메뉴 건너뛰기




Volumn 91, Issue 5, 2013, Pages 325-331

Beneficial effect of flax seeds in streptozotocin (STZ) induced diabetic mice: Isolation of active fraction having islet regenerative and glucosidase inhibitory properties

Author keywords

Diabetes; Flax seeds; Glucosidase inhibition; Insulin; Islet differentiation; Islet regeneration

Indexed keywords

ANTIDIABETIC AGENT; C PEPTIDE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSIDASE; HERBACEOUS AGENT; INSULIN; PLANT EXTRACT;

EID: 84877339468     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2011-0428     Document Type: Article
Times cited : (13)

References (38)
  • 1
    • 77957821707 scopus 로고    scopus 로고
    • In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats
    • doi:10.1016/j.phymed. 2010.03.019. PMID:20537514
    • Ahmed, B.A.A., Rao, A.S., and Rao, M.V. 2010. In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats. Phytomedicine, 17: 1033-1039.doi:10.1016/j.phymed. 2010.03.019. PMID:20537514.
    • (2010) Phytomedicine , vol.17 , pp. 1033-1039
    • Ahmed, B.A.A.1    Rao, A.S.2    Rao, M.V.3
  • 3
    • 0042090266 scopus 로고    scopus 로고
    • Islet generation from intra islet precursor cells of diabetic pancreas: In vitro studies depicting in vivo differentiation
    • PMID:12853681
    • Banerjee, M., and Bhonde, R.R. 2003. Islet generation from intra islet precursor cells of diabetic pancreas: in vitro studies depicting in vivo differentiation. J. Pancreas, 4: 137-145. PMID:12853681.
    • (2003) J. Pancreas , vol.4 , pp. 137-145
    • Banerjee, M.1    Bhonde, R.R.2
  • 4
    • 83755178931 scopus 로고    scopus 로고
    • Syzygium cuminii seeds: Potential for islet regeneration in experimental diabetes
    • doi:10. 3736/jcim20111216. PMID:22152779
    • Bhat, M.D., and Joshi, B.N. 2011. Syzygium cuminii seeds: potential for islet regeneration in experimental diabetes. J. Chin. Integr. Med. 9: 1380-1387. doi:10. 3736/jcim20111216. PMID:22152779.
    • (2011) J. Chin. Integr. Med , vol.9 , pp. 1380-1387
    • Bhat, M.D.1    Joshi, B.N.2
  • 6
    • 80052698364 scopus 로고    scopus 로고
    • Antidiabetic properties of Azardiracta indica and Bougainvillea spectabilis: In vivo studies in murine diabetes model
    • doi:10.1093/ecam/nep033. PMID:19389871, nen033
    • Bhat, M., Kothiwale, S.K., Tirmale, A.R., Bhargava, S.Y., and Joshi, B.N. 2009. Antidiabetic properties of Azardiracta indica and Bougainvillea spectabilis: in vivo studies in murine diabetes model. Evid. Based Complement. Alternat. Med. nen033: 1-8. doi:10.1093/ecam/nep033. PMID:19389871.
    • (2009) Evid. Based Complement. Alternat. Med , pp. 1-8
    • Bhat, M.1    Kothiwale, S.K.2    Tirmale, A.R.3    Bhargava, S.Y.4    Joshi, B.N.5
  • 7
    • 0027404995 scopus 로고
    • High _-linoleic flaxseed (Linum usitaissimum): Some nutritional properties
    • doi:10.1079/BJN19930046. PMID:8098222
    • Cunnane, S.C., Ganguli, S., Menard, C., Liede, A.C., Hamadeh, M.J., Chen, Z.Y., et al. 1993. High _-linoleic flaxseed (Linum usitaissimum): some nutritional properties. Br. J. Nutr. 69: 443-453. doi:10.1079/BJN19930046. PMID:8098222.
    • (1993) Br. J. Nutr , vol.69 , pp. 443-453
    • Cunnane, S.C.1    Ganguli, S.2    Menard, C.3    Liede, A.C.4    Hamadeh, M.J.5    Chen, Z.Y.6
  • 8
    • 31044445367 scopus 로고    scopus 로고
    • Effects of flax fiber on laxation and glycemic response in healthy volunteers
    • doi:10.1089/jmf.2005.8.508. PMID:16379563
    • Dahl, W.J., Lockert, E.A., Cammer, A.L., and Whiting, S.J. 2005. Effects of flax fiber on laxation and glycemic response in healthy volunteers. J. Med. Food. 8(4): 508-511. doi:10.1089/jmf.2005.8.508. PMID:16379563.
    • (2005) J. Med. Food , vol.8 , Issue.4 , pp. 508-511
    • Dahl, W.J.1    Lockert, E.A.2    Cammer, A.L.3    Whiting, S.J.4
  • 9
    • 0029963856 scopus 로고    scopus 로고
    • Effect of leaf extract of Aegle marmelos (L.) on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats
    • PMID:8698423
    • Das, A.V., Padayatti, P.S., and Paulose, C.S. 1996. Effect of leaf extract of Aegle marmelos (L.) on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats. Ind. J. Expt. Biol. 34: 341-345. PMID:8698423.
    • (1996) Ind. J. Expt. Biol , vol.34 , pp. 341-345
    • Das, A.V.1    Padayatti, P.S.2    Paulose, C.S.3
  • 10
    • 0035200186 scopus 로고    scopus 로고
    • Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucosidehydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed
    • doi:10.1021/np010367x. PMID:11720519
    • Ford, J.D., Huang, K.S., Wang, H.B., Davin, L.B., and Lewis, N.G. 2001. Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucosidehydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed. J. Nat. Prod. 64: 1388-1397. doi:10.1021/np010367x. PMID:11720519.
    • (2001) J. Nat. Prod , vol.64 , pp. 1388-1397
    • Ford, J.D.1    Huang, K.S.2    Wang, H.B.3    Davin, L.B.4    Lewis, N.G.5
  • 11
    • 49649121328 scopus 로고    scopus 로고
    • Flax seed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice
    • doi:10.1017/ S0007114508911570. PMID:18252024
    • Fukumitsu, S., Aida, K., Ueno, N., Ozawa, S., Takahashi, Y., and Kobori, M. 2008. Flax seed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. Br. J. Nutr. 100(3): 669-676. doi:10.1017/ S0007114508911570. PMID:18252024.
    • (2008) Br. J. Nutr , vol.100 , Issue.3 , pp. 669-676
    • Fukumitsu, S.1    Aida, K.2    Ueno, N.3    Ozawa, S.4    Takahashi, Y.5    Kobori, M.6
  • 12
    • 0032932825 scopus 로고    scopus 로고
    • Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
    • doi: 10.1007/s001250051111. PMID:10610330, 10027577
    • Greig, N.H., Holloway, H.W., DeOre, K.A., Jani, D., Wang, Y., Zhou, J., et al. 1999. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia, 42: 45-50. doi: 10.1007/s001250051111. PMID:10610330, 10027577.
    • (1999) Diabetologia , vol.42 , pp. 45-50
    • Greig, N.H.1    Holloway, H.W.2    Deore, K.A.3    Jani, D.4    Wang, Y.5    Zhou, J.6
  • 13
    • 77749298792 scopus 로고    scopus 로고
    • Enicostemma littorale: A new therapeutic target for islet neogenesis
    • Gupta, S., Dadheech, N., Singh, A., Soni, S., and Bhonde, R.R. 2010. Enicostemma littorale: a new therapeutic target for islet neogenesis. Int. J. Integr. Biol. 9(1): 49-53.
    • (2010) Int. J. Integr. Biol , vol.9 , Issue.1 , pp. 49-53
    • Gupta, S.1    Dadheech, N.2    Singh, A.3    Soni, S.4    Bhonde, R.R.5
  • 14
    • 38949148753 scopus 로고    scopus 로고
    • The effects of dietary flaxseed supplementation on lipid metabolism in streptozotocininduced diabetic hamsters
    • PMID:17983187
    • Haliga, R., Mocanu, V., Oboroceanu, T., Stitt, P.A., and Luca, V.C. 2007. The effects of dietary flaxseed supplementation on lipid metabolism in streptozotocininduced diabetic hamsters. Rev. Med. Chir. Soc. Med. Nat. Iasi, 111(2): 472-476. PMID:17983187.
    • (2007) Rev. Med. Chir. Soc. Med. Nat. Iasi , vol.111 , Issue.2 , pp. 472-476
    • Haliga, R.1    Mocanu, V.2    Oboroceanu, T.3    Stitt, P.A.4    Luca, V.C.5
  • 15
    • 0037795466 scopus 로고    scopus 로고
    • Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates
    • doi:10.1073/pnas.1232230100. PMID: 12799459
    • Hardikar, A.A.M, Arcus-Samuels, B.G, Eras-Raaka, E., Raaka, B.M., and Gershengorn, M.C. 2003. Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates. Proc. Natl. Acad. Sci. U.S.A. 100: 7117-7122. doi:10.1073/pnas.1232230100. PMID: 12799459.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 7117-7122
    • Hardikar, A.A.M.1    Arcus-Samuels, B.G.2    Eras-Raaka, E.3    Raaka, B.M.4    Gershengorn, M.C.5
  • 16
    • 78649925797 scopus 로고    scopus 로고
    • Plant natural products in antidiabetic drug discovery
    • Harvey, L.A. 2010. Plant natural products in antidiabetic drug discovery. Curr. Org. Chem. 14: 16070-1677.
    • (2010) Curr. Org. Chem , vol.14 , pp. 16070-16770
    • Harvey, L.A.1
  • 17
    • 33644846314 scopus 로고    scopus 로고
    • Conophylline: A novel differentiation inducer for pancreatic beta cells
    • doi:10.1016/j. biocel.2005.09.019. PMID:16337165
    • Itaru, K., and Kazuo, U. 2006. Conophylline: a novel differentiation inducer for pancreatic beta cells. Int. J. Biochem. Cell Biol. 38: 923-930.doi:10.1016/j. biocel.2005.09.019. PMID:16337165.
    • (2006) Int. J. Biochem. Cell Biol , vol.38 , pp. 923-930
    • Itaru, K.1    Kazuo, U.2
  • 18
    • 0035850944 scopus 로고    scopus 로고
    • An oligomer from flaxseed composed of secoisolariciresinol diglucoside and 3-hydroxy-3-methyl glutaric acid residues
    • doi:10.1016/S0031-9422(01)00279-5. PMID: 11576603
    • Kamal-Eldin, A., Peerlkamp, N., Johnsson, P., Andersson, R., Anderson, R.E., Lundgren, L.N., and Aman, P. 2001. An oligomer from flaxseed composed of secoisolariciresinol diglucoside and 3-hydroxy-3-methyl glutaric acid residues. Phytochemistry, 58: 587-590. doi:10.1016/S0031-9422(01)00279-5. PMID: 11576603.
    • (2001) Phytochemistry , vol.58 , pp. 587-590
    • Kamal-Eldin, A.1    Peerlkamp, N.2    Johnsson, P.3    Andersson, R.4    Anderson, R.E.5    Lundgren, L.N.6    Aman, P.7
  • 19
    • 85056056318 scopus 로고    scopus 로고
    • Existence of islet regenerating factors within the pancreas
    • doi:10.1900/RDS.2004.1. 185. PMID:17491703
    • Kanitkar, M., and Bhonde, R.R. 2004. Existence of islet regenerating factors within the pancreas. Rev. Diabet. Stud. 1(4): 185-192. doi:10.1900/RDS.2004.1. 185. PMID:17491703.
    • (2004) Rev. Diabet. Stud , vol.1 , Issue.4 , pp. 185-192
    • Kanitkar, M.1    Bhonde, R.R.2
  • 20
    • 1642544733 scopus 로고    scopus 로고
    • Partial regeneration/ proliferation of the β-cells 414 in the islets of langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats
    • PMID:14690013
    • Kanter, M., Meral, I., Yener, Z., Ozbek, H., and Demir, H. 2003. Partial regeneration/ proliferation of the β-cells 414 in the islets of langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J. Exp. Med. 201: 213-219. PMID:14690013.
    • (2003) Tohoku J. Exp. Med , vol.201 , pp. 213-219
    • Kanter, M.1    Meral, I.2    Yener, Z.3    Ozbek, H.4    Demir, H.5
  • 21
    • 0346537113 scopus 로고
    • Artemia salina as a test organism for a bioassay
    • doi:10.1126/science.123.3194. 464. PMID:17775415, 17775414
    • Michael, A.S., Thompson, C.G., and Abramovitz, M. 1956. Artemia salina as a test organism for a bioassay. Science, 123: 464-464. doi:10.1126/science.123.3194. 464. PMID:17775415, 17775414.
    • (1956) Science , vol.123 , pp. 464
    • Michael, A.S.1    Thompson, C.G.2    Abramovitz, M.3
  • 22
    • 20144380224 scopus 로고    scopus 로고
    • 3,5,30-Triiodo-L-thyronine enhances the differentiation of a human pancreatic duct cell line (hPANC-1) towards a beta-cell-like phenotype
    • doi:10.1002/jcp.20293. PMID:15648097
    • Misiti, S., Anastasi, E., Sciacchitano, S., VergaFalzacappa, C., Panacchia, L., Bucci, B., et al. 2005. 3,5,30-Triiodo-L-thyronine enhances the differentiation of a human pancreatic duct cell line (hPANC-1) towards a beta-cell-like phenotype. J. Cell. Physiol. 204: 286-296. doi:10.1002/jcp.20293. PMID:15648097.
    • (2005) J. Cell. Physiol , vol.204 , pp. 286-296
    • Misiti, S.1    Anastasi, E.2    Sciacchitano, S.3    Vergafalzacappa, C.4    Panacchia, L.5    Bucci, B.6
  • 23
    • 65649084065 scopus 로고    scopus 로고
    • Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice
    • doi:10.1124/jpet.108.148056. PMID:19208898
    • Moritoh, Y., Takeuchi, K., and Hazama, M. 2009. Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J. Pharmacol. Exp. Ther. 329: 669-676. doi:10.1124/jpet.108.148056. PMID:19208898.
    • (2009) J. Pharmacol. Exp. Ther , vol.329 , pp. 669-676
    • Moritoh, Y.1    Takeuchi, K.2    Hazama, M.3
  • 24
    • 0343224865 scopus 로고    scopus 로고
    • I, 3rd ed. M/s Popular Prakashan Pvt, Ltd., Bombay
    • Nadkarni, K.M., and Nadkarni, A.K. 1999. Indian Materia Medica, I, 3rd ed. M/s Popular Prakashan Pvt, Ltd., Bombay. pp. 743-746.
    • (1999) Indian Materia Medica , pp. 743-746
    • Nadkarni, K.M.1    Nadkarni, A.K.2
  • 25
    • 0031731553 scopus 로고    scopus 로고
    • Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root
    • doi:10.1254/jjp.78.395. PMID: 9869276
    • Peungvicha, P., Thirawarapan, S.S., and Watanabe, H. 1998. Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root. Jpn. J. Pharmacol. 78: 395-398. doi:10.1254/jjp.78.395. PMID: 9869276.
    • (1998) Jpn J. Pharmacol , vol.78 , pp. 395-398
    • Peungvicha, P.1    Thirawarapan, S.S.2    Watanabe, H.3
  • 26
    • 0033574164 scopus 로고    scopus 로고
    • Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    • doi:10.1161/01.CIR.99.10.1355. PMID: 10077521
    • Prasad, K. 1999. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation, 99: 1355-1362. doi:10.1161/01.CIR.99.10.1355. PMID: 10077521.
    • (1999) Circulation , vol.99 , pp. 1355-1362
    • Prasad, K.1
  • 27
    • 14944371679 scopus 로고    scopus 로고
    • Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed
    • doi:10. 1016/j.atherosclerosis.2004.11.012. PMID:15777541
    • Prasad, K. 2005. Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed. Atherosclerosis, 179: 269-275. doi:10. 1016/j.atherosclerosis.2004.11.012. PMID:15777541.
    • (2005) Atherosclerosis , vol.179 , pp. 269-275
    • Prasad, K.1
  • 28
    • 1942518128 scopus 로고    scopus 로고
    • Carbohydrates
    • New Age International Pvt. Ltd., New Delhi
    • Sadasivam, S., and Manickam, A. 1996. Carbohydrates. In Methods in biochemistry. New Age International Pvt. Ltd., New Delhi. pp. 11-12.
    • (1996) Methods In Biochemistry , pp. 11-12
    • Sadasivam, S.1    Manickam, A.2
  • 29
    • 0025107852 scopus 로고
    • Possible regeneration of the islets of Langerhans in streptozotocin diabetic rats given Gymnema sylvestre leaf extracts
    • doi:10.1016/0378-8741(90)90106-4. PMID:2259215
    • Shanmugasundaram, E.R., Gopinath, K.L., Shanmugasundaram, R.K., and Rajendran, V.M. 1990. Possible regeneration of the islets of Langerhans in streptozotocin diabetic rats given Gymnema sylvestre leaf extracts. J. Ethnopharmacol. 30: 265-279. doi:10.1016/0378-8741(90)90106-4. PMID:2259215.
    • (1990) J. Ethnopharmacol , vol.30 , pp. 265-279
    • Shanmugasundaram, E.R.1    Gopinath, K.L.2    Shanmugasundaram, R.K.3    Rajendran, V.M.4
  • 30
    • 33644827251 scopus 로고    scopus 로고
    • Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus
    • doi:10.1016/j.jep.2005.10.033. PMID: 16386863
    • Sharma, S.B., Nasir, A., Prabhu, K.M., and Murthy, P.S. 2006. Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. J. Ethnopharmacol. 104: 367-373.doi:10.1016/j.jep.2005.10.033. PMID: 16386863.
    • (2006) J. Ethnopharmacol , vol.104 , pp. 367-373
    • Sharma, S.B.1    Nasir, A.2    Prabhu, K.M.3    Murthy, P.S.4
  • 31
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • doi:10.2337/diabetes.49. 5.741. PMID:10905482
    • Stoffers, D.A., Kieffer, T.J., Hussain, M.A., Drucker, D.J.B, Onner-Weir, S., Habener, J.F., and Egan, J.M. 2000. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes, 49: 741-748. doi:10.2337/diabetes.49. 5.741. PMID:10905482.
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.B.4    Onner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 32
    • 0742287637 scopus 로고    scopus 로고
    • Analysis and bioavailability of lignans
    • 2nd ed. Edited by L.U. Thompson and S.C. Cunnane. AOCS Press, Champaign, Ill
    • Thompson, L.U. 2003. Analysis and bioavailability of lignans. In Flaxseed in human nutrition. 2nd ed. Edited by L.U. Thompson and S.C. Cunnane. AOCS Press, Champaign, Ill. pp. 92-116.
    • (2001) Flaxseed In Human Nutrition , pp. 92-116
    • Thompson, L.U.1
  • 33
    • 0025745357 scopus 로고
    • Mammalian lignan production from various foods
    • doi:10.1080/ 01635589109514139. PMID:1656395
    • Thompson, L.U., Robb, P., Serraino, M., and Cheung, F. 1991. Mammalian lignan production from various foods. Nutr. Cancer, 16: 43-52. doi:10.1080/ 01635589109514139. PMID:1656395.
    • (1991) Nutr. Cancer , vol.16 , pp. 43-52
    • Thompson, L.U.1    Robb, P.2    Serraino, M.3    Cheung, F.4
  • 34
    • 58149295120 scopus 로고    scopus 로고
    • Nutritional regulation of glucagon-like peptide-1 secretion
    • doi:10.1113/jphysiol. 2008.164012. PMID:19001044
    • Tolhurst, G., Reimann, F., and Gribble, F.M. 2009. Nutritional regulation of glucagon-like peptide-1 secretion. J. Physiol. 587(1): 27-32. doi:10.1113/jphysiol. 2008.164012. PMID:19001044.
    • (2009) J. Physiol , vol.587 , Issue.1 , pp. 27-32
    • Tolhurst, G.1    Reimann, F.2    Gribble, F.M.3
  • 35
    • 0041589462 scopus 로고    scopus 로고
    • Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats
    • doi:10.1016/S1532-0456(03)00140-6. PMID:12927910
    • Vessal, M., Hemmati, M., and Vasei, M. 2003. Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 3: 357-364. doi:10.1016/S1532-0456(03)00140-6. PMID:12927910.
    • (2003) Comp. Biochem. Physiol. C Toxicol. Pharmacol , vol.3 , pp. 357-364
    • Vessal, M.1    Hemmati, M.2    Vasei, M.3
  • 36
    • 30344461929 scopus 로고    scopus 로고
    • Trypsin and thrombin accelerate aggregation of human endocrine pancreas precursor cells
    • doi:10.1002/jcp.20459. PMID:16021635
    • Wei, C.G, Eras-Raaka, E.M, Arcus-Samuels, B., Oron, Y., and Gershengorn, M.C. 2006. Trypsin and thrombin accelerate aggregation of human endocrine pancreas precursor cells. J. Cell. Physiol. 206: 322-328. doi:10.1002/jcp.20459. PMID:16021635.
    • (2006) J. Cell. Physiol , vol.206 , pp. 322-328
    • Wei, C.G.1    Eras-Raaka, E.M.2    Arcus-Samuels, B.3    Oron, Y.4    Gershengorn, M.C.5
  • 37
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
    • doi:10.2337/diabetes.48.12.2270. PMID:10580413
    • Xu, G., Stoffers, D.A., Habener, J.F., and Bonner-Weir, S. 1999. Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes, 48, 2270-2276. doi:10.2337/diabetes.48.12.2270. PMID:10580413.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 38
    • 77956248555 scopus 로고    scopus 로고
    • c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells
    • doi:10.1038/labinvest. 2010.106. PMID:20531294
    • Wu, Y., Li, J., Saleem, S., Yee, S.-P., Hardikar, A.A., and Wang, R. 2010, c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Lab. Invest. 90: 1373-1384.doi:10.1038/labinvest. 2010.106. PMID:20531294.
    • (2010) Lab. Invest , vol.90 , pp. 1373-1384
    • Wu, Y.1    Li, J.2    Saleem, S.3    Yee, S.-P.4    Hardikar, A.A.5    Wang, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.