Cutaneous presentation of post-renal transplant lymphoproliferative disorder: A series of four cases

Journal of Cutaneous Pathology

Volumn 37, Issue 6, 2010, Pages 641-653

  Salama, Samih ^a   Todd, Stanley ^a   Cina, Davide Pietro ^a   Margetts, Peter ^a  

^a ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; B CELL LYMPHOMA; EPSTEIN BARR VIRUS; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN TUMOR; T CELL LYMPHOMA; VIROLOGY;

AGED; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY TRANSPLANTATION; LYMPHOMA, B-CELL; LYMPHOMA, T-CELL; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS;

EID: 77950828678     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2009.01449.x     Document Type: Article

References (78)

1. Nalesnik MA, Makowka L, Starzl TE. The diagnosis and treatment of posttransplant lymphoproliferative disorders. Curr Probl Surg 1988 25 : 367.
2. Penn I. Cancers complicating organ transplantation. N Engl J Med 1990 323 : 1767.
3. Opelz G, Henderson R. Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 1993 342 : 1514.
4. Leblond V, Sutton L, Dorent R, et al. Lymphoproliferative disorders after organ transplantation: a report of 24 cases observed in a single center. J Clin Oncol 1995 13 : 961.
5. Hanto DW, Frizzera G, Purtilo DT, et al. Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res 1981 41 : 4253.
6. Niaudet P. Postransplant lymphoproliferative disease following renal transplantation: a multicenter retrospective study of 41 cases observed between 1992 and 1996. French Speaking Transplantation Workshop. Transplant Proc 1998 30 : 2816.
7. Cockfield SM, Preiksaitis JK, Jewell LD, Parfrey NA. Post-transplant lymphoproliferative disorder in renal allograft recipients. Clinical experience and risk factor analysis in a single center. Transplantation 1993 56 : 88.
8. Frizzera G, Hanto DW, Gajl-Peczalska KJ, et al. Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 1981 41 : 4262.
9. Starzl TE, Nalesnik MA, Porter KA, et al. Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1984 1 : 583.
10. Swerdlow SH. Post-transplant lymphoproliferative disorders: a morphologic, phenotypic and genotypic spectrum of disease. Histopathology 1992 20 : 373.
11. Craig FE, Gulley ML, Banks PM. Posttransplantation lymphoproliferative disorders. Am J Clin Pathol 1993 99 : 265.
12. Knowles DM, Cesarman E, Chadburn A, et al. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood 1995 85 : 552.
13. McCune JM. Epstein-Barr virus associated lymphoproliferative disease in mice and men. Lab Invest 1991 65 : 377.
14. Penn I. The changing pattern of posttransplant malignancies. Transplant Proc 1991 23 : 1101.
15. Nalesnik MA, Jaffe R, Starzl TE, et al. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 1988 133 : 173.
16. Webb MC, Compton F, Andrews PA, Koffman CG. Skin tumours posttransplantation: a retrospective analysis of 28 years' experience at a single centre. Transplant Proc 1997 29 : 828.
17. Arbiser JL, Mann KP, Losken EM, et al. Presence of p16 hypermethylation and Epstein-Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin. J Am Acad Dermatol 2006 55 : 794.
18. Dabbs CR, Creel NB, Krivda SJ, Cruser DL, Norton SA. Elevated serum immunoglobulin preceding primary cutaneous posttransplant lymphoproliferative disorder. J Am Acad Dermatol 2005 52 : S123.
19. Hanasono MM, Parrett BM, Breitbart AS. Posttransplant lymphoproliferative disorder presenting as a cutaneous forehead mass. Otolaryngol Head Neck Surg 2004 130 : 372.
20. Robinson C, Burroughs S, Addis B, Mason J. Cutaneous post-transplant lymphoproliferative disorder with atypical Hodgkin and Reed-Sternberg-like cells. Histopathology 2007 50 : 403.
21. Beynet DP, Wee SA, Horwitz SS, Kohler S, et al. Clinical and pathological features of posttransplantation lymphoproliferative disorders presenting with skin involvement in 4 patients. Arch Dermatol 2004 140 : 1140.
22. Blokx WAM, Andriessen MPM, van Hamersvelt HW, van Krieken JHJM. Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoproliferative disease. Am J Dermatopathol 2002 24 : 414.
23. Capaldi L, Robinson-Bostom L, Kerr P, Gohh R. Localized cutaneous posttransplant Epstein-Barr virus-associated lymphoproliferative disorder. J Am Acad Dermatol 2004 51 : 778.
24. Coyne JD, Banerjee SS, Bromley M, et al. Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature. Histopathology 2004 44 : 387.
25. Salama S. Primary "cutaneous" T-cell anaplastic large cell lymphoma, CD30+, neutrophil-rich variant with subcutaneous panniculitic lesions, in a post-renal transplant patient: report of unusual case and literature review. Am J Dermatopathol 2005 27 : 217.
26. Tang MBY, Tan EST, Tan SH. Late-onset Epstein-Barr virus-negative post-transplant lymphoproliferative disorder presenting as ulcerated necrotic papules and nodules in a renal transplant patient. Australas J Dermatol 2008 49 : 100.
27. Verma S, Nuovo GJ, Porcu P, et al. Epstein-Barr virus- and human herpesvirus 8-associated primary cutaneous plasmablastic lymphoma in the setting of renal transplantation. J Cutan Pathol 2005 32 : 35.
28. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994 84 : 1361.
29. Popper HH, Winter E, Höfler G. DNA of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissue in tuberculosis and sarcoidosis detected by polymerase chain reaction. Am J Clin Pathol 1994 101 : 738.
30. Diss TC, Watts M, Pan LX, et al. The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas. J Clin Pathol 1995 48 : 1045.
31. Slack DN, McCarthy KP, Wiedemann LM, Sloane JP. Evaluation of sensitivity, specificity, and reproducibility of an optimized method for detecting clonal rearrangements of immunoglobulin and T-cell receptor genes in formalin-fixed, paraffin-embedded sections. Diagn Mol Pathol 1993 2 : 223.
32. McCarthy KP, Sloane JP, Kabarowski JH, Matutes E, Wiedemann LM. A simplified method of detection of clonal rearrangements of the T-cell receptor-gamma chain gene. Diagn Mol Pathol 1992 1 : 173.
33. Wan JH, Trainor KJ, Brisco MJ, Morley AA. Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction. J Clin Pathol 1990 43 : 888.
34. Saito I, Servenius B, Compton T, Fox RI. Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome. J Exp Med 1989 169 : 2191.
35. Inghirami G, Simon, J, Balow JE, et al. Molecular characterization of CD 30+ anaplastic large-cell lymphoma: high frequency of c-myc proto-oncogene activation. Blood 1994 83 : 3581.
36. Delecluse HJ, Kremmer E, Rouault JP, et al. The expression of Epstein-Barr virus latent proteins is related to the pathological features of post-transplant lymphoproliferative disorders. Am J Pathol 1995 146 : 1113.
37. Wang F, Gregory C, Sample C, et al. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J Virol 1990 64 : 2309.
38. Hanto DW, Frizzera G, Gajl-Peczalska KJ, et al. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. N Engl J Med 1982 306 : 913.
39. Mosialos G, Birkenbach M, Yalamanchili R, et al. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 1995 80 : 389.
40. Izumi KM, Kaye KM, Kieff ED. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A 1997 94 : 1447.
41. Rea D, Fourcade C, Leblond V, et al. Patterns of Epstein-Barr virus latent and replicative gene expression in Epstein-Barr virus B cell lymphoproliferative disorders after organ transplantation. Transplantation 1994 58 : 317.
42. Waller EK, Ziemianska M, Bangs CD, et al. Characterization of posttransplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice. Blood 1993 82 : 247.
43. Ross CW, Schlegelmilch JA, Grogan TM, et al. Detection of Epstein-Barr virus genome in Ki-1 (CD30)-positive, large-cell anaplastic lymphomas using the polymerase chain reaction. Am J Pathol 1992 141 : 457.
44. Mozzanica N, Cattaneo A, Fracchiolla N, et al. Posttransplantation cutaneous B-cell lymphoma with monoclonal Epstein-Barr virus infection, responding to acyclovir and reduction in immunosuppression. J Heart Lung Transplant 1997 16 : 964.
45. Pirsch JD, Stratta RJ, Sollinger HW, et al. Treatment of severe Epstein-Barr virus-induced lymphoproliferative syndrome with ganciclovir: two cases after solid organ transplantation. Am J Med 1989 86 : 241.
46. Darenkov IA, Marcarelli MA, Basadonna GP, et al. Reduced incidence of Epstein-Barr virus-associated posttransplant lymphoproliferative disorder using preemptive antiviral therapy. Transplantation 1997 64 : 848.
47. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Simmons RL. Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation 1985 39 : 461.
48. Hanto DW, Birkenbach M, Frizzera G, et al. Confirmation of the heterogeneity of posttransplant Epstein-Barr virus-associated B cell proliferations by immunoglobulin gene rearrangement analyses. Transplantation 1989 47 : 458.
49. Randhawa PS, Yousem SA, Paradis IL et al. The clinical spectrum, pathology, and clonal analysis of Epstein-Barr virus-associated lymphoproliferative disorders in heart-lung transplant recipients. Am J Clin Pathol 1989 92 : 177.
50. Chadburn A, Chen JM, Hsu DT, et al. The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant. Cancer 1998 82 : 1978.
51. Perera SM, Thomas JA, Burke M, Crawford DH. Analysis of the T-cell micro-environment in Epstein-Barr virus-related post-transplantation B lymphoproliferative disease. J Pathol 1998 184 : 177.
52. Daoud MS, Lust JA, Kyle RA, Pittelkow MR. Monoclonal gammopathies and associated skin disorders. J Am Acad Dermatol 1999 40 : 507 quiz 536.
53. Llamas-Martin R, Postigo-Llorente C, Vanaclocha- Sebastian F, Gil-Martin R, Iglesias-Diez L. Primary cutaneous extramedullary plasmacytoma secreting lambda IgG. Clin Exp Dermatol 1993 18 : 351. (Pubitemid 23212835)
54. Wong KF, Chan JK, Li LP, Yau TK, Lee AW. Primary cutaneous plasmacytoma-report of two cases and review of the literature. Am J Dermatopathol 1994 16 : 392.
55. Torne R, Su WP, Winkelmann RK, Smolle J, Kerl H. Clinicopathologic study of cutaneous plasmacytoma. Int J Dermatol 1990 29 : 562. (Pubitemid 20345107)
56. Vallisa D, Pagani L, Bertè R, et al. Extramedullary plasmacytoma in a patient with AIDS: report of a case and review of the literature. Tumori 1998 84 : 511. (Pubitemid 28502706)
57. Gold JE, Schwam L, Castella A, et al. Malignant plasma cell tumors in human immunodeficiency virus-infected patients. Cancer 1990 66 : 363. (Pubitemid 20205921)
58. Strickler JG, Audeh MW, Copenhaver CM, Warnke RA. Immunophenotypic differences between plasmacytoma/ multiple myeloma and immunoblastic lymphoma. Cancer 1988 61 : 1782.
59. Strand WR, Banks PM, Kyle RA. Anaplastic plasma cell myeloma and immunoblastic lymphoma. Clinical, pathologic, and immunologic comparison. Am J Med 1984 76 : 861.
60. Al Saati T, Caveriviere P, Gorguet B, et al. Epithelial membrane antigen in hematopoietic neoplasms. Hum Pathol 1986 17 : 533.
61. Korbjuhn P, Anagnostopoulos I, Hummel M, et al. Frequent latent Epstein-Barr virus infection of neoplastic T cells and bystander B cells in human immunodeficiency virus-negative European peripheral pleomorphic T-cell lymphomas. Blood 1993 82 : 217. (Pubitemid 23188767)
62. Herbst H, Dallenbach F, Hummel M, et al. Epstein-Barr virus DNA and latent gene products in Ki-1 (CD30)-positive anaplastic large cell lymphomas. Blood 1991 78 : 2666.
63. Ferry JA, Harris NL. Lymphoproliferative disorders following organ transplantation. AdvPathol Lab Med 1994 7 : 359.
64. Patterson JW, Parsons JM, White RM, Fitzpatrick JE, Kohout-Dutz E. Cutaneous involvement of multiple myeloma and extramedullary plasmacytoma. J Am Acad Dermatol 1988 19 : 879. (Pubitemid 18260999)
65. Swanson NA, Keren DF, Headington JT. Extramedullary IgM plasmacytoma presenting in skin. Am J Dermatopathol 1981 3 : 79.
66. Tüting T, Bork K. Primary plasmacytoma of the skin. J Am Acad Dermatol 1996 34 : 386. (Pubitemid 26059488)
67. Van Gorp J. Posttransplant T-cell Lymphoma: A Review. Adv Anat Pathol 1995 2 : 132.
68. Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H. Neutrophil-rich, Ki-1-positive anaplastic large-cell malignant lymphoma. Am J Surg Pathol 1995 19 : 407.
69. McCluggage WG, Walsh MY, Bharucha H. Anaplastic large cell malignant lymphoma with extensive eosinophilic or neutrophilic infiltration. Histopathology 1998 32 : 110. (Pubitemid 28126176)
70. von den Driesch P, Staib G, Simon M, Sterry, W. Subcutaneous T-cell lymphoma. J Am Acad Dermatol 1997 36 : 285. (Pubitemid 27078888)
71. Beljaards RC, Meijer CJ, Scheffer E, et al. Prognostic significance of CD30 (Ki-1/Ber-H2) expression in primary cutaneous large-cell lymphomas of T-cell origin. A clinicopathologic and immunohistochemical study in 20 patients. Am J Pathol 1989 135 : 1169. (Pubitemid 20026536)
72. Beljaards RC, Kaudewitz P, Berti E, et al. Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. A European Multicenter Study of 47 patients. Cancer 1993 71 : 2097. (Pubitemid 23068561)
73. Chetty R, Biddolph S, Kaklamanis L, et al. bcl-2 protein is strongly expressed in post-transplant lymphoproliferative disorders. J Pathol 1996 180 : 254. (Pubitemid 26393672)
74. Anagnostopoulos I, Hummel M, Finn T, et al. Heterogeneous Epstein-Barr virus infection patterns in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. Blood 1992 80 : 1804.
75. Weiss LM, Jaffe ES, Liu XF, et al. Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Blood 1992 79 : 1789.
76. Medeiros LJ, Jaffe ES, Chen YY, Weiss LM. Localization of Epstein-Barr viral genomes in angiocentric immunoproliferative lesions. Am J Surg Pathol 1992 16 : 439.
77. Borisch B, Gatter KC, Tobler A, et al. Epstein-Barr virus-associated anaplastic large cell lymphoma in renal transplant patients. Am J Clin Pathol 1992 98 : 312.
78. de Bruin PC, Jiwa M, Oudejans JJ, et al. Presence of Epstein-Barr virus in extranodal T-cell lymphomas: differences in relation to site. Blood 1994 83 : 1612. (Pubitemid 24081576)