Serotonergic signaling inhibits hyperalgesia induced by spinal cord damage

Brain Research

Volumn 963, Issue 1-2, 2003, Pages 312-320

  Horiuchi, Hideki ^a   Ogata, Tadanori ^a   Morino, Tadao ^a   Takeba, Jun ^a   Yamamoto, Haruyasu ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 HT; Hyperalgesia; Pain; Serotonin; Spinal cord injury

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; ALPHA METHYLSEROTONIN; ASCORBIC ACID; BEMESETRON; FLUVOXAMINE MALEATE; KETANSERIN; METERGOLINE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APPARATUS; ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DYSESTHESIA; FEMALE; HINDLIMB; HYPERALGESIA; LATENT PERIOD; NERVE COMPRESSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SPINAL CORD LESION; THERMAL STIMULATION; THORACIC SPINAL CORD;

ANIMALS; BRAIN STEM; FEMALE; FLUVOXAMINE; HEAT; HYPERALGESIA; METERGOLINE; NOCICEPTORS; PAIN MEASUREMENT; PHYSICAL STIMULATION; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD COMPRESSION; SPINAL CORD INJURIES;

EID: 0037435885     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)04055-6     Document Type: Article

References (40)

1. Alhaider A.A., Lei S.Z., Wilcox G.L. Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J. Neurosci. 11:1991;1881-1888.
2. Ankeny D.P., McTigue D.M., Guan Z., Yan Q., Kinstler O., Stokes B.T., Jakeman L.B. Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury. Exp. Neurol. 170:2001;85-100.
3. Attal N. Chronic neuropathic pain: mechanisms and treatment. Clin. J. Pain. 16:2000;118-130.
4. Bardin L., Bardin M., Lavarenne J., Eschalier A. Effect of intrathecal serotonin on nociception in rats: influence of the pain test used. Exp. Brain Res. 113:1997;81-87.
5. Baron R. Peripheral neuropathic pain: from mechanisms to symptoms. Clin. J. Pain. 16:2000;12-20.
6. Bennet G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
7. Bouhassia D. Neuropathic pain: the clinical syndrome revisited. Acta Neurol. Belg. 101:2001;47-52.
8. Coggeshall R.E., Dougherty P.M., Pover C.M., Carlton S.M. Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat? Pain. 52:1993;233-242.
9. Eaton M.J., Santiago D.J., Dancausse H.A., Whittemore S.R. Lumbar transplants of immortalized serotonergic neurons alleviate chronic neuropathic pain. Pain. 72:1997;59-69.
10. Eide P.K., Hole K. Interactions between serotonin and substance P in the spinal regulation of nociception. Brain Res. 550:1991;225-230.
11. Ferreira S.H., Lorenzetti B.B. Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception. Neuropharmacology. 33:1994;1479-1485.
12. Fundytus M.E. Glutamate receptors and nociception: implications for the drug treatment of pain. CNS Drugs. 15:2001;29-58.
13. Giordano J. Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats. Eur. J. Pharmacol. 199:1991;233-236.
14. Glaum S.R., Proudfit H.K., Anderson E.G. 5-HT3 receptors modulate spinal nociceptive reflexes. Brain Res. 510:1990;12-16.
15. 3 receptors in the anesthetized rat. Pain. 89:2000;81-88.
16. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
17. Henry J.L. Substance P and inflammatory pain: potential of substance P antagonists as analgesics. Agents Actions Suppl. 41:1993;75-87.
18. Holland L.N., Goldstein B.D. Examination of tonic nociceptive behavior using a method of substance P-receptor desensitization in the dorsal horn. Pain. 56:1994;339-346.
19. Jones S.L. Descending noradrenergic influences on pain. Prog. Brain Res. 88:1991;381-394.
20. Kim D.H., Gutin P.H., Noble L.J., Nathan D., Yu J.S., Nockels R.P. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. NeuroReport. 7:1996;2221-2225.
21. Kjorsvik A., Tjolsen A., Hole K. Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat. Brain Res. 910:2001;179-181.
22. Kocsia J.D. Restoration of function by glial cell transplantation into demyelinated spinal cord. J. Neurotrauma. 16:1999;695-703.
23. Koyanagi I., Tator C.H. Effect of a single huge dose of methylprednisolone on blood flow, evoked potentials, and histology after acute spinal cord injury in the rat. Neurol. Res. 19:1997;289-299.
24. Lopez-Garcia J.A. Serotonergic modulation of the responses to excitatory amino acids of rat dorsal horn neurons in vitro: implication for somatosensory transmission. Eur. J. Neurosci. 10:1998;1341-1349.
25. Ma J., Qiao J.T., Dafuny N. Opiate-like substances mediate norepinephrine-induced but not serotonin induced antinociception at spinal level: reevaluation by an electrophysiological model of formalin test in rats. Life Sci. 69:2001;969-976.
26. Mjellem N., Lund A., Eide P.K., Storkson R., Tjolsen A. The role of 5-HT1A and 5-HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour. NeuroReport. 12:1992;1061-1064.
27. Naso W.B., Perot P.L. Jr., Cox R.D. The neuroprotective effect of high-dose methylprednisolone in rat spinal cord hemisection. Neurosci. Lett. 189:1995;176-178.
28. Obata H., Saito S., Sasaki M., Ishizaki K., Goto F. Antiallodynic effect of intrathecally administered 5-HT2 agonists in rats nerve ligation. Pain. 90:2001;173-179.
29. Ogata T., Morino T., Takeba J., Matsuda Y., Okumura H., Shibata T., Schubert P., Kataoka K. Mild hypothermia amelioration of damage during rat spinal cord injury: inhibition of pathological microglial proliferation and improvement of hind-limb motor function. Hayashi N. Brain Hypothermia. 2000;47-54 Springer-Verlag, Tokyo.
30. Oyama T., Ueda M., Kuraishi Y., Akaike A. Dual effect of serotonin on formalin-induced nociception in the rat spinal cord. Neurosci. Res. 25:1996;129-135.
31. Oudega M., Vargas C.G., Weber A.B., Kleitman N., Bunge M.B. Long-term effects of methylprednisolone following transection of adult rat spinal cord. Eur. J. Neurosci. 11:1999;2453-2464.
32. Rabchevsky A.G., Streit W.J. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. J. Neurosci. Res. 47:1997;34-48.
33. 3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test. Eur. J. Pharmacol. 424:2001;1341-1349.
34. Schaible H.G., Neugebauer V., Cervero F., Schmidt R.F. Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat. J. Neurophysiol. 66:1991;1021-1032.
35. Singh V.P., Jain N.K., Kulkarni S.K. On the antinociceptive effect of fluxetine, a selective serotonin reuptake inhibitor. Brain Res. 915:2001;218-226.
36. Treeede R.D., Meyer R.A., Raja S.N., Campbell J.M. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog. Neurobiol. 38:1992;397-421.
37. Wang Y.X., Bowersox S.S., Pettus M., Gao D. Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy. J. Pharmacol. Exp. Ther. 291:1999;1008-10016.
38. A response in the rat sacral dorsal commissural neurons. Br. J. Pharmacol. 124:1998;779-787.
39. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.
40. Zimmermann M. Pathobiology of neuropathic pain. Eur. J. Pharmacol. 429:2001;23-37.