Hepatosplenic gamma-delta T-cell lymphoma as a late-onset posttransplant lymphoproliferative disorder in renal transplant recipients

American Journal of Clinical Pathology

Volumn 113, Issue 4, 2000, Pages 487-496

  Wu, Hong ^a   Wasik, Mariusz A ^a,d   Przybylski, Grzegorz ^c   Finan, Janet ^a   Haynes, Brenda ^a   Moore, Halle ^a   Leonard, Debra G B ^a   Montone, Kathleen T ^b   Naji, Ali ^a   Nowell, Peter C ^a   Kamoun, Malek ^a   Tomaszewski, John E ^a   Salhany, Kevin E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Abington Hospital   (United States)

^c Institute of Human Genetics PASc   (Poland)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hepatosplenic gamma delta T cell lymphoma; Immunosuppression; Posttransplant lymphoproliferative disorder; T cell lymphoma

Indexed keywords

ANTINEOPLASTIC AGENT; CD2 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DNA; DOXORUBICIN; ETOPOSIDE; FAS LIGAND; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR; METHYLPREDNISOLONE; OKT 3; PREDNISONE; PROTEIN; T LYMPHOCYTE RECEPTOR; VINCRISTINE;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CYTOGENETICS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GRAFT REJECTION; HEPATOSPLENOMEGALY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPHENOTYPING; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; T CELL LYMPHOMA; T LYMPHOCYTE; WHOLE BODY RADIATION;

EID: 18144453452     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/yttc-f55w-k9cp-epx5     Document Type: Article

References (39)

1. Penn I. The changing pattern of posttransplant malignancies. Transplant Proc. 1991;23:1101-1103.
2. van Gorp J, Doornewaard H, Verdonck LF, et al. Posttransplant T-cell lymphoma: report of three cases and a review of the literature. Cancer. 1994;73:3064-3072.
3. Swerdlow SH. Post-transplant lymphoproliferative disorders: a morphologic, phenotypic and genotypic spectrum of disease. Histopathology. 1992;20:373-385.
4. Ross CW, Schnitzer B, Sheldon S, et al. Gamma/delta T-cell posttransplantation lymphoproliferative disorder primarily in the spleen. Am J Clin Pathol. 1994;102:310-315.
5. Waller EK, Ziemianska M, Bangs CD, et al. Characterization of posttransplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice. Blood. 1993;82:247-261.
6. Francois A, Lesesve J-F, Stamatoullas A, et al. Hepatosplenic gamma/delta T-cell lymphoma: a report of two cases in immunocompromised patients, associated with isochromosome 7q. Am J Surg Pathol. 1997;21:781-790.
7. Garvin AJ, Self S, Sahovic EA, et al. The occurrence of a peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient. Am J Surg Pathol. 1988;12:64-70.
8. Hanson MN, Morrison VA, Peterson BA, et al. Posttransplant T-cell lymphoproliferative disorders: an aggressive, late complication of solid-organ transplantation. Blood. 1996;88:3626-3633.
9. Salhany KE, Feldman M, Kahn MJ, et al. Hepatosplenic gamma-delta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation. Hum Pathol. 1997;28:674-685.
10. Wong KF, Chan JKC, Matutes E, et al. Hepatosplenic gamma-delta T-cell lymphoma: a distinctive aggressive lymphoma type. Am J Surg Pathol. 1995;19:718-726.
11. Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975;98:503-517.
12. Breit TM, Wolvers-Tettero ILM, Beishuizen A, et al. Southern blot patterns, frequencies, and functional diversity of T-cell receptor-delta gene rearrangement in acute lymphoblastic leukemia. Blood. 1993;82:3063-3074.
13. Schmidt CA, Przybylski G, Tietze A, et al. Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRdelta gene rearrangements. Br J Haematol. 1996;92:929-936.
14. Raab-Traub N, Flynn K. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell. 1986;47:883-889.
15. Wasik MA, Sioutos N, Turtle M, et al. Constitutive secretion of soluble IL-2 receptor by human T-cell lymphoma xenografted into SCID mice: correlation of tumor volume with concentration of tumor-derived soluble IL-2R in body fluids of the host mice. Am J Pathol. 1994;144:1089-1097.
16. Wasik M, Vonderheid E, Bigler R, et al. Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma: clinical and prognostic implications. Arch Dermatol. 1996;132:42-47.
17. Audouin J, LeTourneau A, Diebold J, et al. Primary intestinal lymphoma of Ki-1 large cell anaplastic type with mesenteric lymph node and spleen involvement in a renal transplant recipient. Hematol Oncol. 1989;7:441-449.
18. Avinoach I, Halvey S, Argov S, et al. gamma-delta T-cell lymphoma involving the subcutaneous tissue and associated with a hemophagocytic syndrome. Am J Dermatopathol. 1994:16:426-433.
19. Borisch B, Hennig I, Horber F, et al. Enteropathy-associated T-cell lymphoma in a renal transplant patient with evidence of Epstein-Barr virus involvement. Virchows Arch A Pathol Anat Histopathol. 1992;421:443-447.
20. Griffith RC, Saha BK, Janney CM, et al. Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient. Am J Clin Pathol. 1990;93: 280-285.
21. Hacker SM, Knight BP, Lunde NM, et al. A primary central nervous system T cell lymphoma in a renal transplant patient. Transplantation. 1992;53:691-692.
22. Kaplan MA, Jacobson JO, Ferry JA, et al. T-cell lymphoma of the vulva in a renal allograft recipient with associated hemophagocytosis. Am J Surg Pathol. 1993;17:842-849.
23. Kemnitz J, Cremer J, Gebel M, et al. T-cell lymphoma after heart transplantation. Am J Clin Pathol. 1990;94:95-101.
24. Kumar S, Kumar D, Kingma DW, et al. Epstein-Barr virus-associated T-cell lymphoma in a renal transplant patient. Am J Surg Pathol. 1993;17:1046-1053.
25. Lippman SM, Grogan TM, Carry P, et al. Post-transplantation T cell lymphoblastic lymphoma. Am J Med. 1987;82:814-816.
26. Rostaing L, Tkaczuk J, Rigal-Huguet F, et al. T-cell gamma-delta lymphoproliferative disorders after renal transplantation. Transplant Proc. 1995;27:1774-1775.
27. Shiong YS, Lian JD, Lin CY, et al. Epstein-Barr virus-associated T-cell lymphoma of the maxillary sinus in a renal transplant recipient. Transplant Proc. 1992;24: 1929-1931.
28. Ulrich W, Chott A, Watschinger B, et al. Primary peripheral T cell lymphoma in a kidney transplant under immunosuppression with cyclosporine A. Hum Pathol. 1989;20:1027-1030.
29. Macon WR, Williams ME, Greer JP, et al. Natural killer-like T-cell lymphoma: aggressive lymphomas of T-large granular lymphocytes. Blood. 1996;87:1474-1483.
30. Natkunam Y, Warnke RA, Zehnder JL, et al. Aggressive natural killer-like T-cell malignancy with leukemic presentation following solid organ transplantation. Am J Clin Pathol. 1999;111:663-671.
31. Leblond V, Sutton L, Dorent R, et al. Lymphoproliferative disorders after organ transplantation: a report of 24 cases observed in a single center. J Clin Oncol. 1995;13:961-968.
32. Nalesnik MA, Jaffe R, Starzl TE, et al. The pathology of postransplant lymphoproliferative disorders occurring in the setting ot cyclosporine A-prednisone immunosuppression. Am J Pathol. 1988;133:173-192.
33. Jonveaux P, Daniel MT, Martel V, et al. Isochromosome 7q and trisomy 8 are consistent primary, non-random chromosomal abnormalities associated with hepatosplenic T gamma/delta lymphoma. Leukemia. 1996;10:1453-1455.
34. Kraus MD, Crawford DF, Kaleem Z, et al. T gamma/delta hepatosplenic lymphoma in a heart transplant patient after an Epstein-Barr virus positive lymphoproliferative disorder: a case report. Cancer. 1998;82:983-992.
35. Flament C, Benmerah A, Bonneville M, et al. Human TCR-gamma/delta alloreactive response to HLA-DR molecules. J Immunol. 1994;153:2890-2904.
36. Vandekerckhove B, Datema G, Koning F, et al. Analysis of the donor-specific cytotoxic T lymphocyte repertoire in a patient with a long term surviving allograft: frequency, specificity and phenotype of donor-reactive T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ clone. J Immunol. 1990;144:1288-1294.
37. Kirk AD, Ibrahim S, Dawson DV, et al. Characterization of T cells expressing the gamma/delta antigen receptor in human renal allografts. Hum Immunol. 1993;36:11-19.
38. Cheung WY, Chan ACL, Loke SL, et al. Latent sites of Epstein-Barr virus infection. Am J Gin Pathol. 1993;100:502-506.
39. Rothenberg ME, Weber WEJ, Longtine JA, et al. Cytotoxic gamma-delta T lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clin Immunol Immunopathol. 1996;80:266-272.