Hepatosplenic γδ T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature

Liver Transplantation

Volumn 15, Issue 7, 2009, Pages 686-692

  Roelandt, Philip R ^a   Maertens, Johan ^a   Vandenberghe, Peter ^a   Verstype, Chris ^a   Roskams, Tania ^a   Aerts, Raymond ^a   Nevens, Frederik ^a   Dierickx, Daan ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ALKALINE PHOSPHATASE; AZATHIOPRINE; BLEOMYCIN; C REACTIVE PROTEIN; CISPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; HYDROXYUREA; LACTATE DEHYDROGENASE; METHOTREXATE; METHYLPREDNISOLONE; MITOXANTRONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; VINCRISTINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BUDD CHIARI SYNDROME; CASE REPORT; COUGHING; DIARRHEA; DISEASE COURSE; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; ECCHYMOSIS; FEMALE; FEVER; GRAFT REJECTION; HEPATOSPLENIC GAMMA DELTA T CELL LYMPHOMA; HEPATOSPLENOMEGALY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERSPLENISM; HYPOALBUMINEMIA; IMMUNOPHENOTYPING; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER BIOPSY; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LOW DRUG DOSE; LUNG ASPERGILLOSIS; LYMPHOCYTE COUNT; MACROCYTIC ANEMIA; MALE; MYALGIA; POSITRON EMISSION TOMOGRAPHY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PYREXIA IDIOPATHICA; SINUS TACHYCARDIA; SPLENECTOMY; T CELL LYMPHOMA; T LYMPHOCYTE; THROMBOCYTOPENIA; ALGORITHM; LIVER TUMOR; METABOLISM; METHODOLOGY; ONCOLOGY; PROGNOSIS; SPLEEN TUMOR; T CELL LEUKEMIA; TREATMENT OUTCOME;

ADULT; ALGORITHMS; FEMALE; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA-LYMPHOMA, ADULT T-CELL; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MEDICAL ONCOLOGY; POSITRON-EMISSION TOMOGRAPHY; PROGNOSIS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPLENIC NEOPLASMS; TREATMENT OUTCOME;

EID: 68349135026     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.21748     Document Type: Article

References (42)

1. Hanson MN, Morrison VA, Peterson BA, Stieglbauer KT, Kubic VL, McCormick SR, et al. Posttransplant T-cell lymphoproliferative disorder - an aggressive, late complication of solid-organ transplantation. Blood 1996;88:3626-3633.
2. Jaffe ES, Ralfkiaer E. Hepatosplenic T-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours: Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissue. Lyon, France: IARC Press; 2001:210.
3. Weidmann E. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000;14:991-997.
4. Belhadj K, Reyes F, Farcet J-P, Tilly H, Bastard C, Angonin R, et al. Hepatosplenic γδ T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood 2003;102:4261-4269.
5. Cockfield SM. Identifying the patient at risk for post-transplant lymphoproliferative disorder. Transpl Infect Dis 2001;3: 70-78.
6. LaCasce AS. Post-transplant lymphoproliferative disorders. Oncologist 2006;11:674-680.
7. Andreone P, Gramenzi A, Lorenzini S, Biselli M, Cursaro C, Pileri S, et al. Posttransplantation lymphoproliferative disorders. Arch Intern Med 2003;163:1997-2004.
8. Jain A, Nalesnik M, Reyes J, Pokhama R, Mazarlegos G, Green M, et al. Posttransplant lymphoproliferative disorders in liver transplantation: a 20-year experience. Ann Surg 2002;236:429-436.
9. Harris NL, Swerdlow S, Frizzera G, Knowles DM. Posttransplant lymphoproliferative disorders. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours: Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissue. Lyon, France: IARC Press; 2001:264-269.
10. Ghobrial IM, Habermann TM, Maurer MJ, Geyer SM, Ristow KM, Larson TS, et al. Prognostic analysis for survival in adult solid organ transplant recipients with post-transplantation lymphoproliferative disorders. J Clin Oncol 2005;23:7574-7582.
11. Hézode C, Duvoux C, Germanidis G, Roudot-Thoraval F, Vincens A-L, Gaulard P, et al. Role of hepatitis C virus in lymphoproliferative disorders after liver transplantation. Hepatology 1999;30:775-778.
12. Morton LM, Landgren O, Chatterjee N, Castenson D, Parsons R, Hoover RN, et al. Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipients. Blood 2007;110: 4599-4605.
13. De Wolf-Peeters C, Achten R. γδ T-cell lymphomas: a homogenous entity? Histopathology 2000;36:294-305.
14. Alonsozana EL, Stamberg J, Kumar D, Jaffe ES, Medeiros LJ, Frantz C, et al. Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T cell lymphoma. Leukemia 1997;11:1367-1372.
15. Przybylski GK, Wu H, Macon WR, Finan J, Leonard DGB, Felgar RE, et al. Hepatosplenic and subcutaneous panniculitis-like γ/δ T cell lymphomas are derived from different Vδ subsets of γ/δ T lymphocytes. J Mol Diagn 2000;2:11-19.
16. Suarez F, Wlodarska I, Rigal-Huguet F, Mempel M, Martin-Garcia N, Farcet J-P, et al. Hepatosplenic αβ T-cell lymphoma: an unusual case with clinical, histologic, and cytogenetic features of γδ hepatosplenic T-cell lymphoma. Am J Surg Pathol 2000;24:1027-1032.
17. Bank I, Duvdevani M, Livneh A. Expansion of γδ T-cells in Behçet's disease: role of disease activity and microbial flora in oral ulcers. J Lab Clin Med 2003;141:33-40.
18. Aljurf M, Ezzat A, O Musa M. Emerging role of γδ T-cells in health and disease. Blood Rev 2002;16:203-206.
19. Saito T, Matsuno Y, Tanosaki R, Watanabe T, Kobayashi Y, Tobinai K. γδ T-cell neoplasms: a clinicopathological study of 11 cases. Ann Oncol 2002;13:1792-1798.
20. Hviid L, Akanmori BD, Loizon S, Kurtzhals JAL, Ricke CH, Lim A, et al. High frequency of circulating γδ T cells with dominance of the Vδ1 subset in a healthy population. Int Immunol 2000; 12:797-805.
21. Ohshima K, Haraoka S, Harada N, Kamimura T, Suzumiya J, Kanda M, et al. Hepatosplenic γδ T-cell lymphoma: relation to Epstein-Barr virus and activated cytotoxic molecules. Histopathology 2000;36:127-135.
22. Tseng C-TK, Miskovsky E, Houghton M, Klimpel GR. Characterization of liver T-cell receptor γδ T cells obtained from individuals chronically infected with hepatitis C virus (HCV): evidence for these T cells playing a role in the liver pathology associated with HCV infections. Hepatology 2001;33:1312-1320.
23. Jones D, Vega F, Sarris A, Medeiros LJ. CD4- CD8- 'double-negative' cutaneous T-cell lymphomas share common histologic features and an aggressive clinical course. Am J Surg Pathol 2002;26:225-231.
24. Narazaki H, Watari E, Shimizu M, Owaki A, Das H, Fukunaga Y, et al. Perforin-dependent killing of tumor cells by Vγ1Vδ1-bearing T-cells. Immunol Lett 2003;86:113-119.
25. Salhany KE, Feldman M, Peritt D, Nowell PC. Cytotoxic T-lymphocyte differentiation and cytogenetic alterations in γδ hepatosplenic T-cell lymphoma and posttransplant lymphoproliferative disorders. Blood 1997;89:3490-3491.
26. Macon WR, Levy NB, Kurtin PJ, Salhany KE, Elkhalifa MY, Casey TT, et al. Hepatosplenic γδ T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic γδ T-cell lymphomas. Am J Surg Pathol 2001;25:285-296.
27. Falini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli MF, et al. Distribution of T cells bearing different forms of the T cell receptor γ/δ in normal and pathological human tissues. J Immunol 1989;143:2480-2488.
28. Weidmann E, Hinz T, Klein S, Schui DK, Harder S, Kriener S, et al. Cytotoxic hepatosplenic γδ T-cell lymphoma following acute myeloid leukemia bearing two distinct γ chains of the T-cell receptor. Biologic and clinical features. Haematologica 2000; 85:1024-1031.
29. Greer JP, Kinney MC, Loughran TP Jr. T cell and NK cell lymphoproliferative disorders. Hematology 2001;259-281.
30. Dinçol G, Nalçaci M, Yavuz AS, Keskin H, Aktan M, Dogan Ö, et al. Case of hepatosplenic γδ T-cell lymphoma presenting with severe hypersplenism. Am J Hematol 1999; 60:313-314.
31. Nosari A, Oreste PL, Biondi A, Constantini MC, Santoleri L, Intropido L, et al. Hepato-splenic γδ T-cell lymphoma: a rare entity mimicking the hemophagocytic syndrome. Am J Hematol 1999;60:61-65.
32. Sallah S, Smith SV, Lony LCL, Woodard P, Schmitz JL, Folds JD. Gamma/ delta T-cell hepatosplenic lymphoma: review of the literature, diagnosis by flow cytometry and concomitant autoimmune hemolytic anemia. Ann Hematol 1997;74:139-142.
33. Blakolmer K, Gaulard P, Mannhalter C, Swerdlow S, Fassati LR, Rossi G, et al. Unusual peripheral T cell lymphoma presenting as acute liver failure and reappearing in the liver allograft. Transplantation 2000;70:1802-1805.
34. Cooke CB, Krenacs L, Stetler-Stevenson M, Greiner TC, Raffeld M, Kingma DW, et al. Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic γδ T-cell origin. Blood 1996; 88:4265-4274.
35. Macon WR, Williams ME, Greer JP, Hammer RD, Glick AD, Collins RD, et al. Natural killer-like T-cell lymphomas: aggressive lymphomas of T-large granular lymphocytes. Blood 1996;87:1474-1483.
36. Mason J, O'Leary T. Effects of formaldehyde fixation on protein secondary structure: a calorimetric and infrared spectroscopic investigation. J Histochem Cytochem 1991; 39:225-229.
37. Rossbach H-C, Chamizo W, Dumont D, Barbosa J, Sutcliffe M. Hepatosplenic γ/δ T-cell lymphoma with isochromosome 7q, translocation t(7; 21), and tetrasomy 8 in a 9-year-old girl. J Pediatr Hematol Oncol 2002;24:154-157.
38. Wlodarska I, Martin-Garcia N, Achten R, De Wolf-Peeters C, Pauwels P, Tulliez M, et al. Fluorescence in situ hybridization study of chromosome 7 aberrations in hepatosplenic T-cell lymphoma: isochromosome 7q as a common abnormality accumulating in forms with features of cytologic progression. Genes Chromosomes Cancer 2002;33: 243-251.
39. Konuma T, Ooi J, Takahashi S, Tomonari A, Tsukada N, Kobayashi T, et al. Allogeneic stem cell transplantation for hepatosplenic gammadelta T-cell lymphoma. Leuk Lymphoma 2007;48:630-632.
40. Paya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, et al. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and the Mayo Clinic Organized International Consensus Development Meeting. Transplantation 1999;68: 1517-1525.
41. Ganne V, Siddiqi N, Kamaplath B, Chang C-C, Cohen EP, Bresnahan BA, et al. Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorder. Clin Transpl 2003;17:417-422.
42. Yedibela S, Reck T, Niedobitek G, Gramatzki M, Repp R, Hohenberger W, et al. Anti-CD20 monoclonal antibody treatment of Epstein-Barr virus-induced intrahepatic lymphoproliferative disorder following liver transplantation. Transpl Int 2003;16:197-201.