Complications of injectable fillers, part i

Aesthetic Surgery Journal

Volumn 33, Issue 4, 2013, Pages 561-575

  Delorenzi, Claudio ^a  

^a not available   (Canada)

Author keywords

biofilms; dermal filler technique; filler complication; filler infection; filler technique; hyaluronidase

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; COLLAGEN; FAMCICLOVIR; HYALURONIC ACID; HYALURONIDASE; HYDROXYAPATITE; MELANIN; POLY(METHYL METHACRYLATE); POLYLACTIC ACID; RECOMBINANT HYALURONIDASE; TRIAMCINOLONE ACETONIDE; VALACICLOVIR;

ANAPHYLAXIS; BACTERIAL INFECTION; BIOFILM; BIOPSY; BREAST IMPLANT; CHEMICAL COMPOSITION; COMPLICATION; CONSULTATION; DERMIS; DISEASE SEVERITY; EYE SURGERY; EYELID RECONSTRUCTION; FACIAL ABSCESS; GRANULOMA; GRANULOMATOUS INFLAMMATION; HERPES SIMPLEX; HUMAN; HYDROPHILICITY; IMMUNITY; IMMUNOGENICITY; MONGOLIAN SPOT; MYCOSIS; PARTICLE SIZE; PREMALAR EDEMA; PRIORITY JOURNAL; RETROBULBAR ANESTHESIA; REVIEW; SKIN BIOPSY; SURFACE CHARGE; TYNDAL LEFFECT; TYNDALL EFFECT;

EID: 84877144730     PISSN: 1090820X     EISSN: 1527330X     Source Type: Journal    
DOI: 10.1177/1090820X13484492     Document Type: Review

References (236)

1. Meyer K, Palmer JW. The polysaccharide of the vitreous humour. J Biol Chem. 1934 ; 107: 629-634
2. Garg HG, Hales CA Chemistry and Biology of Hyaluronan. Amsterdam: Elsevier ; 2004 :
3. Nusgens BV. [Hyaluronic acid and extracellular matrix: a primitive molecule? [in French]. Ann Dermatol Venereol. 2010 ; 137: S3 - S8
4. Ascher B, Cerceau M, Baspeyras M, et al. Soft tissue filling with hyaluronic acid [in French]. Ann Chir Plast Esthet. 2004 ; 49: 465-485
5. Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997 ; 242: 27-33
6. Fraser JR, Dahl LB, Kimpton WG, et al. Elimination and subsequent metabolism of circulating hyaluronic acid in the fetus. J Dev Physiol. 1989 ; 11: 235-242
7. Fraser JR, Laurent TC. Turnover and metabolism of hyaluronan. Ciba Found Symp. 1989 ; 143: 41 53 281-53 59 285
8. Laurent TC. Biochemistry of hyaluronan. Acta Otolaryngol Suppl. 1987 ; 442: 7-24
9. Laurent TC, Dahl IM, Dahl LB, et al. The catabolic fate of hyaluronic acid. Connect Tissue Res. 1986 ; 15: 33-41
10. Fraser JR, Laurent TC, Engstrom-Laurent A, et al. Elimination of hyaluronic acid from the blood stream in the human. Clin Exp Pharmacol Physiol. 1984 ; 11: 17-25
11. Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008 ; 10: 35-42
12. Lowe NJ, Maxwell CA, Patnaik R. Adverse reactions to dermal fillers: review. Dermatol Surg. 2005 ; 31: 1616-1625
13. Curcio NM, Parish LC. Injectable fillers: an American perspective. G Ital Dermatol Venereol. 2009 ; 144: 271-279
14. Ellis DA, Segall L. Review of non-FDA-approved fillers. Facial Plast Surg Clin North Am. 2007 ; 15: 239 vii - 246
15. Kontis TC, Rivkin A. The history of injectable facial fillers. Facial Plast Surg. 2009 ; 25: 67-72
16. Wesley NO, Dover JS. The filler revolution: a six-year retrospective. J Drugs Dermatol. 2009 ; 8: 903-907
17. Rivkin A. New fillers under consideration: what is the future of injectable aesthetics?. Facial Plast Surg. 2009 ; 25: 120-123
18. Goldberg DJ. Breakthroughs in US dermal fillers for facial soft-tissue augmentation. J Cosmet Laser Ther. 2009 ; 11: 240-247
19. Smith KC, Reversible vs. nonreversible fillers in facial aesthetics: concerns and considerations. Dermatol Online J. 2008 ; 14: 3
20. Park TH, Seo SW, Kim JK, et al. Clinical experience with hyaluronic acid-filler complications. J Plast Reconstr Aesthetic Surg. 2011 ; 64: 892-896
21. Menon H, Thomas M, D'Silva J. Low dose of hyaluronidase to treat over correction by HA filler - a case report. J Plast Reconstr Aesthetic Surg. 2010 ; 63: e416 - e417
22. Rzany B, Becker-Wegerich P, Bachmann F, et al. Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use. J Cosmet Dermatol. 2009 ; 8: 317-323
23. Hirsch RJ, Brody HJ, Carruthers JD. Hyaluronidase in the office: a necessity for every dermasurgeon that injects hyaluronic acid. J Cosmet Laser Ther. 2007 ; 9: 182-185
24. Pierre A, Levy PM. Hyaluronidase offers an efficacious treatment for inaesthetic hyaluronic acid overcorrection. J Cosmet Dermatol. 2007 ; 6: 159-162
25. Brody HJ. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement. Dermatol Surg. 2005 ; 31: 893-897
26. Lambros V. The use of hyaluronidase to reverse the effects of hyaluronic acid filler. Plast Reconstr Surg. 2004 ; 114: 277
27. Soparkar CN, Patrinely JR, Tschen J. Erasing Restylane. Ophthal Plast Reconstr Surg. 2004 ; 20: 317-318
28. Park TH, Seo SW, Kim JK, et al. Clinical outcome in a series of 173 cases of foreign body granuloma: improved outcomes with a novel surgical technique. J Plast Reconstr Aesthetic Surg. 2012 ; 65: 29-34
29. Park TH, Seo SW, Kim JK, et al. Clinical experience with polymethylmethacrylate microsphere filler complications. Aesthetic Plast Surg. 2012 ; 36: 421-426
30. Lemperle G, Gauthier-Hazan N. Foreign body granulomas after all injectable dermal fillers: part 2. Treatment options. Plast Reconstr Surg. 2009 ; 123: 1864-1873
31. Stewart DB, Morganroth GS, Mooney MA, et al. Management of visible granulomas following periorbital injection of poly-L-lactic acid. Ophthal Plast Reconstr Surg. 2007 ; 23: 298-301
32. Lemperle G, Rullan PP, Gauthier-Hazan N. Avoiding and treating dermal filler complications. Plast Reconstr Surg. 2006 ; 118: 92S - 107S
33. Nicolau PJ. Long-lasting and permanent fillers: biomaterial influence over host tissue response. Plast Reconstr Surg. 2007 ; 119: 2271-2286
34. Rohrich RJ, Monheit G, Nguyen AT, et al. Soft-tissue filler complications: the important role of biofilms. Plast Reconstr Surg. 2010 ; 125: 1250-1256
35. Narins RS, Coleman WP, Glogau RG. Recommendations and treatment options for nodules and other filler complications. Dermatol Surg. 2009 ; 35: 1667-1671
36. Christensen LH. Host tissue interaction, fate, and risks of degradable and nondegradable gel fillers. Dermatol Surg. 2009 ; 35: 1612-1619
37. Bjarnsholt T, Tolker-Nielsen T, Givskov M, et al. Detection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesions. Dermatol Surg. 2009 ; 35: 1620-1624
38. Bentkover SH. The biology of facial fillers. Facial Plast Surg. 2009 ; 25: 73-85
39. Christensen L. Normal and pathologic tissue reactions to soft tissue gel fillers. Dermatol Surg. 2007 ; 33: S168 - S175
40. Bachmann F, Erdmann R, Hartmann V, et al. Adverse reactions caused by consecutive injections of different fillers in the same facial region: risk assessment based on the results from the Injectable Filler Safety study. J Eur Acad Dermatol Venereol. 2011 ; 25: 902-912
41. Lemperle G, Hazan-Gauthier N, Lemperle M. PMMA microspheres (Artecoll) for skin and soft-tissue augmentation, part II: clinical investigations. Plast Reconstr Surg. 1995 ; 96: 627-634
42. Laeschke K. Biocompatibility of microparticles into soft tissue fillers. Semin Cutan Med Surg. 2004 ; 23: 214-217
43. Meyer K. The biological significance of hyaluronic acid and hyaluronidase. Physiol Rev. 1947 ; 27: 335-359
44. Atkinson WS. Use of hyaluronidase with local anesthesia in ophthalmology: preliminary report. Arch Ophthal. 1949 ; 42: 628-633
45. Hechter O, Dopkeen SK, Yudell MH. The clinical use of hyaluronidase in hypodermoclysis. J Pediatr. 1947 ; 30: 645-656
46. Greenberg BE, Gargill SL. The relation of hyaluronidase in the seminal fluid to fertility. Hum Fertil. 1946 ; 11: 1
47. Kurzrok R. Hyaluronidase; an enzyme essential for human fertility. Manitoba Med Rev. 1948 ; 28: 216
48. Riisfeldt O. Studies on hyaluronidase in semen from men in sterile and fertile marriages. Ann Ostet Ginecol. 1951 ; 73: 853-871
49. Jadin L, Bookbinder LH, Frost GI. A comprehensive model of hyaluronan turnover in the mouse. Matrix Biol. 2012 ; 31: 81-89
50. Hofinger ES, Hoechstetter J, Oettl M, et al. Isoenzyme-specific differences in the degradation of hyaluronic acid by mammalian-type hyaluronidases. Glycoconj J. 2008 ; 25: 101-109
51. Delaere L, Zeyen T, Foets B, et al. Allergic reaction to hyaluronidase after retrobulbar anaesthesia: a case series and review. Int Ophthalmol. 2009 ; 29: 521-528
52. Leibovitch I, Tamblyn D, Casson R, et al. Allergic reaction to hyaluronidase: a rare cause of orbital inflammation after cataract surgery. Graefes Arch Clin Exp Ophthalmol. 2006 ; 244: 944-949
53. Patil B, Agius-Fernandez A, Worstmann T. Hyaluronidase allergy after peribulbar anesthesia with orbital inflammation. J Cataract Refract Surg. 2005 ; 31: 1480-1481
54. Escolano F, Pares N, Gonzalez I, et al. Allergic reaction to hyaluronidase in cataract surgery. Eur J Anaesthesiol. 2005 ; 22: 729-730
55. Quhill F, Bowling B, Packard RB. Hyaluronidase allergy after peribulbar anesthesia with orbital inflammation. J Cataract Refract Surg. 2004 ; 30: 916-917
56. Eberhart AH, Weiler CR, Erie JC. Angioedema related to the use of hyaluronidase in cataract surgery. Am J Ophthalmol. 2004 ; 138: 142-143
57. Nicholson G, Hall GM. Allergic reaction to hyaluronidase after a peribulbar injection. Anaesthesia. 2003 ; 58: 814-815
58. Ahluwalia HS, Lukaris A, Lane CM. Delayed allergic reaction to hyaluronidase: a rare sequel to cataract surgery. Eye. 2003 ; 17: 263-266
59. Agrawal A, McLure HA, Dabbs TR. Allergic reaction to hyaluronidase after a peribulbar injection. Anaesthesia. 2003 ; 58: 493-494
60. Kirby B, Butt A, Morrison AM, et al. Type I allergic reaction to hyaluronidase during ophthalmic surgery. Contact Dermatitis. 2001 ; 44: 52
61. Minning CA. Hyaluronidase allergy simulating expulsive choroidal hemorrhage. Arch Ophthalmol. 1994 ; 112: 585-586
62. Sakamoto K, Nagai H, Koda A. Role of hyaluronidase in immediate hypersensitivity reaction. Immunopharmacology. 1980 ; 2: 139-146
63. Richter G, Richter W. The risk of intravenous treatment with hyaluronidase from a dermatological viewpoint [in German]. Dermatol Monatschr. 1975 ; 161: 952-955
64. McEwen LM, Starr MS. Enzyme-potentiated hyposensitisation, I: the effect of pre-treatment with -glucuronidase, hyaluronidase, and antigen on anaphylactic sensitivity of guinea-pigs, rats and mice. Int Arch Allergy Appl Immunol. 1972 ; 42: 152-158
65. Kind LS, Roffler S. Allergic reactions to hyaluronidase. Proc Soc Exp Biol Med. 1961 ; 106: 734-735
66. Ebo DG, Goossens S, Opsomer F, et al. Flow-assisted diagnosis of anaphylaxis to hyaluronidase. Allergy. 2005 ; 60: 1333-1334
67. Muller U, Bircher A, Bischof M. Allergic angioedema after local dental anesthesia and a hyaluronidase-containing preanesthetic injection solution [in German]. Schweiz Med Wochenschr. 1986 ; 116: 1810-1813
68. Lee HK, Choi EJ, Lee PB, et al. Anaphylactic shock caused by the epidurally-administered hyalurinidase. Korean J Pain. 2011 ; 24: 221-225
69. Morley AM, Malhotra R. Use of hyaluronic acid filler for tear-trough rejuvenation as an alternative to lower eyelid surgery. Ophthal Plast Reconstr Surg. 2011 ; 27: 69-73
70. Van Dyke S, Hays GP, Caglia AE, et al. Severe acute local reactions to a hyaluronic acid-derived dermal filler. J Clin Aesthetic Dermatol. 2010 ; 3: 32-35
71. Skeie L, Bugge H, Negaard A, et al. Large particle hyaluronic acid for the treatment of facial lipoatrophy in HIV-positive patients: 3-year follow-up study. HIV Med. 2010 ; 11: 170-177
72. Menon H, Thomas M, D'Silva J. Low dose of hyaluronidase to treat over correction by HA filler - a case report. J Plast Reconstr Aesthetic Surg. 2010 ; 63: e416 - e417
73. Volpi N, Schiller J, Stern R, et al. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem. 2009 ; 16: 1718-1745
74. Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009 ; 35: 1672-1680
75. Grunebaum LD, Bogdan Allemann I, Dayan S, et al. The risk of alar necrosis associated with dermal filler injection. Dermatol Surg. 2009 ; 35: 1635-1640
76. Goldman MP. Pressure-induced migration of a permanent soft tissue filler. Dermatol Surg. 2009 ; 35: 403 405-405 406
77. Cox SE. Clinical experience with filler complications. Dermatol Surg. 2009 ; 35: 1661-1666
78. Hirsch RJ, Brody HJ, Carruthers JD. Hyaluronidase in the office: a necessity for every dermasurgeon that injects hyaluronic acid. J Cosmet Laser Ther. 2007 ; 9: 182-185
79. Goldberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections. Ophthal Plast Reconstr Surg. 2006 ; 22: 335 341-341 343
80. Glaich AS, Cohen JL, Goldberg LH. Injection necrosis of the glabella: protocol for prevention and treatment after use of dermal fillers. Dermatol Surg. 2006 ; 32: 276-281
81. Hirsch RJ, Carruthers JD, Carruthers A. Infraorbital hollow treatment by dermal fillers. Dermatol Surg. 2007 ; 33: 1116-1119
82. Morris CL, Stinnett SS, Woodward JA. Patient-preferred sites of Restylane injection in periocular and facial soft-tissue augmentation. Ophthal Plast Reconstr Surg. 2008 ; 24: 117-121
83. Pessa JE, Zadoo VP, Adrian EK, et al. Anatomy of a "black eye": a newly described fascial system of the lower eyelid. Clin Anat. 1998 ; 11: 157-161
84. Pessa JE, Garza JR. The malar septum: the anatomic basis of malar mounds and malar edema. Aesthetic Surg J. 1997 ; 17: 11-17
85. Funt DK. Avoiding malar edema during midface/cheek augmentation with dermal fillers. J Clin Aesthetic Dermatol. 2011 ; 4: 32-36
86. Zhang H, Liu C, Peng C, et al. Blending of the eyelid-cheek junction and removal of protruding fat: an intraoral approach to blepharoplasty of the lower eyelid. Br J Oral Maxillofac Surg. 2009 ; 47: 541-544
87. Hwang SH, Hwang K, Jin S, et al. Location and nature of retro-orbicularis oculus fat and suborbicularis oculi fat. J Craniofac Surg. 2007 ; 18: 387-390
88. Yousif NJ, Sonderman P, Dzwierzynski WW, et al. Anatomic considerations in transconjunctival blepharoplasty. Plast Reconstr Surg. 1995 ; 96: 1271 1277-1276 1278
89. Ilankovan V. Transconjunctival approach to the infraorbital region: a cadaveric and clinical study. Br J Oral Maxillofac Surg. 1991 ; 29: 169-172
90. Laurent TC, Fraser JR. Hyaluronan. Faseb J. 1992 ; 6: 2397-2404
91. Brandt FS, Cazzaniga A. Hyaluronic acid gel fillers in the management of facial aging. Clin Interv Aging. 2008 ; 3: 153-159
92. Douse-Dean T, Jacob CI. Fast and easy treatment for reduction of the Tyndall effect secondary to cosmetic use of hyaluronic acid. J Drugs Dermatol. 2008 ; 7: 281-283
93. Fezza JP. Nonsurgical treatment of cicatricial ectropion with hyaluronic acid filler. Plast Reconstr Surg. 2008 ; 121: 1009-1014
94. Hirsch RJ, Narurkar V, Carruthers J. Management of injected hyaluronic acid induced Tyndall effects. Lasers Surg Med. 2006 ; 38: 202-204
95. Alijotas-Reig J, Garcia-Gimenez V. Delayed immune-mediated adverse effects related to hyaluronic acid and acrylic hydrogel dermal fillers: clinical findings, long-term follow-up and review of the literature. J Eur Acad Dermatol Venereol. 2008 ; 22: 150-161
96. Bachmann F, Erdmann R, Hartmann V, et al. The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study. Dermatol Surg. 2009 ; 35: 1629-1634
97. Bergeret-Galley C, Latouche X, Illouz YG. The value of a new filler material in corrective and cosmetic surgery: DermaLive and DermaDeep. Aesthetic Plast Surg. 2001 ; 25: 249-255
98. Braun M, Braun S. Nodule formation following lip augmentation using porcine collagen-derived filler. J Drugs Dermatol. 2008 ; 7: 579-581
99. Christensen L, Breiting V, Janssen M, et al. Adverse reactions to injectable soft tissue permanent fillers. Aesthetic Plast Surg. 2005 ; 29: 34-48
100. Massone C, Horn M, Kerl H, et al. Foreign body granuloma due to Matridex injection for cosmetic purposes. Am J Dermatopathol. 2009 ; 31: 197-199
101. Rossner M, Rossner F, Bachmann F, et al. Risk of severe adverse reactions to an injectable filler based on a fixed combination of hydroxyethylmethacrylate and ethylmethacrylate with hyaluronic acid. Dermatol Surg. 2009 ; 35: 367-374
102. Wiest LG, Stolz W, Schroeder JA. Electron microscopic documentation of late changes in permanent fillers and clinical management of granulomas in affected patients. Dermatol Surg. 2009 ; 35: 1681-1688
103. Zielke H, Wolber L, Wiest L, et al. Risk profiles of different injectable fillers: results from the Injectable Filler Safety Study (IFS Study). Dermatol Surg. 2008 ; 34: 326 335-335
104. Alam M, Yoo SS. Technique for calcium hydroxylapatite injection for correction of nasolabial fold depressions. J Am Acad Dermatol. 2007 ; 56: 285-289
105. Alcalay J, Alkalay R, Gat A, et al. Late-onset granulomatous reaction to Artecoll. Dermatol Surg. 2003 ; 29: 859-862
106. Alijotas-Reig J, Garcia-Gimenez V, Miro-Mur F, et al. Delayed immune-mediated adverse effects of polyalkylimide dermal fillers: clinical findings and long-term follow-up. Arch Dermatol. 2008 ; 144: 637-642
107. Alijotas-Reig J, Garcia-Gimenez V, Miro-Mur F, et al. Delayed immune-mediated adverse effects related to polyacrylamide dermal fillers: clinical findings, management, and follow-up. Dermatol Surg. 2009 ; 35: 360-366
108. Alijotas-Reig J, Garcia-Gimenez V, Vilardell-Tarres M. Late-onset immune-mediated adverse effects after poly-L-lactic acid injection in non-HIV patients: clinical findings and long-term follow-up. Dermatology. 2009 ; 219: 303-308
109. Amin SP, Marmur ES, Goldberg DJ. Complications from injectable polyacrylamide gel, a new nonbiodegradable soft tissue filler. Dermatol Surg. 2004 ; 30: 1507-1509
110. Anwar MU, Sharpe DT. Skin nodules after semipermanent cosmetic dermal filler. Aesthetic Plast Surg. 2007 ; 31: 401-402
111. Bass LS, Smith S, Busso M, et al. Calcium hydroxylapatite (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy results. Aesthetic Surg J. 2010 ; 30: 235-238
112. Belmontesi M, Grover R, Verpaele A. Transdermal injection of Restylane SubQ for aesthetic contouring of the cheeks, chin, and mandible. Aesthetic Surgery J. 2006 ; 26: S28 - S34
113. Burgess CM, Quiroga RM. Assessment of the safety and efficacy of poly-L-lactic acid for the treatment of HIV-associated facial lipoatrophy. J Am Acad Dermatol. 2005 ; 52: 233-239
114. Cosatti M, Fernandez Romero DS, Juri MC, et al. Facial angioedema after filler injections: description of five cases [in Spanish]. Medicina. 2010 ; 70: 513-517
115. Heinz BC, Ladhoff U, Kahl C, et al. Survey of incidents associated with injectable dermal fillers reported to the German Medical Devices Vigilance System [in German]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2008 ; 51: 787-792
116. Jansen DA, Graivier MH. Evaluation of a calcium hydroxylapatite-based implant (Radiesse) for facial soft-tissue augmentation. Plast Reconstr Surg. 2006 ; 118: 22S 31S - 30S 33S
117. Lemperle G, Gauthier-Hazan N, Wolters M. [Complications after dermal fillers and their treatment [in German]. Handchir Mikrochir Plast Chir. 2006 ; 38: 354-369
118. Moscona RA, Fodor L. A retrospective study on liquid injectable silicone for lip augmentation: long-term results and patient satisfaction. J Plast Reconstr Aesthetic Surg. 2010 ; 63: 1694-1698
119. Narins RS. Minimizing adverse events associated with poly-L-lactic acid injection. Dermatol Surg. 2008 ; 34: S100 - S104
120. Ross AH, Malhotra R. Long-term orbitofacial complications of polyalkylimide 4% (bio-alcamid). Ophthal Plast Reconstr Surg. 2009 ; 25: 394-397
121. Rossner F, Rossner M, Hartmann V, et al. Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety study. J Cosmet Dermatol. 2009 ; 8: 14-18
122. Sadick NS, Katz BE, Roy D. A multicenter, 47-month study of safety and efficacy of calcium hydroxylapatite for soft tissue augmentation of nasolabial folds and other areas of the face. Dermatol Surg. 2007 ; 33: S122 S126-126 S127
123. Schwartzfarb EM, Hametti JM, Romanelli P, et al. Foreign body granuloma formation secondary to silicone injection. Dermatol Online J. 2008 ; 14: 20
124. Thyssen JP, Christensen LH, Zachariae CO. Cosmetic soft-tissue augmentation treatment [in Danish]. Ugesk Laeger. 2007 ; 169: 2198-2201
125. Tzikas TL. Evaluation of the Radiance FN soft tissue filler for facial soft tissue augmentation. Arch Facial Plast Surg. 2004 ; 6: 234-239
126. Wang YB, Huang JJ, Qiao Q, et al. Clinically analyzing the possible side-effects after injecting hydrophilic polyacrylamide gel as a soft-tissue filler in Chinese]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2003 ; 19: 328-330
127. Wiest LG. History and use of fillers for treating wrinkles [in German]. Hautarzt. 2007 ; 58: 224-231
128. Cassuto D, Marangoni O, De Santis G, et al. Advanced laser techniques for filler-induced complications. Dermatol Surg. 2009 ; 35: 1689-1695
129. Cohen JL. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg. 2008 ; 34: S92 - S99
130. Laube S. Skin infections and ageing. Ageing Res Rev. 2004 ; 3: 69-89
131. Diaz LA, Giudice GJ. End of the century overview of skin blisters. Arch Dermatol. 2000 ; 136: 106-112
132. Oranje AP, Folkers E, Choufoer-Habova J, et al. Diagnostic value of Tzanck smear in herpetic and non-herpetic vesicular and bullous skin disorders in pediatric practice. Acta Derm Venereol. 1986 ; 66: 127-133
133. Klastersky J. Infections in immunocompromised patients, I: pathogenesis, etiology, and diagnosis. Clin Ther. 1985 ; 8: 90-99
134. Sadashivaiah AB, Mysore V. Biofilms: their role in dermal fillers. J Cutan Aesthetic Surg. 2010 ; 3: 20-22
135. Wilson M. Bacterial biofilms and human disease. Sci Progress. 2001 ; 84: 235-254
136. Costerton JW, Montanaro L, Arciola CR. Biofilm in implant infections: its production and regulation. Int J Artif Organs. 2005 ; 28: 1062-1068
137. Wadstrom T. Molecular aspects of bacterial adhesion, colonization, and development of infections associated with biomaterials. J Invest Surg. 1989 ; 2: 353-360
138. Ramage G, Culshaw S, Jones B, et al. Are we any closer to beating the biofilm: novel methods of biofilm control. Curr Opin Infect Dis. 2010 ; 23: 560-566
139. McCann MT, Gilmore BF, Gorman SP. Staphylococcus epidermidis device-related infections: pathogenesis and clinical management. J Pharm Pharmacol. 2008 ; 60: 1551-1571
140. Uckay I, Pittet D, Vaudaux P, et al. Foreign body infections due to Staphylococcus epidermidis. Ann Med. 2009 ; 41: 109-119
141. Miclau T, Schmidt AH, Wenke JC, et al. Infection. J Orthop Trauma. 2010 ; 24: 583-586
142. Rossi C, Thys JP. Prosthesis-related infections [in French]. Rev Med Brux. 2000 ; 21: 143-148
143. El-Shafey el SI. Complications from repeated injection or puncture of old polyacrylamide gel implant sites: case reports. Aesthetic Plast Surg. 2008 ; 32: 162-165
144. Gallo J, Kolar M, Novotny R, et al. Pathogenesis of prosthesis-related infection. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 ; 147: 27-35
145. Costerton JW. Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res. 2005 ; (437). 7-11
146. Winkler H. Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft. Int J Med Sci. 2009 ; 6: 247-252
147. Marusza W, Mlynarczyk G, Olszanski R, et al. Probable biofilm formation in the cheek as a complication of soft tissue filler resulting from improper endodontic treatment of tooth 16. Int J Nanomed. 2012 ; 7: 1441-1447
148. Dayan SH, Arkins JP, Brindise R. Soft tissue fillers and biofilms. Facial Plast Surg. 2011 ; 27: 23-28
149. Hassid VJ. Soft-tissue filler complications: the important role of biofilms. Plast Reconstr Surg. 2010 ; 126: 1801 1802-1802
150. Crosby CT, Tsj E, Lambert PA, et al. Preoperative skin preparation: a historical perspective. Br J Hosp Med (Lond). 2009 ; 70: 579-582
151. Yokoe DS, Mermel LA, Anderson DJ, et al. A compendium of strategies to prevent healthcare-associated infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008 ; 29: S12 - S21
152. Pratt RJ, O'Malley B. Supporting evidence-based infection prevention and control practice in the National Health Service in England. The NHS/TVU/Intuition Approach. J Hosp Infect. 2007 ; 65: 142-147
153. Pratt RJ, Pellowe CM, Wilson JA, et al. epic2: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect. 2007 ; 65: S1 - S64
154. Inwood S. Skin antisepsis: using 2% chlorhexidine gluconate in 70% isopropyl alcohol. Br J Nurs. 2007 ; 16 1390: 1392-1394
155. Caldellas AV, de Castro CC, Aboudib JH, et al. The polymethylmethacrylate effects on auricle conchal cartilage: report of 21 cases. Aesthetic Surg J. 2010 ; 30: 434-438
156. Fischer J, Metzler G, Schaller M. Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies. Arch Dermatol. 2007 ; 143: 507-510
157. Judodihardjo H, Dykes P. Objective and subjective measurements of cutaneous inflammation after a novel hyaluronic acid injection. Dermatol Surg. 2008 ; 34: S110 - S114
158. Winslow CP. The management of dermal filler complications. Facial Plast Surg. 2009 ; 25: 124-128
159. ChildsD.Boosting butts with cement, Fix-A-Flat, leads to arrest. http://abcnews.go.com/blogs/health/2011/11/18/man-arrested-for-boosting-butts- with-cement-fix-a-flat/. Accessed March 25, 2013.
160. Crimesider staff alleged "Fix-a-Flat" fake surgeon Oneal Ron Morris arrested again after more victims come forward. http://www.cbsnews.com/ 8301-504083-162-57397200-504083/alleged-fix-a-flat-fake-surgeon-oneal-ron- morris-arrested-again-after-more-victims-come-forward/. Accessed March 25, 2013
161. Florida Department of Health Press Release. Florida Department of Health's joint efforts result in felony arrest-partnered investigation highlights department's unlicensed activity unit, July27, 2012. http://newsroom.doh.state.fl.us/wp-content/uploads/newsroom/2011/08/72712Brwrd. pdf. Accessed March 25, 2013
162. Sachdev M, Anantheswar Y, Ashok B, et al. Facial granulomas secondary to injection of semi-permanent cosmetic dermal filler containing acrylic hydrogel particles. J Cutan Aesthetic Surg. 2010 ; 3: 162-166
163. Planas J. The use of Integra in rhinoplasty. Aesthetic Plast Surg. 2010 ; 35: 5-12
164. Manafi A, Emami AH, Pooli AH, et al. Unacceptable results with an accepted soft tissue filler: polyacrylamide hydrogel. Aesthetic Plast Surg. 2010 ; 34: 413-422
165. Sneistrup C, Holmich LR, Dahlstrom K. Long-term complications after injection of permanent tissue-fillers to the lips [in Danish]. Ugeskr Laeger. 2009 1414 ; 171 :
166. Shaeer O, Shaeer K. Delayed complications of gel injection for penile girth augmentation. J Sex Med. 2009 ; 6: 2072-2078
167. Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009 ; 35: 1672-1680
168. Schelke LW, van den Elzen HJ, Canninga M, et al. Complications after treatment with polyalkylimide. Dermatol Surg. 2009 ; 35: 1625-1628
169. Sanchis-Bielsa JM, Bagan JV, Poveda R, et al. Foreign body granulomatous reactions to cosmetic fillers: a clinical study of 15 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 ; 108: 237-241
170. Sage RJ, Chaffins ML, Kouba DJ. Granulomatous foreign body reaction to hyaluronic acid: report of a case after melolabial fold augmentation and review of management. Dermatol Surg. 2009 ; 35: 1696-1700
171. Reszko AE, Sadick NS, Magro CM, et al. Late-onset subcutaneous nodules after poly-L-lactic acid injection. Dermatol Surg. 2009 ; 35: 380-384
172. Pons-Guiraud A. Adverse reactions to injectable fillers [in French]. Ann Dermatol Venereol. 2009 ; 136: S293 - S298
173. Monheit GD, Rohrich RJ. The nature of long-term fillers and the risk of complications. Dermatol Surg. 2009 ; 35: 1598-1604
174. Manafi A, Emami AH, Pooli AH, et al. Unacceptable results with an accepted soft tissue filler: polyacrylamide hydrogel. Aesthetic Plast Surg. 2010 ; 34: 413-422
175. Mamelak AJ, Katz TM, Goldberg LH, et al. Foreign body reaction to hyaluronic acid filler injection: in search of an etiology. Dermatol Surg. 2009 ; 35: 1701-1703
176. Lemperle G, Sadick NS, Knapp TR, et al. ArteFill permanent injectable for soft tissue augmentation, II: indications and applications. Aesthetic Plast Surg. 2010 ; 34: 273-286
177. Lemperle G, Gauthier-Hazan N, Wolters M, et al. Foreign body granulomas after all injectable dermal fillers, part 1: possible causes. Plast Reconstr Surg. 2009 ; 123: 1842-1863
178. Humphrey CD, Arkins JP, Dayan SH. Soft tissue fillers in the nose. Aesthetic Surg J. 2009 ; 29: 477-484
179. Furmanczyk PS, Wolgamot GM, Argenyi ZB, et al. Extensive granulomatous reaction occurring 1.5 years after DermaLive injection. Dermatol Surg. 2009 ; 35: 385-388
180. da Costa Miguel MC, Nonaka CF, dos Santos JN, et al. Oral foreign body granuloma: unusual presentation of a rare adverse reaction to permanent injectable cosmetic filler. Int J Oral Maxillofac Surg. 2009 ; 38: 385-387
181. Beer K. Clinicopathologic correlation of delayed-onset periorbital poly-L-lactic acid nodules. Dermatol Surg. 2009 ; 35: 399-402
182. Beer K. Delayed onset nodules from liquid injectable silicone: report of a case, evaluation of associated histopathology and results of treatment with minocycline and celocoxib. J Drugs Dermatol. 2009 ; 8: 952-954
183. Altmeyer MD, Anderson LL, Wang AR. Silicone migration and granuloma formation. J Cosmet Dermatol. 2009 ; 8: 92-97
184. Thioly-Bensoussan D. Non-hyaluronic acid fillers. Clin Dermatol. 2008 ; 26: 160-176
185. Salles AG, Lotierzo PH, Gemperli R, et al. Complications after polymethylmethacrylate injections: report of 32 cases. Plast Reconstr Surg. 2008 ; 121: 1811-1820
186. Rongioletti F. Granulomatous reactions from aesthetic dermal micro-implants [in French]. Ann Dermatol Venereol. 2008 ; 135: 1S59-1S65
187. Pons-Guiraud A. Adverse reactions to injectable fillers [in French]. Ann Dermatol Venereol. 2008 ; 135: S171 - S174
188. Hirsch RJ, Stier M. Complications of soft tissue augmentation. J Drugs Dermatol. 2008 ; 7: 841-845
189. Gonzalez-Vela MC, Armesto S, Gonzalez-Lopez MA, et al. Perioral granulomatous reaction to Dermalive. Dermatol Surg. 2008 ; 34: 986-988
190. Fitzgerald R, Vleggaar D, Burgess C. Facial dermal fillers. Aesthetic Surg J. 2008 ; 28: 699 701-701
191. Dayan SH, Bassichis BA. Facial dermal fillers: selection of appropriate products and techniques. Aesthetic Surg J. 2008 ; 28: 335-347
192. Anastassov GE, Schulhof S, Lumerman H. Complications after facial contour augmentation with injectable silicone: diagnosis and treatment. Report of a severe case. Int J Oral Maxillofac Surg. 2008 ; 37: 955-960
193. Mustacchio V, Cabibi D, Minervini MI, et al. A diagnostic trap for the dermatopathologist: granulomatous reactions from cutaneous microimplants for cosmetic purposes. J Cutan Pathol. 2007 ; 34: 281-283
194. Edwards PC, Fantasia JE. Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers. Clin Interv Aging. 2007 ; 2: 509-519
195. Chasan PE. The history of injectable silicone fluids for soft-tissue augmentation. Plast Reconstr Surg. 2007 ; 120: 2034 2041-2040 2043
196. Bardazzi F, Ruffato A, Antonucci A, et al. Cutaneous granulomatous reaction to injectable hyaluronic acid gel: another case. J Dermatol Treat. 2007 ; 18: 59-62
197. Baijens L, Speyer R, Linssen M, et al. Rejection of injectable silicone "Bioplastique" used for vocal fold augmentation. Eur Arch Otorhinolaryngol. 2007 ; 264: 565-568
198. Al-Shraim M, Jaragh M, Geddie W. Granulomatous reaction to injectable hyaluronic acid (Restylane) diagnosed by fine needle biopsy. J Clin Pathol. 2007 ; 60: 1060-1061
199. Wolfram D, Tzankov A, Piza-Katzer H. Surgery for foreign body reactions due to injectable fillers. Dermatology. 2006 ; 213: 300-304
200. Vargas-Machuca I, Gonzalez-Guerra E, Angulo J, et al. Facial granulomas secondary to Dermalive microimplants: report of a case with histopathologic differential diagnosis among the granulomas secondary to different injectable permanent filler materials. Am J Dermatopathol. 2006 ; 28: 173-177
201. Sidwell RU, McL Johnson N, Francis N, et al. Cutaneous sarcoidal granulomas developing after Artecoll facial cosmetic filler in a patient with newly diagnosed systemic sarcoidosis. Clin Exp Dermatol. 2006 ; 31: 208-211
202. Poveda R, Bagan JV, Murillo J, et al. Granulomatous facial reaction to injected cosmetic fillers - a presentation of five cases [in English, Spanish]. Med Oral Patol Oral Cir Bucal. 2006 ; 11: E1 - E5
203. Lemperle G, de Fazio S, Nicolau P. ArteFill: a third- generation permanent dermal filler and tissue stimulator. Clin Plast Surg. 2006 ; 33: 551-565
204. Kopera D. Permanent filler augmentation: common complications. Arch Dermatol. 2006 1508 ; 142 :
205. Ghislanzoni M, Bianchi F, Barbareschi M, et al. Cutaneous granulomatous reaction to injectable hyaluronic acid gel. Br J Dermatol. 2006 ; 154: 755-758
206. Edwards PC, Fantasia JE, Iovino R. Foreign body reaction to hyaluronic acid (Restylane): an adverse outcome of lip augmentation. J Oral Maxillofac Surg. 2006 1299 ; 64: 1296-1299
207. Coleman SR. Cross-linked hyaluronic acid fillers. Plast Reconstr Surg. 2006 ; 117: 661-665
208. Bauer U, Vleggaar D. Response to "New-fill injections may induce late-onset foreign body granulomatous reaction.". Plast Reconstr Surg. 2006 ; 118: 265 265-266
209. Angus JE, Affleck AG, Leach IH, et al. Two cases of delayed granulomatous reactions to the cosmetic filler Dermalive, a hyaluronic acid and acrylic hydrogel. Br J Dermatol. 2006 ; 155: 1077-1078
210. Soparkar CN, Patrinely JR. Managing inflammatory reaction to restylane. Ophthal Plast Reconstr Surg. 2005 ; 21: 151-153
211. Pinheiro MV, Bagatin E, Hassun KM, et al. Adverse effect of soft tissue augmentation with hyaluronic acid. J Cosmet Dermatol. 2005 ; 4: 184-186
212. Parada MB, Michalany NS, Hassun KM, et al. A histologic study of adverse effects of different cosmetic skin fillers. Skinmed. 2005 ; 4: 345-349
213. Lloret P, Espana A, Leache A, et al. Successful treatment of granulomatous reactions secondary to injection of esthetic implants. Dermatol Surg. 2005 ; 31: 486-490
214. Fulton JE, Porumb S, Caruso JC, et al. Lip augmentation with liquid silicone. Dermatol Surg. 2005 ; 31: 1577 1586-1585
215. Duffy DM. Complications of fillers: overview. Dermatol Surg. 2005 ; 31: 1626-1633
216. Dijkema SJ, van der Lei B, Kibbelaar RE. New-fill injections may induce late-onset foreign body granulomatous reaction. Plast Reconstr Surg. 2005 ; 115: 76e - 78e
217. Dal Sacco D, Cozzani E, Parodi A, et al. Scar sarcoidosis after hyaluronic acid injection. Int J Dermatol. 2005 ; 44: 411-412
218. Carruthers A, Carruthers JD. Polymethylmethacrylate microspheres/collagen as a tissue augmenting agent: personal experience over 5 years. Dermatol Surg. 2005 ; 31: 1561 1565-1564
219. Beljaards RC, de Roos KP, Bruins FG. NewFill for skin augmentation: a new filler or failure?. Dermatol Surg. 2005 ; 31: 772 776-776
220. Andre P, Lowe NJ, Parc A, et al. Adverse reactions to dermal fillers: a review of European experiences. J Cosmet Laser Ther. 2005 ; 7: 171-176
221. Zimmermann US, Clerici TJ. The histological aspects of fillers complications. Semin Cutan Med Surg. 2004 ; 23: 241-250
222. Vochelle D. The use of poly-L-lactic acid in the management of soft-tissue augmentation: a five-year experience. Semin Cutan Med Surg. 2004 ; 23: 223-226
223. Sidwell RU, Dhillon AP, Butler PE, et al. Localized granulomatous reaction to a semi-permanent hyaluronic acid and acrylic hydrogel cosmetic filler. Clin Exp Dermatol. 2004 ; 29: 630-632
224. Patrick T. Polyacrylamide gel in cosmetic procedures: experience with Aquamid. Semin Cutan Med Surg. 2004 ; 23: 233-235
225. Lombardi T, Samson J, Plantier F, et al. Orofacial granulomas after injection of cosmetic fillers: histopathologic and clinical study of 11 cases. J Oral Pathol Med. 2004 ; 33: 115-120
226. Haneke E. Polymethyl methacrylate microspheres in collagen. Semin Cutan Med Surg. 2004 ; 23: 227-232
227. De Boulle K. Management of complications after implantation of fillers. J Cosmet Dermatol. 2004 ; 3: 2-15
228. Bui P, Pons-Guiraud A, Kuffer R, et al. Slowly absorbable and non absorbable injectable products [in French]. Ann Chir Plast Esthet. 2004 ; 49: 486-502
229. Bedir S, Kilciler M, Ozgok Y, et al. Long-term complication due to dextranomer based implant: granuloma causing urinary obstruction. J Urol. 2004 ; 172: 247-248
230. Lemperle G, Morhenn V, Charrier U. Human histology and persistence of various injectable filler substances for soft tissue augmentation. Aesthetic Plast Surg. 2003 ; 27: 354 367-366
231. Honig JF, Brink U, Korabiowska M. Severe granulomatous allergic tissue reaction after hyaluronic acid injection in the treatment of facial lines and its surgical correction. J Craniofac Surg. 2003 ; 14: 197-200
232. Fernandez-Acenero MJ, Zamora E, Borbujo J. Granulomatous foreign body reaction against hyaluronic acid: report of a case after lip augmentation. Dermatol Surg. 2003 ; 29: 1225-1226
233. Christensen LH, Breiting VB, Aasted A, et al. Long-term effects of polyacrylamide hydrogel on human breast tissue. Plast Reconstr Surg. 2003 ; 111: 1883-1890
234. Friedman PM, Mafong EA, Kauvar AN, et al. Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg. 2002 ; 28: 491-494
235. Requena C, Izquierdo MJ, Navarro M, et al. Adverse reactions to injectable aesthetic microimplants. Am J Dermatopathol. 2001 ; 23: 197-202
236. Teuber SS, Reilly DA, Howell L, et al. Severe migratory granulomatous reactions to silicone gel in 3 patients. J Rheumatol. 1999 ; 26: 699-704