Clinicopathological characteristics of posttransplant lymphoproliferative disorders of T-cell origin: Single-center series of nine cases and meta-analysis of 147 reported cases

Leukemia and Lymphoma

Volumn 54, Issue 10, 2013, Pages 2190-2199

  Herreman, An ^a   Dierickx, Daan ^b   Morscio, Julie ^a   Camps, Jordi ^a   Bittoun, Emilie ^a   Verhoef, Gregor ^b   De Wolf Peeters, Christiane ^a,b   Sagaert, Xavier ^a,b   Tousseyn, Thomas ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

EBV; Posttransplant lymphoproliferative disorder; PTLD; T cell lymphoma

Indexed keywords

ALEMTUZUMAB; ANTIMETABOLITE; AZATHIOPRINE; CALCINEURIN INHIBITOR; CISPLATIN; CORTICOSTEROID; CYCLOSPORIN A; FLUDARABINE; MYCOPHENOLIC ACID; RITUXIMAB; TACROLIMUS;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; EPSTEIN BARR VIRUS; FEMALE; HEART GRAFT; HUMAN; INCIDENCE; KIDNEY GRAFT; LARGE CELL LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); PERIPHERAL T CELL LYMPHOMA; PRIORITY JOURNAL; SURVIVAL; T CELL LYMPHOMA; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; LYMPHOMA, T-CELL; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; YOUNG ADULT;

EID: 84877306645     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.775436     Document Type: Article

References (112)

1. Swerdlow SH. T-cell and NK-cell posttransplantation lymphoproliferative disorders. Am J Clin Pathol 2007; 127: 887-895.
2. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2008.
3. Hoshida Y, Li T, Dong Z. et al. Lymphoproliferative disorders in renal transplant patients in Japan. Int J Cancer 2001; 91: 869-875.
4. Magro CM, Weinerman DJ, Porcu PL, et al. Post-transplant EBVnegative anaplastic large-cell lymphoma with dual rearrangement: A propos of two cases and review of the literature. J Cutan Pathol 2007; 34(Suppl. 1): 1-8.
5. Teye K, Arima N, Nakamura Y, et al. Expression of Myc target gene mina53 in subtypes of human lymphoma. Oncol Rep 2007; 18: 841-848.
6. Mahesha V, Joshi K, Jha V, et al. Primary cardiac posttransplantation lympho proliferative disorder-T cell type: A case report and review of the literature. J Clin Pathol 2007; 60: 447-448.
7. Williams L, Chang PY, Park E, et al. Successful treatment of dermatomyositis during pregnancy with intravenous immunoglobulin monotherapy. Obstet Gynecol 2007; 109: 561-563.
8. Omori N, Narai H, Tanaka T, et al. Epstein-Barr virus-associated T/NK cell-type central nervous system lymphoma which manifested as a post-transplantation lymphoproliferative disorder in a renal transplant recipient. J Neurooncol 2008; 87: 189-191.
9. Miloh T, Magid M, Yurovitsky A, et al. T-cell PTLD presenting as acalculous cholecystitis. Pediatr Transplant 2008; 12: 717-720.
10. Santos-Briz A, Romo A, Antúnez P, et al. Primary cutaneous T-cell lymphoproliferative disorder of donor origin after allogeneic haematopoietic stem-cell transplantation. Clin Exp Dermatol 2009; 34: E778-e781.
11. Chiu LS, Choi PC, Luk NM, et al. Spontaneous regression of primary cutaneous Epstein-Barr virus-positive, CD30-positive anaplastic large T-cell lymphoma in a heart-transplant recipient. Clin Exp Dermatol 2009; 34: E21-e24.
12. Kfoury HK, Alghonaim M, AlSuwaida AK, et al. Nasopharyngeal T-cell monomorphic posttransplant lymphoproliferative disorders and combined IgA nephropathy and membranous glomerulonephritis in a patient with renal transplantation: A case report with literature review. Transplant Proc 2010; 42: 4653-4657.
13. Balachandran I, Walker JW Jr, Broman J. Fine needle aspiration cytology of ALK1(-), CD30 + anaplastic large cell lymphoma post renal transplantation: A case report and literature review. Diagn Cytopathol 2010; 38: 213-216.
14. Ratuapli SK, Murarka S, Miller KA, et al. Epstein Barr virus-positive large T-cell lymphoma presenting as acute appendicitis 17 years after cadaveric renal transplant: A case report. J Med Case Rep 2011; 5: 5.
15. Azhir A, Reisi N, Taheri D, et al. Post transplant anaplastic large T-cell lymphoma. Saudi J Kidney Dis Transpl 2009; 20: 646-651.
16. Morovic A, Jaffe ES, Raffeld M, et al. Metachronous EBVassociated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. Am J Surg Pathol 2009; 33: 149-154.
17. Al Ajroush N, Rafique Sheikh K, Kadry R, et al. T -cell lymphoma/Sezary syndrome in a liver transplant recipient. J Cutan Med Surg 2012; 16: 68-71.
18. Yuan L, Sun L, B o J, et al. Durable remission in a patient with refractory subcutaneous panniculitis-like T-cell lymphoma relapse after allogeneic hematopoietic stem cell transplantation through withdrawal of cyclosporine. Ann Transplant 2011; 16: 135-138.
19. Nishida A, Yamamoto H, Ohta Y, et al. T-cell post-transplant lymphoproliferative disorder in a patient with chronic idiopathic myelofibrosis following allogeneic PBSC transplantation. Bone Marrow Transplant 2010; 45: 1372-1374.
20. Lippman SM, Grogan TM, Carry P, et al. Post-transplantation T cell lymphoblastic lymphoma. Am J Med 1987; 82: 814-816.
21. Garvin AJ, Self S, Sahovic LA, et al. The occurrence of a peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient. Am J Surg Pathol 1988; 12: 64-70.
22. Audouin J, Le Tourneau A, Diebold J, et al. Primary intestinal lymphoma of Ki-1 large cell anaplastic type with mesenteric lymph node and spleen involvement in a renal transplant recipient. Hematol Oncol 1989; 7: 441-449.
23. Ulrich W, Chott A, Watschinger B, et al. Primary peripheral T cell lymphoma in a kidney transplant under immunosuppression with cyclosporine A. Hum Pathol 1989; 20: 1027-1030.
24. Griffith RC, Saha BK, Janney CM, et al. Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient. Am J Clin Pathol 1990; 93: 280-285.
25. Kemnitz J, Cremer J, Gebel M, et al. T-cell lymphoma after heart transplantation. Am J Clin Pathol 1990; 94: 95-101.
26. Ng K, Trotter J, Metcalf C, et al. Extranodal Ki-1 lymphoma in a renal transplant patient. Aust NZ J Med 1992; 22: 51-53.
27. Euvrard S, Noble CP, Kanitakis J, et al. Brief report: Successive occurrence of T-cell and B-cell lymphomas after renal transplantation in a patient with multiple cutaneous squamous-cell carcinomas. N Engl J Med 1992; 327: 1924-1926.
28. Kumar S, Kumar D, Kingma DW, et al. Epstein-Barr virusassociated T-cell lymphoma in a renal transplant patient. Am J Surg Pathol 1993; 17: 1046-1053.
29. McGregor JM, Y u C C, L u Q L, et al. Posttransplant cutaneous lymphoma. J Am Acad Dermatol 1993; 29: 549-554.
30. Kaplan MA, Jacobson JO, Ferry JA, et al. T-cell lymphoma of the vulva in a renal allograft recipient with associated hemophagocytosis. Am J Surg Pathol 1993; 17: 842-849.
31. Ross CW, Schnitzer B, Sheldon S, et al. Gamma/delta T-cell posttransplantation lymphoproliferative disorder primarily in the spleen. Am J Clin Pathol 1994; 102: 310-315.
32. van Gorp J, Doornewaard H, Verdonck LF, et al. Posttransplant T-cell lymphoma. Report of three cases and a review of the literature. Cancer 1994; 73: 3064-3072.
33. Leblond V, Sutton L, Dorent R, et al. Lymphoproliferative disorders after organ transplantation: A report of 24 cases observed in a single center. J Clin Oncol 1995; 13: 961-968.
34. Labouyrie E, Morel D, Boiron JM, et al. Peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient. Mod Pathol 1995; 8: 355-359.
35. Feher O, Barilla D, Locker J, et al. T-cell large granular lymphocytic leukemia following orthotopic liver transplantation. Am J Hematol 1995; 49: 216-220.
36. Macon WR, Williams ME, Greer JP, et al. Natural killer-like T-cell lymphomas: Aggressive lymphomas of T-large granular lymphocytes. Blood 1996; 87: 1474-1483.
37. Hanson MN, Morrison VA, Peterson BA, et al. Posttransplant Tcell lymphoproliferative disorders-an aggressive, late complication of solid-organ transplantation. Blood 1996; 88: 3626-3633.
38. Wu TT, Swerdlow SH, Locker J, et al. Recurrent Epstein-Barr virus-associated lesions in organ transplant recipients. Hum Pathol 1996; 27: 157-164.
39. Yasunaga C, Kasai T, Nishihara G, et al. Early development of Epstein-Barr virus-associated T-cell lymphoma after a living-related renal transplantation. Transplantation 1998; 65: 1642-1644.
40. Dockrell DH, Strickler JG, Paya CV, et al. Epstein-Barr virusinduced T cell lymphoma in solid organ transplant recipients. Clin Infect Dis 1998; 26: 180-182.
41. Masud M, Arai Y, Nishina H, et al. Large granular lymphocyte leukemia with pure red cell aplasia in a renal transplant recipient. Am J Hematol 1998; 57: 72-76.
42. Hsi ED, Picken MM, Alkan S, et al. Post-transplantation lymphoproliferative disorder of the NK-cell type: A case report and review of the literature. Mod Pathol 1998; 11: 479-484.
43. Kraus MD, Crawford DF, Kaleem Z, et al. Tgamma/delta hepatosplenic lymphoma in a heart transplant patient after an Epstein-Barr virus positive lymphoproliferative disorder: A case report. Cancer 1998; 82: 983-992.
44. Natkunam Y, Warnke RA, Zehnder JL, et al. Aggressive natural killer-like T-cell malignancy with leukemic presentation following solid organ transplantation. Am J Clin Pathol 1999; 111: 663-671.
45. Tsai DE, Aqui NA, Vogl DT, et al. Successful treatment of T-cell post-transplant lymphoproliferative disorder with the retinoid analog bexarotene. Am J Transplant 2005; 5: 2070-2073.
46. Chang H, Kamel-Reid S, Hussain N, et al. T-cell large granular lymphocytic leukemia of donor origin occurring after allogeneic bone marrow transplantation for B-cell lymphoproliferative disorders. Am J Clin Pathol 2005; 123: 196-199.
47. Awaya N, Adachi A, Mori T, et al. Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma. Leuk Res 2006; 30: 1059-1062.
48. Yang F, Li Y, Braylan R, et al. Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation. Pediatr Blood Cancer 2008; 50: 415-418.
49. Waller EK, Ziemianska M, Bangs CD, et al. Characterization of posttransplant lymphomas that express T-cell-associated markers: Immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice. Blood 1993; 82: 247-261.
50. S uiC, Lien HC, Chen CM. Primary brain T-cell lymphoma after kidney transplantation: A case report. Surg Neurol 2006; 66(Suppl. 2): S60-S63.
51. Salama S, Todd S, Cina DP, et al. Cutaneous presentation of post-renal transplant lymphoproliferative disorder: A series of four cases. J Cutan Pathol 2010; 37: 641-653.
52. Belloni-Fortina A, Montesco MC, Piaserico S, et al. Primary cutaneous CD30 + anaplastic large cell lymphoma in a heart transplant patient: Case report and literature review. Acta Derm Venereol 2009; 89: 74-77.
53. Tamiolakis D, Venizelos I, Nikolaidou S, et al. Malignant pleural effusion of post-transplant neutrophil-rich anaplastic large cell lymphoma. Cytopathology 2004; 15: 167-168.
54. Treaba D, Assad L, Goldberg C, et al. Anaplastic T large cell lymphoma diagnosed by exfoliative cytology in a post renal transplant patient. Diagn Cytopathol 2002; 27: 35-37.
55. Mills KC, Sangüeza OP, Beaty MW, et al. Composite B-cell and T-cell lineage post-transplant lymphoproliferative disorder of the lung with unusual cutaneous manifestations of mycosis fungoides. Am J Dermatopathol 2012; 34: 220-225.
56. D e Nisi MC, D 'Amuri A, Lalinga AV, et al. Posttransplant primary cutaneous CD30 (Ki-1)-positive anaplastic large T-cell lymphoma. A case report. Br J Dermatol 2005; 152: 1068-1070.
57. Roelandt PR, Maertens J, Vandenberghe P, et al. Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature. Liver Transpl 2009; 15: 686-692.
58. Mukai HY, Kojima H, Suzukawa K, et al. N asal natural killer cell lymphoma in a post-renal transplant patient. Transplantation 2000; 69: 1501-1503.
59. Lin WC, Moore JO, Mann KP, et al. Post transplant CD8 + gammadelta T-cell lymphoma associated with human herpes virus-6 infection. Leuk Lymphoma 1999; 33: 377-384.
60. Berho M, Viviana A, Weppler D, et al. Tcell lymphoma involving the graft of a multivisceral organ recipient. Transplantation 1999; 68: 1135-1139.
61. Frias C, Lauzurica R, Vaquero M, et al. Detection of Epstein-Barr virus in posttransplantation T cell lymphoma in a kidney transplant recipient: Case report and review. Clin Infect Dis 2000; 30: 576-578.
62. Yufu Y, Kimura M, Kawano R, et al. Epstein-Barr virus-associated T cell lymphoproliferative disorder following autologous blood stem cell transplantation for relapsed Hodgkin's disease. Bone Marrow Transplant 2000; 26: 1339-1341.
63. Wu H, Wasik MA, Przybylski G, et al. Hepatosplenic gamma-delta T-cell lymphoma as a late-onset posttransplant lymphoproliferative disorder in renal transplant recipients. Am J Clin Pathol 2000; 113: 487-496.
64. Roncella S, Cutrona G, Truini M, et al. Late Epstein-Barr virus infection of a hepatosplenic gamma delta T-cell lymphoma arising in a kidney transplant recipient. Haematologica 2000; 85: 256-262.
65. Kwong YL, Lam CC, Chan TM. Post-transplantation lymphoproliferative disease of natural killer cell lineage: A clinicopathological and molecular analysis. Br J Haematol 2000; 110: 197-202.
66. Lye WC. Successful treatment of Epstein-Barr virus-associated T-cell cutaneous lymphoma in a renal allograft recipient: Case report and review of the literature. Transplant Proc 2000; 32: 1988-1989.
67. Wang LC, Lu MY, Yu J, et al. Tcell lymphoproliferative disorder following bone marrow transplantation for severe aplastic anemia. Bone Marrow Transplant 2000; 26: 893-897.
68. McMullan DM, Radovaneevica B, Jackow CM, et al. Cutaneous T-cell lymphoma in a cardiac transplant recipient. Tex Heart Inst J 2001; 28: 203-207.
69. Stadlmann S, Fend M, Moser P, et al. Epstein-Barr virusassociated extranodal NK/T-cell lymphoma, nasal type of the hypopharynx, in a renal allograft recipient: Case report and review of literature. Hum Pathol 2001; 32: 1264-1268.
70. Gentile TC, Hadlock KG, Uner AH, et al. Large granular lymphocyte leukaemia occurring after renal transplantation. Br J Haematol 1998; 101: 507-512.
71. Kluin PM, Feller A, Gaulard P, et al. Peripheral T/NK-cell lymphoma: A report of the IXth Workshop of the European Association for Haematopathology. Histopathology 2001; 38: 250-270.
72. Ward HA, Russo GG, McBurney E, et al. Posttransplant primary cutaneous T-cell lymphoma. J Am Acad Dermatol 2001; 44: 675-680.
73. Seckin D, Demirhan B, Oguz Güleç T, et al. Posttransplantation primary cutaneous CD30 (Ki-1)-positive large-cell lymphoma. J Am Acad Dermatol 2001; 45(Suppl.): S197-S199.
74. Canoz O, Soyuer I, Taskapan H, et al. Tcell extranodal lymphoma case involving pleura and pericardium in a renal transplant patient. Clin Nephrol 2001; 55: 416-418.
75. Mandel L, Surattanont F, Dourmas M. et al. T-cell lymphoma in the parotid region after cardiac transplant: Case report. J Oral Maxillofac Surg 2001; 59: 673-677.
76. Costes-Martineau V, Delfour C, Obled S, et al. Anaplastic lymphoma kinase (ALK) protein expressing lymphoma after liver transplantation: Case report and literature review. J Clin Pathol 2002; 55: 868-871.
77. Jimenez-Heffernan JA, Viquer JM, Vicandi B, et al. Posttransplant CD30 (Ki-1)-positive anaplastic large cell lymphoma. Report of a case with presentation as a pleural effusion. Acta Cytol 1997; 41: 1519-1524.
78. Steurer M, Stauder R, Grünewald K, et al. Hepatosplenic gammadelta-T-cell lymphoma with leukemic course after renal transplantation. Hum Pathol 2002; 33: 253-258.
79. Haldas J, Wang W, Lazarchick J. Post-transplant lymphoproliferative disorders: T-cell lymphoma following cardiac transplant. Leuk Lymphoma 2002; 43: 447-450.
80. Defossez-Tribout C, Carmi E, Lok C, et al. [Cutaneous T-cell lymphoma following renal transplantation]. Ann Dermatol Venereol 2003; 130: 47-49.
81. Belhadj K, Reyes F, Farcet JP, et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: Report on a series of 21 patients. Blood 2003; 102: 4261-4269.
82. Yurtsever H, Kempf W, Laeng RH. Posttransplant CD30 + anaplastic large cell lymphoma with skin and lymph node involvement. Dermatology 2003; 207: 107-110.
83. Cooper SM, Turner GD, Hollowood K, et al. Primary cutaneous large cell CD30 + lymphoma in a renal transplant recipient. Br J Dermatol 2003; 149: 426-428.
84. Michael J, Greenstein S, Schnechner R, et al. Primary intestinal posttransplant T-cell lymphoma. Transplantation 2003; 75: 2131-2132.
85. Au WY, Lam CC, Lie AK, et al. T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. Am J Clin Pathol 2003; 120: 626-630.
86. Pitman SD, Rowsell EH, Cao JD, et al. Anaplastic large cell lymphoma associated with Epstein-Barr virus following cardiac transplant. Am J Surg Pathol 2004; 28: 410-415.
87. Lucioni M, Ippoliti G, Campana C, et al. EBV positive primary cutaneous CD30 + large T-cell lymphoma in a heart transplanted patient: Case report. Am J Transplant 2004; 4: 1915-1920.
88. Tsao L, Draoua HY, Mansukhani M, et al. EBV-associated, extranodal NK-cell lymphoma, nasal type of the breast, after heart transplantation. Mod Pathol 2004; 17: 125-130.
89. Rajakariar R, Bhattacharyya M, Norton A, et al. Post transplant T-cell lymphoma: A case series of four patients from a single unit and review of the literature. Am J Transplant 2004; 4: 1534-1538.
90. Sebire NJ, Malone M, Ramsay AD. Posttransplant lymphoproliferative disorder presenting as CD30 +, ALK +, anaplastic large cell lymphoma in a child. Pediatr Dev Pathol 2004; 7: 290-293.
91. Coyne JD, Banerjee SS, Bromley M, et al. Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: A report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature. Histopathology 2004; 44: 387-393.
92. Narumi H, Kojima K, Matsuo Y, et al. T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2004; 33: 99-101.
93. Lau LG, Tan LK, Salto-Tellez M, et al. T -cell post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: Another case and a review of the literature. Bone Marrow Transplant 2004; 34: 821-822.
94. Lundell R, Elenitoba-Johnson KS, Lim MS. T-cell posttransplant lymphoproliferative disorder occurring in a pediatric solid-organ transplant patient. Am J Surg Pathol 2004; 28: 967-973.
95. Collins MH, Montone KT, Leahey AM, et al. Post-transplant lymphoproliferative disease in children. Pediatr Transplant 2001; 5: 250-257.
96. Draoua HY, Tsao L, Mancini DM, et al. T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: A single institutional experience. Br J Haematol 2004; 127: 429-432.
97. Yin CC, Medeiros LJ, Abruzzo LV, et al. EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient. Am J Clin Pathol 2005; 123: 222-228.
98. George TI, Jeng M, Berquist W, et al. Epstein-Barr virus-associated peripheral T-cell lymphoma and hemophagocytic syndrome arising after liver transplantation: Case report and review of the literature. Pediatr Blood Cancer 2005; 44: 270-276.
99. Salama S. Primary ' cutaneous ' T-cell anaplastic large cell lymphoma, CD30 +, neutrophil-rich variant with subcutaneous panniculitic lesions, in a post-renal transplant patient: Report of unusual case and literature review. Am J Dermatopathol 2005; 27: 217-223.
100. Bregman SG, Yeanev GA, Greig BW, et al. Subcutaneous panniculitic T-cell lymphoma in a cardiac allograft recipient. J Cutan Pathol 2005; 32: 366-370.
101. Arora N, Nair S, Srivastava A. T /NK-cell post-transplant lymphoproliferative disorder of the urinary bladder: A case report. J Clin Pathol 2010; 63: 1042.
102. Borisch B, Hennig I, Horber F, et al. Enteropathy-associated T-cell lymphoma in a renal transplant patient with evidence of Epstein-Barr virus involvement. Virchows Arch A Pathol Anat Histopathol 1992; 421: 443-447.
103. Jamali FR, Otrock ZK, Soweid AM, et al. An overview of the pathogenesis and natural history of post-transplant T-cell lymphoma (corrected and republished article originally printed in Leukemia & Lymphoma, June 2007; 48(6): 1237 - 1241). Leuk Lymphoma 2007; 48: 1780-1784.
104. Dierickx D, Tousseyn T, Sagaert X, et al. Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: Incidence, clinicopathological characteristics and prognostic factors. Leuk Lymphoma 2013 Feb 27; [Epub ahead of print].
105. Rizvi MA, Evens AM, Talmans MS, et al. T-cell non-Hodgkin lymphoma. Blood 2006; 107: 1255-1264.
106. Pasquale MA, Weppler D, Smith J, et al. Burkitt s lymphoma variant of post-transplant lymphoproliferative disease (PTLD). Pathol Oncol Res 2002; 8: 105-108.
107. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2 000; 343: 481-492.
108. Fischer E, Delibrias C, Kazatchkine MD. Expression of CR2 (the C3dg/EBV receptor, CD21) on normal human peripheral blood T lymphocytes. J Immunol 1991; 146: 865-869.
109. Morscio J, Dierickx D, Ferreiro JF, et al. Gene expression profiling reveals clear differences between EBV-positive and EBV-negative post-transplant lymphoproliferative disorders. A J Transplant; art.nr. AJT-O-12-01471.
110. Leblond V, Davi F, Charlotte F, et al. Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: A distinct entity? J Clin Oncol 1998; 16: 2052-2059.
111. Nelson BP, Nalesnik MA, Bahler DW, et al. Epstein-Barr virusnegative post-transplant lymphoproliferative disorders: A distinct entity? Am J Surg Pathol 2000; 24: 375-385.
112. Leblond V, Dhedin N, Mamzer Bruneel MF, et al. Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders. J Clin Oncol 2001; 19: 772-778.