A novel matrix for the short-term storage of cells: Utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes

Xenobiotica

Volumn 43, Issue 6, 2013, Pages 487-497

  Palmgren, Anna Pia ^a   Fihn, Britt Marie ^a   Bird, James ^a   Courtney, Paul ^a   Grime, Ken ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Dog; Enzyme activity; Fresh Hepatocytes; Human; Rat; Storage; Transporter activity

Indexed keywords

1 HYDROXYBUFURALOL; 1 HYDROXYMIDAZOLAM; 4 HYDROXYDICLOFENAC; 4 HYDROXYMEPHENYTOIN; AMFEBUTAMONE; AMODIAQUINE; ANESTHETIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUFURALOL; DEETHYLAMODIAQUINE; DICLOFENAC; DICLOFENAC DERIVATIVE; ESTRONE SULFATE; ETHINYLESTRADIOL; GEMFIBROZIL; GLUTAMINE; KETOPROFEN; MEPHENYTOIN; MIDAZOLAM; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1B1; PARACETAMOL; PHENACETIN; PHENYTOIN DERIVATIVE; RADAFAXINE; TAUROCHOLIC ACID; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BATCH PROCESS; CELL ISOLATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; CRYOPRESERVATION; DOG; DRUG CLEARANCE; DRUG INDUSTRY; DRUG METABOLISM; DRUG STORAGE; DRUG TRANSPORT; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LIVER CELL; NONHUMAN; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; CELL SEPARATION; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HEPTANOIC ACIDS; HUMANS; ORGANIC ANION TRANSPORTERS; PHARMACEUTICAL PREPARATIONS; PYRROLES; RATS; SUBSTRATE SPECIFICITY; SUSPENSIONS; TIME FACTORS;

EID: 84877251596     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.738316     Document Type: Article

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