Anaplastic Lymphoma Kinase Is Required for Neurogenesis in the Developing Central Nervous System of Zebrafish

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Yao, Sheng ^a   Cheng, Mangeng ^b   Zhang, Qian ^c   Wasik, Mariusz ^c   Kelsh, Robert ^d   Winkler, Christoph ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MORPHOLINE DERIVATIVE;

ANAPLASTIC LYMPHOMA KINASE GENE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE SILENCING; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; ORTHOLOGY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; DNA PRIMERS; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MICROINJECTIONS; MORPHOLINOS; NEUROGENESIS; RECEPTOR PROTEIN-TYROSINE KINASES; SEQUENCE ANALYSIS, DNA; ZEBRAFISH;

EID: 84877302754     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063757     Document Type: Article

References (59)

1. Benz-Lemoine E, Brizard A, Huret JL, Babin P, Guilhot F, et al. (1988) Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature. Blood 72: 1045-1047.
2. Fischer P, Nacheva E, Mason DY, Sherrington PD, Hoyle C, et al. (1988) A Ki-1 (CD30)-positive human cell line (Karpas 299) established from a high-grade non-Hodgkin's lymphoma, showing a 2;5 translocation and rearrangement of the T-cell receptor beta-chain gene. Blood 72: 234-240.
3. Shiota M, Nakamura S, Ichinohasama R, Abe M, Akagi T, et al. (1995) Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity. Blood 86: 1954-1960.
4. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, et al. (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448: 561-566.
5. Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G, (2008) The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer 8: 11-23.
6. Dirks WG, Fahnrich S, Lis Y, Becker E, MacLeod RA, et al. (2002) Expression and functional analysis of the anaplastic lymphoma kinase (ALK) gene in tumor cell lines. Int J Cancer 100: 49-56.
7. Maris JM, Hogarty MD, Bagatell R, Cohn SL, (2007) Neuroblastoma. Lancet 369: 2106-2120.
8. Chen Y, Takita J, Choi YL, Kato M, Ohira M, et al. (2008) Oncogenic mutations of ALK kinase in neuroblastoma. Nature 455: 971-974.
9. George RE, Sanda T, Hanna M, Frohling S, Luther W, (2008) Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 455: 975-978.
10. Janoueix-Lerosey I, Lequin D, Brugieres L, Ribeiro A, de Pontual L, et al. (2008) Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature 455: 967-970.
11. Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, et al. (2008) Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455: 930-935.
12. Hurley SP, Clary DO, Copie V, Lefcort F, (2006) Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system. J Comp Neurol 495: 202-212.
13. Degoutin J, Brunet-de Carvalho N, Cifuentes-Diaz C, Vigny M, (2009) ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction. Eur J Neurosci 29: 275-286.
14. Vernersson E, Khoo NK, Henriksson ML, Roos G, Palmer RH, et al. (2006) Characterization of the expression of the ALK receptor tyrosine kinase in mice. Gene Expr Patterns 6: 448-461.
15. Reiff T, Huber L, Kramer M, Delattre O, Janoueix-Lerosey I, et al. (2011) Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition. Development 138: 4699-4708.
16. Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, et al. (1997) Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14: 439-449.
17. Lopes SS, Yang X, Muller J, Carney TJ, McAdow AR, et al. (2008) Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genet 4: e1000026.
18. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF, (1995) Stages of embryonic development of the zebrafish. Dev Dyn 203: 253-310.
19. Bajoghli B, Aghaallaei N, Heimbucher T, Czerny T, (2004) An artificial promoter construct for heat-inducible misexpression during fish embryogenesis. Dev Biol 271: 416-430.
20. To TT, Witten PE, Renn J, Bhattacharya D, Huysseune A, et al. (2012) Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. Development 139: 141-150.
21. Thermes V, Grabher C, Ristoratore F, Bourrat F, Choulika A, et al. (2002) I-SceI meganuclease mediates highly efficient transgenesis in fish. Mech Dev 118: 91-98.
22. Liedtke D, Winkler C, (2008) Midkine-b regulates cell specification at the neural plate border in zebrafish. Dev Dyn 237: 62-74.
23. Dolbeare F, (1995) Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part I: Historical perspectives, histochemical methods and cell kinetics. Histochem J 27: 339-369.
24. Link V, Shevchenko A, Heisenberg CP, (2006) Proteomics of early zebrafish embryos. BMC Dev Biol 6: 1.
25. Ott GR, Tripathy R, Cheng MG, McHugh R, Anzalone AV, et al. (2010) Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity. Acs Medicinal Chemistry Letters 1: 493-498.
26. Cooper MS, Szeto DP, Sommers-Herivel G, Topczewski J, Solnica-Krezel L, et al. (2005) Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP. Dev Dyn 232: 359-368.
27. Godinho L, (2011) Using intravital dyes to ubiquitously label embryonic zebrafish. Cold Spring Harb Protoc 2011: 877-878.
28. Palmer RH, Vernersson E, Grabbe C, Hallberg B, (2009) Anaplastic lymphoma kinase: signalling in development and disease. Biochem J 420: 345-361.
29. Lyons DA, Guy AT, Clarke JD, (2003) Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain. Development 130: 3427-3436.
30. Grandel H, Kaslin J, Ganz J, Wenzel I, Brand M, (2006) Neural stem cells and neurogenesis in the adult zebrafish brain: origin, proliferation dynamics, migration and cell fate. Dev Biol 295: 263-277.
31. Dong Z, Yang N, Yeo SY, Chitnis A, Guo S, (2012) Intralineage directional notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron 74: 65-78.
32. Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL, (2011) Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 11: 558-572.
33. Englund C, Loren CE, Grabbe C, Varshney GK, Deleuil F, et al. (2003) Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion. Nature 425: 512-516.
34. Lee HH, Norris A, Weiss JB, Frasch M, (2003) Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers. Nature 425: 507-512.
35. Loren CE, Englund C, Grabbe C, Hallberg B, Hunter T, et al. (2003) A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Rep 4: 781-786.
36. Loren CE, Scully A, Grabbe C, Edeen PT, Thomas J, et al. (2001) Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. Genes Cells 6: 531-544.
37. Robu ME, Larson JD, Nasevicius A, Beiraghi S, Brenner C, et al. (2007) p53 activation by knockdown technologies. PLoS Genet 3: e78.
38. Langheinrich U, Hennen E, Stott G, Vacun G, (2002) Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol 12: 2023-2028.
39. Kageyama R, Ohtsuka T, Kobayashi T, (2008) Roles of Hes genes in neural development. Dev Growth Differ 50Suppl 1: S97-103.
40. Pasini A, Henrique D, Wilkinson DG, (2001) The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites. Mech Dev 100: 317-321.
41. Diez del Corral R, Storey KG, (2001) Markers in vertebrate neurogenesis. Nat Rev Neurosci 2: 835-839.
42. Bertrand N, Castro DS, Guillemot F, (2002) Proneural genes and the specification of neural cell types. Nat Rev Neurosci 3: 517-530.
43. Kageyama R, Ohtsuka T, Hatakeyama J, Ohsawa R, (2005) Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res 306: 343-348.
44. Lo L, Dormand E, Greenwood A, Anderson DJ, (2002) Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Development 129: 1553-1567.
45. Cheng M, Quail MR, Gingrich DE, Ott GR, Lu L, et al. (2012) CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther 11: 670-679.
46. Kim CH, Ueshima E, Muraoka O, Tanaka H, Yeo SY, et al. (1996) Zebrafish elav/HuC homologue as a very early neuronal marker. Neurosci Lett 216: 109-112.
47. Park HC, Hong SK, Kim HS, Kim SH, Yoon EJ, et al. (2000) Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. Neurosci Lett 279: 81-84.
48. Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, et al. (1997) ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14: 2175-2188.
49. Roll JD, Reuther GW, (2012) ALK-activating homologous mutations in LTK induce cellular transformation. PLoS One 7: e31733.
50. Schlessinger J, (2000) Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
51. Weiss A, Schlessinger J, (1998) Switching signals on or off by receptor dimerization. Cell 94: 277-280.
52. Perez-Pinera P, Zhang W, Chang Y, Vega JA, Deuel TF, (2007) Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation. J Biol Chem 282: 28683-28690.
53. Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, et al. (2012) The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma. Cancer Cell 22: 117-130.
54. Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, et al. (2012) Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell 21: 362-373.
55. Loeb-Hennard C, Kremmer E, Bally-Cuif L, (2005) Prominent transcription of zebrafish N-myc (nmyc1) in tectal and retinal growth zones during embryonic and early larval development. Gene Expr Patterns 5: 341-347.
56. Di Paolo D, Ambrogio C, Pastorino F, Brignole C, Martinengo C, et al. (2011) Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma. Mol Ther 19: 2201-2212.
57. Tomita K, Moriyoshi K, Nakanishi S, Guillemot F, Kageyama R, (2000) Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J 19: 5460-5472.
58. Pogoda HM, von der Hardt S, Herzog W, Kramer C, Schwarz H, et al. (2006) The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis. Development 133: 1079-1089.
59. Yi SH, Jo AY, Park CH, Koh HC, Park RH, et al. (2008) Mash1 and neurogenin 2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action. Mol Ther 16: 1873-1882.