Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

Human Vaccines and Immunotherapeutics

Volumn 9, Issue 4, 2013, Pages 744-752

  Thomas, Justin C ^a   O'Hara, Joanne M ^b,c   Hu, Lei ^a   Gao, Fei P ^a   Joshi, Sangeeta B ^a   Volkin, David B ^a   Brey, Robert N ^d   Fang, Jianwen ^a   Karanicolas, John ^a   Mantis, Nicholas J ^b,c   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b WADSWORTH CENTER   (United States)

^c UNIVERSITY AT ALBANY   (United States)

^d Soligenix Inc   (United States)

Author keywords

Antigen; Computational protein design; Immunogenicity; Protein stability; Ricin; Vaccine

Indexed keywords

ANTITOXIN; NEUTRALIZING ANTIBODY; RECOMBINANT RICIN A CHAIN SUBUNIT VACCINE ANTIGEN; RICIN A; RICIN ANTIBODY; RIVAX; SUBUNIT VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STABILITY; IC 50; IMMUNIZATION; IMMUNOGENICITY; INTOXICATION; LD 50; MOUSE; MUTANT; NONHUMAN; PH; POINT MUTATION; THERMOSTABILITY;

ANTIGEN; COMPUTATIONAL PROTEIN DESIGN; IMMUNOGENICITY; PROTEIN STABILITY; RICIN; VACCINE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTITOXINS; BLOOD GLUCOSE; CALORIMETRY; CIRCULAR DICHROISM; DISEASE MODELS, ANIMAL; DRUG STABILITY; MICE; MICE, INBRED BALB C; MUTANT PROTEINS; POINT MUTATION; POISONING; PROTEIN CONFORMATION; PROTEIN STABILITY; RICIN; SPECTROMETRY, FLUORESCENCE; SURVIVAL ANALYSIS; VACCINES, SUBUNIT; VACCINES, SYNTHETIC;

EID: 84877146713     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.22998     Document Type: Article

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