOCHEMISTRY; CELL PROLIFERATION; COLD ISCHEMIA TIME; COLLAGEN METABOLISM; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; DOWN REGULATION; FIBROSIS; GENE EXPRESSION; GENETIC TRANSDUCTION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY; ISCHEMIA; LIVER FUNCTION; LIVER TRANSPLANTATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SERUM; UPREGULATION;

ANIMALS; ANTIGENS, NEOPLASM; BILE DUCTS; FIBROSIS; GENE EXPRESSION REGULATION; INTEGRINS; ISCHEMIA; LIVER TRANSPLANTATION; MICE; MYOFIBROBLASTS; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84877577550     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182884866     Document Type: Article

References (35)

1. Akamatsu N, Sugawara Y, Hashimoto D. Biliary reconstruction, its complications and management of biliary complications after adult liver transplantation: a systematic review of the incidence, risk factors and outcome. Transpl Int 2011; 24: 379.
2. Gastaca M. Biliary complications after orthotopic liver transplantation: a review of incidence and risk factors. Transplant Proc 2012; 44: 1545.
3. Jay CL, Lyuksemburg V, Ladner DP, et al. Ischemic cholangiopathy after controlled donation after cardiac death liver transplantation: a meta-analysis. Ann Surg 2011; 253: 259.
4. Buis CI, Verdonk RC, Van der Jagt EJ, et al. Nonanastomotic biliary strictures after liver transplantation, part 1: radiological features and risk factors for early vs. late presentation. Liver Transpl 2007; 13: 708.
5. den Dries S, Sutton ME, Lisman T, et al. Protection of bile ducts in liver transplantation: looking beyond ischemia. Transplantation 2011; 92: 373.
6. Buis CI, Hoekstra H, Verdonk RC, et al. Causes and consequences of ischemic-type biliary lesions after liver transplantation. J Hepatobiliary Pancreat Surg 2006; 13: 517.
7. Cameron AM, Busuttil RW. Ischemic cholangiopathy after liver transplantation. Hepatobiliary Pancreat Dis Int 2005; 4: 495.
8. Strazzabosco M, Fabris L, Spirli C. Pathophysiology of cholangiopathies. J Clin Gastroenterol 2005; 39: S90.
9. Demetris AJ, Lunz JG, Specht S, et al. Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease. World J Gastroenterol 2006; 12: 3512.
10. Lu HW, Chen YB, Li YM, et al. Role of hepatic arterial ischemia in biliary fibrosis following liver transplantation. Chin Med J 2010; 123: 907.
11. Kinnman N, Housset C. Peribiliary myofibroblasts in biliary type liver fibrosis. Front Biosci 2002; 2: d496.
12. Hinz B, Gabbiani G. Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives. F1000 Biol Rep 2010; 2:78.
13. Hinz B, Phan SH, Thannickal VJ, et al. The myofibroblasts: one function, multiple origins. Am J Pathol 2007; 170: 1807
14. Sedlaczek N, Jia JD, Bauer M, et al. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol 2001; 158: 1239.
15. Beaussier M, Wendum D, Fouassier L, et al. Adaptative bile duct proliferative response in experimental bile duct ischemia. J Hepatol 2005; 42: 257.
16. Priester S, Wise C, Glaser SS. Involvement of cholangiocyte proliferation in biliary fibrosis. World J Gastrointest Pathophysiol 2010; 1:30.
17. del Pilar Alatorre-Carranza M, Miranda-Diaz A, Yanez-Sanchez I, et al. Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins. BMC Gastroenterol 2009; 9:81.
18. Wang B, Dolinski BM, Kikuchi N, et al. Role of >vA6 integrin in acute biliary fibrosis. Hepatology 2007; 46: 1404.
19. Popov Y, Patsenker E, Stickel F, et al. Integrin >vA6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 2008; 48: 453.
20. Patsenker E, Popov Y, Stickel F, et al. Inhibition of integrin >vA6 on cholangiocytes blocks transforming growth factorYA activation and retards biliary fibrosis progression. Gastroenterology 2008; 135: 660.
21. Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology 2009; 50: 1294.
22. Cheng L, Zhao LJ, Li DJ, et al. Role of cholangiocyte bile acid transporters in large bile duct injury after rat liver transplantation. Transplantation 2010; 90: 127.
23. Hoekstra H, Tian YH, Jochum W, et al. Dearterialization of the liver causes intrahepatic cholestasis due to reduced bile transporter expression. Transplantation 2008; 85: 1159.
24. Wagner M, Zollner G, Trauner M. Ischemia and cholestasis: more than (just) the bile ducts. Transplantation 2008; 85: 1083.
25. Chen G, Wang SG, Bie P, et al. Endogenous bile salts are associated with bile duct injury in the rat liver transplantation model. Transplantation 2009; 87: 330.
26. Geuken E, Visser D, Kuipers F, et al. Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation. J Hepatol 2004; 41: 1017.
27. Greif F, Bronsther OL, Van Thiel DH, et al. The incidence, timing, and management of biliary tract complications after orthotopic liver transplantation. Ann Surg 1994; 219:40.
28. Ramadori G, Saile B. Portal tract fibrogenesis in the liver. Lab Invest 2004; 84: 153.
29. Dranoff JA, Wells RG. Portal fibroblasts: underappreciated mediators of biliary fibrosis. Hepatology 2010; 51: 1438.
30. Osterreicher CH, Trauner M. Animal models of biliary tract injury. Curr Opin Gastroenterol 2012; 28: 239.
31. Weinreb PH, Simon KJ, Rayhorn KJ, et al. Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand- mimetic classes. J Biol Chem2004; 279: 17875.
32. Qian S, Fung JJ, Demetris AV, et al. Orthotopic liver transplantation in the mouse. Transplantation 1991; 52: 562.
33. Chen ZY, Zhang YJ, Wang SG, et al. Modified orthotopic liver transplantation in mice. Chin J Exp Surg 2006; 23: 1261.
34. Fickert P, Thueringer A, Moustafa T, et al. The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice. Lab Invest 2010; 90: 844.
35. Venturi C, Sempoux C, Bueno J, et al. Novel histologic scoring system for long-term allograft fibrosis after liver transplantation in children. Am J Transplant 2012; 12: 2986.