Systemic administration of 5-HT2C receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model

Pharmacology Biochemistry and Behavior

Volumn 108, Issue , 2013, Pages 8-15

  Ogino, Shinichi ^a   Nagakura, Yukinori ^a   Tsukamoto, Mina ^a   Watabiki, Tomonari ^a   Ozawa, Tohru ^a   Oe, Tomoya ^a   Shimizu, Yasuaki ^a   Ito, Hiroyuki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

5 HT2C receptor; Fibromyalgia; Lorcaserin; Pain; Reserpine; Vabicaserin

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; BUSPIRONE; LORCASERIN; RESERPINE; SEROTONIN; SEROTONIN 2C AGONIST; SEROTONIN AGONIST; SEROTONIN RECEPTOR AFFECTING AGENT; TCB 2; UNCLASSIFIED DRUG; VABICASERIN; YM 348;

ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CHRONIC PAIN; CONTROLLED STUDY; DRUG EFFICACY; FIBROMYALGIA; HYPERALGESIA; MALE; MICRODIALYSIS; MUSCLE CONTRACTION; MUSCULAR HYPERALGESIA; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; RESERPINE INDUCED MYALGIA; SPINAL CORD; SYMPTOM;

ANIMALS; HYPERALGESIA; LOCOMOTION; MICRODIALYSIS; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RESERPINE; SEROTONIN; SEROTONIN RECEPTOR AGONISTS; SPINAL CORD;

ANIMALIA; RATTUS;

EID: 84877273708     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.04.007     Document Type: Article

References (55)

1. U.M. Anderberg, I. Marteinsdottir, and L. Von Knorring Citalopram in patients with fibromyalgia - a randomized, double-blind, placebo-controlled study Eur J Pain 4 2000 27 35 (Pubitemid 30230793)
2. L.M. Arnold, E.V. Hess, J.I. Hudson, J.A. Welge, S.E. Berno, and P.E. Keck A randomized, placebo-controlled, double-blind flexible-dose study of fluoxetine in the treatment of women with fibromyalgia Am J Med 112 2002 191 197
3. L. Bardin The complex role of serotonin and 5-HT receptors in chronic pain Behav Pharmacol 22 2011 390 404
4. D. Buskila, and P. Sarzi-Puttini Biology and therapy of fibromyalgia: genetic aspects of fibromyalgia syndrome Arthritis Res Ther 8 2006 218
5. E. Chojnacka-Wójcik, A. Kłodzińska, and A. Dereń-Wesołek Involvement of 5-HT2C receptors in the m-CPP-induced antinociception in mice Pol J Pharmacol 46 1994 423 428 (Pubitemid 24349158)
6. F.C. Colpaert Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat Neuropharmacology 26 1987 1431 1440 (Pubitemid 17160562)
7. S. Doly, J. Fischer, M.J. Brisorgueil, D. Vergé, and M. Conrath Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: immunocytochemical evidence J Comp Neurol 490 2005 256 269 (Pubitemid 41140992)
8. J. Dunlop, S.W. Watts, J.E. Barrett, J. Coupet, B. Harrison, and H. Mazandarani Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist J Pharmacol Exp Ther 337 2011 673 680
9. A. Fernández-Guasti, R. Reyes, L. Martínez-Mota, and F.J. López-Muñoz Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats Psychopharmacology (Berl) 180 2005 399 407 (Pubitemid 40905029)
10. M.C. Fidler, M. Sanchez, B. Raether, N.J. Weissman, S.R. Smith, and W.R. Shanahan A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial J Clin Endocrinol Metab 96 2011 3067 3077
11. M.I. Fonseca, Y.G. Ni, D.D. Dunning, and R. Miledi Distribution of serotonin 2A, 2C and 3 receptor mRNA in spinal cord and medulla oblongata Brain Res Mol Brain Res 89 2001 11 19 (Pubitemid 32322730)
12. M.A. Fox, H.T. French, J.L. LaPorte, A.R. Blackler, and D.L. Murphy The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis Psychopharmacology (Berl) 212 2010 13 23
13. Z. Gorka, and P. Adamik The effect of reserpine and stress on feeding behaviour in the light and dark phases of the diurnal cycle in rats J Pharm Pharmacol 45 1993 137 138 (Pubitemid 23081892)
14. 2C receptors reduces the locomotor and rewarding effects of nicotine Psychopharmacology (Berl) 157 2001 292 298 (Pubitemid 32905571)
15. E.A. Hackler, G.H. Turner, P.J. Gresch, S. Sengupta, A.Y. Deutch, and M.J. Avison 5-Hydroxytryptamine2C receptor contribution to m- chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation J Pharmacol Exp Ther 320 2007 1023 1029 (Pubitemid 46294062)
16. A.E. Halaris, and D.X. Freedman Loss of body weight as a predictor of reserpine-induced amine depletion Eur J Pharmacol 32 1975 93 101
17. J.C. Halford, E.J. Boyland, C.L. Lawton, J.E. Blundell, and J.A. Harrold Serotonergic anti-obesity agents: past experience and future prospects Drugs 71 2011 2247 2255
18. A. Hayashi, R. Sonoda, Y. Kimura, T. Takasu, M. Suzuki, and M. Sasamata Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats Brain Res 1011 2004 221 227 (Pubitemid 38638688)
19. A. Hayashi, M. Suzuki, M. Sasamata, and K. Miyata Agonist diversity in 5-HT2C receptor-mediated weight control in rats Psychopharmacology (Berl) 178 2005 241 249 (Pubitemid 40379219)
20. M. Honda, K. Uchida, M. Tanabe, and H. Ono Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors Neuropharmacology 51 2006 866 872 (Pubitemid 44286938)
21. H. Horiuchi, T. Ogata, T. Morino, J. Takeba, and H. Yamamoto Serotonergic signaling inhibits hyperalgesia induced by spinal cord damage Brain Res 963 2003 312 320 (Pubitemid 36126313)
22. N. Hovelsø, T.N. Sager, and A. Mørk Combination of escitalopram and a 5-HT(1A) receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT(2C) receptor stimulation; suggestive of antipsychotic potential Pharmacol Biochem Behav 97 2011 479 485
23. D. Hoyer, D.E. Clarke, J.R. Fozard, P.R. Hartig, G.R. Martin, and E.J. Mylecharane International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin) Pharmacol Rev 46 1994 157 203 (Pubitemid 24185150)
24. T. Kawamata, K. Omote, M. Toriyabe, M. Kawamata, and A. Namiki Intracerebroventricular morphine produces antinociception by evoking gamma-aminobutyric acid release through activation of 5-hydroxytryptamine 3 receptors in the spinal cord Anesthesiology 96 2002 1175 1182 (Pubitemid 34462580)
25. E.J. Kidd, A.M. Laporte, X. Langlois, C.M. Fattaccini, C. Doyen, and M.C. Lombard 5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals Brain Res 612 1993 289 298 (Pubitemid 23167293)
26. Y. Kimura, K. Hatanaka, Y. Naitou, K. Maeno, I. Shimada, and A. Koakutsu Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist Eur J Pharmacol 483 2004 37 43 (Pubitemid 38056602)
27. Y.C. Lee, and P.P. Chen A review of SSRIs and SNRIs in neuropathic pain Expert Opin Pharmacother 11 2010 2813 2825
28. Y.H. Lee, S.J. Choi, J.D. Ji, and G.G. Song Candidate gene studies of fibromyalgia: a systematic review and meta-analysis Rheumatol Int 32 2012 417 426
29. L. Marlier, J.R. Teilhac, C. Cerruti, and A. Privat Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord Brain Res 550 1991 15 23
30. K.L. Marquis, A.L. Sabb, S.F. Logue, J.A. Brennan, M.J. Piesla, and T.A. Comery WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1, 4]diazepino[6,7,1hi]indole]: a novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity J Pharmacol Exp Ther 320 2007 486 496 (Pubitemid 46025760)
31. M.J. Millan Descending control of pain Prog Neurobiol 66 2002 355 474 (Pubitemid 34606906)
32. Y. Nagakura, T. Oe, T. Aoki, and N. Matsuoka Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: a putative animal model of fibromyalgia Pain 146 2009 26 33
33. Y. Nagakura, M. Takahashi, T. Noto, T. Sekizawa, T. Oe, and E. Yoshimi Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats Behav Brain Res 226 2012 242 249
34. K. Nakai, A. Nakae, S. Oba, T. Mashimo, and K. Ueda 5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain Eur J Pain 14 2010 999 1006
35. M. Nishiyori, J. Nagai, T. Nakazawa, and H. Ueda Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia Neurosci Lett 472 2010 184 187
36. H. Obata, S. Saito, S. Sakurazawa, M. Sasaki, T. Usui, and F. Goto Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury Pain 108 2004 163 169 (Pubitemid 38251686)
37. H. Obata, N. Ito, M. Sasaki, S. Saito, and F. Goto Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury Eur J Pharmacol 567 2007 89 94 (Pubitemid 46805094)
38. T. Oe, M. Tsukamoto, and Y. Nagakura Reserpine causes biphasic nociceptive sensitivity alteration in conjunction with brain biogenic amine tones in rats Neuroscience 169 2010 1860 1871
39. P.M. O'Neil, S.R. Smith, N.J. Weissman, M.C. Fidler, M. Sanchez, and J. Zhang Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study Obesity 20 2012 1426 1436
40. A.A. Patkar, P.S. Masand, S. Krulewicz, P. Mannelli, K. Peindl, and K.L. Beebe A randomized, controlled, trial of controlled release paroxetine in fibromyalgia Am J Med 120 2007 448 454 (Pubitemid 46656247)
41. M. Pompeiano, J.M. Palacios, and G. Mengod Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors Brain Res Mol Brain Res 23 1994 163 178
42. R.H. Porter, K.R. Benwell, H. Lamb, C.S. Malcolm, N.H. Allen, and D.F. Revell Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells Br J Pharmacol 128 1999 13 20 (Pubitemid 29425262)
43. M.H. Roberts 5-Hydroxytryptamine and antinociception Neuropharmacology 23 1984 1529 1536 (Pubitemid 15152979)
44. I.J. Russell, J.E. Michalek, G.A. Vipraio, E.M. Fletcher, M.A. Javors, and C.A. Bowden Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome J Rheumatol 19 1992 104 109
45. I.J. Russell, H. Vaeroy, M. Javors, and F. Nyberg Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis Arthritis Rheum 35 1992 550 556
46. M. Schäfers, L.S. Sorkin, and C. Sommer Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats Pain 104 2003 579 588 (Pubitemid 37289057)
47. J.H.Q. Shen, Y. Zhao, S. Rosenzweig-Lipson, D. Popp, J.B.W. Williams, and E. Giller A 6-week randomized, double-blind, placebo-controlled, comparator referenced, multicenter trial of vabicaserin in subjects with acute exacerbation of schizophrenia Neuropsychopharmacology 36 2011 S106
48. S.R. Skilling, D.H. Smullin, A.J. Beitz, and A.A. Larson Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation J Neurochem 51 1988 127 132
49. W.J. Thomsen, A.J. Grottick, F. Menzaghi, H. Reyes-Saldana, S. Espitia, and D. Yuskin Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization J Pharmacol Exp Ther 325 2008 577 587 (Pubitemid 351574813)
50. N. Uceyler, W. Häusar, and C. Sommer A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome Arthritis Rheum 59 2008 1279 1298
51. D.A. Wacker, and K.J. Miller Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases Curr Opin Drug Discov Dev 11 2008 438 445 (Pubitemid 351950839)
52. H. Wang, Z. Huang, L. Huang, S. Niu, X. Rao, and J. Xu Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C receptor J Biol Chem 287 2012 2237 2246
53. F. Wolfe, M.A. Cathey, and D.J. Hawley A double-blind placebo controlled trial of fluoxetine in fibromyalgia Scand J Rheumatol 23 1994 255 259 (Pubitemid 24334031)
54. F. Wolfe, I.J. Russell, G. Vipraio, K. Ross, and J. Anderson Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population J Rheumatol 24 1997 555 559 (Pubitemid 27153424)
55. M. Yoshimura, and H. Furue Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord J Pharmacol Sci 101 2006 107 117 (Pubitemid 43938761)