Synthesis and evaluation of the bioactivity of simplified analogs of the seco-pseudopterosins; progress toward determining a pharmacophore

Tetrahedron

Volumn 64, Issue 47, 2008, Pages 10649-10663

  Tanis, Virginia M ^a   Moya, Claudia ^a   Jacobs, R S ^a   Little, R Daniel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenosine receptors; Anti inflammatory activity; Marine natural products; Minimal pharmacophore; Phagocytosis; Pseudopterosins; Seco pseudopterosins; Structural analogs; Total synthesis

Indexed keywords

2 [5 (5 METHYLHEX 4 ENYL) 5,6,7,8 TETRAHYDRONAPHTHALEN 1 YLOXY]BETA DEXTRO XYLOPYRANOSIDE; 2 [5 (5 METHYLHEX 4 ENYL) 5,6,7,8 TETRAHYDRONAPHTHALEN 1 YLOXY]BETA LEVO ARABINOPYRANOSIDE; 2 [5 (5 METHYLHEX 4 ENYL) 5,6,7,8 TETRAHYDRONAPHTHALEN 2 HYDROXY 1 YLOXY]BETA DEXTRO XYLOPYRANOSIDE; 2 [5 (5 METHYLHEX 4 ENYL) 5,6,7,8 TETRAHYDRONAPTHALEN 2 HYDROXY 1 YLOXY]BETA LEVO ARABINOPYRANOSIDE; 2 METHYL 6 [5 (5 METHYLHEX 4 ENYL) 5,6,7,8 TETRAHYDRONAPHTHALEN 1 YLOXY]BETA LEVO FUCOPYRANOSIDE; 2 METHYL 6 [5 (5 METHYLHEX 4 ENYL) 5,6,7,8 TETRAHYDRONAPHTHALEN 2 HYDROXY 1 YLOXY]BETA LEVO FUCOPYRANOSIDE; ADENOSINE A2A RECEPTOR; AGLYCONE; AROMATIC COMPOUND; DITERPENE; NATURAL PRODUCT; OXYGEN; PSEUDOPTEROSIN DERIVATIVE; PYRANOSIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOASSAY; CHEMICAL REACTION; DRUG ACTIVITY; EVALUATION; NONHUMAN; PHAGOCYTOSIS; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 53149154805     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.09.025     Document Type: Article

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