Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity

Acta Pharmacologica Sinica

Volumn 34, Issue 4, 2013, Pages 522-530

  Wan, Chun Ping ^a,c   Gao, Li Xin ^b   Hou, Li Fei ^b   Yang, Xiao Qian ^b   He, Pei Lan ^b   Yang, Yi Fu ^a   Tang, Wei ^b   Yue, Jian Min ^b   Li, Jia ^b   Zuo, Jian Ping ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c YUNNAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Astragaloside II; Astragalus membranaceus Bge; CD45 PTPase; Cyclophosphamide; IFN ; IL 2; Immunomodulating agent; LCK; Splenocyte; Src family kinase; T cell

Indexed keywords

ALLOANTIGEN; ASTRAGALOSIDE I; ASTRAGALOSIDE II; ASTRAGALOSIDE III; ASTRAGALOSIDE IV; ASTRAGALUS MEMBRANACEUS EXTRACT; CD45 ANTIGEN; CD69 ANTIGEN; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; PROTEIN KINASE LCK; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTRAGALUS MEMBRANACEUS; CELL PROLIFERATION; COLORIMETRY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOMODULATION; MOUSE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD45; ASTRAGALUS MEMBRANACEUS; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTEIN TYROSINE PHOSPHATASES; RANDOM ALLOCATION; SAPONINS; T-LYMPHOCYTES; TYROSINE;

EID: 84877295488     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.208     Document Type: Article

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