Role of hepatic arterial ischaemia in biliary fibrosis following liver transplantation

Chinese Medical Journal

Volumn 123, Issue 7, 2010, Pages 907-911

  Lu, Hong Wei ^a,b   Chen, Yong Bing ^c   Li, Yi Ming ^b   Dong, Jia Hong ^a   Yang, Hui Ning ^d  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c Beijing Military Region General Hospital   (China)

^d GENERAL HOSPITAL OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Biliary fibrosis; Hepatic arterial ischaemia; Liver transplantation; Transforming growth factor beta 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA ACTIN; COLLAGEN; MESSENGER RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY TRACT FIBROSIS; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DOG; EPITHELIUM CELL; HEPATIC ARTERY; HISTOPATHOLOGY; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MALE; MYOFIBROBLAST; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DOGS; HEPATIC ARTERY; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LIVER CIRRHOSIS, BILIARY; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER TRANSPLANTATION; MALE; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77950884051     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.07.026     Document Type: Article

References (27)

1. Brockmann JG, August C, Wolters HH, Hömme R, Palmes D, Baba H, et al. Sequence of reperfusion influences ischemia/reperfusion injury and primary graft function following porcine liver transplantation. Liver Transpl 2005; 11: 1214-1222.
2. Polak WG, Porte RJ. The sequence of revascularization in liver transplantation: it does make a difference. Liver Transpl 2006; 12: 1607-1614.
3. Yang Y, Li H, Fu BS, Zhang Q, Zhang YC, Lu MQ, et al. Hepatic artery complications after orthotopic liver transplantation: interventional treatment or retransplantation? Chin Med J 2008; 121: 1997-2000.
4. Chen GH, Fu BS, Yang Y, Cai CJ, Lu MQ, Li H, et al. Early liver retransplantation versus late liver retransplantation: analysis of a single-center experience. Chin Med J 2008; 121: 1992-1996.
5. Yan LN, Wu H, Chen ZY, Lin YX. Current status of adult-to-adult living donor liver transplantation: surgical techniques and innovations. Chin Med J 2009; 122: 3066-3071.
6. Sankary HN, McChesney L, Frye E, Cohn S, Foster P, Williams J. A simple modification in operative technique can reduce the incidence of nonanastomotic biliary strictures after orthotopic liver transplantation. Hepatology 1995; 21: 63-69.
7. As AB, Lotz Z, Tyler M, Kahn D. Impact of early arterialization in the liver allograft. Transplant Proc 1999; 31: 406-407.
8. Noun R, Sauvanet A, Belghiti J. Appraisal of the order of revascularization in human liver grafting. A controlled study. J Am Coll Surg 1997; 185: 70-73.
9. Sadler KM, Walsh TS, Garden OJ, Lee A. Comparison of hepatic artery and portal vein reperfusion during orthotopic liver transplantation. Transplantation 2001; 72: 680-684.
10. Vellar ID. The blood supply of the biliary ductal system and its relevance to vasculobiliary injuries following cholecystectomy. Aust N Z J Surg 1999; 9: 16-20.
11. Northover JM, Terblanche J. A new look at the arterial supply of the bile duct in man and its surgical implications. Br J Surg 1979; 66: 379-384.
12. Nishida S, Nakamura N, Kadono J, Komokata T, Sakata R, Madariaga JR, et al. Intrahepatic biliary strictures after liver transplantation. J Hepatobiliary Pancreat Surg 2006; 13: 511-516.
13. Ma Y, Wang GD, Guo ZY, Guo ZG, He XS, Chen GH. Surgical techniques of arterialized orthotopic liver transplantation in rats. Chin Med J 2007; 120: 1914-1917.
14. Toledo Pereyra LH, Toledo AH, Walsh J, Lopez Neblina F. Molecular signaling pathways in ischaemia/reperfusion. Exp Clin Transplant 2004; 2: 174-177.
15. Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117: 524-529.
16. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210.
17. Liang TJ, Yuan JH, Tan YR, Ren WH, Han GQ, Zhang J, et al. Effect of ursodeoxycholic acid on TGF beta1/Smad signaling pathway in rat hepatic stellate cells. Chin Med J 2009; 122: 1209-1213.
18. Wang R, Ghahary A, Shen Q, Scott PG, Roy K, Tredget EE. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor beta1 mRNA and protein than normal skin and cells. Wound Repair Regen 2000; 8: 128-137.
19. Gran JT, Molberg O, Midtvedt O. Pathophysiologic aspects of systemic sclerosis. Tidsskr Nor Laegeforen 2005; 125: 2622-2623.
20. Xu L. Regulation of Smad activities. Biochem Biophys Acta 2006; 1759: 503-513.
21. Chen W, Fu X, Sheng Z. Review of current progress in the structure and function of Smad proteins. Chin Med J 2006; 119: 57-62.
22. Hinz B, Gabbiani G. Cell matrix and cell cell contacts of myofibroblasts: role in connective tissue remodeling. Thromb Haemost 2003; 90: 993-1002.
23. Eyden B. The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. J Cell Mol Med 2008; 12: 22-37.
24. Zhao HF, Chen J, Xu ZS, Zhang KQ. Distribution and differentiation of mesenchymal stem cells in tumor tissue. Chin Med J 2009; 122: 712-715.
25. Li MX, Liu BC. Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis. Chin Med J 2007; 120: 1925-1930.
26. Liu YH. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15: 1-12.
27. Zeisberg M, Kalluri R. The role of epithelial to mesenchymal transition in renal fibrosis. J Mol Med 2004; 82: 175-181.